Partial vascular wall injury device for animal model construction

Abstract

The utility model relates to a partial vascular wall injury device for animal model construction, which comprises a device seat provided with a middle vascular clamp, and a left vascular clamp and a right vascular clamp which are positioned on the left side and the right side of the middle vascular clamp, each of the left vascular clamp, the right vascular clamp and the middle vascular clamp comprises an upper clamping arm and a lower clamping arm which can relatively move under the action of elastic force to clamp a corresponding blood vessel, and the two clamping arms of the middle vascular clamp are both of a hollow structure and are provided with clamping parts made of a heat conduction material; scale marks are marked on the clamping face and the corresponding side face of the clamping part so as to mark the position of the clamping part and adjust the injury position, and the partial blood vessel wall injury device further comprises a liquid injection device used for introducing temperature liquid into inner cavities of the two clamping arms of the middle blood vessel clamp. The utility model provides the partial blood vessel wall injury device for constructing the animal model, which can be used for performing different-temperature injury on a blood vessel with a certain length.

Description

Technical Field

[0001] This utility model relates to the field of experimental instruments, and in particular to a device for partially damaging blood vessel walls in animal model construction. Background Technology

[0002] Animal models play an important role in biomedical research, not only helping to understand the mechanisms of diseases, but also being used to test the efficacy of new drugs and novel treatment strategies.

[0003] When creating animal blood vessel models, a controllable blood vessel damage device is needed to precisely control the degree of damage to the blood vessels. Currently, there is a lack of devices that can accurately and repeatedly damage a portion of the blood vessel. Some instruments cause damage to the blood vessel by excessively dilating the blood vessel or injecting irritating liquids into the blood vessel. However, this method will damage the entire blood vessel wall of that segment of the blood vessel and cannot meet all experimental requirements. Utility Model Content

[0004] The purpose of this invention is to provide a partial blood vessel wall damage device for constructing animal models that can cause damage at different temperatures to a certain length of blood vessel.

[0005] To solve the above-mentioned technical problems, the technical solution of the partial blood vessel wall injury device for animal model construction in this utility model is as follows:

[0006] A partial vascular wall injury device for constructing an animal model includes a device base, on which a central vascular clamp and a left and right vascular clamp located on either side of the central vascular clamp are provided. The left, right, and central vascular clamps each include an upper clamping arm and a lower clamping arm that can move relative to each other under the action of elastic force to clamp the corresponding blood vessel. The two clamping arms of the central vascular clamp are hollow structures, and the opposite sides of the two clamping arms of the central vascular clamp have clamping parts made of thermally conductive material. The partial vascular wall injury device also includes a liquid injection device for introducing a warm liquid into the inner cavity of the two clamping arms of the central vascular clamp.

[0007] Furthermore, the device base includes a connecting bracket for fixing the lower clamping arms of the left vascular clamp, the middle vascular clamp, and the right vascular clamp into an integral structure, and the injection device includes a vertically arranged injection funnel fixed on the connecting bracket, the injection funnel being connected to the inner cavities of the upper and lower clamping arms of the middle vascular clamp via flexible tubes.

[0008] Furthermore, the upper and lower clamping arms of the intermediate vascular clamp are provided with inlet ports for connecting to the tubing, and the upper and lower clamping arms of the intermediate vascular clamp are also provided with vent holes connected to the corresponding hollow structures, and vent plugs are threadedly connected to the vent holes.

[0009] Furthermore, silicone pads are provided on the opposite sides of the upper and lower clamping arms of the left and right vascular clamps.

[0010] Furthermore, the device base includes a silicone pad, and the connecting bracket is disposed on the silicone pad.

[0011] Furthermore, the lateral width of the upper and lower clamping arms of the middle vascular clamp is greater than the lateral width of the upper and lower clamping arms of the left and right vascular clamps.

[0012] Furthermore, the intermediate vascular clamp includes an upper elastic arm and a lower elastic arm that are connected at the front end and tend to approach each other at the rear end. The upper clamping arm of the intermediate vascular clamp is detachably connected to the upper elastic arm by an upper screw, and the lower clamping arm of the intermediate vascular clamp is detachably connected to the lower elastic arm by a lower screw.

[0013] The beneficial effects of this invention are as follows: When using the partial vascular wall damage device of this invention, the left-side vascular clamp is first used to clamp the blood vessel. Then, the blood on the right side of the clamped area is drained to the right. The right-side vascular clamp is then used to clamp the right end of the drained section of the blood vessel, preventing thrombosis due to blood in the blood vessel between the left and right vascular clamps. Subsequently, the clamping part of the middle vascular clamp is used to clamp the drained section of the blood vessel. A liquid of a certain temperature is injected into the upper and lower clamping arms of the middle vascular clamp through an injection device, so that the upper and lower clamping arms of the middle blood vessel receive a certain temperature. Different temperatures can achieve different degrees of damage to the blood vessel wall, thereby achieving the purpose of controllable damage. Furthermore, only the section of the blood vessel wall clamped by the middle vascular clamp will be damaged by temperature, thus achieving quantitative damage to a certain length of blood vessel, thereby achieving the purpose of controllable damage to a portion of the blood vessel wall and realizing the construction of an ideal animal model. Attached Figure Description

[0014] The above and other objects, features, and advantages of this disclosure will become readily apparent from the following detailed description of exemplary embodiments with reference to the accompanying drawings. In the drawings, several embodiments of this disclosure are illustrated by way of example and not limitation, and like or corresponding reference numerals denote like or corresponding portions, wherein:

[0015] Figure 1 This is a schematic diagram of the structure of one embodiment of the present invention;

[0016] Figure 2 yes Figure 1 A schematic diagram showing the interaction between the left-side vascular clip and the blood vessel;

[0017] Figure 3 yes Figure 1 The diagram shows the interaction between the intermediate vascular clamp and the blood vessel.

[0018] 1. Silicone pad; 2. Left vascular clamp; 3. Upper clamping arm of the left vascular clamp; 4. Vascular vessel; 5. Middle vascular clamp; 6. Upper clamping arm of the middle vascular clamp; 7. Right vascular clamp; 8. Tube; 9. Infusion funnel; 10. Left connecting rod; 11. Right connecting rod; 12. Upper elastic arm; 13. Lower elastic arm; 14. Lower clamping arm of the left vascular clamp; 15. Silicone pad; 16. Upper screw; 17. Lower screw; 18. Lower clamping arm of the middle vascular clamp; 19. Inner cavity of the clamping arm; 20. Clamping part. Detailed Implementation

[0019] To facilitate understanding of this utility model, a more detailed description is provided below with reference to the accompanying drawings and specific embodiments. The accompanying drawings show preferred embodiments of this utility model. However, this utility model can be implemented in many different forms and is not limited to the embodiments described herein. Rather, these embodiments are provided to provide a more thorough and complete understanding of the disclosure of this utility model.

[0020] It should be noted that, unless otherwise defined, all technical and scientific terms used in this specification have the same meaning as commonly understood by one of ordinary skill in the art to which this invention pertains. The terminology used in this specification is for the purpose of describing particular embodiments only and is not intended to limit the scope of the invention.

[0021] An example of an embodiment of the partial vascular wall injury device for animal model construction in this utility model is shown below. Figures 1-3 As shown:

[0022] The device includes a base, which includes a silicone pad 1. The silicone pad 1 is provided with a central vascular clamp 5 and a left vascular clamp 2 and a right vascular clamp 7 located on the left and right sides of the central vascular clamp 5.

[0023] Each vascular clamp includes an upper elastic arm 12 and a lower elastic arm 13 connected at the front end and tending to move closer together at the rear end. Each vascular clamp also includes an upper clamping arm and a lower clamping arm that can move relative to each other under the action of elastic force to clamp the corresponding blood vessel 4. The upper clamping arm is connected to the front end of the upper elastic arm, and the lower clamping arm is connected to the rear end of the lower elastic arm. In the figure, item 3 represents the upper clamping arm of the left vascular clamp, item 14 represents the lower clamping arm of the left vascular clamp; item 6 represents the upper clamping arm of the middle vascular clamp, and item 18 represents the lower clamping arm of the middle vascular clamp.

[0024] The left and right vascular clips have the same structure and can use conventional vascular clips available in the prior art. The difference between the middle and left vascular clips is that:

[0025] The upper clamping arm 6 of the intermediate vascular clamp is detachably connected to the corresponding upper elastic arm via an upper screw 16, and the lower clamping arm 18 of the intermediate vascular clamp is detachably connected to the corresponding lower elastic arm via a lower screw 17. For the left vascular clamp, the upper clamping arm 3 of the left vascular clamp is integrally formed with the corresponding upper elastic arm, and the lower clamping arm 14 of the left vascular clamp is integrally formed with the corresponding elastic arm. The purpose of this design is to allow for the replacement of the upper and lower clamping arms of the intermediate vascular clamp with arms of corresponding lengths to adjust the length of the damaged vessel.

[0026] The width of the upper and lower clamping arms of the middle vascular clamp in the left-right direction is greater than the width of the upper and lower clamping arms of the left and right vascular clamps in the left-right direction.

[0027] Furthermore, the two clamping arms of the intermediate vascular clamp have clamping portions 20 made of thermally conductive material on opposite sides. In this embodiment, the clamping portions 20 are made of stainless steel, and their length is less than half the circumferential length of the clamped blood vessel. This avoids causing circumferential damage to the clamped blood vessel. Both clamping arms of the intermediate vascular clamp are hollow structures. The partial vascular wall damage device also includes a liquid injection device 9 for introducing warm liquid into the inner cavity of the two clamping arms of the intermediate vascular clamp. The clamping surface and corresponding side of the clamping portion are marked with scale lines to indicate the position of the clamping portion for adjusting the damage position. In this embodiment, the two clamping arms of the intermediate vascular clamp are made of stainless steel. For the left and right vascular clamps, their thermal conductivity is not limited; they can be made of thermally conductive or non-thermally conductive materials.

[0028] The upper and lower clamping arms of the left and right vascular clamps are provided with silicone pads 15 on opposite sides. The silicone pads are used to reduce damage to the blood vessels when clamping them.

[0029] The device base includes a connecting bracket for fixing the lower clamping arms of the left, middle, and right vascular clamps into an integral structure. In this embodiment, the connecting bracket includes a left connecting rod 10 connecting the lower clamping arms of the left and middle vascular clamps, and a right connecting rod 11 connecting the lower clamping arms of the middle and right vascular clamps. The infusion device includes a vertically arranged infusion funnel fixed to the connecting bracket. The infusion funnel is connected to the inner cavities 19 of the upper and lower clamping arms of the middle vascular clamp via two parallel flexible tubes 8.

[0030] In practical use, first clamp one end of the test vessel with the left vascular clamp, then drain the blood from the test vessel. Next, clamp the other end of the test vessel with the right vascular clamp, and clamp the middle of the test vessel with the middle clamp. Add a warm liquid (which can cause damage to the blood vessel; this can be hot or cold water) to the injection funnel. The parallel-connected tubing ensures that the heat conduction process of the warm liquid to the upper and lower clamping arms is essentially the same, ensuring that the damage to the upper and lower sides of the blood vessel is essentially the same. By changing the temperature of the warm liquid, the degree of damage to the blood vessel caused by the middle vascular clamp can be changed, thus achieving controlled damage.

[0031] For the intermediate vascular clamp, the lengths of the upper and lower clamping arms can be selected to change the clamping length of the intermediate vascular clamp on the blood vessel, thereby achieving damage to a quantitative length of blood vessel. In other words, this invention can achieve controllable damage to different degrees to a quantitative length of blood vessel, thus realizing the construction of an ideal animal model.

[0032] In the foregoing description of this specification, unless otherwise expressly specified and limited, the terms "fixed," "installed," "connected," or "joined" should be interpreted broadly. For example, the term "joined" can refer to a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium; or it can refer to the internal communication of two components or the interaction between two components. Therefore, unless otherwise expressly limited in this specification, those skilled in the art can understand the specific meaning of the above terms in this utility model based on the specific circumstances.

[0033] Based on the above description in this specification, those skilled in the art will also understand that terms used, such as "upper," "lower," "front," "rear," "left," "right," "length," "width," "thickness," "vertical," "horizontal," "top," "bottom," "inner," "outer," "axial," "radial," "circumferential," "center," "longitudinal," "transverse," "clockwise," or "counterclockwise," are terms indicating orientation or positional relationships based on the orientation or positional relationships shown in the accompanying drawings of this specification. They are only for the purpose of facilitating the explanation of the present invention and simplifying the description, and do not imply that the device or element involved must have the specific orientation, or be constructed and operated in a specific orientation. Therefore, the above-mentioned orientation or positional relationship terms should not be understood or interpreted as limitations on the present invention.

[0034] Furthermore, the terms "first" or "second," etc., used in this specification to refer to numbers or ordinal numbers are for descriptive purposes only and should not be construed as indicating, explicitly or implicitly, relative importance or specifying the number of indicated technical features. Therefore, a feature defined as "first" or "second" may explicitly or implicitly include at least one of that feature. In the description of this specification, "a plurality of" means at least two, such as two, three, or more, unless otherwise explicitly specified.

[0035] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of this utility model, and not to limit it. Although this utility model has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some of the technical features. Such modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the spirit and scope of the technical solutions of the embodiments of this utility model.

Claims

1. A device for partially damaging the blood vessel wall in animal model construction, characterized in that: The device includes a base on which a central vascular clamp and a left and right vascular clamp located on either side of the central vascular clamp are mounted. The left, right, and central vascular clamps each include an upper clamping arm and a lower clamping arm that can move relative to each other under the action of elastic force to clamp the corresponding blood vessel. The two clamping arms of the central vascular clamp are hollow structures, and the opposite sides of the two clamping arms of the central vascular clamp have clamping parts made of thermally conductive material. The partial vascular wall damage device also includes a liquid injection device for introducing a warm liquid into the inner cavity of the two clamping arms of the central vascular clamp.

2. The partial blood vessel wall damage device according to claim 1, characterized in that: The device base includes a connecting bracket for fixing the lower clamping arms of the left vascular clamp, the middle vascular clamp, and the right vascular clamp into an integral structure. The infusion device includes a vertically arranged infusion funnel fixed on the connecting bracket. The infusion funnel is connected to the inner cavities of the upper and lower clamping arms of the middle vascular clamp via flexible tubing.

3. The partial blood vessel wall damage device according to claim 2, characterized in that: The upper and lower clamping arms of the intermediate vascular clamp are provided with inlet ports for connecting to the tubing. The upper and lower clamping arms of the intermediate vascular clamp are also provided with vent holes connected to the corresponding hollow structures, and vent plugs are threaded to the vent holes.

4. The partial blood vessel wall damage device according to claim 1, characterized in that: Silicone pads are provided on the opposite sides of the upper and lower clamping arms of the left and right vascular clamps.

5. The partial blood vessel wall injury device according to claim 2, characterized in that: The device base includes a silicone pad, and the connecting bracket is mounted on the silicone pad.

6. The partial blood vessel wall injury device according to any one of claims 1 to 5, characterized in that: The width of the upper and lower clamping arms of the middle vascular clamp in the left-right direction is greater than the width of the upper and lower clamping arms of the left and right vascular clamps in the left-right direction.

7. The partial blood vessel wall injury device according to any one of claims 1 to 5, characterized in that: The intermediate vascular clamp includes an upper elastic arm and a lower elastic arm that are connected at the front end and tend to approach each other at the rear end. The upper clamping arm of the intermediate vascular clamp is detachably connected to the upper elastic arm by an upper screw, and the lower clamping arm of the intermediate vascular clamp is detachably connected to the lower elastic arm by a lower screw.

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