Concentration and crystallization kettle for producing carbohydrate reagent

Abstract

The utility model discloses a concentration and crystallization kettle for producing carbohydrate reagents. The concentration and crystallization kettle comprises a kettle body, the jacket is arranged outside the kettle body and is used for heating the kettle body; the stirring device is rotationally arranged in the kettle body; the discharge valve is arranged at the bottom of the kettle body; and the crushing device is arranged on the inner wall of the kettle body and is used for crushing the caked carbohydrate reagent in the stirring process. According to the concentration and crystallization kettle disclosed by the utility model, the crushing device with the annular structure is arranged on the inner wall of the kettle body, so that a caked carbohydrate reagent can impact on the crushing device to be crushed in the stirring process, and the phenomenon that the discharging opening of the kettle body is blocked by the caked carbohydrate reagent falling off in the crystallization stage can be avoided. According to the concentration crystallization kettle disclosed by the utility model, the phenomena of frosting and wall hanging caused by the adhesion of the carbohydrate reagent on the inner wall of the kettle body can be reduced by arranging the crushing device, so that more sugar can be crystallized and recycled, and the yield of the carbohydrate reagent is improved.

Description

Technical Field

[0001] This utility model relates to the field of crystallization reactor technology, specifically to a concentrated crystallization reactor for producing sugar reagents. Background Technology

[0002] The preparation processes of sugar reagents such as sucrose, lactose, and trehalose all require the use of a concentration crystallization reactor for concentration and crystallization. Currently, a commonly used concentration crystallization reactor mainly consists of a reactor body, a jacket, and a stirring device. In the concentration crystallization process, a pre-concentrated solution is first injected into the reactor body, and a heat source such as steam is introduced into the jacket to heat the pre-concentrated solution. The solution is then concentrated under reduced pressure until the desired crystallization concentration is reached. Finally, a cooling liquid is introduced to cool and crystallize the solution. This concentration crystallization method is widely used in the preparation of pharmaceutical excipient-grade sugar reagents, as it can shorten the production process and enable the production of the same series of products in a clean production workshop.

[0003] However, in actual production, whether it is an enamel-lined kettle or a stainless steel crystallizing kettle, the kettle wall of this common concentration crystallizing kettle is prone to "frost-covering" during the concentration and crystallization of dilute sugar reagent solutions. The sugar that is stuck to the wall falls off to the bottom of the kettle during the crystallization stage, forming large-diameter particles or clumps, which in turn causes blockage of the discharge port of the crystallizing kettle. Utility Model Content

[0004] The purpose of this invention is to address the problem of easy clogging of the discharge port in existing concentration crystallization kettles, and to propose a concentration crystallization kettle for producing sugar reagents, which can effectively solve the above-mentioned problems of existing concentration crystallization kettles.

[0005] To achieve the above objectives, this utility model is implemented through the following technical solution:

[0006] This utility model designs a concentration and crystallization kettle for producing sugar reagents, which includes the following structural configuration:

[0007] The vessel body;

[0008] A jacket is disposed outside the vessel body for heating the vessel body;

[0009] A stirring device, which is rotatably mounted inside the vessel;

[0010] A discharge valve is located at the bottom of the vessel body;

[0011] And a crushing device, which is installed on the inner wall of the vessel, for breaking up clumps of sugar reagents during the stirring process.

[0012] Furthermore, a concentration crystallization vessel for producing sugar reagents: the vessel body is formed by sequentially splicing together a top, a middle, and a bottom; wherein the top and bottom of the vessel body are elliptical structures, and the middle of the vessel body is cylindrical.

[0013] Furthermore, a concentrated crystallization vessel for producing sugar reagents: the jacket is disposed on the outer side of the bottom of the vessel body.

[0014] Furthermore, a concentration crystallization vessel for producing sugar reagents: the stirring device is disposed in the vessel body and its two ends are rotatably connected to the top and bottom of the vessel body, respectively.

[0015] Furthermore, a concentration crystallization reactor for producing sugar reagents: the crushing device is located at the junction of the middle part and the bottom of the reactor body.

[0016] Furthermore, a concentration crystallization reactor for producing sugar reagents: the stirring device includes a stirring rod and a stirring paddle; the crushing device is disposed around the inner wall of the reactor body, and the crushing device is located in the gap between the stirring paddle and the inner wall of the reactor body, and the crushing device does not contact the stirring paddle.

[0017] Specifically, the crushing device is configured not to contact the agitator, that is, it will not interfere with the rotation of the agitator.

[0018] Furthermore, a concentration crystallization reactor for producing sugar reagents includes a crushing device comprising a ring frame and several baffles for crushing agglomerated sugar reagents; wherein the ring frame is disposed around the inner wall of the reactor body, and the several baffles are disposed circumferentially between the ring frame and the inner wall of the reactor body.

[0019] Furthermore, a concentrated crystallization reactor for producing sugar reagents: several crushing rods are arranged side by side in the baffle, and the crushing rods are parallel to the inner wall of the reactor body.

[0020] Furthermore, a concentrated crystallization vessel for producing sugar reagents: the discharge valve is an upper / lower discharge valve, a plunger-type bottom valve, or a bottom ball valve.

[0021] Specifically, the sugar reagents include: sucrose, maltose, trehalose, lactose, glucose, maltotriose, etc.

[0022] Specifically, the vessel body is made of stainless steel (such as 304 or 316L stainless steel), the interior of the vessel body is smooth, and the bottom of the vessel body has an elliptical structure. The stirring device has a rotation speed range of 20 to 50 rpm.

[0023] The beneficial effects of this utility model are:

[0024] This invention relates to a concentrated crystallizing kettle for producing sugar reagents. By installing a ring-shaped crushing device on the inner wall of the kettle, the clumps of sugar reagents can be crushed by impacting the crushing device during stirring. This prevents the sugar reagents that fall off during the crystallization stage from clumping together and blocking the discharge port (i.e., unloading valve) of the kettle, thus solving the problem of easy clogging of the discharge port in existing concentrated crystallizing kettles.

[0025] The concentration and crystallization kettle for producing sugar reagents designed in this utility model can also reduce the "frost-like" phenomenon on the inner wall of the kettle caused by the adhesion of sugar reagents by setting the above-mentioned crushing device, so that more sugar can be crystallized and recovered, thereby improving the yield of sugar reagents. Attached Figure Description

[0026] To more clearly illustrate the technical solutions of the embodiments of this utility model, the drawings used in the description of the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this utility model. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0027] Figure 1 A schematic diagram of the planar structure of a concentration crystallization kettle for producing sugar reagents designed for Embodiment 1 of this utility model;

[0028] Figure 2 A top view of the connection structure between the vessel body and the crushing device inside a concentration crystallization kettle for producing sugar reagents, designed for Embodiment 1 of this utility model;

[0029] Figure 3 This is a schematic diagram of the structure of a baffle in a concentration crystallization kettle for producing sugar reagents, as designed in Embodiment 1 of this utility model;

[0030] Figure 4 A schematic diagram of the general-purpose concentration crystallization vessel provided for Comparative Example 1.

[0031] The markings in the diagram are: 1-Cup body, 2-Jacket, 3-Stirring device, 4-Discharge valve, 5-Crushing device, 11-Top of the vessel body, 12-Middle of the vessel body, 13-Bottom of the vessel body, 31-Stirring rod, 32-Stirring paddle, 51-Ring frame, 52-Baffle, 53-Crushing rod. Detailed Implementation

[0032] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. The following description of at least one exemplary embodiment is merely illustrative and is in no way intended to limit the present utility model or its application or use. All other embodiments obtained by those skilled in the art based on the embodiments of the present utility model without creative effort are within the scope of protection of the present utility model.

[0033] In the description of this utility model, it should be understood that the terms "upper," "lower," "left," "right," "top," and "bottom," etc., indicating orientation or positional relationships, are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this utility model. Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of indicated technical features. Thus, features defined with "first" and "second" may explicitly or implicitly include one or more of that feature. Moreover, the terms "first," "second," etc., are used to distinguish similar objects and are not necessarily used to describe a specific order or sequence. It should be understood that such data can be interchanged where appropriate so that embodiments of this utility model described herein can be implemented in orders other than those illustrated or described herein.

[0034] Example 1

[0035] like Figures 1-3 As shown, this embodiment 1 designs a concentration and crystallization kettle for producing sugar reagents. The concentration and crystallization kettle includes the following specific structural configuration:

[0036] The vessel body 1 is made of 304 or 316L stainless steel. The interior of the vessel body 1 is smooth. The vessel body 1 is formed by sequentially splicing the top 11, the middle 12 and the bottom 13 of the vessel body. The top 11 and the bottom 13 of the vessel body are set as elliptical structures, and the middle 12 of the vessel body is set as a cylindrical structure.

[0037] A jacket 2 is disposed on the outside of the bottom 13 of the vessel body for heating the vessel body 1;

[0038] The stirring device 3 includes a stirring rod 31 and a stirring paddle 32. The stirring device 3 is disposed in the vessel body 1 and its two ends are rotatably connected to the top 11 and the bottom 13 of the vessel body, respectively.

[0039] Discharge valve 4 is located at the bottom of the vessel body 1;

[0040] And a crushing device 5, which is arranged around the inner wall of the vessel body 1 and located at the junction of the middle part 12 and the bottom 13 of the vessel body. At the same time, the crushing device 5 is also located in the gap between the stirring paddle 32 and the inner wall of the vessel body 1 and the crushing device 5 does not contact the stirring paddle 32. The crushing device 5 is used to crush the clumps of sugar reagents during the stirring process.

[0041] The crushing device 5 includes a ring frame 51 and four baffles 52 for crushing agglomerated sugar reagents. The ring frame 51 is arranged around the inner wall of the vessel body 1. The baffles 52 are arranged circumferentially around the ring frame 51 between the ring frame 51 and the inner wall of the vessel body 1. Several crushing rods 53 are arranged side by side in the baffles 52, and the crushing rods 53 are arranged parallel to the inner wall of the vessel body 1.

[0042] When using the concentrated crystallization kettle for producing sugar reagents designed in Example 1 above: 250L of purified water is added to the dissolving kettle, heated to 70℃, and stirred at 30rpm. 250kg of sucrose is then added. After the sucrose is completely dissolved, 5.0kg of activated carbon is added for decolorization. The solution is then filtered, and the clarified filtrate is pumped into the concentrated crystallization kettle of Example 1. This crystallization kettle has a bottom discharge valve 4. The sucrose solution in the concentrated crystallization kettle is stirred at 30rpm. Then, it is concentrated to 80% concentration under reduced pressure at 70℃. 150kg of ethanol is added for overnight crystallization. After crystallization, the solution can be smoothly discharged. After centrifugation to remove the mother liquor, the product is dried and weighed. The product yield is calculated to be 86%, and the product particle size D50 is 0.45mm.

[0043] Comparative Example 1

[0044] like Figure 4 As shown, Comparative Example 1 provides a general-purpose concentration crystallization vessel, which includes the following structural configuration:

[0045] The vessel body 1 is made of 304 or 316L stainless steel. The interior of the vessel body 1 is smooth. The vessel body 1 is formed by sequentially splicing the top 11, the middle 12 and the bottom 13 of the vessel body. The top 11 and the bottom 13 of the vessel body are set as elliptical structures, and the middle 12 of the vessel body is set as a cylindrical structure.

[0046] A jacket 2 is disposed on the outside of the bottom 13 of the vessel body for heating the vessel body 1;

[0047] The stirring device 3 includes a stirring rod 31 and a stirring paddle 32. The stirring device 3 is disposed in the vessel body 1 and its two ends are rotatably connected to the top 11 and the bottom 13 of the vessel body, respectively.

[0048] And a discharge valve 4, which is located at the bottom of the vessel body 1.

[0049] The difference between Comparative Example 1 and Example 1 is that Comparative Example 1 does not have the crushing device 5 as in Example 1, but the rest of the structural design is the same.

[0050] The general-purpose concentration and crystallization vessel provided in Comparative Example 1 was used as follows: 250L of purified water was added to the dissolving vessel, heated to 70°C, and stirred at 30rpm. 250kg of sucrose was then added. After the sucrose was completely dissolved, 5.0kg of activated carbon was added for decolorization. The solution was then filtered, and the clarified filtrate was pumped into the concentration and crystallization vessel of Comparative Example 1. This crystallization vessel had a bottom discharge valve 4. The sucrose solution in the concentration and crystallization vessel was stirred at 30rpm, and then concentrated under reduced pressure to 80% concentration at 70°C. 150kg of ethanol was added for overnight crystallization. After crystallization, the discharge valve 4 became blocked, preventing discharge. After clearing the discharge valve 4, discharge was attempted again. Although some product could be recovered, the calculated product yield was approximately 53%, significantly lower than that of Example 1.

[0051] Therefore, this utility model improves the structure of the concentration crystallization kettle by setting a ring-shaped crushing device 5 in the kettle body, which can not only solve the problem of easy clogging of the existing crystallization kettle, but also improve the product yield.

[0052] The above-described preferred embodiments of this utility model are for illustrative purposes only and are not intended to limit the scope of this utility model. Any obvious variations or modifications derived from the technical solutions of this utility model are still within the protection scope of this utility model.

Claims

1. A concentration and crystallization kettle for producing sugar reagents, characterized in that, The concentration crystallization vessel includes the following structural configuration: The vessel body (1); A jacket (2) is disposed outside the vessel body (1) for heating the vessel body (1); A stirring device (3) is rotatably disposed in the vessel body (1); Discharge valve (4) is located at the bottom of the vessel body (1); And a crushing device (5), which is disposed on the inner wall of the vessel (1) for crushing clumps of sugar reagents during the stirring process.

2. The concentration and crystallization kettle for producing sugar reagents according to claim 1, characterized in that, The vessel body (1) is formed by sequentially splicing together the top (11), the middle (12), and the bottom (13); The top (11) and bottom (13) of the vessel body are set as elliptical structures, and the middle part (12) of the vessel body is set as a cylindrical structure.

3. The concentration and crystallization kettle for producing sugar reagents according to claim 2, characterized in that, The jacket (2) is located on the outside of the bottom (13) of the vessel body.

4. The concentration and crystallization kettle for producing sugar reagents according to claim 2, characterized in that, The stirring device (3) is located in the vessel body (1) and its two ends are rotatably connected to the top (11) and bottom (13) of the vessel body, respectively.

5. A concentration and crystallization kettle for producing sugar reagents according to claim 2, characterized in that, The crushing device (5) is located at the junction of the middle part (12) and the bottom part (13) of the vessel body.

6. A concentration and crystallization kettle for producing sugar reagents according to claim 1 or 5, characterized in that, The stirring device (3) includes a stirring rod (31) and a stirring paddle (32); The crushing device (5) is disposed around the inner wall of the vessel body (1), and the crushing device (5) is located in the gap between the stirring paddle (32) and the inner wall of the vessel body (1), and the crushing device (5) does not contact the stirring paddle (32).

7. The concentration and crystallization kettle for producing sugar reagents according to claim 6, characterized in that, The crushing device (5) includes a ring frame (51) and several baffles (52) for crushing agglomerated sugar reagents; The ring frame (51) is disposed around the inner wall of the vessel body (1), and a plurality of baffles (52) are disposed circumferentially between the ring frame (51) and the inner wall of the vessel body (1).

8. The concentration and crystallization kettle for producing sugar reagents according to claim 7, characterized in that, The baffle (52) has several crushing rods (53) arranged side by side, and the crushing rods (53) are parallel to the inner wall of the vessel body (1).

9. A concentration and crystallization kettle for producing sugar reagents according to claim 1, characterized in that, The unloading valve (4) is an upper / lower discharge valve, a plunger-type tank bottom valve, or a tank bottom ball valve.

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