Purification mechanism for heparin sodium

Abstract

The utility model discloses a purification mechanism for heparin sodium, which comprises a centrifugal machine tank, one end of the centrifugal machine tank is hermetically connected with a membrane separation bin through a pipeline, the membrane separation bin is hermetically connected with a heating bin through a pipeline, and the heating bin is hermetically connected with a condenser bin through a hot air delivery pipe. A liquid collecting funnel is installed at the bottom of the condenser bin and connected with a liquid collecting box through a pipeline. According to the utility model, the centrifugal machine tank is arranged, so that a heparin sodium solution can be centrifugally precipitated in advance, part of impurities can be precipitated to the bottom of the centrifugal machine tank, then the heparin sodium solution subjected to primary centrifugal filtration is conveyed into the membrane separation bin through the pipeline, and the impurities in the solution can be further filtered and removed by utilizing the membrane separation device; finally, a heating bin is arranged to be matched with a condenser bin, the purified solution can be further heated and evaporated into water vapor, the water vapor is condensed and liquefied into water to be collected after being pre-cooled, and the good purification effect is achieved.

Description

Technical Field

[0001] This utility model relates to the field of heparin sodium purification technology, specifically to a purification mechanism for heparin sodium. Background Technology

[0002] Heparin sodium is an anticoagulant with strong negatively charged physicochemical properties. It can interfere with multiple steps of blood coagulation and has anticoagulant effects both in vivo and in vitro. Its anticoagulant mechanism is relatively complex. It mainly works by binding to antithrombin III, thereby inhibiting activated coagulation factors.

[0003] Chinese patent document CN222342155U discloses a purification mechanism for heparin sodium, belonging to the field of heparin sodium technology. It includes a stirring tank, a filter box located on the outside of the stirring tank, a water storage tank fixedly connected to the upper surface of the filter box, and a water pump fixedly connected to the upper surface of the filter box. The input end of the water pump's power passes through the water storage tank and extends into its interior, while the output end of the water pump passes through the filter box and extends into its interior. The output end of the water pump's power is fixedly connected to a water outlet pipe. This purification mechanism for heparin sodium, by incorporating a miniature reversible motor, a threaded rod, a moving plate, and a cleaning plate, provides the power required for cleaning under the action of the miniature reversible motor. The rotation of the miniature reversible motor drives the threaded rod to rotate, which in turn drives the moving plate and the cleaning plate to move, thereby cleaning impurities adsorbed on the filter plate.

[0004] The existing technology mentioned above cannot perform in-depth removal of impurity particles in heparin sodium solution, resulting in low purification efficiency of heparin sodium. Therefore, it is necessary to develop a purification mechanism for heparin sodium. Utility Model Content

[0005] The purpose of this invention is to provide a purification mechanism for heparin sodium, so as to solve the problem mentioned in the background art that the prior art cannot perform in-depth removal of impurity particles in heparin sodium solution, resulting in low purification efficiency of heparin sodium.

[0006] To achieve the above objectives, this utility model provides the following technical solution: a purification mechanism for heparin sodium, comprising a centrifuge tank, one end of which is sealed to a membrane separation chamber via a pipeline, the membrane separation chamber being sealed to a heating chamber via a pipeline, the heating chamber being sealed to a condenser chamber via a hot gas delivery pipe, a liquid collection funnel being installed at the bottom of the condenser chamber, and the liquid collection funnel being connected to a liquid collection box via a pipeline.

[0007] Preferably, a centrifugal motor is installed on the top of the centrifuge tank, and a centrifugal stirring rod is fixedly connected to the output end of the centrifugal motor via a rotating shaft.

[0008] Preferably, the membrane separation chamber is provided with a pre-filtration membrane, an ultrafiltration membrane, and a nanofiltration membrane, respectively. The pore size of the pre-filtration membrane is larger than that of the ultrafiltration membrane, and the pore size of the nanofiltration membrane is smaller than that of the ultrafiltration membrane.

[0009] Preferably, the heating chamber is equipped with an electric heating pipe, and the condenser chamber is equipped with a condenser pipe.

[0010] Preferably, the centrifuge tank and the membrane separation chamber are connected by a first infusion pipe, and a first filtrate pump is installed on the first infusion pipe.

[0011] Preferably, the membrane separation chamber and the heating chamber are connected by a second infusion pipe, and a second filtrate pump is installed on the second infusion pipe.

[0012] Preferably, the condenser tube is used to liquefy the hot steam entering the condenser chamber into water and collect and store it in a collection box.

[0013] Compared with the prior art, the beneficial effects of this utility model are:

[0014] This invention incorporates a centrifuge tank for pre-centrifugation and precipitation of heparin sodium solution, allowing some impurities to settle to the bottom of the tank. The pre-centrifuged and filtered heparin sodium solution is then transported to a membrane separation chamber via pipeline. The membrane separation device further filters and removes impurities from the solution. Finally, a heating chamber combined with a condenser chamber further heats and evaporates the purified solution into water vapor. The water vapor is pre-cooled, condensed, and collected as water, achieving a good purification effect. Attached Figure Description

[0015] Figure 1 This is a schematic diagram of the external structure of this utility model;

[0016] Figure 2 This is a schematic diagram of the internal installation structure of this utility model;

[0017] Figure 3 This is the overall front view of this utility model.

[0018] In the diagram: 1. Centrifuge motor; 2. Centrifuge tank; 3. First filtrate pump; 4. First infusion pipe; 5. Membrane separation chamber; 6. Second filtrate pump; 7. Second infusion pipe; 8. Heating chamber; 9. Centrifugal stirring rod; 10. Rotating shaft; 11. Primary filtration membrane; 12. Ultrafiltration membrane; 13. Nanofiltration membrane; 14. Electric heating pipe; 15. Hot gas delivery pipe; 16. Condenser; 17. Condenser chamber; 18. Collection funnel; 19. Collection box. Detailed Implementation

[0019] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments of the present utility model. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments.

[0020] Please see Figure 1-3 An embodiment of this utility model provides a purification mechanism for heparin sodium, comprising a centrifuge tank 2, one end of which is sealed to a membrane separation chamber 5 via a pipeline, the membrane separation chamber 5 is sealed to a heating chamber 8 via a pipeline, the heating chamber 8 is sealed to a condenser chamber 17 via a hot gas delivery pipe 15, a liquid collection funnel 18 is installed at the bottom of the condenser chamber 17, and the liquid collection funnel 18 is connected to a liquid collection box 19 via a pipeline.

[0021] Furthermore, a centrifugal motor 1 is installed on the top of the centrifuge tank 2. The output end of the centrifugal motor 1 is fixedly connected to a centrifugal stirring rod 9 via a rotating shaft 10. By turning on the centrifugal motor 1, the rotating shaft 10 is driven to rotate the centrifugal stirring rod 9 at high speed, thereby pre-centrifuging and stirring the heparin sodium solution inside the centrifuge tank 2, which can precipitate some impurities to the bottom of the centrifuge tank 2.

[0022] Furthermore, the membrane separation chamber 5 is equipped with a primary filtration membrane 11, an ultrafiltration membrane 12, and a nanofiltration membrane 13. The pore size of the primary filtration membrane 11 is larger than that of the ultrafiltration membrane 12, and the pore size of the nanofiltration membrane 13 is smaller than that of the ultrafiltration membrane 12. By layering the primary filtration membrane 11, ultrafiltration membrane 12, and nanofiltration membrane 13, the membrane filtration structure can further filter and remove tiny impurities in the heparin sodium solution, ensuring the high purity of the heparin sodium solution.

[0023] Furthermore, an electric heating pipe 14 is installed inside the heating chamber 8. The electric heating pipe 14 can be used to heat the heparin sodium solution entering the heating chamber 8, causing it to generate water vapor. A condenser pipe 16 is installed inside the condenser chamber 17. The condenser pipe 16 can condense and liquefy the water vapor entering the condenser chamber 17 into water.

[0024] Furthermore, the centrifuge tank 2 and the membrane separation chamber 5 are connected by a first infusion pipe 4. A first filtrate pump 3 is installed on the first infusion pipe 4. By turning on the first filtrate pump 3, the solution after centrifugation and filtration inside the centrifuge tank 2 can be drawn into the membrane separation chamber 5 through the first infusion pipe 4.

[0025] Furthermore, the membrane separation chamber 5 and the heating chamber 8 are connected by a second infusion pipe 7. A second filtrate pump 6 is installed on the second infusion pipe 7. By turning on the second filtrate pump 6, the solution filtered inside the membrane separation chamber 5 can be sent into the heating chamber 8 through the second infusion pipe 7.

[0026] Furthermore, the condenser tube 16 is used to liquefy the hot steam entering the condenser chamber 17 into water and collect and store it in the liquid collection box 19, thereby achieving a good purification effect on the heparin sodium solution.

[0027] Working principle: During use, the centrifugal motor 1 is turned on to drive the control shaft 10, which in turn drives the centrifugal stirring rod 9 to rotate rapidly. This pre-centrifuges and stirs the heparin sodium solution inside the centrifuge tank 2, allowing some impurities to settle to the bottom of the centrifuge tank 2. By turning on the first filtrate pump 3, the centrifuged and filtered solution inside the centrifuge tank 2 is drawn into the membrane separation chamber 5 through the first infusion pipe 4. The membrane separation chamber 5 is equipped with a primary filtration membrane 11, an ultrafiltration membrane 12, and a nanofiltration membrane 13. Through the layered arrangement of the primary filtration membrane 11, ultrafiltration membrane 12, and nanofiltration membrane 13, the membrane filtration structure can effectively filter the heparin sodium solution. Tiny impurities in the solution are further removed through layer-by-layer filtration to ensure high purity of the heparin sodium solution. By turning on the second filtrate pump 6, the solution filtered inside the membrane separation chamber 5 can be sent to the interior of the heating chamber 8 via the second infusion pipe 7. The heating chamber 8 is equipped with an electric heating pipe 14, which can be used to heat the heparin sodium solution entering the heating chamber 8, causing it to generate water vapor. The condenser chamber 17 is equipped with a condenser pipe 16, which can condense and liquefy the water vapor entering the condenser chamber 17 into water and store it in the collection box 19, achieving a good purification effect.

[0028] It should be noted that, in this document, relational terms such as "first" and "second" are used only to distinguish one entity or operation from another, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Furthermore, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such process, method, article, or apparatus.

[0029] All standard parts used in this application can be purchased from the market. The specific connection methods of each part are all conventional methods such as bolts, rivets, and welding that are mature in the prior art. The machinery, parts and equipment are all conventional models in the prior art. In addition, the circuit connection adopts conventional connection methods in the prior art, and will not be described in detail here.

[0030] Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A purification apparatus for heparin sodium, comprising a centrifuge tank (2), characterized in that, One end of the centrifuge tank (2) is sealed to a membrane separation chamber (5) via a pipeline. The membrane separation chamber (5) is sealed to a heating chamber (8) via a pipeline. The heating chamber (8) is sealed to a condenser chamber (17) via a hot gas delivery pipe (15). A liquid collection funnel (18) is installed at the bottom of the condenser chamber (17). The liquid collection funnel (18) is connected to a liquid collection box (19) via a pipeline.

2. The purification apparatus for heparin sodium according to claim 1, characterized in that: The centrifuge tank (2) is equipped with a centrifugal motor (1) at its outer top, and the output end of the centrifugal motor (1) is fixedly connected to a centrifugal stirring rod (9) via a rotating shaft (10).

3. The purification apparatus for heparin sodium according to claim 1, characterized in that: The membrane separation chamber (5) is equipped with a primary filtration membrane (11), an ultrafiltration membrane (12), and a nanofiltration membrane (13). The pore size of the primary filtration membrane (11) is larger than that of the ultrafiltration membrane (12), and the pore size of the nanofiltration membrane (13) is smaller than that of the ultrafiltration membrane (12).

4. The purification apparatus for heparin sodium according to claim 1, characterized in that: The heating chamber (8) is equipped with an electric heating pipe (14), and the condenser chamber (17) is equipped with a condenser pipe (16).

5. A purification apparatus for heparin sodium according to claim 1, characterized in that: The centrifuge tank (2) and the membrane separation chamber (5) are connected by a first infusion pipe (4), and a first filter pump (3) is installed on the first infusion pipe (4).

6. The purification apparatus for heparin sodium according to claim 1, characterized in that: The membrane separation chamber (5) and the heating chamber (8) are connected by a second infusion pipe (7), and a second filtrate pump (6) is installed on the second infusion pipe (7).

7. A purification apparatus for heparin sodium according to claim 4, characterized in that: The condenser tube (16) is used to liquefy the hot steam entering the condenser chamber (17) into water and collect and store it in the liquid collection box (19).

Images