Granulator for producing nifedipine controlled release tablets

Abstract

The utility model relates to a granulator for producing nifedipine controlled release tablets, which aims to solve the technical problems that the maintenance cost is increased and the production continuity is reduced because equipment needs to be opened or parts need to be disassembled when a cutter is cleaned or materials are discharged, and the operation is complicated and time-consuming, and comprises a partition plate, a transmission rod and a material barrel, the transmission rod vertically penetrates through the center of the bottom of the centrifugal screen drum and is fixedly connected with the centrifugal screen drum, an insertion opening is formed in one side of the bottom of the centrifugal screen drum, an insertion plate is movably inserted into the inner side of the insertion opening, and a bottom frame is fixedly connected to the bottom, under the insertion plate, of the centrifugal screen drum; a connecting rod is fixedly connected to the surface of the top end of the inserting plate, a cutter is fixedly connected to the top end of the connecting rod, and two cleaning plates are fixedly connected to the side wall of the transmission rod below the cutter. Discharging is facilitated by arranging the pushing ring and the scraping plate, so that the device does not need to be disassembled, and the device is convenient, rapid and high in efficiency.

Description

Technical Field

[0001] This utility model relates to the field of granulation technology, specifically to a granulation machine for producing nifedipine controlled-release tablets. Background Technology

[0002] Nifedipine controlled-release tablets are a drug dosage form manufactured using a special process, characterized by slow and constant drug release. Through its non-absorbable outer shell, the drug is gradually released in the gastrointestinal tract, thereby maintaining a constant drug concentration in the blood and achieving a sustained therapeutic effect. Currently, granulation machines are used to produce the drug granules during production.

[0003] Currently, some pharmaceutical granulators on the market produce granules using a rotating cutter. However, after a period of use, material may accumulate on the cutter, requiring cleaning by opening the equipment or disassembling parts. This process is cumbersome and time-consuming, increasing maintenance costs. Furthermore, defective granules often remain inside the device during production, requiring manual intervention or disassembly to remove them, further reducing production continuity.

[0004] For example, some pellet mills have a screening mechanism inside to screen the produced pellets and intercept unqualified pellets. However, the screening mechanism needs to be cleaned after a period of time, otherwise it will accumulate and block. However, the screening mechanism is located inside the machine, so the machine needs to be stopped for manual cleaning, which not only affects the overall production efficiency, but may also cause problems with the precision of the equipment during disassembly. Utility Model Content

[0005] The purpose of this utility model is to overcome the shortcomings of the existing technology, adapt to the needs of reality, and provide a waterproof equipment for distribution boxes to solve the technical problem that the current operation of opening the equipment or disassembling parts is cumbersome and time-consuming when cleaning the cutter or discharging materials, which leads to increased maintenance costs and reduced production continuity.

[0006] To achieve the purpose of this utility model, the technical solution adopted by this utility model is as follows: A granulator for producing controlled-release nifedipine tablets is designed, comprising a partition, a transmission rod, and a material cylinder. The transmission rod vertically penetrates the center of the bottom of a centrifugal sieve cylinder and is fixedly connected to the centrifugal sieve cylinder. An insertion port is provided on one side of the bottom of the centrifugal sieve cylinder, and an insertion plate is movably inserted into the inner side of the insertion port. A base frame is fixedly connected to the bottom of the centrifugal sieve cylinder directly below the insertion plate. A second electric push rod is fixedly connected between the base frame and the insertion plate. A connecting rod is fixedly connected to the top surface of the insertion plate, and a cutter is fixedly connected to the top of the connecting rod. Two cleaning plates are fixedly connected to the side wall of the transmission rod below the cutter. A top rod is fixedly connected to the bottom of the partition, and a shrinking block is fixedly connected to the side wall of the top rod. An impact block is slidably connected to the inner side of the shrinking block. A lifting block is vertically slidably connected to the inner side of the bottom end of the top rod, and a scraper is fixedly connected to the bottom of the lifting block. A pushing ring is fixedly connected to the side wall of the connecting rod above the scraper.

[0007] In this design, the cutter and centrifugal screen rotate under the drive of the transmission rod, screening larger particles and improving the yield rate of particle production. During this process, the shrinkage block and impact block on the side wall of the top rod impact the screen, generating vibration and reducing screen clogging. When the cutter needs cleaning, the second electric push rod lowers the insert plate. At this time, not only will the cutter follow the descent to the cleaning plate for cleaning, but also the unqualified particles intercepted in the centrifugal screen will be discharged. The push ring descends, pushing the lifting block and scraper down. During the descent, the scraper contacts the inner bottom surface of the centrifugal screen, thus pushing the particles out of the inlet during rotation, completing the discharge. This design links the cleaning of the cutter and the discharge, making it convenient, fast, and highly practical.

[0008] Preferably, the partition is fixedly connected to the inner wall of the cylinder, and a circular groove is provided at the center of the top of the cylinder. The material cylinder is detachably connected to the top of the partition at the circular groove by bolts.

[0009] In practical applications, the material cylinder, as the part that produces granules, can be replaced when producing granules of different shapes because the holes on its surface are fixed. It can simply be removed from the circular groove.

[0010] Preferably, the top of the cylinder is provided with a top cover, and a first electric actuator is fixedly connected to the center of the top of the top cover. The telescopic end of the first electric actuator passes through the surface of the top cover and is fixedly connected to a pressure plate. The pressure plate is located directly above the material cylinder.

[0011] In practical applications, the No. 1 electric actuator starts and drives the pressure plate to descend. The pressure plate squeezes the material in the material cylinder downward, causing it to pass through the holes in the material cylinder and be cut off by the cutter to form particles. The diameter of the pressure plate is the same as the inner diameter of the material cylinder, so the extrusion force can be applied to the material evenly.

[0012] Preferably, a horizontal plate is fixedly connected between the inner sidewalls of the centrifugal sieve cylinder below the cylinder, and a servo motor is fixedly connected to the center of the bottom of the horizontal plate. The tail end of the drive shaft of the servo motor passes through the surface of the horizontal plate and is fixedly connected to the bottom end of the drive rod.

[0013] In practical applications, the horizontal plate serves as a support component with high strength and an inclined surface to facilitate the passage of particles. The servo motor starts and drives the transmission rod above and the centrifugal screen cylinder to rotate, thereby screening the particles.

[0014] Preferably, a first spring is fixedly connected between the inner walls of the impact block and the retraction block, and a second spring is fixedly connected between the top of the lifting block and the inner wall of the top rod.

[0015] In practical applications, spring number one applies a pushing force to the impact block, enabling it to pop out quickly, while spring number two applies a pulling force to the lifting block, keeping it inside the top rod and preventing it from falling, thus avoiding affecting the normal rotation of the centrifugal screen cylinder.

[0016] Preferably, the top end of the transmission rod and the top end of the centrifugal sieve cylinder do not contact the bottom of the partition plate, and the top end of the insert plate and the inner bottom surface of the centrifugal sieve cylinder are located on the same plane.

[0017] In practical applications, although it does not contact the partition, the distance is small, which can prevent particles from flying out. Furthermore, since the insert plate and the inner bottom of the centrifugal screen cylinder are flush, it can prevent the accumulation of particles or the obstruction of normal particle movement.

[0018] Compared with the prior art, the beneficial effects of this utility model are as follows:

[0019] 1. This utility model uses a second electric push rod to drive the connecting rod and the moving cutter to move up and down, so that the cutter passes over the cleaning plate. The bristles on the cleaning plate will sweep off the material remaining on the surface of the cutter. Thus, the cleaning operation can be completed without disassembling the cutter, reducing maintenance costs and improving the convenience and production efficiency of the device.

[0020] 2. This utility model, by setting a push ring and a scraper, can discharge material after cleaning the cutter. When the connecting rod descends, the push ring follows, thereby driving the scraper and lifting block to descend. When the scraper approaches the inner bottom surface of the centrifugal screen cylinder, the insert plate disengages from the insertion port, exposing the insertion port. The cleaning screen cylinder continues to rotate while the scraper remains in its original position. Therefore, the scraper will push the particles and materials inside the centrifugal screen cylinder to the insertion port and discharge them during rotation, thus eliminating the need for separate disassembly and cleaning, and improving the convenience of the device. Attached Figure Description

[0021] Figure 1 This is an external view of the present invention;

[0022] Figure 2 This is a cross-sectional structural diagram of the present invention;

[0023] Figure 3 This is a schematic diagram of the internal structure of this utility model;

[0024] Figure 4 This is a schematic diagram of the centrifugal sieve cylinder structure of this utility model;

[0025] Figure 5 This is a diagram showing the positional relationship between the lever and the vertical frame of this utility model;

[0026] Figure 6 This is a partial enlarged view of point A of this utility model;

[0027] In the diagram: 1. Cylinder; 101. Top cover; 2. Partition plate; 201. Circular groove; 3. Electric actuator rod No. 1; 301. Pressure plate; 302. Material cylinder; 4. Horizontal plate; 401. Servo motor; 402. Transmission rod; 403. Centrifugal sieve cylinder; 5. Inlet; 6. Insert plate; 601. Base frame; 602. Electric actuator rod No. 2; 7. Connecting rod; 701. Push ring; 702. Cutter; 703. Cleaning plate; 8. Top rod; 801. Shrink block; 802. Impact block; 803. Spring No. 1; 804. Lifting block; 805. Spring No. 2; 9. Scraper. Detailed Implementation

[0028] The present invention will be further described below with reference to the accompanying drawings and embodiments:

[0029] Example 1: A pellet mill for producing nifedipine controlled-release tablets, see [link to example]. Figures 1 to 6 The centrifugal sieve cylinder 403 includes a partition 2, a transmission rod 402, and a material cylinder 302. The transmission rod 402 vertically penetrates the bottom center of the centrifugal sieve cylinder 403 and is fixedly connected to the centrifugal sieve cylinder 403. The top of the transmission rod 402 and the top of the centrifugal sieve cylinder 403 do not contact the bottom of the partition 2, thus ensuring that they are not affected by the partition 2 above during rotation. A horizontal plate 4 is fixedly connected between the inner walls of the cylinder 1 below the centrifugal sieve cylinder 403. A servo motor 401 is fixedly connected to the bottom center of the horizontal plate 4. The servo motor 401 is equipped with a protective shell to prevent particles from entering through the gaps. The servo motor 401 is inserted into the motor. The tail end of the drive shaft of the servo motor 401 passes through the surface of the horizontal plate 4 and is fixedly connected to the bottom end of the drive rod 402. After the servo motor 401 is started, it drives the drive rod 402 to rotate. The drive rod 402 simultaneously drives the centrifugal screen cylinder 403 to rotate, thereby screening the particles, intercepting larger particles, and allowing normal-sized particles to pass through the centrifugal screen cylinder 403 and be discharged normally, thus improving the yield of particle production. At the same time as the rotation, the cutter 702 also cuts and scrapes the material passing through the holes of the material cylinder 302, thereby realizing the production of particles.

[0030] Specifically, such as Figure 2 and Figure 3 As shown, a slot 5 is provided on one side of the bottom of the centrifugal sieve cylinder 403. A plate 6 is movably inserted into the inner side of the slot 5. The top of the plate 6 is on the same plane as the inner bottom surface of the centrifugal sieve cylinder 403. A base frame 601 is fixedly connected to the bottom of the centrifugal sieve cylinder 403 directly below the plate 6. A second electric actuator 602 is fixedly connected between the base frame 601 and the plate 6. The plate 6 is normally stored in the slot 5. When it is necessary to clean the scraper or discharge material, it is driven downward by the second electric actuator 602 to expose the slot 5 for easy material discharge.

[0031] Furthermore, such as Figure 5 As shown, a connecting rod 7 is fixedly connected to the top surface of the insert plate 6, and a cutter 702 is fixedly connected to the top of the connecting rod 7. The cutter 702 is attached to the bottom surface of the material cylinder 302. Two cleaning plates 703 are fixedly connected to the side wall of the transmission rod 402 below the cutter 702. There are cleaning bristles between the two cleaning plates 703. The bristles are relatively hard and can brush off the material remaining or attached to the surface of the cutter 702 during the process of the cutter 702 passing through, so as to ensure the cleanliness of the cutter 702 without disassembly, making cleaning more convenient.

[0032] Furthermore, such as Figure 5 and Figure 6 As shown, a top rod 8 is fixedly connected to the bottom of the partition 2, a shrink block 801 is fixedly connected to the side wall of the top rod 8, an impact block 802 is slidably connected to the inner side of the shrink block 801, and a No. 1 spring 803 is fixedly connected between the impact block 802 and the inner side wall of the shrink block 801. Since the top rod 8 is fixed to the bottom of the partition 2, it will not rotate with the centrifugal screen cylinder 403. During the rotation, the outer end of the impact block 802 in the shrink block 801 on the side wall of the top rod 8 is hemispherical and very smooth. Therefore, when passing through the frame of the centrifugal screen cylinder 403, it will be continuously squeezed back into the shrink block 801 and then popped out, thereby impacting the screen, realizing vibration, reducing clogging, and improving screening efficiency.

[0033] It is worth noting that, such as Figure 5 and Figure 6A lifting block 804 is vertically slidably connected to the inner side of the bottom end of the top rod 8. A scraper 9 is fixedly connected to the bottom of the lifting block 804. A second spring 805 is fixedly connected between the top of the lifting block 804 and the inner wall of the top rod 8. A push ring 701 is fixedly connected to the side wall of the connecting rod 7 above the scraper 9. The bottom of the push ring 701 is very smooth. When the scraper descends to clean, the push ring 701 will also descend. During the descent, it will push the scraper 9 and the lifting block 804, allowing the scraper 9 to reach the inner bottom of the centrifugal screen cylinder 403. Then, as the centrifugal screen cylinder 403 rotates... During the process, the particles and materials will be pushed out from the inlet 5, which improves convenience. For example, in traditional screening equipment, the material will remain in the screening screen after screening. At this time, the machine will be stopped, the equipment will be opened, and then the screening screen will be removed to dump the intercepted material, thereby avoiding blockage and allowing for the secondary use of the material. This process is quite troublesome. It is fine for simple machines, but for machines that require more structures and parts, disassembly is very inconvenient. It not only wastes time and affects the overall production efficiency, but may also cause machine parts to be lost or damaged during disassembly and assembly.

[0034] In practical use, this solution integrates the discharge and cleaning structures. After cleaning the cutter 702, it can continue to clean the material and particles in the centrifugal screen cylinder 403. The scraper 9 moves downward under the drive of the push ring 701, and then the particles and materials are pushed out from the inlet 5 during the rotation of the centrifugal screen cylinder 403, thus completing the discharge process. The process is convenient and quick, saves time, and does not require disassembly of the equipment, avoiding unnecessary damage.

[0035] It should be noted that the screen of the centrifugal screen cylinder 403 is installed on the outer edge and is made of a relatively hard metal material. Therefore, when the impact block 802 reaches the frame of the centrifugal screen cylinder 403, it will be squeezed back into the shrink block 801. When it leaves the frame, due to the certain gap between it and the screen, the impact block 802 will impact the screen when it pops out. The resulting vibration can reduce particle blockage and improve the screening effect.

[0036] It should be noted that, in order not to obstruct the connecting rod 7 when rotating, the end of the scraper 9 facing the transmission rod 402 does not reach the connecting rod 7, thus ensuring that the connecting rod 7 and the cutter 702 above it rotate normally. Due to the centrifugal effect, the particles will move towards the outer edge of the centrifugal screen cylinder 403. Therefore, even if the end of the scraper 9 facing the transmission rod 402 is shorter, it will not affect the normal pushing of the particles.

[0037] It is worth noting that, such as Figure 2 As shown, the partition 2 is fixedly connected to the inner wall of the cylinder 1. A circular groove 201 is provided in the center of the top of the cylinder 1. The material cylinder 302 is detachably connected to the top of the partition 2 at the circular groove 201 by bolts and can be freely replaced as needed.

[0038] For example, when it is necessary to produce round granules, a material cylinder 302 with a perfectly round hole shape can be selected and installed at the circular groove 201. Then, under the drive of the first electric push rod 3 and the pressure plate 301, the material in the material cylinder 302 is squeezed to pass through the circular hole, thereby completing the production of round granules, which is more convenient and practical.

[0039] Specifically, such as Figure 2 As shown, the top of the cylinder 1 is provided with a top cover 101. A first electric push rod 3 is fixedly connected to the center of the top of the top cover 101. The telescopic end of the first electric push rod 3 passes through the surface of the top cover 101 and is fixedly connected to the pressure plate 301. The pressure plate 301 is located directly above the material cylinder 302. The top cover 101 is opened to add the mixed material into the material cylinder 302. Then the top cover 101 is closed. At this time, the first electric push rod 3 is started to drive the pressure plate 301 to move downward. The pressure plate 301 will squeeze the material and make the material pass through the hole of the material cylinder 302, so that it is cut by the cutter 702 below to realize the production of the material.

[0040] It should be noted that this device is used to compress the mixed materials to cut them into granules. The mixing process can be achieved by stirring. There are many stirring devices, and the technology is mature, so we will not go into too much detail about stirring. During the granule production process, the freshly produced granules may contain some moisture, resulting in poor screening. At this time, screening is temporarily suspended, and the speed of the drive rod 402 and the cutter 702 is slow. After the granules are produced, the inside of the cylinder 1 is heated by the electric heating tube 10 installed on the inner wall of the cylinder 1. After it is completely dry, normal screening and discharge operations can be carried out.

[0041] In addition, all components designed in this utility model are general standard parts or components known to those skilled in the art. Their structure and principle can be learned by those skilled in the art through technical manuals or conventional experimental methods. Those skilled in the art can fully implement them, so there is no need to elaborate. The content protected by this utility model does not involve improvements to the internal structure and method.

[0042] The embodiments disclosed herein are preferred embodiments, but are not limited thereto. Those skilled in the art can readily grasp the spirit of this utility model based on the above embodiments and make different extensions and variations. However, as long as they do not depart from the spirit of this utility model, they are all within the protection scope of this utility model.

Claims

1. A granulator for producing nifedipine controlled-release tablets, comprising a partition (2), a transmission rod (402), and a material cylinder (302), characterized in that, The transmission rod (402) vertically penetrates the bottom center of the centrifugal sieve cylinder (403) and is fixedly connected to the centrifugal sieve cylinder (403). An insertion port (5) is provided on one side of the bottom of the centrifugal sieve cylinder (403). An insertion plate (6) is movably inserted into the inner side of the insertion port (5). A base frame (601) is fixedly connected to the bottom of the centrifugal sieve cylinder (403) directly below the insertion plate (6). A second electric push rod (602) is fixedly connected between the base frame (601) and the insertion plate (6). A connecting rod (7) is fixedly connected to the top surface of the insertion plate (6). A cutter (702) is fixedly connected to the top of the connecting rod (7). Two cleaning plates (703) are fixedly connected to the side wall of the transmission rod (402) below the cutter (702). A top rod (8) is fixedly connected to the bottom of the partition (2). A shrink block (801) is fixedly connected to the side wall of the top rod (8). An impact block (802) is slidably connected to the inner side of the shrink block (801). A lifting block (804) is vertically slidably connected to the inner side of the bottom end of the top rod (8). A scraper (9) is fixedly connected to the bottom of the lifting block (804). A push ring (701) is fixedly connected to the side wall of the connecting rod (7) above the scraper (9).

2. The granulator for producing nifedipine controlled-release tablets as described in claim 1, characterized in that, The partition (2) is fixedly connected to the inner wall of the cylinder (1). A circular groove (201) is provided at the center of the top of the cylinder (1). The material cylinder (302) is detachably connected to the top of the partition (2) at the circular groove (201) by bolts.

3. A pellet mill for producing nifedipine controlled-release tablets as described in claim 2, characterized in that, The top of the cylinder (1) is provided with a top cover (101). A first electric push rod (3) is fixedly connected to the center of the top of the top cover (101). The telescopic end of the first electric push rod (3) passes through the surface of the top cover (101) and is fixedly connected to the pressure plate (301). The pressure plate (301) is located directly above the material cylinder (302).

4. A pellet mill for producing nifedipine controlled-release tablets as described in claim 1, characterized in that, A horizontal plate (4) is fixedly connected between the inner walls of the cylinder (1) below the centrifugal sieve cylinder (403). A servo motor (401) is fixedly connected to the center of the bottom of the horizontal plate (4). The tail end of the drive shaft of the servo motor (401) passes through the surface of the horizontal plate (4) and is fixedly connected to the bottom end of the drive rod (402).

5. A pellet mill for producing nifedipine controlled-release tablets as described in claim 1, characterized in that, A first spring (803) is fixedly connected between the inner walls of the impact block (802) and the retraction block (801), and a second spring (805) is fixedly connected between the top of the lifting block (804) and the inner wall of the top rod (8).

6. A pellet mill for producing nifedipine controlled-release tablets as described in claim 1, characterized in that, The top of the transmission rod (402) and the top of the centrifugal sieve cylinder (403) do not contact the bottom of the partition plate (2), and the top of the insert plate (6) and the inner bottom surface of the centrifugal sieve cylinder (403) are on the same plane.

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