Shaking device for immune cell culture bag

Abstract

The utility model discloses a shaking device for an immune cell culture bag, which comprises a box body, a tray and a rotating device and consists of a plurality of support rods, the tray is fixed in the box body through a suspension rod; comprising a rotating motor, a rotating rod, a first connecting rod and a second connecting rod; the rotating motor is fixed on the box body; the rotating rod is fixed on a driving shaft of the rotating motor; one end of the first connecting rod is rotatably connected with the rotating rod, the other end of the first connecting rod is rotatably connected with the second connecting rod, and the side edge of the tray is connected with the second connecting rod. According to the technical scheme, the tray can be shaken through the rotating device, so that immune cells in the immune cell culture bag are shaken, adverse effects caused by violent shaking are prevented while cell deposition is avoided, and the immune cell culture device is more suitable for growth of the immune cells.

Description

Technical Field

[0001] This utility model relates to the field of cell culture device technology, and in particular to a shaking device for immune cell culture bags. Background Technology

[0002] Statistics show that the cancer rate in my country has been on the rise in recent years, and the adverse effects of cancer are self-evident. With the rapid development of biotechnology and the medical field, immunotherapy for tumors has become an indispensable and important method. Immunotherapy refers to the process of collecting peripheral blood or umbilical cord blood, isolating immune cells in vitro, culturing and expanding them, and finally reinfusing them into the patient's body to kill tumor cells, inhibit tumor cell growth, and regulate the body's immune function. With the continuous increase in the number of cancer patients in recent years, the demand for immune cells has also expanded, making immune cell culture technology particularly important.

[0003] Currently, immune cell culture is mostly conducted in immune cell culture bags. However, most immune cells remain stationary within these bags. Due to gravity, as the culture time increases, immune cells tend to settle, adhere to the bag walls, and accumulate, hindering their growth and affecting their final use. While existing devices that shake the immune cell culture bags can prevent cell deposition to some extent, they also suffer from drawbacks such as excessive shaking, wasted manpower, limited scale, and narrow gas exchange area.

[0004] In summary, how to design an immune cell culture bag shaking device that saves manpower, is suitable for large-scale production, and has a shaking intensity and gas exchange area more suitable for the growth of immune cells is a problem that urgently needs to be solved by those skilled in the art. Utility Model Content

[0005] The technical solution of this utility model to solve the above-mentioned technical problems is to provide a shaking device for immune cell culture bags, including: a box, a tray and a rotating device, which is composed of multiple support rods; the tray is fixed to the box by a suspension rod; it includes a rotating motor, a rotating rod, a first connecting rod and a second connecting rod; the rotating motor is fixed to the box; the rotating rod is fixed to the drive shaft of the rotating motor; one end of the first connecting rod is rotatably connected to the rotating rod and the other end is rotatably connected to the second connecting rod; the side of the tray is connected to the second connecting rod.

[0006] Furthermore, it also includes: a power supply device and a timing device, comprising a drive power supply and a battery, wherein the drive power supply and the battery are fixed inside the housing and electrically connected, and the drive power supply is electrically connected to the rotating motor; the timing device includes terminals, a timer, a power adapter and a plug, wherein the plug is electrically connected to the power adapter, the power adapter is electrically connected to the timer, the timer is electrically connected to the terminals, and the terminals are electrically connected to the drive power supply.

[0007] Furthermore, the support rod is designed as a hollow structure to conceal the wires; a reinforcing rod is installed inside the vertical support rod within the housing.

[0008] Furthermore, the tray is provided with multiple round holes, and the suspension rod passes through the round holes and is fixed to the box body.

[0009] Furthermore, rubber sleeves are provided at both ends of the suspension rod, and the rubber sleeves are fitted over both ends of the suspension rod and located between the box and the tray to fix the tray.

[0010] Furthermore, it also includes a water tank, which is fixed inside the box and located below the tray.

[0011] Furthermore, the rotating motor is fixed to the housing by a second fixing plate.

[0012] Furthermore, the battery is fixed inside the casing by a first fixing plate.

[0013] The technical solution of this utility model uses a rotating device to make the tray shake up and down, causing the immune cells in the immune cell culture bag to move and preventing cell deposition while avoiding adverse effects caused by violent shaking. A timer sets the device's running time, making operation convenient and quick, saving manpower. The device can hold multiple immune cell culture bags simultaneously, making it more suitable for large-scale production. The tray has multiple round holes, ensuring that the gas exchange area of ​​the culture bags is not significantly reduced when placed on the tray, allowing the cells to have sufficient contact with air. This utility model solves the problems of cell deposition during cell culture, excessive shaking in existing devices, limited gas exchange area of ​​cell culture bags, need for manual operation, and small scale in current technologies, thus improving the practicality and effectiveness of the device. Attached Figure Description

[0014] To more clearly illustrate the technical solutions in the embodiments of this utility model or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this utility model. For those skilled in the art, other drawings can be obtained based on the structures shown in these drawings without creative effort.

[0015] Figure 1 This is a schematic diagram of the shaking device for immune cell culture bags described in this utility model;

[0016] Figure 2 This is a cross-sectional structural diagram of the shaking device for immune cell culture bags described in this utility model;

[0017] Figure 3 This is a schematic diagram of the circuit connection structure of the shaking device for the immune cell culture bag described in this utility model;

[0018] Figure 4 This is a schematic diagram of the structure of the tray described in this utility model;

[0019] Figure 5 This is a schematic diagram of the rotating device described in this utility model.

[0020] Explanation of icon numbers:

[0021] label name label name 10 Box 35 Second fixing plate 11 First fixing plate 41 Drive power supply 20 tray 42 Storage battery 21 suspension rod 51 Terminal blocks 22 rubber sleeve 52 timer 31 Rotary motor 53 power adapter 32 Rotating rod 54 plug 33 First connecting rod 60 sink 34 Second connecting rod Detailed Implementation

[0022] The technical solutions of the embodiments of this utility model will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only a part of the embodiments of this utility model, and not all of them. Based on the embodiments of this utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of this utility model.

[0023] It should be noted that all directional indicators (such as up, down, left, right, front, back, etc.) in this utility model embodiment are only used to explain the relative positional relationship and movement of each component in a certain specific posture (as shown in the figure). If the specific posture changes, the directional indicator will also change accordingly.

[0024] Furthermore, in this utility model, the use of terms such as "first" and "second" is for descriptive purposes only and should not be construed as indicating or implying their relative importance or implicitly specifying the number of technical features indicated. Therefore, a feature defined as "first" or "second" may explicitly or implicitly include at least one of that feature. In the description of this utility model, "several" or "multiple" means at least two, such as two, three, etc., unless otherwise explicitly specified.

[0025] In this utility model, unless otherwise explicitly specified and limited, the terms "connection," "fixing," etc., should be interpreted broadly. For example, "fixing" can mean a fixed connection, a detachable connection, or an integral part; it can mean a mechanical connection or an electrical connection; it can mean a direct connection or an indirect connection through an intermediate medium; it can mean the internal communication of two components or the interaction between two components, unless otherwise explicitly limited. Those skilled in the art can understand the specific meaning of the above terms in this utility model according to the specific circumstances.

[0026] Furthermore, the technical solutions of the various embodiments of this utility model can be combined with each other, but only if they are based on the ability of those skilled in the art to implement them. When the combination of technical solutions is contradictory or cannot be implemented, it should be considered that such combination of technical solutions does not exist and is not within the scope of protection claimed by this utility model.

[0027] This invention proposes a shaking device for immune cell culture bags, aiming to design an immune cell culture bag shaking device that saves manpower, is suitable for large-scale production, and has shaking intensity and gas exchange area that are more suitable for the growth of immune cells.

[0028] The shaking device for immune cell culture bags proposed in this utility model will be described below in specific embodiments:

[0029] In the technical solution of this embodiment, such as Figure 1 , Figure 2 , Figure 3 , Figure 4 , Figure 5 As shown, a shaking device for an immune cell culture bag includes: a housing 10, a tray 20, and a rotating device composed of multiple support rods; the tray 20 is fixed inside the housing 10 by a suspension rod 21; it includes a rotating motor 31, a rotating rod 32, a first connecting rod 33, and a second connecting rod 34; the rotating motor 31 is fixed to the housing 10; the rotating rod 32 is fixed to the drive shaft of the rotating motor 31; one end of the first connecting rod 33 is rotatably connected to the rotating rod 32, and the other end is rotatably connected to the second connecting rod 34; the side of the tray 20 is connected to the second connecting rod 34.

[0030] Specifically, the box 10 has four layers and is composed of multiple support rods. Four support rods form a rectangular structure, which is then connected by vertical support rods to form a four-layer box 10 (used to house three trays 20 and one water tank 60). The support rods are all hollow structures, and the vertical support rods have reinforcing rods to make the box 10 more robust. The suspension rod 21 is fixed to the support rods of the box 10. The trays 20 can rotatably pass through the suspension rod 21. When the rotating motor 31 runs, it drives the rotating rod 32 to rotate, which in turn drives the first connecting rod 33 to swing, which in turn drives the second connecting rod 34 to swing, and the second connecting rod 34 drives the trays 20 to swing.

[0031] Furthermore, the shaking device for the immune cell culture bag also includes: a power supply and a timing device, including a drive power supply 41 and a battery 42, the drive power supply 41 and the battery 42 being fixed inside the housing 10 and electrically connected, the drive power supply 41 being electrically connected to the rotating motor 31; the timing device includes a terminal block 51, a timer 52, a power adapter 53 and a plug 54, the plug 54 being electrically connected to the power adapter 53, the power adapter 53 being electrically connected to the timer 52, the timer 52 being electrically connected to the terminal block 51, and the terminal block 51 being electrically connected to the drive power supply 41.

[0032] Furthermore, the support rod is designed as a hollow structure to conceal the wires; a reinforcing rod is installed inside the vertical support rod inside the housing 10.

[0033] Furthermore, the tray 20 is provided with a plurality of round holes, and the suspension rod 21 passes through the round holes and is fixed to the box body 10.

[0034] Furthermore, rubber sleeves 22 are provided at both ends of the suspension rod 21. The rubber sleeves 22 are fitted over both ends of the suspension rod 21 and are located between the box body 10 and the tray 20 to fix the tray 20.

[0035] Furthermore, the shaking device for the immune cell culture bag also includes a water tank 60, which is fixed inside the housing 10 and located below the tray 20.

[0036] Furthermore, the rotating motor 31 is fixed inside the housing 10 by the second fixing plate 35.

[0037] Furthermore, the battery 42 is fixed inside the housing 10 by the first fixing plate 11.

[0038] Specifically, the box body 10, tray 20, first fixing plate 11, second fixing plate 35, rotating rod 32, first connecting rod 33, second connecting rod 34, suspension rod 21, reinforcing rod, and water tank 60 are all made of stainless steel, which is sturdy and easy to clean, and can be autoclaved to meet the sterile environment required for cell culture.

[0039] Working principle: When in use, place the immune cell culture bag stably on the tray 20, plug 54 is powered on, and the current flows to the drive power supply 41 after being adjusted by the power adapter 53 to the appropriate current and voltage of the timer 52. The timer 52 is set to start, stop and overall shaking time. The drive power supply 41 adjusts the current and voltage to the state suitable for the operation of the rotating motor 31. After the rotating motor 31 starts, it drives the rotating rod 32 to rotate. The rotating rod 32 drives the first connecting rod 33 to swing. The first connecting rod 33 drives the second connecting rod 34 to swing, which in turn drives the tray 20 connected to the second connecting rod 34 to swing, preventing cells from dying due to deposition and violent rotation.

[0040] The above description is merely a preferred embodiment of this utility model, but the protection scope of this utility model is not limited thereto. Any variations or substitutions that can be easily conceived by those skilled in the art within the technical scope disclosed in this utility model should be included within the protection scope of this utility model. Therefore, the protection scope of this utility model should be determined by the scope of the claims.

Claims

1. A shaking device for an immune cell culture bag, characterized in that, include: The housing is composed of multiple support rods; The pallet is fixed inside the box by a suspension rod; and The rotating device includes a rotating motor, a rotating rod, a first connecting rod, and a second connecting rod; the rotating motor is fixed to the housing; the rotating rod is fixed to the drive shaft of the rotating motor; one end of the first connecting rod is rotatably connected to the rotating rod, and the other end is rotatably connected to the second connecting rod; the side of the tray is connected to the second connecting rod.

2. The shaking device for an immune cell culture bag according to claim 1, characterized in that, Also includes: The power supply device includes a drive power supply and a storage battery. The drive power supply and the storage battery are fixed inside the housing and are electrically connected. The drive power supply is electrically connected to the rotating motor. A timing device includes a terminal block, a timer, a power adapter, and a plug. The plug is electrically connected to the power adapter, the power adapter is electrically connected to the timer, the timer is electrically connected to the terminal block, and the terminal block is electrically connected to the drive power supply.

3. The shaking device for an immune cell culture bag according to claim 1, characterized in that, The support rod is designed as a hollow structure to conceal the wires; a reinforcing rod is installed inside the vertical support rod of the housing.

4. The shaking device for an immune cell culture bag according to claim 1, characterized in that, The tray has multiple round holes, and the suspension rod passes through the round holes and is fixed to the box.

5. The shaking device for an immune cell culture bag according to claim 1, characterized in that, The suspension rod has rubber sleeves at both ends, which are fitted over the suspension rod and located between the box and the tray.

6. The shaking device for an immune cell culture bag according to claim 1, characterized in that, Also includes: A water tank, which is fixed inside the box and located below the tray.

7. The shaking device for an immune cell culture bag according to claim 1, characterized in that, The rotating motor is fixed to the housing by a second fixing plate.

8. The shaking device for an immune cell culture bag according to claim 2, characterized in that, The battery is fixed inside the box by a first fixing plate.

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