Traditional Chinese medicine effective component extraction device

Abstract

The utility model discloses a traditional Chinese medicine active ingredient extraction device which comprises a traditional Chinese medicine extraction tank, the cooling mechanism is connected with the traditional Chinese medicine extraction tank; the elution mechanism is communicated with the cooling mechanism through a first pipeline, and a first valve is arranged on the first pipeline; the elution mechanism comprises at least three exchange columns which are connected in parallel, the adjacent exchange columns are further connected through a series connection pipe, and a plurality of pipeline valves are further arranged on parallel connection pipelines and the series connection pipes in the elution mechanism; the collecting mechanism is respectively connected with the eluting mechanism and the cooling mechanism, so that the traditional Chinese medicine active ingredient extraction device can be switched between a direct extraction mode and an extraction and purification mode; and the purity detector is connected in parallel with the outlet pipeline of the exchange column. The traditional Chinese medicine effective component extraction device can perform crude extraction or fine extraction on traditional Chinese medicine effective components as required, can detect each purification process in the fine extraction process so as to ensure the final purification effect, and also can avoid influence on the purification effect of an exchange column due to too high temperature of an extracting solution.

Description

TECHNICAL FIELD

[0001] The utility model relates to traditional Chinese medicine extraction equipment technical field especially relates to a traditional Chinese medicine effective component extraction device. BACKGROUND

[0002] The extraction of traditional Chinese medicine effective components (such as alkaloids, flavones, polysaccharides and the like) is the key link of the modernization production of traditional Chinese medicine, and directly influences the quality of medicine, curative effect and industrialization application. For the traditional Chinese medicine with lower purity requirement, the effective components are generally extracted by decocting at present;For the traditional Chinese medicine with relatively higher purity requirement, further purification is needed, and macroporous resin is generally used to carry out adsorption and elution to reach the production requirement, but the preliminary decocting extraction and further purification of the effective components of general traditional Chinese medicine are carried out separately, so that the overall step operation of the extraction of the effective components of traditional Chinese medicine is cumbersome. In addition, the general traditional Chinese medicine extraction device can only realize the rough extraction or the fine extraction of the effective components singly, and the applicable range is poor.

[0003] Therefore, it is necessary to design a traditional Chinese medicine effective component extraction device to solve the above problems. UTILITY MODEL CONTENT

[0004] The utility model discloses a kind of traditional Chinese medicine effective component extraction devices, which can carry out rough extraction or fine extraction of traditional Chinese medicine effective components according to needs, and can detect each purification process in fine extraction process to ensure the final purification effect, and also can avoid the adsorption purification effect of exchange column being influenced by the temperature of extractant being too high.

[0005] To achieve the above object, the utility model provides the following technical scheme:

[0006] A traditional Chinese medicine effective component extraction device, comprising:

[0007] Traditional Chinese medicine extraction tank, the outlet of the traditional Chinese medicine extraction tank is provided with a filter element;

[0008] Cooling mechanism, connected with the outlet of the traditional Chinese medicine extraction tank, to cool the extraction liquid output by the traditional Chinese medicine extraction tank;

[0009] Elution mechanism, communicated with the cooling mechanism by first pipeline, and a first valve is arranged on the first pipeline;The elution mechanism includes at least three parallelly connected exchange columns, and adjacent exchange columns are also connected by series connection pipe, and a plurality of pipe valves are also arranged on the parallel pipeline and series connection pipe in the elution mechanism, so that the plurality of exchange columns can be connected with the cooling mechanism by parallel connection, series connection or single mode;

[0010] The collecting mechanism is connected with the elution mechanism and the cooling mechanism through a first pipeline and a second pipeline respectively, and a first control valve is arranged on each of the two pipelines, so that the traditional Chinese medicine effective component extraction device can be switched between a direct extraction mode and an extraction and purification mode.

[0011] A purity detector is connected in parallel with the outlet pipeline of the exchange column.

[0012] As a further improvement of the utility model, the filter is a first filter screen.

[0013] As a further improvement of the utility model, a filtering mechanism for secondary filtering of the traditional Chinese medicine extraction liquid is further arranged on the first pipeline.

[0014] As a further improvement of the utility model, the filtering mechanism is a second filter screen with a smaller pore size than the first filter screen and is detachably arranged on the first pipeline.

[0015] As a further improvement of the utility model, the cooling mechanism comprises a cooling tank and a cooling pipe wound around the cooling tank.

[0016] As a further improvement of the utility model, the purity detector is connected in parallel with the outlet pipeline of the exchange column through a detection pipeline, and a second control valve for controlling the communication state between the purity detector and the outlet of the exchange column is arranged on the detection pipeline.

[0017] As a further improvement of the utility model, the purity detector is an ultraviolet absorption wavelength detector.

[0018] As a further improvement of the utility model, a plurality of heaters are arranged on the traditional Chinese medicine extraction tank in a circumferential direction.

[0019] As a further improvement of the utility model, a stirrer is further arranged on the traditional Chinese medicine extraction tank.

[0020] As a further improvement of the utility model, a delivery pump is further arranged on the first pipeline.

[0021] The utility model has the advantages of:

[0022] 1. The utility model connects at least three exchange columns in parallel, connects the plurality of exchange columns in series through a series pipeline, and correspondingly arranges pipeline valves on the parallel pipeline and the series pipeline, so that the plurality of exchange columns can be connected in parallel, connected in series or connected with the traditional Chinese medicine extraction tank alone, and the diversified production requirements of traditional Chinese medicine effective components are met. In addition, the collecting mechanism is connected with the elution mechanism and the cooling mechanism respectively, so that the traditional Chinese medicine effective component extraction device can meet the requirements of traditional Chinese medicine extraction and also meet the requirements of traditional Chinese medicine extraction, and has wide applicability.

[0023] 2. The utility model discloses a cooling mechanism is provided between traditional Chinese medicine extraction tank and elution mechanism, can reduce the temperature of the extraction liquid of entering the elution mechanism, avoid because the extraction liquid temperature is too high and directly enter the exchange column to make the exchange column sustained in high temperature state and influence the purification effect of exchange column, effectively prolong the service life of exchange column.

[0024] 3. The utility model discloses a purity detector is connected in parallel on the outlet pipeline of exchange column, can carry out the detection to the liquid purity of flowing out from exchange column, understands the purification process in real time, when the purity of the purified liquid of final obtaining can not reach the expectation, judges the purity reduction reason through purity detector. DRAWINGS

[0025] Fig. 1 It is the whole structure schematic diagram of traditional Chinese medicine effective component extraction device.

[0026] Fig. 2 It is the connection schematic diagram of purity detector and exchange column.

[0027] Fig. 3 It is the structure schematic diagram of traditional Chinese medicine extraction tank part.

[0028] REFERENCE NUMERALS

[0029] 10, traditional Chinese medicine extraction tank;11, heater;121, stirring column;122, stirring paddle;13, conveying pump;20, cooling tank;21, first pipeline;22, first valve;31, first ion exchange column;32, second ion exchange column;33, third ion exchange column;41, first branch pipe;42, second branch pipe;43, first main pipe;44, second main pipe;51, second pipeline;52, third pipeline;60, fourth pipeline;71, second valve;72, third valve;73, fourth valve;74, fifth valve;75, sixth valve;76, seventh valve;77, eighth valve;78, ninth valve;81, purity detector;82, detection pipeline;83, tenth valve;90, collection mechanism. DETAILED DESCRIPTION

[0030] In order to make the utility model's purpose, technical scheme and advantage more clearly, below combining with the drawing and concrete embodiment to the utility model carries out the detailed description.

[0031] Here, it also needs to be explained that, in order to avoid because unnecessary details and obscure the utility model, in the drawing only shows the structure and / or processing step closely related with the scheme of the utility model, and omits other details not related with the utility model.

[0032] It is also important to note that the term "comprising" or "including" or any other variation thereof is intended to cover a non-exclusive inclusion, such that processes, methods, articles, or apparatuses that comprise a list of elements are not required to comprise only those elements but can include other elements not expressly listed or inherent to such processes, methods, articles, or apparatuses.

[0033] Referring to Figs. 1-3 The utility model provides a traditional Chinese medicine effective component extraction device, including:

[0034] Traditional Chinese medicine extraction tank 10, the outlet of traditional Chinese medicine extraction tank 10 is provided with a filter piece;

[0035] Cooling mechanism, with the outlet of traditional Chinese medicine extraction tank 10 is connected to, to the cooling of traditional Chinese medicine extraction tank 10 output extraction liquid;

[0036] Elution mechanism, through first pipeline 21 with the cooling mechanism is communicated and the first pipeline 21 is provided with first valve 22;The elution mechanism includes at least three parallelly connected exchange columns, adjacent exchange columns are also connected through series connection pipe, and a plurality of pipe valves are also provided on the parallel pipeline and series connection pipe in the elution mechanism, so that a plurality of exchange columns can be connected with the cooling mechanism through parallel connection, series connection or single mode;

[0037] Collecting mechanism 90, with the elution mechanism and cooling mechanism are connected through first pipe line and second pipe line respectively, and first control valve is arranged on both pipe lines, so that the traditional Chinese medicine effective component extraction device can be converted between direct extraction mode and extraction and purification mode;And

[0038] Purity detector 81, with the outlet pipeline of exchange column is connected in parallel.

[0039] Specifically, the filter piece is a first filter screen to separate the filter residue and the filtrate in the traditional Chinese medicine extraction tank 10.

[0040] Specifically, the first pipeline 21 is also provided with a filtering mechanism (not shown in the figure) for secondary filtering of the traditional Chinese medicine extraction liquid. Exemplarily, the filtering mechanism is a second filter screen with a smaller aperture than the first filter screen, which is detachably arranged on the first pipeline 21, to perform secondary separation of the extraction liquid flowing out of the filtering mechanism by the second filter screen, so as to avoid affecting the elution of the exchange column due to the presence of too many impurities in the liquid flowing into the elution mechanism. In addition, the detachable arrangement of the filtering mechanism facilitates timely cleaning and replacement of the second filter screen, ensuring the smoothness of the liquid flow in the first pipeline 21.

[0041] Specifically, the first pipeline 21 is also provided with a delivery pump 13.

[0042] Exemplarily, the exchange columns are provided with three, including the first ion exchange column 31, the second ion exchange column 32 and the third ion exchange column 33 which are sequentially arranged along the direction away from the cooling mechanism.

[0043] The first main pipe 43 is connected to the first branch pipe 41 at the inlet of each of the three exchange columns, and the second main pipe 44 is connected to the second branch pipe 42 at the outlet of each of the three exchange columns, and the first main pipe 43 is communicated with the first pipe 21, and the second main pipe 44 is communicated with the collection mechanism 90, so that the three exchange columns are connected in parallel under the connection of the first main pipe 43, the first branch pipe 41, the second main pipe 44 and the second branch pipe 42.

[0044] The series connection pipe includes the second pipe 51 for connecting the first ion exchange column 31 and the second ion exchange column 32, and the third pipe 52 for connecting the second ion exchange column 32 and the third ion exchange column 33, so that the three exchange columns are connected in series under the connection of the second pipe 51 and the third pipe 52.

[0045] As to the arrangement of the valves, the second valve 71 is arranged on each of the three first branch pipes 41, the third valve 72 is arranged on each of the three second branch pipes 42, the fourth valve 73 is arranged on the second pipe 51 and the third pipe 52, the fifth valve 74 is arranged on the pipe segment between the outlet of the first ion exchange column 31 and the outlet of the second ion exchange column 32 of the second main pipe 44, and the sixth valve 75 is arranged on the pipe segment between the outlet of the second ion exchange column 32 and the outlet of the third ion exchange column 33 of the second main pipe 44, so as to switch the elution mechanism between the parallel mode, the series connection mode and the single mode by controlling the working states of the second valve 71, the third valve 72, the fourth valve 73, the fifth valve 74 and the sixth valve 75, that is, when the fourth valve 73 is closed, the second valve 71, the third valve 72, the fifth valve 74 and the sixth valve 75 are opened, the three exchange columns are in the parallel mode; when the fourth valve 73 is opened, the fifth valve 74 and the sixth valve 75 are closed, and the working states of the second valve 71 and the third valve 72 are adjusted so that the extract liquid delivered from the first pipe 21 can flow through the first ion exchange column 31, the second ion exchange column 32 and the third ion exchange column 33 in sequence, the three exchange columns are in the series connection mode; when the fourth valve 73 is closed, the corresponding second valve 71 and the third valve 72 of a single exchange column are opened, the corresponding second valve 71 and the third valve 72 of the remaining exchange columns are closed, and the working states of the fifth valve 74 and the sixth valve 75 are adjusted so that the liquid delivered from the first pipe 21 only purifies through the single exchange column and then flows to the collection mechanism 90, the current is the single mode.

[0046] Specifically, the first main pipe 43 is also connected with the second main pipe 44 through the fourth pipe 60, that is, the first pipe 21, the first main pipe 43, the fourth pipe 60 and the second main pipe 44 form the first pipe connecting the cooling mechanism and the collecting mechanism 90, and the second main pipe 44 serves as the second pipe connecting the elution mechanism and the collecting mechanism 90; the fourth pipe 60 is also provided with a seventh valve 76, so that when the three second valves 71 are closed and the seventh valve 76 is opened, the cooling mechanism and the collecting mechanism 90 are directly connected, at this time, the traditional Chinese medicine effective component extraction device is in a direct extraction mode, and after the traditional Chinese medicine effective component is extracted by the traditional Chinese medicine extraction tank 10, the traditional Chinese medicine extraction liquid is collected, and the traditional Chinese medicine extraction liquid is obtained; when the seventh valve 76 is closed, the traditional Chinese medicine effective component extraction device is in an extraction and purification mode, at this time, by controlling the working states of the second valve 71 to the sixth valve 75, the three exchange columns in the elution mechanism can be connected with the cooling mechanism in a parallel, series or single mode, and the purified traditional Chinese medicine extraction liquid is collected in the collecting mechanism 90, thereby meeting different production requirements.

[0047] The fillers in the first ion exchange column 31, the second ion exchange column 32 and the third ion exchange column 33 can be filled according to needs. For example, cation exchange resin can be filled in the first ion exchange column 31, anion exchange resin can be filled in the second ion exchange column 32, and amphoteric ion exchange resin can be filled in the third ion exchange column 33, so that different impurities in the extraction liquid are fully adsorbed by connecting the three exchange columns in series, and the purity of the traditional Chinese medicine purification liquid is effectively improved.

[0048] The same type of exchange resin can also be filled in the three exchange columns, when the three exchange columns are connected in series, a certain kind or a certain type of impurities in the extraction liquid can be fully adsorbed without adding the height of the exchange column; when the three exchange columns are connected in parallel, the instantaneous elution capacity of the elution mechanism can be effectively improved; in addition, the exchange columns can also be connected in a single mode to meet the demand of traditional Chinese medicine purification with relatively small production capacity.

[0049] Specifically, the second main pipe 44 is also provided with an eighth valve 77 between the third ion exchange column 33 outlet and the fourth pipe 60 close to one end of the collecting mechanism 90, and the eighth valve 77 serves as the output valve of the elution mechanism.

[0050] Specifically, in actual use, since the pipe has a certain length, corresponding valves can be added as needed to avoid liquid loss caused by the liquid flowing into the disconnected pipe. For example, a ninth valve 78 can be arranged between the first main pipe 43 corresponding to the third ion exchange column 33 inlet and the fourth pipe 60 away from one end of the collecting mechanism 90.

[0051] Specifically, as shown in FIG. 2, the traditional Chinese medicine effective component extraction device comprises a traditional Chinese medicine extraction tank 10, a cooling mechanism 20, an elution mechanism 30 and a collecting mechanism 90. Fig. 2As shown, the purity detector 81 is connected in parallel with the outlet pipe of the exchange column, i.e. the second branch pipe 42, through a detection pipe 82, and the tenth valve 83 is arranged on the detection pipe 82 to control the communication state between the purity detector 81 and the outlet of the exchange column; and the third valve 72 is arranged on the pipe section between the inlet and the outlet of the second branch pipe 42 corresponding to the detection pipe 82, so that when the third valve 72 is closed and the tenth valve 83 is opened, the liquid flowing out of the exchange column flows through the purity detector 81 for purity detection; and when the third valve 72 is opened and the tenth valve 83 is closed, the purity of the liquid flowing out of the exchange column is not detected.

[0052] The purity detector 81 can detect the purity of the liquid flowing out of each exchange column, and can know the purification process in real time. When the purity of the purified liquid fails to reach the expected value, the purity detector 81 can determine whether the failure of one exchange column leads to the decrease of the purity of the purified liquid, thereby improving the purification efficiency and ensuring the purification result.

[0053] For example, the purity detector 81 is an ultraviolet absorption wavelength detector.

[0054] Specifically, the cooling mechanism includes a cooling tank 20 and a cooling pipe arranged around the cooling tank 20. The inlet of the cooling tank 20 is connected with the outlet of the traditional Chinese medicine extraction tank 10, and the outlet of the cooling tank 20 is connected with the first pipe 21. The inlet of the cooling tank 20 is located at the upper part of the cooling tank 20, and the outlet of the cooling tank 20 is located at the lower part of the cooling tank 20. The extracted liquid flowing out of the traditional Chinese medicine extraction tank 10 flows into the cooling tank 20, is cooled by the cooling pipe, and then flows into the elution mechanism after the temperature of the extracted liquid is reduced to a certain range. This avoids the direct entry of the extracted liquid with high temperature into the exchange column, which causes the exchange column to be in a high-temperature state for a long time and affects the purification effect of the exchange column, thereby effectively prolonging the service life of the exchange column.

[0055] Specifically, as shown in the figure, the traditional Chinese medicine extraction tank 10 is provided with a plurality of heaters 11 arranged at intervals in the circumferential direction. Fig. 3 For example, the traditional Chinese medicine extraction tank 10 is provided with four heaters 11 arranged at intervals in the circumferential direction to achieve uniform heating.

[0056] Specifically, the traditional Chinese medicine extraction tank 10 is further provided with a stirrer to further improve the extraction effect of traditional Chinese medicine. For example, the stirrer includes a stirring column 121 rotationally connected with the bottom of the traditional Chinese medicine extraction tank 10 and a plurality of stirring paddles 122 arranged at intervals in the vertical direction on the stirring column 121.

[0057] In use, the traditional Chinese medicine is placed in the traditional Chinese medicine extraction tank 10 to extract effective components; after the extraction is completed, the outlet of the traditional Chinese medicine extraction tank 10 is opened, the extraction liquid is partially flowed into the cooling tank 20 to be cooled, and then the cooled extraction liquid is transported to the elution mechanism through the first pipeline 21; the connection mode of the exchange column in the elution mechanism and the traditional Chinese medicine extraction tank 10 is adjusted according to the need, and then the flow rate of the extraction liquid flowing from the traditional Chinese medicine extraction tank 10 into the cooling tank 20 can be adjusted according to the elution flow rate, so that the extraction liquid in the traditional Chinese medicine extraction tank 10 is sequentially cooled in the cooling tank 20 and then flowed into the elution mechanism to be eluted and purified, and the continuous operation of the extraction and purification of the traditional Chinese medicine is realized.

[0058] In addition, when only the rough extraction of the traditional Chinese medicine is needed, after the extraction of the traditional Chinese medicine is completed, the outlet of the traditional Chinese medicine extraction tank 10 is opened, the extraction liquid is partially flowed into the cooling tank 20 to be cooled, and then the extraction liquid is directly flowed to the collection mechanism 90 through the first pipeline 21, the first main pipeline 43 and the fourth pipeline 60.

[0059] The traditional Chinese medicine effective component extraction device can realize the continuous operation of extraction and purification, reduce the intermediate transfer steps, shorten the production cycle by 30%-50%, and effectively avoid the oxidation or degradation of effective components.

[0060] The above examples are only used to illustrate the technical solutions of the utility model and not to limit it. Although the utility model has been described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that the technical solutions of the utility model can be modified or replaced equivalently without departing from the spirit and scope of the technical solutions of the utility model.

Claims

1. A traditional Chinese medicine effective component extraction device, characterized in that, The utility model relates to a traditional Chinese medicine extraction device, which comprises the following: a traditional Chinese medicine extraction tank (10) provided with a filter at its outlet; a cooling mechanism connected to the outlet of the traditional Chinese medicine extraction tank (10) to cool the extraction liquid output by the traditional Chinese medicine extraction tank (10); an elution mechanism connected to the cooling mechanism through a first pipeline (21) provided with a first valve (22); the elution mechanism comprises at least three exchange columns connected in parallel, and adjacent exchange columns are further connected through series pipelines, and a plurality of pipeline valves are further arranged on the parallel pipelines and series pipelines in the elution mechanism to enable the plurality of exchange columns to be connected to the cooling mechanism in parallel, series or single mode; a collection mechanism (90) connected to the elution mechanism and the cooling mechanism through a first pipeline and a second pipeline respectively, and a first control valve is arranged on each of the two pipelines to enable the traditional Chinese medicine active ingredient extraction device to be switched between direct extraction mode and extraction and purification mode; and a purity detector (81) connected in parallel to the outlet pipeline of the exchange column.

2. The traditional Chinese medicine effective component extraction device according to claim 1, characterized in that: The filter is a first filter screen.

3. The traditional Chinese medicine effective component extraction device according to claim 1, characterized in that: The first pipeline (21) is further provided with a filtering mechanism for secondary filtering of the traditional Chinese medicine extraction liquid.

4. The traditional Chinese medicine effective component extraction device according to claim 3, characterized in that: The filtering mechanism is a second filter screen with a smaller aperture than the first filter screen and detachably arranged on the first pipeline (21).

5. The traditional Chinese medicine effective component extraction device according to claim 1, characterized in that: The cooling mechanism comprises a cooling tank (20) and a cooling pipe wound around the cooling tank (20).

6. The traditional Chinese medicine effective ingredient extraction device according to claim 1, characterized in that: The purity detector (81) is connected in parallel to the outlet pipeline of the exchange column through a detection pipeline (82) provided with a second control valve for controlling the communication state between the purity detector (81) and the outlet of the exchange column.

7. The traditional Chinese medicine effective component extraction device according to claim 6, characterized in that: The purity detector (81) is an ultraviolet absorption wavelength detector.

8. The traditional Chinese medicine effective component extraction device according to claim 1, characterized in that: A plurality of heaters (11) are arranged on the traditional Chinese medicine extraction tank (10) at intervals in the circumferential direction.

9. The traditional Chinese medicine effective component extraction device according to claim 8, characterized in that: The traditional Chinese medicine extraction tank (10) is further provided with a stirrer.

10. The traditional Chinese medicine effective component extraction device according to claim 1, characterized in that: The first pipeline (21) is further provided with a delivery pump (13).

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