Shell structure, nucleic acid extractor and gene sequencing pretreatment system

Abstract

The utility model provides a shell structure, a nucleic acid extraction instrument and a gene sequencing pretreatment system.The shell structure comprises a base table, a shell body, a first electrode and a second electrode, the machine case is fixedly connected to the base table, a closed cavity is defined by the machine case and the base table, and an opening is formed in one side wall of the machine case; the cabin door is connected to the case in a sliding manner and is used for opening or closing the opening; and the driving mechanism is arranged on the case, is connected with the cabin door and is used for driving the cabin door to slide relative to the case so as to open or block the opening. According to the technical scheme, the driving mechanism is arranged to drive the cabin door to achieve opening and closing actions, manual operation of workers is not needed, use convenience is improved, and the risk of cross contamination with the outside is reduced.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of medical devices, in particular to a shell structure, a nucleic acid extractor and a gene sequencing pre-processing system. BACKGROUND

[0002] In the field of biological medicine, whether it is an automated instrument or manual operation, there is a risk of biochemical contamination, and the air convection in the experimental space often causes contamination to the sample, especially the nucleic acid purification and amplification link is easy to form aerosol, thereby causing cross contamination of the sample, or nucleic acid residues causing contamination to the following samples.

[0003] At present, most of the instrument cabin doors are manual cabin doors, which are complicated to operate and prone to sealing problems, which can easily cause contamination between samples and other problems. CONTENT OF THE INVENTION

[0004] The present application provides a shell structure, a nucleic acid extractor and a gene sequencing pre-processing system to reduce the phenomenon of easy pollution in the existing structure.

[0005] In a first aspect, the present application provides a shell structure, comprising,

[0006] a base;

[0007] a case fixedly connected to the base and surrounding the base to form an enclosed cavity, one side wall of the case being provided with an opening;

[0008] a cabin door slidingly connected to the case for opening or closing the opening;

[0009] a drive mechanism arranged on the case and connected to the cabin door to drive the cabin door to slide relative to the case, thereby opening or closing the opening.

[0010] In a specific implementation, the drive mechanism includes a rack, a gear and a drive motor;

[0011] the rack is fixedly connected to the cabin door;

[0012] the gear is rotatably connected to the inside of the case and engaged with the rack;

[0013] the drive motor is fixedly connected to the case and connected to the gear to drive the gear to rotate.

[0014] In a specific implementation, the drive mechanism further includes a transmission shaft, which is rotatably connected to the case;

[0015] the transmission shaft is arranged in a direction perpendicular to the sliding direction of the cabin door;

[0016] The gear has two, respectively fixedly connected in the transmission shaft both ends;

[0017] The rack is also provided with two, with two gear one-to-one correspondence.

[0018] In a specific embodiment, also includes fixedly connected in the fixed metal sheet of the machine case inner wall;

[0019] The drive motor and the transmission shaft are connected to the fixed metal sheet.

[0020] In a specific embodiment, the machine case includes a baffle, the opening is provided on the baffle;

[0021] The machine case upper side wall is provided with a through hole for the hatch to pass through;

[0022] The opening edge is fixedly connected with the stop edge;

[0023] When the hatch closes the opening, the surface of the hatch towards the outside of the cavity abuts against the baffle and the stop edge.

[0024] In a specific embodiment, the edge of the hatch towards the outside of the cavity and the side towards the base are fixedly connected with a flexible sealing strip.

[0025] In a specific embodiment, also includes a guide mechanism, the guide mechanism includes a slide rail fixedly connected to the machine case inner side wall and a guide block fixedly connected to the hatch;

[0026] The slide rail is arranged along the sliding direction of the hatch;

[0027] The guide block is provided with a guide groove matched with the slide rail, and the slide rail is clamped in the guide groove and in sliding cooperation with the guide block.

[0028] In a specific embodiment, the guide mechanism is provided with two, and the two guide mechanisms are respectively located on the two sides of the hatch away from each other in the first direction;

[0029] The first direction is perpendicular to the sliding direction of the hatch.

[0030] In a specific embodiment, also includes a controller and a position sensor, the position sensor and the drive mechanism are signal connected with the controller;

[0031] The position sensor is provided with at least two, and the hatch in the closed position and the open position respectively triggers the corresponding position sensor;

[0032] The controller is configured to control the driving mechanism to stop driving the hatch to move when the hatch triggers the in-place sensor.

[0033] In one specific implementation, two in-place sensors are provided, and the two in-place sensors are respectively arranged at two ends of the sliding rail in the extending direction.

[0034] The guide block triggers the two in-place sensors respectively when the hatch is in the closed position and the open position.

[0035] In one specific implementation, the side wall of the cabinet is provided with an air inlet and an air outlet.

[0036] The air outlet is provided with a ventilation member, which drives the airflow to enter the cabinet through the air inlet, flow through the working area in the cabinet, and be discharged out of the cabinet through the air outlet.

[0037] In one specific implementation, the air outlet is provided with a rear sealing plate, which is detachably connected with the cabinet to seal the air outlet.

[0038] The ventilation member is arranged on the rear sealing plate.

[0039] The rear sealing plate is provided with dustproof cotton at the connection with the cabinet.

[0040] In a second aspect, the present application also provides a nucleic acid extraction instrument comprising the shell structure as described in any one of the above.

[0041] In a third aspect, the present application also provides a gene sequencing pretreatment system comprising the nucleic acid extraction instrument as described above. BRIEF DESCRIPTION OF DRAWINGS

[0042] Figure 1 The schematic diagram of the gene sequencing pretreatment system provided by the embodiments of the present application is shown in the figure;

[0043] Figure 2 The overall structure schematic diagram of the shell structure provided by the embodiments of the present application is shown in the figure;

[0044] Figure 3 The schematic diagram of the driving mechanism and the guide mechanism of the shell structure provided by the embodiments of the present application is shown in the figure;

[0045] Figure 4 The enlarged schematic diagram of part A in the figure is shown in the figure; Figure 3

[0046] Figure 5 The signal transmission schematic diagram of the related components provided by the embodiments of the present application is shown in the figure. DETAILED DESCRIPTION ​

[0047] In order to make the purposes, technical solutions and advantages of the present application clearer, the present application will be further described in detail below with reference to the drawings.

[0048] It should be noted that, unless otherwise defined, technical terms or scientific terms used in one or more embodiments of the present application should be understood as their common meanings to those skilled in the art to which the present disclosure belongs. The terms "first", "second" and the like used in one or more embodiments of the present application do not represent any order, number or importance, but are only used to distinguish different components. The terms "include" or "contain" and the like mean that the elements or objects before the terms encompass the elements or objects listed after the terms and their equivalents, without excluding other elements or objects. The terms "connect" or "connected" and the like are not limited to physical or mechanical connections, but can include electrical connections, whether direct or indirect. The terms "upper", "lower", "left", "right" and the like are only used to represent relative positional relationships, which can change accordingly when the absolute positions of the described objects change.

[0049] To facilitate the understanding of the shell structure provided by the embodiments of the present application, the application scenario thereof is first described. The shell structure provided by the embodiments of the present application is used as a base structure of a medical instrument, and is mainly applied to instruments that need to complete corresponding processing work in a relatively closed space, such as a gene sequencing pre-processing system in the field of gene detection. The gene sequencing pre-processing system (or pre-processing instrument) includes a nucleic acid extraction system, a library construction system, a quality control system, an electrical control system and a host computer. The nucleic acid extraction system 10 mainly includes a nucleic acid extractor, which is used for nucleic acid extraction, reaction, detection and the like. All of these processes need to be performed in a relatively closed environment to avoid pollution of samples by other systems of the gene sequencing pre-processing system, so as to cause a large error between the detection result and the actual result. Taking the nucleic acid extractor as an example, a relatively closed space is formed inside the shell structure, which is used as an environment for performing the nucleic acid extraction process.

[0050] The key to preventing pollution is to seal the medical instrument. At present, most instrument cabin doors are manual cabin doors, which are complicated to operate and not tightly sealed, and are prone to cause pollution between samples. Therefore, the shell structure provided by the embodiments of the present application is used to reduce the risk of sample pollution during use of the medical instrument. The shell structure will be described in detail below in combination with specific drawings and embodiments.

[0051] It should be noted that the embodiments of the present application are only described by taking the application of the shell structure to the nucleic acid extractor as an example. In actual application, the shell structure can also be applied to other medical instruments that need to ensure that the working space has good sealing to reduce pollution problems.

[0052] Referring first to Figure 1 , Figure 1 The overall schematic diagram of the gene sequencing pre-processing system is shown, including a nucleic acid extraction system 10, a library construction system 20, a quality control system 30, an electrical control system 40, and a host computer 50. Among them:

[0053] The nucleic acid extraction system 10 is configured to controllably release nucleic acid molecules (such as DNA or RNA) from biological samples;

[0054] The library construction system 20 is configured to controllably prepare nucleic acid molecules (such as DNA or RNA) into a library for on-machine sequencing;

[0055] The quality control system 30 is configured to controllably detect the concentration of nucleic acid molecules in the nucleic acid extraction product, and adjust the concentration of nucleic acid molecules to a pre-required concentration range according to the detection result, and / or controllably detect the concentration of the library of the library construction product, and adjust the concentration of the library to a pre-required concentration range according to the detection result;

[0056] The electrical control system 40 is configured to control the operation and work of the nucleic acid extraction system 10, the library construction system 20, and the quality control system 30 according to the instructions of the host computer 50;

[0057] The host computer 50 is configured to control the operation and work of the nucleic acid extraction system 10, the library construction system 20, and the quality control system 30 by sending control instructions to the electrical control system 40.

[0058] The above-mentioned nucleic acid extraction system 10, i.e. nucleic acid extraction instrument, is used for nucleic acid extraction, reaction, detection and other processes. The nucleic acid extraction instrument includes a shell structure and a sample processing module, a reagent storage and distribution module, a nucleic acid extraction module, a temperature control module, etc. disposed in the shell structure. The nucleic acid extraction system 10 performs nucleic acid extraction, reaction, detection and other processes, which all need to be performed in a relatively closed environment to avoid contamination of the sample by other systems of the gene sequencing pre-processing system, resulting in a large error between the detection result and the actual result. Taking the nucleic acid extraction instrument as an example, a relatively closed space is formed inside the shell structure as the environment for the nucleic acid extraction process.

[0059] Referring to Figure 2 , Figure 2 The schematic diagram of the shell structure is shown. The shell structure includes a base 1 and a cabinet 2 fixedly connected to the base 1. The cabinet 2 and the base 1 combine to form a closed cavity, which serves as a space for the corresponding operation of the medical device. One side wall of the cabinet 2 is provided with an opening 21 as an operation channel for taking, placing and / or conveying articles between the outside and the above-mentioned closed cavity. Specifically, the opening 21 is located on one of the vertical side walls of the cabinet 2.

[0060] Referring to Figure 2 and Figure 3 The shell structure further comprises a hatch 3 which is slidingly connected to the cabinet 2 and used to open or close the opening 21. The opening 21 is opened when taking, placing and / or conveying the articles, and is closed during the operation to form a closed cavity inside the cabinet 2.

[0061] The hatch 3 of the shell structure is driven to open and close by the driving mechanism 4, and no manual operation is required during the opening and closing process, which improves the convenience of use. In addition, the opening and closing of the hatch 3 is more rapid, which shortens the time when the opening 21 is in an open state and reduces the risk of cross-contamination with the outside.

[0062] By setting the hatch 3 to open and close under the driving of the driving mechanism 4, the shell structure, i.e., the corresponding medical instrument, can be placed in another independent cavity which is closed relative to the outside. During use, if it is necessary to take, place and / or convey the articles, the hatch 3 and the above-mentioned independent cavity can be opened respectively, which can further reduce the probability of pollution.

[0063] Referring to Figure 2 and Figure 3 The cabinet 2 comprises a baffle 22, and the opening 21 is arranged on the baffle 22. The hatch 3 is located on the side of the baffle 22 facing the inside of the cabinet 2, and the hatch 3 is attached to the side of the baffle 22 facing the inside of the cabinet 2. A through hole 23 is formed in the upper side wall of the cabinet 2 for the hatch 3 to pass through. The hatch 3 passes through the through hole 23 during the sliding process, which avoids hindering the sliding path of the hatch 3 and provides sufficient sliding space for the hatch 3.

[0064] In addition, the edge of the opening 21 is fixedly connected with a stopper 24 which is in the same plane as the baffle 22, and the surface of the hatch 3 facing the inside of the cabinet 2 is attached to the stopper 24. In this way, in the state that the hatch 3 blocks the opening 21, the hatch 3 and the adjacent structures (i.e., the baffle 22, the stopper 24 and the base 1) maintain good sealing at the joint position, so that the overall sealing performance of the shell structure is better.

[0065] Referring to Figure 4On the edge of the cabin door 3 towards the surface of the cavity outside and towards the side of the base 1, a flexible sealing strip 5 is fixedly connected, which is attached to the base 1, the baffle 22 and the stopper 24, so that the cabin door 3 and the adjacent structure are flexibly connected at the joint position, and the sealing performance is better. In actual use, the cabin door 3 exerts a certain extrusion force on the flexible sealing strip 5, so that the flexible sealing strip 5 deforms under the action of the extrusion force in the state that the cabin door 3 blocks the opening 21, further improving the sealing performance at the joint position, and avoiding the problem of cross contamination caused by the exchange of substances in the closed cavity in the cabinet 2 with the outside.

[0066] It should be noted that the flexible sealing gasket 5 defined in the present application can be made of rubber, silicone or the like, as long as it can satisfy the condition that the joint position has good sealing performance in the state that the cabin door 3 blocks the opening 21.

[0067] Reference Figure 3 A fixed sheet metal 25 is fixedly connected to the inner wall of the cabinet 2, and the driving mechanism 4 is connected between the fixed sheet metal 25 and the cabin door 3. The driving mechanism 4 includes a rack 41, a transmission shaft 42, a gear 43 and a driving motor 44. The rack 41 is provided with two racks, which are fixedly connected to the cabin door 3 and arranged along the sliding direction of the cabin door 3, respectively arranged on the two side edges of the cabin door 3 which are away from each other, and the arrangement direction of the two racks 41 is perpendicular to the extension direction of the rack 41 itself. The transmission shaft 42 is rotatably connected to the fixed sheet metal 25. The gear 43 is provided with two gears, which are fixedly connected to the two ends of the transmission shaft 42 which are away from each other. The two gears 43 correspond to the two racks 41 respectively and are engaged with the corresponding racks 41. The driving motor 44 is fixedly connected to the fixed sheet metal 25 and connected to the transmission shaft 42 to drive the transmission shaft 42 to rotate, and then drive the gear 43 to rotate synchronously, and drive the rack 41, i.e. the cabin door 3 to slide through the meshing transmission of the gear 43 and the rack 41.

[0068] The above-mentioned driving structure 4 can ensure stable and precise movement of the cabin door 3, and the rack 41 and the gear 43 are provided with two gears respectively, which are driven to rotate synchronously by the transmission shaft 42, thereby improving the stability of driving the cabin door 3 to slide. For example, the position of the transmission shaft 42 connected to the driving motor 44 is located at the middle position of the two gears 43. During the driving process of the driving motor 44, the force remains symmetrical, thereby improving the stability.

[0069] For example, the driving motor 44 and the transmission shaft 42 are also connected through a gear structure for transmission. The transmission mode of the gear structure can ensure accurate transmission ratio, which is more convenient to control in actual use, and can avoid the problems of not sliding to the position or sliding to the position of the cabin door 3.

[0070] In addition, in the embodiment of the present application, the transmission shaft 42 and the driving motor 44 are mounted on the fixed sheet metal 25. On the one hand, compared with being directly mounted on the side wall of the cabinet 2, a more stable mounting foundation is provided, and the stability of the driving cabin door 3 moving process is improved. On the other hand, after the continuous use time reaches a certain length, the shell structure is overhauled, or the driving motor 44, the transmission shaft 42 and the gear 43 are replaced, etc. The fixed sheet metal 25 can be directly removed from the cabinet 2, avoiding being limited by the small internal space of the cabinet 2, and being more convenient for operation.

[0071] With reference to Figure 3 and Figure 4 , a guide mechanism 6 is arranged between the cabin door 3 and the cabinet 2, the cabin door 3 is slidably connected with the cabinet 2 through the guide mechanism 6, and the sliding track of the cabin door 3 is limited through the guide mechanism 6, so as to ensure the stability of the sliding of the cabin door 3. Specifically, the guide mechanism 6 includes a sliding rail 61 fixedly connected to the inner side wall of the cabinet 2 and a guide block 62 fixedly connected to the cabin door, wherein the sliding rail 61 is arranged along the sliding direction of the cabin door 3, the guide block 62 is provided with a guide groove 621 matched with the sliding rail 61, and the sliding rail 61 is clamped in the guide groove 621 and slidably matched with the guide block 62.

[0072] Exemplarily, the sliding rail 61 is also provided with a groove matched with the guide block 62, and the two are clamped and slidably matched, which can improve the stability of the sliding of the two. Of course, in other embodiments, the sliding rail 61 can also be provided with a protruding structure, and the protruding structure is arranged in the guide groove 621 to achieve the sliding matching of the guide block 62 and the sliding rail 61.

[0073] Through the guide mechanism 6, the sliding track of the cabin door 3 is limited, and the stability of the sliding of the cabin door 3 relative to the cabinet 2 is ensured. In addition, considering that the flexible sealing gasket 5 is arranged on the cabin door 3, the flexible sealing gasket 5 is extruded at the joint of the cabin door 3 and the baffle 22 and the baffle 24, and through the guide mechanism 6, the stability of the cabin door 3 can be improved to a certain extent, so as to avoid the position deviation of the cabin door 3 due to the extrusion force, and then cause damage to the gear transmission structure and other problems.

[0074] Exemplarily, the guide mechanism 6 is provided with two, and the two guide mechanisms 6 are arranged on the two sides of the cabin door 3 away from each other in the first direction, and the cabin door 3 is limited through the cooperation of the two guide mechanisms 6, so as to further improve the stability of the sliding of the cabin door 3. The first direction is perpendicular to the sliding direction of the cabin door 3.

[0075] In addition, with reference to Figure 5The shell structure further comprises a controller 7, which is in signal connection with the driving mechanism 4, specifically with the driving motor 44, and controls the cabin door 3 by regulating the working state of the driving motor 44; the controller 7 can input a corresponding control program in advance to regulate the action of the driving motor 44, or regulate the action of the driving motor 44 according to the real-time detection information.

[0076] Exemplarily, referring to Figure 3 The inner side wall of the case 2 is fixedly connected with a position sensor 8, and the position sensor 8 is provided with at least two, and two are taken as an example for description in the embodiment of the application, and the two position sensors 8 are respectively arranged at the two ends of the extension direction of one of the slide rails 61, and the guiding block 62 triggers the two position sensors 8 when the cabin door 3 is in the closed position and the open position; wherein, when the cabin door 3 is in the closed position, the opening 21 is completely blocked, and when the cabin door 3 is in the open position, the opening 21 is completely opened.

[0077] The position sensor 8 is in signal connection with the controller 7, the controller 7 receives the information of the position sensor 8, and adjusts the working state of the driving motor 44 according to the received information of the position sensor 8; when the controller 7 receives the information that the position sensor 8 is triggered, it indicates that the cabin door 3 has been moved to the expected position, and the driving motor 44 is controlled to stop moving, and the cabin door 3 is stopped at the expected position.

[0078] In other embodiments, the position sensor 8 can also be arranged at other positions in the case 2, so that the cabin door 3 directly contacts the position sensor 8 to trigger the position sensor 8 when moving to the closed position and the open position, or another structure for triggering the position sensor 8 is additionally arranged on the cabin door 3.

[0079] In the embodiment of the application, the position sensor 8 is triggered by the guiding block 62 arranged, and the position sensor 8 is arranged at the two side edges in the case 2 to avoid interference with other structures in the case 2 or problems of blocking the opening 21, and the position sensor 8 cooperates with the guiding block 62 to realize the detection of the position of the cabin door 3, effectively utilizes the existing component structure, and does not need to separately install other triggering structures, thereby simplifying the complexity of the overall structure.

[0080] In addition, referring to Figure 2 and Figure 3 The side wall of the case 2 is provided with an air inlet 26 and an air outlet 27, the air outlet 27 is provided with a rear sealing plate 28, the rear sealing plate 28 is provided with a ventilation piece 29, the ventilation piece 29 drives the airflow to enter the case 2 from the air inlet 26, flows through the working area in the case 2, and is discharged to the outside of the case 2 through the air outlet 27.

[0081] Specifically, the rear sealing plate 28 is detachably fixedly connected with the cabinet 2 to block the air outlet 27; a through hole is formed in the rear sealing plate 28, and the ventilation member 29 is installed in the through hole and fixedly connected with the rear sealing plate 28; the ventilation member 29 is communicated with the two sides away from each other of the rear sealing plate 28, and in the state that the rear sealing plate 28 is fixed on the cabinet 2 at the air outlet 27, the ventilation member 29 is communicated with the inside and outside of the cabinet 2 to realize ventilation.

[0082] Exemplarily, the ventilation member 29 comprises a fan and a filter, and one or more fans and filters can be provided, but it is ensured that each fan is provided with one filter. In some embodiments, in the case that multiple fans are provided, one filter can be provided for each fan, or only one filter can be provided to cover all the fans. In this way, it is ensured that harmful and polluting substances are absorbed during ventilation of the inside of the cabinet 2, and the problem of pollution of the internal environment or exchange of internal gas to the external environment or harm to the health of the staff is avoided.

[0083] In addition, dustproof cotton is provided at the connection position of the rear sealing plate 28 and the cabinet 2 to improve the sealing performance of the connection position of the rear sealing plate 28 and the cabinet 2, reduce the situation that gas enters the inside of the cabinet 2 from the connection position of the rear sealing plate 28 and the cabinet 2 or escapes from the inside of the cabinet 2, and reduce the risk of cross-contamination. In addition, the dustproof cotton can reduce the adverse effects of the vibration generated by the fan 28 during operation on the cabinet 2 and the related components in the inside of the cabinet 2.

[0084] In addition, a wire outlet is also provided on the cabinet 2 to provide a channel for the connection of a wire, and it is explained that a corresponding sealing structure is also provided at the wire outlet structure to ensure the sealing performance of the corresponding channel in the state that the wire passes through it. In some other embodiments, in the case that other through hole structures are provided on the cabinet 2, corresponding sealing structures can also be provided as needed to ensure stable sealing effect and reduce the risk of pollution.

[0085] One or more embodiments of the present disclosure are intended to cover all such alternatives, modifications, and variations falling within the broad scope of the appended claims. Therefore, any omission, modification, equivalent replacement, improvement, etc. made in the spirit and principle of one or more embodiments of the present disclosure should be included in the protection scope of the present disclosure.

[0086] The above is only a specific implementation of the present application, but the protection scope of the present application is not limited thereto, and any person skilled in the art can easily think of changes or replacements within the technical scope disclosed in the present application, which should be included in the protection scope of the present application. Therefore, the protection scope of the present application should be subject to the protection scope of the claims.

Claims

1. A housing structure, characterized by, The utility model relates to a kind of portable air conditioner, including, Base station; Cabinet, fixedly connected on the base station, with the base station is enclosed to form enclosed cavity, one side wall of the cabinet is equipped with opening; Hatch, slidingly connected on the cabinet, for opening or closing the opening; Driving mechanism, provided on the cabinet, and connected with the hatch, drive the hatch relative to the cabinet sliding, open or block the opening.

2. The housing structure of claim 1, wherein The driving mechanism includes a rack, a gear and a drive motor; The rack is fixedly connected on the hatch; The gear is rotatably connected inside the cabinet, and is engaged with the rack; The drive motor is fixedly connected with the cabinet, and is connected with the gear to drive the gear to rotate.

3. The housing structure of claim 2, wherein, The driving mechanism further includes a transmission shaft, and the transmission shaft is rotatably connected with the cabinet; The arrangement direction of the transmission shaft is perpendicular to the sliding direction of the hatch; The gear has two, and is fixedly connected at both ends of the transmission shaft respectively; The rack is also provided with two, corresponding to the two gears.

4. The housing structure of claim 3, wherein Further comprising a fixed metal sheet fixedly connected to the inner wall of the cabinet; The drive motor and the transmission shaft are connected to the fixed metal sheet.

5. The housing structure of claim 1, wherein The cabinet includes a baffle, and the opening is provided on the baffle; A through hole is formed in the upper side wall of the cabinet for the hatch to pass through; The edge of the opening is fixedly connected with a stopper; When the hatch closes the opening, the surface of the hatch facing the outside of the cavity abuts against the baffle and the stopper.

6. The housing structure of claim 5, wherein The edge of the surface of the hatch facing the outside of the cavity and the side facing the base station are fixedly connected with a flexible sealing strip.

7. The enclosure structure of claim 1, wherein, Further comprising a guide mechanism, the guide mechanism includes a slide rail fixedly connected to the inner side wall of the cabinet and a guide block fixedly connected to the hatch; The slide rail is arranged in the sliding direction of the hatch; A guide groove is formed in the guide block to match the slide rail, and the slide rail is clamped in the guide groove to slide with the guide block.

8. The housing structure of claim 7, wherein, The guide mechanism is provided with two, and the two guide mechanisms are located on the two sides of the hatch away from each other in a first direction. The first direction is perpendicular to the sliding direction of the hatch.

9. The housing structure of claim 7, wherein, Further comprising a controller and a position sensor, the position sensor and the driving mechanism are signal-connected with the controller; The position sensor is provided with at least two, and the corresponding position sensor is triggered when the hatch is in the closed position and the open position respectively. The controller is used to control the driving mechanism to stop driving the hatch to move when the hatch triggers the position sensor.

10. The housing structure of claim 9, wherein, The position sensor is provided with two, and the two position sensors are arranged at both ends of the slide rail in the extension direction. The guide block triggers the two position sensors when the hatch is in the closed position and the open position respectively.

11. The enclosure structure of any of claims 1-10, wherein, The side wall of the cabinet is provided with an air inlet and an air outlet; A ventilation member is arranged at the air outlet, which drives the airflow to enter the cabinet from the air inlet, flow through the working area in the cabinet, and be discharged out of the cabinet through the air outlet.

12. The enclosure structure of claim 11, wherein, A rear baffle is arranged at the air outlet, and the rear baffle is detachably fixedly connected with the cabinet to block the air outlet. The ventilation piece is arranged on the rear sealing plate. Dustproof cotton is arranged at the connection between the rear sealing plate and the case.

13. A nucleic acid extraction instrument, characterized by, The housing structure according to any one of claims 1-12.

14. A system for pre-processing of genetic sequencing, characterized in that, The nucleic acid extractor according to claim 13.

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