Mass spectrometer for measuring tea phenol amine metabolites

Abstract

The utility model discloses a mass spectrometer for measuring tea phenolamine metabolite, which relates to the technical field of tea phenolamine metabolite detection, and comprises a mass spectrometer body and a lofting mechanism arranged at one end in the mass spectrometer body, and the lofting mechanism comprises a movable plate arranged at the bottom of one end in the mass spectrometer body. An electric cylinder is mounted on one side of the inner wall of the movable plate, a mounting seat is mounted on a piston rod of the electric cylinder, a servo motor is mounted on the inner wall of the top of the mounting seat, an output shaft of the servo motor is sleeved with a placement plate, and a plurality of placement grooves are formed in the inner wall of the top of the placement plate. The placing plate can extend out of the mass spectrometer body through the movement of the movable plate, the electric cylinder works to drive the mounting seat to move along the inner wall of the movable plate, and the placing plate can be driven to further move, so that a worker can conveniently place and replace a sample, and the working efficiency of the mass spectrometer can be improved.

Description

Technical Field

[0001] This utility model relates to the field of detection technology of catecholamine metabolites, specifically to a mass spectrometer for determining catecholamine metabolites. Background Technology

[0002] Catecholamines are a collective term for adrenaline, noradrenaline, and dopamine. They are a class of neurotransmitters containing catecholamines and amino groups. The most important catecholamines include adrenaline, noradrenaline, and dopamine. These substances play important regulatory roles in the nervous, cardiovascular, and endocrine systems. Plasma catecholamine metabolite testing reflects the body's catecholamine levels and is significant for the early diagnosis of some cardiovascular and endocrine disorders. Elevated plasma catecholamine metabolite levels may lead to coronary artery constriction, increased myocardial oxygen consumption, and consequently, worsened coronary artery stenosis and myocardial ischemia, increasing the risk of arrhythmias and cardiovascular disease.

[0003] A mass spectrometer with announcement number CN221007457U for accurately determining catecholamine metabolites includes a mass spectrometer housing, an evaporation chamber inside the housing, and connecting pipes at both ends of the evaporation chamber. Solenoid valves are installed inside the connecting pipes. A heating evaporation device is installed on the inner wall of the evaporation chamber. A placement chamber is opened on one side of the outer wall of the mass spectrometer housing, and a mounting plate is rotatably connected to the inner wall of the placement chamber. This invention uses the solenoid valves installed in the connecting pipes at both ends of the evaporation chamber to control the amount of urine, body fluid, or blood entering the evaporation chamber from test tubes. This allows the urine, body fluid, or blood in the evaporation chamber to be heated and evaporated in batches and sprayed into the interior of the mass spectrometer, enabling the mass spectrometer to accurately determine the catecholamine metabolites within the urine, body fluid, or blood.

[0004] The existing technology has the following shortcomings: When measuring catecholamine metabolites, the sample placement components of the existing mass spectrometer cannot be conveniently extended into the mass spectrometer, making it difficult for operators to conveniently place and replace samples. At the same time, it is not convenient to place multiple samples into the mass spectrometer at the same time, making it difficult to conveniently add multiple samples to the ion source of the mass spectrometer. Consequently, the mass spectrometer cannot stably measure catecholamine metabolites from multiple samples, which will affect the measurement efficiency of catecholamine metabolites. Utility Model Content

[0005] The utility model discloses a purpose is provided with a mass spectrometer for determining catecholamine metabolite, through the movement of movable plate makes that the placement board can extend from the mass spectrometer body inside, and the electric cylinder work can drive the mounting seat along movable plate inner wall and move, can drive the placement board further activity, so that the staff can conveniently place and replace sample, can improve the work efficiency of mass spectrometer, to solve the above insufficient place in the technology.

[0006] In order to realize the above-mentioned purpose, the utility model provides the following technical scheme: a mass spectrometer for determining catecholamine metabolite, including mass spectrometer body, still includes:

[0007] The sample placing mechanism arranged at one end inside the mass spectrometer body is used for placing the sample for catecholamine metabolite determination;

[0008] The sample placing mechanism includes the movable plate arranged at the bottom of one end inside the mass spectrometer body, both ends of the side close to the inner wall of the mass spectrometer body of movable plate are rotatably installed with movable gear, the inner wall side of movable plate is fixedly installed with electric cylinder, the piston rod of electric cylinder is fixedly installed with mounting seat, the top inner wall of mounting seat is fixedly installed with servo motor, the output shaft of servo motor is fixedly sleeved with placement board, and the top inner wall of placement board is equally spaced annularly provided with a plurality of placing grooves.

[0009] Preferably, the mass spectrometer body includes a mass spectrometer shell, a control panel is fixedly installed at one end of the outer wall of one side of the mass spectrometer shell, a display screen is fixedly installed at the top of the outer wall of one side of the mass spectrometer shell, and a sealing plate is rotatably installed at the other end of the outer wall of one side of the mass spectrometer shell.

[0010] Preferably, a receiving groove is formed at the bottom of the inner side of one end of the mass spectrometer shell close to the sealing plate, fixed racks are fixedly installed at both ends of the inner wall of the receiving groove, the fixed racks are engaged with adjacent movable gears, and a movable groove is formed at the top of the movable plate.

[0011] Preferably, a hydraulic cylinder is fixedly installed at the top of the inner wall away from the opening side of the inner side of one end of the mass spectrometer shell close to the sealing plate, an activity seat is fixedly installed on the piston rod of the hydraulic cylinder, a sample injection probe is fixedly inserted into one side of the activity seat away from the inner wall of the mass spectrometer shell, and a liquid inlet pipe is arranged between the top of the sample injection probe and the ion source inside the mass spectrometer shell.

[0012] Preferably, one side of the inner wall of the movable groove is fixedly connected with the electric cylinder, the inner wall of the movable groove is movably connected with the outer wall of the mounting seat, and a limiting groove is formed at both ends of the inner wall of the movable groove.

[0013] Preferably, sliding blocks are fixedly installed at both ends of the outer wall of the mounting seat, and the outer wall of the sliding block is movably connected with the inner wall of the adjacent limiting groove.

[0014] In the above technical solutions, the utility model provides technical effect and advantage:

[0015] 1, through the meshing effect between the movable gear and the fixed rack makes the movable plate can extend from the inside of the mass spectrometer shell, and the electric cylinder work makes the mounting seat move along the inner wall of the movable plate, and then makes the placing plate can conveniently extend from the inside of the mass spectrometer shell, so that the staff can conveniently place and replace the sample for catecholamine metabolite determination, and a plurality of placing grooves can conveniently place a plurality of determination samples, and the servo motor work can drive the placing plate to rotate, so that the mass spectrometer body can conveniently determine the catecholamine metabolite of a plurality of samples, and the efficiency of sample determination can be improved;

[0016] 2, the height of the movable seat can be adjusted through the work of the hydraulic cylinder, so that the sample inlet probe can conveniently insert into the sample test tube of different heights, so that the sample in the test tube can conveniently enter the ion source inside the mass spectrometer shell through the sample inlet probe and the liquid inlet pipe, and then the catecholamine metabolite in the sample can be conveniently determined. BRIEF DESCRIPTION OF DRAWINGS

[0017] In order to more clearly illustrate the technical solutions in the embodiments or prior art, the drawings needed in the embodiments will be briefly introduced below, and obviously, the drawings in the following description are only some embodiments described in the utility model, and other drawings can be obtained by those skilled in the art according to these drawings.

[0018] Figure 1 It is the overall structure schematic diagram of the utility model.

[0019] Figure 2 It is the local sectional structure diagram of the utility model.

[0020] Figure 3 It is the A part enlarged view of the utility model. Figure 2

[0021] Figure 4 It is the mass spectrometer body of the utility model stereoscopic structure explosion map.

[0022] Figure 5 It is the sample placing mechanism of the utility model stereoscopic structure explosion map.

[0023] Explanation of reference signs:

[0024] 1, mass spectrometer body;101, mass spectrometer shell;102, control panel;103, display screen;104, sealing plate;105, hydraulic cylinder;106, movable seat;107, sample inlet probe;108, liquid inlet pipe;109, storage groove;110, fixed rack; ​

[0025] 2. Lofting mechanism; 201. Movable plate; 202. Movable gear; 203. Movable groove; 204. Limiting groove; 205. Electric cylinder; 206. Mounting base; 207. Slider; 208. Servo motor; 209. Placement plate; 210. Placement groove. Detailed Implementation

[0026] This utility model provides, for example Figure 1 The mass spectrometer shown is for determining catecholamine metabolites, including a mass spectrometer body 1, and further comprising:

[0027] The sample placement mechanism 2, located at one end inside the mass spectrometer body 1, is used to place the sample for the determination of catecholamine metabolites. The sample to be measured is placed into the mass spectrometer body 1 through the sample placement mechanism 2, and then the sample molecules are ionized into charged particles by the ion source inside the mass spectrometer body 1. Then, these charged particles are separated according to the mass-to-charge ratio using the principle of electromagnetics, and finally a mass spectrum is obtained.

[0028] To facilitate the placement and replacement of samples, such as Figures 1-5 As shown, the sample placement mechanism 2 includes a movable plate 201 located at the bottom of one end inside the mass spectrometer body 1. Movable gears 202 are rotatably mounted at both ends of the movable plate 201 near the inner wall of the mass spectrometer body 1. An electric cylinder 205 is fixedly mounted on one side of the inner wall of the movable plate 201. A mounting base 206 is fixedly mounted on the piston rod of the electric cylinder 205. A servo motor 208 is fixedly mounted on the inner top wall of the mounting base 206. A placement plate 209 is fixedly sleeved on the output shaft of the servo motor 208. Multiple placement slots 210 are evenly spaced and annularly formed on the inner top wall of the placement plate 209. The control panel 102 causes the two movable gears 202 to rotate. The meshing action between the movable gears 202 and the fixed rack 110 causes the movable plate... The device 201 moves along the inner wall of the receiving slot 109, and then the electric cylinder 205 is activated by the control panel 102, which in turn pushes the mounting base 206 to move along the inner wall of the movable plate 201, so that the placement plate 209 can extend out from inside the mass spectrometer housing 101, allowing the operator to easily place and replace the sample tubes inside the placement slot 210. At the same time, the servo motor 208 is activated by the control panel 102, which drives the placement plate 209 to rotate, changing the position of the placement slot 210 below the injection probe 107, so that the injection probe 107 can easily transport the samples from different test tubes to the ion source inside the mass spectrometer housing 101.

[0029] To facilitate the operation of the control device and the display of detection data, such as Figures 1-2 and Figure 4As shown in the figure, the mass spectrometer body 1 includes a mass spectrometer shell 101, one side of the outer wall of the mass spectrometer shell 101 is fixedly installed with a control panel 102, the top of the outer wall of the mass spectrometer shell 101 is fixedly installed with a display screen 103, the other end of the outer wall of the mass spectrometer shell 101 is rotatably installed with a sealing plate 104, the working of the internal components of the mass spectrometer shell 101 can be controlled through the control panel 102, and the working of the lofting mechanism 2 can also be controlled, the determination data of the catecholamine metabolite in the sample can be displayed through the display screen 103, and the opening of the mass spectrometer shell 101 can be sealed through the sealing plate 104, so that the sample is sealed in the mass spectrometer shell 101 during the sampling and detection process.

[0030] In order to conveniently transport the sample in the test tube into the ion source inside the mass spectrometer shell 101, as shown in Figures 1-2 and Figure 4 As shown in the figure, the mass spectrometer body 1 includes a mass spectrometer shell 101, one side of the outer wall of the mass spectrometer shell 101 is fixedly installed with a control panel 102, the top of the outer wall of the mass spectrometer shell 101 is fixedly installed with a display screen 103, the other end of the outer wall of the mass spectrometer shell 101 is rotatably installed with a sealing plate 104, the working of the internal components of the mass spectrometer shell 101 can be controlled through the control panel 102, and the working of the lofting mechanism 2 can also be controlled, the determination data of the catecholamine metabolite in the sample can be displayed through the display screen 103, and the opening of the mass spectrometer shell 101 can be sealed through the sealing plate 104, so that the sample is sealed in the mass spectrometer shell 101 during the sampling and detection process.

[0031] In order to make the placement plate 209 stable during extension and storage, as shown in Figures 2-5As shown, the mass spectrometer shell 101 is provided with a receiving groove 109 at the bottom of the inner side of one end of the sealing plate 104, and the inner wall of the receiving groove 109 is fixedly provided with a fixed rack 110 at both ends, the fixed rack 110 is engaged with the adjacent movable gear 202, the top of the movable plate 201 is provided with a movable groove 203, one side of the inner wall of the movable groove 203 is fixedly connected with the electric cylinder 205, the inner wall of the movable groove 203 is movably connected with the outer wall of the mounting seat 206, the inner wall of the movable groove 203 is provided with a limiting groove 204 at both ends, the outer wall of the sliding block 207 is movably connected with the inner wall of the adjacent limiting groove 204, the receiving groove 109 can limit the movement of the movable plate 201, so that the movable plate 201 remains stable during extension or storage, the movable groove 203 can install and fix the electric cylinder 205, the sliding block 207 at both ends of the mounting seat 206 can move along the inner wall of the adjacent limiting groove 204 while the mounting seat 206 moves, thereby limiting the movement of the mounting seat 206, so that the mounting seat 206 remains stable during movement, and the placing plate 209 remains stable during storage or extension.

[0032] When the catecholamine metabolite is determined, the sealing plate 104 is opened and the mass spectrometer is opened through the control panel 102, the two movable gears 202 are rotated through the control panel 102, the movable plate 201 can move along the receiving groove 109 to the outside of the mass spectrometer shell 101 through the meshing action between the movable gear 202 and the adjacent fixed rack 110, when the movable gear 202 moves to the port of the fixed rack 110, the electric cylinder 205 is extended outward through the control panel 102, thereby pushing the mounting seat 206 to move outward along the inner wall of the movable groove 203, at the same time, the sliding block 207 at both ends of the mounting seat 206 can move along the inner wall of the adjacent limiting groove 204, thereby driving the placing plate 209 to extend from the inside of the mass spectrometer shell 101, so that the staff can place the collected sample test tube into the placing groove 210 in the inner wall of the placing plate 209;

[0033] When the test tube is placed, the electric cylinder 205 is retracted through the control panel 102, so that the mounting seat 206 can be moved to the inside of the movable groove 203, and then the two movable gears 202 are reversely rotated through the control panel 102, so that the movable plate 201 can be accommodated into the accommodation groove 109, and then the sealing plate 104 is rotated to seal the opening of the mass spectrometer shell 101, and then the hydraulic cylinder 105 is operated through the control panel 102, so that the movable seat 106 can be moved along the inner wall of the mass spectrometer shell 101, and then the height of the sample probe 107 can be adjusted, so that the sample probe 107 can be inserted into the test tube below, and then the liquid inlet pipe 108 of the vacuum pump is operated to transport the sample in the test tube to the ion source in the mass spectrometer shell 101 through the sample probe 107 and the liquid inlet pipe 108, so that the detection component of the mass spectrometer can determine the catecholamine metabolite in the sample, and the display screen 103 can display the determination process and result;

[0034] At the same time, after one determination is completed, the hydraulic cylinder 105 is retracted through the control panel 102, so that the sample probe 107 can be taken out from the test tube, and then the servo motor 208 is operated through the control panel 102, so that the placing plate 209 can be rotated, and the placing groove 210 below the sample probe 107 can be replaced through the equal-angle rotation of the servo motor 208, so that the sample probe 107 can determine the sample in the next test tube, and then the above operation can be repeated to determine the catecholamine metabolite in the sample in the test tube in the plurality of placing grooves 210 on the inner wall of the placing plate 209, so that the mass spectrometer can conveniently determine a plurality of samples, and the efficiency of sample determination can be improved, and the worker can conveniently place and replace the sample, and the embodiment specifically solves the problem that the mass spectrometer cannot conveniently determine a plurality of samples in the prior art, so that the working efficiency is low.

[0035] The above only describes some exemplary embodiments of the present application by way of illustration, without doubt, for ordinary skilled in the art, without departing from the spirit and scope of the present application, the described embodiments can be modified in various ways. Therefore, the above drawings and description are illustrative in nature, and should not be understood as limiting the scope of protection of the claims of the present application.

Claims

1. A mass spectrometer for determining a catecholamine metabolite, comprising a mass spectrometer body (1), characterized in that Also include: The sample mechanism (2) is arranged at one end inside the mass spectrometer body (1), which is used for placing the sample for catecholamine metabolite determination; The sample mechanism (2) includes a movable plate (201) arranged at the bottom of one end inside the mass spectrometer body (1), both ends of the side of the movable plate (201) close to the inner wall of the mass spectrometer body (1) are rotatably installed with movable gears (202), the inner wall of the movable plate (201) is fixedly installed with an electric cylinder (205), the piston rod of the electric cylinder (205) is fixedly installed with a mounting seat (206), the top inner wall of the mounting seat (206) is fixedly installed with a servo motor (208), the output shaft of the servo motor (208) is fixedly sleeved with a placing plate (209), and a plurality of placing grooves (210) are annularly and equidistantly formed in the top inner wall of the placing plate (209).

2. A mass spectrometer for determining catecholamine metabolites according to claim 1, wherein: The mass spectrometer body (1) includes a mass spectrometer shell (101), a control panel (102) is fixedly installed at one end of the outer wall of one side of the mass spectrometer shell (101), a display screen (103) is fixedly installed at the top of the outer wall of one side of the mass spectrometer shell (101), and a sealing plate (104) is rotatably installed at the other end of the outer wall of one side of the mass spectrometer shell (101).

3. A mass spectrometer for determining catecholamine metabolites according to claim 2, wherein: The inner side bottom of one end of the mass spectrometer shell (101) close to the sealing plate (104) is provided with a receiving groove (109), and the inner walls of both ends of the receiving groove (109) are fixedly installed with fixed racks (110), the fixed racks (110) are engaged with adjacent movable gears (202), and the top of the movable plate (201) is provided with a movable groove (203).

4. A mass spectrometer for determining a catecholamine metabolite according to claim 3, wherein: The inner wall top of the inner wall of one end of the mass spectrometer shell (101) away from the opening side close to the sealing plate (104) is fixedly installed with a hydraulic cylinder (105), the piston rod of the hydraulic cylinder (105) is fixedly installed with a movable seat (106), the side of the movable seat (106) away from the inner wall of the mass spectrometer shell (101) is fixedly inserted with a sample injection probe (107), and the top of the sample injection probe (107) and the ion source inside the mass spectrometer shell (101) are provided with a liquid inlet pipe (108).

5. The mass spectrometer for determining catecholamine metabolites according to claim 3, wherein: The inner wall of the movable groove (203) is fixedly connected with the electric cylinder (205), the inner wall of the movable groove (203) is movably connected with the outer wall of the mounting seat (206), and the inner wall of the movable groove (203) is provided with limiting grooves (204) at both ends.

6. A mass spectrometer for determining a catecholamine metabolite according to claim 5, wherein: The outer wall of the mounting seat (206) is fixedly installed with a sliding block (207), and the outer wall of the sliding block (207) is movably connected with the inner wall of the adjacent limiting groove (204).

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