Evaporative crystallization device for preparing aminoglycoside medicines

Abstract

The utility model relates to the technical field of evaporative crystallization, and discloses an evaporative crystallization device for preparing aminoglycoside drugs, which comprises an evaporation tank, a top cover is arranged at the top of the evaporation tank, a heat preservation layer is fixedly connected to the outer wall of the evaporation tank, a heating wire is arranged in the heat preservation layer, a motor is arranged at the top of the top cover, and a motor is arranged on the top of the motor. The output end of the motor is fixedly connected with a first gear, the top of the top cover is rotationally connected with a second gear, the first gear is meshed with the second gear, a scraping assembly is arranged in the evaporation tank and comprises a scraping plate, and the scraping plate is slidably connected to the inner wall of the evaporation tank. According to the evaporative crystallization device, the problems that scaling crystals are left on the inner wall, the heat transfer efficiency is reduced and the energy consumption is increased due to the fact that the scraping plate is generally difficult to be completely attached to the curved surface of the tank body when a traditional evaporative crystallization device for preparing aminoglycoside drugs evaporates are effectively avoided, and the efficient scraping effect on the crystals on the inner wall is achieved.

Description

Technical Field

[0001] This utility model relates to the field of evaporation crystallization technology, and in particular to an evaporation crystallization apparatus for preparing aminoglycoside drugs. Background Technology

[0002] Aminoglycosides are a class of broad-spectrum antibiotics composed of aminocyclic alcohols and amino sugars linked by glycosidic bonds. They are mainly used to treat serious infections caused by Gram-negative bacteria. These drugs have high water solubility and thermal stability. The drug solution is concentrated by heating and reducing pressure in an evaporation crystallization device, and the solvent is gradually removed to increase the supersaturation of the solution, which promotes the directional alignment of drug molecules to form high-purity crystals, thus achieving efficient purification and separation.

[0003] In the traditional preparation of aminoglycoside drugs, an aqueous solution containing the target drug is pumped into an evaporator and heated under reduced pressure to achieve gentle concentration by lowering the boiling point, thus avoiding the destruction of drug activity by high temperature. Subsequently, as the solvent evaporates, the solution concentration gradually increases to a supersaturated state. At this point, the drug molecules are induced to crystallize in a directional manner by controlling the cooling rate and stirring speed.

[0004] In traditional evaporation crystallization apparatuses for the preparation of aminoglycoside drugs, the scraper often fails to fully conform to the curved surface of the tank during evaporation, resulting in scale crystals remaining on the inner wall, reducing heat transfer efficiency and increasing energy consumption. In addition, during cleaning, traditional apparatuses require frequent shutdowns and disassembly, manual cleaning is inefficient, and residual drugs or cleaning agents can easily cause cross-contamination risks. Utility Model Content

[0005] To overcome the above shortcomings, this utility model provides an evaporation crystallization device for the preparation of aminoglycoside drugs, which aims to improve the problem that in traditional evaporation crystallization devices for the preparation of aminoglycoside drugs, the scraper is usually difficult to fully conform to the curved surface of the tank during evaporation, resulting in scale crystals remaining on the inner wall, reducing heat transfer efficiency and increasing energy consumption.

[0006] To achieve the above objectives, this utility model provides the following technical solution: an evaporation crystallization apparatus for preparing aminoglycoside drugs, comprising an evaporation tank, a top cover provided on the top of the evaporation tank, a heat insulation layer fixedly connected to the outer wall of the evaporation tank, a heating wire provided inside the heat insulation layer, a motor provided on the top of the top cover, a gear one fixedly connected to the output end of the motor, a gear two rotatably connected to the top of the top cover, the gear one and the gear two meshing, and a scraping assembly provided inside the evaporation tank;

[0007] The scraping assembly includes a scraper, which is slidably connected to the inner wall of the evaporator. A bracket is fixedly connected to the outer wall of the scraper, and a spring is installed inside the bracket. A rotating shaft is fixedly connected to the middle of the bracket, and a stirring blade is fixedly connected to the outer wall of the rotating shaft. The outer wall of the rotating shaft is fixedly connected to the inside of the second gear.

[0008] Furthermore, two guide pipes are fixedly connected to the outer wall of the rotating shaft, and the ends of the two guide pipes are fixedly connected to the outer wall of the support. A water outlet pipe is provided inside the scraper. A rotary joint is fixedly connected to one end of the rotating shaft. A water outlet pipe is fixedly connected to one end of the rotary joint. A water pump is fixedly connected to one end of the water outlet pipe. A water inlet pipe is fixedly connected to the input end of the water pump. A water storage tank is fixedly connected to one end of the water inlet pipe.

[0009] Furthermore, a base is fixedly connected to the outer side of the bottom of the evaporator, and a discharge pipe is fixedly connected to the bottom of the evaporator.

[0010] Furthermore, the top of the cover is provided with a feed pipe and a condensation pipe, and the outer wall of the evaporator is fixedly connected with a steam pipe.

[0011] Furthermore, one end of the spring is fixedly connected to the inner wall of the bracket, and the other end of the spring is fixedly connected to the outer wall of the scraper.

[0012] Furthermore, the stirring blade is disposed inside the evaporator and between two guide pipes.

[0013] Furthermore, the heating wire is disposed between the insulation layer and the evaporator, and both gear one and gear two are disposed on the upper surface of the top cover.

[0014] Furthermore, the rotary joint is located on one side of the outer wall of the motor, and the water pump is located between the water storage tank and the evaporator.

[0015] This utility model has the following beneficial effects:

[0016] 1. In this utility model, the rotating shaft is driven to rotate at a low speed and stably by a drive motor through a transmission system consisting of gear one and gear two, which drives the scraper and stirring blade to rotate. The scraper achieves adaptive adjustment through the elastic connection structure of the bracket and spring, so that the edge of the scraper always fits the curved surface of the inner wall of the evaporator. This solves the problem that in traditional evaporation crystallization devices for the preparation of aminoglycoside drugs, the scraper usually cannot completely fit the curved surface of the tank during evaporation, resulting in residual scale crystals on the inner wall, reducing heat transfer efficiency and increasing energy consumption. This invention achieves a highly efficient scraping effect for the crystals on the inner wall.

[0017] 2. In this utility model, preheated purified water in the storage tank is pumped through the inlet pipe and injected into the high-speed rotating shaft cavity through the dynamic sealing structure of the rotary joint. Under the action of centrifugal force, the water flow is accelerated along the spiral guide groove inside the shaft. After being diverted and pressurized by the double-sided guide pipes, it forms a high-pressure fan-shaped water curtain from the array of water outlet pipes on the scraper surface. This solves the problems of the need for frequent shutdown and disassembly of traditional devices, low efficiency of manual cleaning, and the risk of cross-contamination caused by residual drugs or cleaning agents, and achieves a highly efficient cleaning effect. Attached Figure Description

[0018] Figure 1 This is a three-dimensional structural schematic diagram of an evaporation crystallization apparatus for preparing aminoglycoside drugs according to the present invention;

[0019] Figure 2 This is a schematic diagram of the internal structure of the evaporator of an evaporation crystallization apparatus for preparing aminoglycoside drugs according to this utility model;

[0020] Figure 3 This is a schematic diagram of one side of the support structure of an evaporation crystallization apparatus for preparing aminoglycoside drugs proposed in this utility model;

[0021] Figure 4 This is a schematic diagram of one side of the rotating shaft of an evaporation crystallization apparatus for preparing aminoglycoside drugs according to the present invention;

[0022] Figure 5 for Figure 4 Enlarged diagram of point A in the middle.

[0023] Legend:

[0024] 1. Evaporator; 2. Top cover; 3. Insulation layer; 4. Base; 5. Condensation pipe; 6. Feed pipe; 7. Discharge pipe; 8. Steam pipe; 9. Rotary joint; 10. Motor; 11. Water outlet pipe; 12. Water pump; 13. Water storage tank; 14. Water inlet pipe; 15. Gear 1; 16. Gear 2; 17. Heating wire; 18. Rotating shaft; 19. Scraper; 20. Support; 21. Stirring blade; 22. Guide pipe; 23. Spring; 24. Water outlet pipe. Detailed Implementation

[0025] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0026] Reference Figure 1 - Figure 5An embodiment of this utility model provides an evaporation crystallization device for preparing aminoglycoside drugs, including an evaporator 1, which serves as the main body of the device for evaporating and crystallizing materials. A top cover 2 is provided on the top of the evaporator 1, and a heat insulation layer 3 is fixedly connected to the outer wall of the evaporator 1. The heat insulation layer 3 is used to reduce heat loss in the evaporator 1 and maintain a stable temperature inside the evaporator 1. A heating wire 17 is provided inside the heat insulation layer 3, which is used to evaporate the solvent in the material, thereby achieving crystallization. A motor 10 is provided on the top of the top cover 2, which is used to drive a gear 16 and a rotating shaft 18 to rotate. A gear 15 is fixedly connected to the output end of the motor 10, and a gear 16 is rotatably connected to the top of the top cover 2. The gear 15 and the gear 16 mesh with each other. A scraping assembly is provided inside the evaporator 1.

[0027] The scraping assembly includes a scraper 19, which is slidably connected to the inner wall of the evaporator 1. The scraper 19 is used to prevent the crystallization layer from accumulating on the inner wall of the evaporator 1. A bracket 20 is fixedly connected to the outer wall of the scraper 19. A spring 23 is installed inside the bracket 20. The spring 23 enables the scraper 19 to self-adjust and always conform to the curved surface of the inner wall of the evaporator 1 to ensure the scraping effect. A rotating shaft 18 is fixedly connected to the middle of the bracket 20. The rotating shaft 18 is used to drive the scraper 19 and the stirring blade 21 to rotate, and also to transport cleaning water. The stirring blade 21 is fixedly connected to the outer wall of the rotating shaft 18. Inside the gear 16, two guide pipes 22 are fixedly connected to the outer wall of the rotating shaft 18. The ends of the two guide pipes 22 are fixedly connected to the outer wall of the bracket 20. A water outlet pipe 24 is provided inside the scraper 19. The water outlet pipe 24 is used to spray cleaning water from the surface of the scraper 19 to clean the inner wall of the evaporator 1. A rotary joint 9 is fixedly connected to one end of the rotating shaft 18. A water outlet pipe 11 is fixedly connected to one end of the rotary joint 9. A water pump 12 is fixedly connected to one end of the water outlet pipe 11. A water inlet pipe 14 is fixedly connected to the input end of the water pump 12. A water storage tank 13 is fixedly connected to one end of the water inlet pipe 14.

[0028] Reference Figure 1 - Figure 5A base 4 is fixedly connected to the outer side of the bottom of the evaporator 1. A discharge pipe 7 is fixedly connected to the bottom of the evaporator 1. The discharge pipe 7 is used to discharge the crystallized product for further processing or storage. A feed pipe 6 and a condensation pipe 5 are provided on the top of the top cover 2. The condensation pipe 5 enables the recycling of condensate. A steam pipe 8 is fixedly connected to the outer wall of the evaporator 1. The steam pipe 8 is used to draw out the steam generated during the evaporation process. One end of the spring 23 is fixedly connected to the inner wall of the support 20, and the other end of the spring 23 is fixedly connected to the outer wall of the scraper 19. The stirring blade 21 is set inside the evaporator 1. The stirring blade 21 is used to stir the material to make the material heat evenly and accelerate the evaporation and crystallization process. The stirring blade 21 is set between the two guide pipes 22. The heating wire 17 is set between the insulation layer 3 and the evaporator 1. Gear 15 and gear 2 16 are both set on the upper surface of the top cover 2. The rotary joint 9 is set on one side of the outer wall of the motor 10. The water pump 12 is set between the water storage tank 13 and the evaporator 1.

[0029] Working principle: During evaporation and crystallization, the motor 10 is first started, driving the rotating shaft 18 to rotate at a low and stable speed via a transmission system consisting of gear 15 and gear 16. This drives the scraper 19 and stirring blade 21 to rotate. The scraper 19 achieves adaptive adjustment through the elastic connection structure between the bracket 20 and the spring 23, ensuring that the edge of the scraper 19 always adheres to the curved surface of the inner wall of the evaporator 1, continuously mechanically peeling off the gradually precipitated crystal layer during evaporation. In addition, during the cleaning stage, the water pump 12 is started to pump preheated purified water from the water storage tank 13 through the inlet pipe 14, injecting it into the high-speed rotating... The water flow is accelerated along the spiral guide groove inside the rotating shaft 18 under the action of centrifugal force. After being divided and pressurized by the double-sided guide pipes 22, it forms a high-pressure fan-shaped water curtain from the water outlet pipes 24 arranged in an array on the surface of the scraper 19, achieving efficient cleaning. Under the continuous heating of the heating wire 17, the material is heated and evaporated. The generated steam is discharged in an orderly manner through the steam pipe 8 for subsequent steam treatment or recycling. The condensate formed after the steam cools down flows out through the condensation pipe 5 and can be collected as needed. Finally, it is smoothly discharged through the discharge pipe 7, completing the collection of crystallized products for further processing or storage.

[0030] Finally, it should be noted that the above description is only a preferred embodiment of the present utility model and is not intended to limit the present utility model. Although the present utility model has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present utility model should be included within the protection scope of the present utility model.

Claims

1. An evaporation and crystallization apparatus for preparing aminoglycoside drugs, comprising an evaporator (1), characterized in that: The evaporator (1) is provided with a top cover (2) on the top. The outer wall of the evaporator (1) is fixedly connected with a heat insulation layer (3). A heating wire (17) is provided inside the heat insulation layer (3). A motor (10) is provided on the top of the top cover (2). A gear one (15) is fixedly connected to the output end of the motor (10). A gear two (16) is rotatably connected to the top of the top cover (2). The gear one (15) and the gear two (16) mesh with each other. A scraping assembly is provided inside the evaporator (1). The scraping assembly includes a scraper (19), which is slidably connected to the inner wall of the evaporator (1). A bracket (20) is fixedly connected to the outer wall of the scraper (19). A spring (23) is provided inside the bracket (20). A rotating shaft (18) is fixedly connected to the middle of the bracket (20). A stirring blade (21) is fixedly connected to the outer wall of the rotating shaft (18). The outer wall of the rotating shaft (18) is fixedly connected to the inside of the gear (16).

2. The evaporation and crystallization apparatus for preparing aminoglycoside drugs according to claim 1, characterized in that: Two guide pipes (22) are fixedly connected to the outer wall of the rotating shaft (18). The ends of the two guide pipes (22) are fixedly connected to the outer wall of the bracket (20). A water outlet pipe (24) is provided inside the scraper (19). A rotary joint (9) is fixedly connected to one end of the rotating shaft (18). A water outlet pipe (11) is fixedly connected to one end of the rotary joint (9). A water pump (12) is fixedly connected to one end of the water outlet pipe (11). A water inlet pipe (14) is fixedly connected to the input end of the water pump (12). A water storage tank (13) is fixedly connected to one end of the water inlet pipe (14).

3. The evaporation and crystallization apparatus for preparing aminoglycoside drugs according to claim 1, characterized in that: The bottom of the evaporator (1) is fixedly connected to a base (4), and the bottom of the evaporator (1) is fixedly connected to a discharge pipe (7).

4. The evaporation and crystallization apparatus for preparing aminoglycoside drugs according to claim 1, characterized in that: The top cover (2) is provided with a feed pipe (6) and a condensation pipe (5), and the outer wall of the evaporator (1) is fixedly connected with a steam pipe (8).

5. The evaporation and crystallization apparatus for preparing aminoglycoside drugs according to claim 1, characterized in that: One end of the spring (23) is fixedly connected to the inner wall of the bracket (20), and the other end of the spring (23) is fixedly connected to the outer wall of the scraper (19).

6. The evaporation and crystallization apparatus for preparing aminoglycoside drugs according to claim 1, characterized in that: The stirring blade (21) is disposed inside the evaporator (1) and is disposed between two guide pipes (22).

7. The evaporation and crystallization apparatus for preparing aminoglycoside drugs according to claim 1, characterized in that: The heating wire (17) is disposed between the insulation layer (3) and the evaporator (1), and the gear one (15) and gear two (16) are both disposed on the upper surface of the top cover (2).

8. The evaporation and crystallization apparatus for preparing aminoglycoside drugs according to claim 2, characterized in that: The rotary joint (9) is located on one side of the outer wall of the motor (10), and the water pump (12) is located between the water storage tank (13) and the evaporator (1).

Images