Reagent heating device

Abstract

The utility model relates to a reagent heating device. The reagent heating device comprises a shell, a heating assembly and a pipeline, a containing cavity is formed in the shell and used for containing the heating assembly. The pipeline is arranged in the heating assembly, and the reagent in the pipeline is heated through the heating assembly. The device has the beneficial effects that through the design of structures such as the heating assembly and the pipeline, a reagent is firstly placed in the pipeline, is preheated to the required temperature through the heating assembly and then is put into the reaction container to react with substances in the reaction container; compared with a traditional mode, the heating time is effectively shortened, and then the FISH detection time is shortened; in addition, the structure is simple, the integration degree is high, installation is easy, and production and later maintenance are convenient.

Description

Technical Field

[0001] This utility model relates to the field of molecular pathology detection technology, specifically a reagent heating device. Background Technology

[0002] In conventional FISH (fluorescence in situ hybridization) detection, paraffin-embedded tissue sections need to undergo dewaxing, penetration with a penetrant, digestion with pepsin, washing, draining, and waste removal. In these steps, the reagents used must react at specific temperatures. Traditionally, the reagents are added to the reaction chamber at room temperature, then heated, and finally the tissue sections are processed. Since some reagents can be heated to as high as 95°C, this traditional method results in a long FISH detection time. Therefore, shortening the FISH detection time is a pressing technical challenge. Utility Model Content

[0003] This invention addresses the technical problems existing in the prior art by providing a reagent heating device that preheats the reagent before it is added to the reaction vessel, greatly shortening the heating time and consequently the FISH detection time.

[0004] The technical solution of this utility model to solve the above-mentioned technical problems is as follows: a reagent heating device, comprising: a shell, a heating component, and a pipeline;

[0005] The housing has an internal cavity for accommodating the heating assembly;

[0006] The pipeline is located in the heating assembly, and the reagent in the pipeline is heated by the heating assembly.

[0007] As a further technical solution, a circuit board is provided at one end of the housing and a pipe connector is installed at the other end. The circuit board is electrically connected to the heating component and is used to control the heating component to heat the pipe.

[0008] The pipe joint is connected to the pipe.

[0009] As a further technical solution, the heating assembly includes a heating profile and a heating rod coaxially disposed in the heating profile, wherein the heating rod is electrically connected to the circuit board;

[0010] The pipe is located in the through groove of the heating profile, so that the heat from the heating profile is transferred to the pipe.

[0011] As a further technical solution, a heat sink is also provided inside the housing. The heat sink is located between the circuit board and the heating component, and the circuit board controls the heat sink to dissipate heat from the heating component.

[0012] As a further technical solution, a temperature probe is also provided in the heating assembly.

[0013] As a further technical solution, the pipeline is provided with a rigid pipe joint that connects to the pipeline joint.

[0014] As a further technical solution, a connector seat is also included, wherein the rigid pipe connector passes through the connector seat and communicates with the pipe connector.

[0015] As a further technical solution, it also includes a spacer sleeve fitted outside the rigid pipe joint, the spacer sleeve being disposed inside the housing and abutting against the end face of the joint seat opposite to the pipe joint.

[0016] As a further technical solution, it also includes an end cap and a baffle. The end cap, the circuit board, and the baffle are arranged sequentially from the outside to the inside on one end of the housing away from the pipe joint, and the end cap, the circuit board, and the baffle are connected by studs.

[0017] The beneficial effects of this utility model are:

[0018] 1. Through the design of the heating components and pipelines, the reagents are first placed in the pipelines and preheated to the required temperature by the heating components before being added to the reaction vessel to react with the substances in the reaction vessel. Compared with the traditional method, the heating time is effectively shortened, thereby shortening the FISH detection time. In addition, the structure is simple, highly integrated, easy to install, and convenient for production and subsequent maintenance.

[0019] 2. This utility model uses a circuit board to control the operation of the heating component, which realizes effective temperature control to adapt to different temperature requirements, thereby improving the practicality and application range of this heating device; in addition, the setting of temperature probe in the heating profile can monitor the temperature of the heating profile in real time and accurately, which facilitates the control of the temperature of reagents in the pipeline.

[0020] 3. The design of the heat dissipation component in the heating device of this utility model can quickly control the temperature of the reagent and effectively cool the heating component at the same time. Attached Figure Description

[0021] Figure 1 This is an exploded structural diagram of a reagent heating device according to Embodiment 1 of this utility model, wherein the connection lines between the circuit board and the heating component and the temperature probe are not shown;

[0022] Figure 2 This is a three-dimensional structural diagram of a reagent heating device according to Embodiment 1 of this utility model;

[0023] Figure 3This is a right-side structural schematic diagram of a reagent heating device according to Embodiment 1 of this utility model;

[0024] Figure 4 for Figure 3 A cross-sectional view of the structure along the AA direction is shown, but the connection lines between the circuit board and the heating components and temperature probe are not drawn.

[0025] The attached diagram lists the components represented by each number as follows:

[0026] Housing 1, circuit board 11, pipe connector 12, stud 13;

[0027] Heating component 2, heating profile 21, heating rod 22;

[0028] Pipeline 3, Rigid pipe connector 31;

[0029] 4. Connector base; 5. Spacer; 6. Heat sink; 7. Temperature probe; 8. End cap; 81. Cable connector; 9. Baffle. Detailed Implementation

[0030] The technical solutions of the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this application, and not all embodiments. Based on the embodiments of this application, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this application.

[0031] In the description of this application, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of indicated technical features. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of the stated features. In the description of this application, "multiple" means two or more, unless otherwise explicitly specified.

[0032] In the description of this application, the term "for example" is used to mean "used as an example, illustration, or description." Any embodiment described as "for example" in this application is not necessarily to be construed as being more preferred or advantageous than other embodiments. The following description is provided to enable any person skilled in the art to implement and use the present invention. Details are set forth in the following description for purposes of explanation. It should be understood that those skilled in the art will recognize that the present invention can be implemented without using these specific details. In other instances, well-known structures and processes will not be described in detail to avoid obscuring the description of the present invention with unnecessary detail. Therefore, the present invention is not intended to be limited to the embodiments shown, but is consistent with the broadest scope of the principles and features disclosed in this application.

[0033] Example 1

[0034] To increase the temperature of the reagents, they are preheated before being placed in the reaction vessel. For example, in the FISH detection process, the conventional method is to add the reagents to the reaction cell (i.e., the aforementioned reaction vessel) and then heat the reaction cell, which prolongs the FISH detection time. Therefore, this embodiment provides a reagent heating device, which allows the reagents to be preheated by the heating device of this embodiment before being added to the reaction cell, so that the reaction can be carried out directly, thus shortening the FISH detection time.

[0035] Specifically, see Figure 1 , Figure 4 The heating device includes a housing 1, a heating component 2, and a pipeline 3;

[0036] The housing 1 has an internal cavity for accommodating the heating assembly 2;

[0037] The pipeline 3 is located in the heating assembly 2. The reagent in the pipeline 3 is heated by the heating assembly 2. That is, the reagent can be preheated by this heating device, and then the heated reagent is placed in the reaction vessel (e.g., the reaction cell in FISH detection) to shorten the FISH detection time.

[0038] It can be noted that the pipe 3 can also contain other substances that need to be heated, such as water; the pipe 3 can be a Teflon pipe, which has high heat resistance, is easy to assemble, and has good corrosion resistance and easy cleaning characteristics.

[0039] In the specific implementation process, see Figures 1-4 One end of the housing 1 is provided with a circuit board 11 and the other end is provided with a pipe connector 12. The circuit board 11 is electrically connected to the heating component 2 and is used to control the heating component 2 to heat the pipe 3. That is, the circuit board 11 enables the heating component 2 to work after being powered on, and then heats the reagent in the pipe 3.

[0040] The pipe connector 12 is connected to the pipe 3, allowing the heated reagent in the pipe 3 to be transported to the reaction vessel via the pipe connector 12. Here, the pipe connector 12 can transport the reagent to the reaction vessel via an external pipe, or it can directly transport the reagent to the reaction vessel via the pipe connector 12. It can be noted that there are at least two pipe connectors 12; if there are two, one is the reagent inlet and the other is the reagent outlet. Therefore, the pipe 3 is provided with two rigid pipe connectors 31 connected to the pipe connector 12 (see [reference]). Figure 1 , Figure 4One pipe connector 12 is connected to the reagent inlet, and the other pipe connector 12 is connected to the reagent outlet. It can be explained that the reagent to be heated enters one of the rigid pipe connectors 31 through the reagent inlet pipe connector 12 and then enters the pipe 3. The reagent is heated as it moves from the inlet side to the outlet side of the pipe 3. When the heated reagent is transported from the other rigid pipe connector 31 to the reagent outlet pipe connector 12, it flows into the reaction vessel.

[0041] For example, see Figure 1 , Figure 4 In this embodiment, the heating device also includes a connector seat 4, which allows the rigid pipe connector 31 to pass through the connector seat 4 and communicate with the pipe connector 12, thereby improving the stability of the connection between the rigid pipe connector 31 and the pipe connector 12, improving the aesthetics of the heating device, and making the structure of the heating device more compact.

[0042] In order to extend the service life of the rigid pipe connector 31 and improve the stability of reagent flow, the heating device in this embodiment also includes a spacer 5 sleeved outside the rigid pipe connector 31. The spacer 5 is located inside the housing 1 and abuts against the end face of the connector seat 4 opposite to the pipe connector 12. That is, the spacer 5 has a through hole (not labeled in the figure) along its axial direction for the rigid pipe connector 31 to pass through, which can improve the aesthetics of the heating device and at the same time, can provide a certain degree of protection for the rigid pipe connector 31.

[0043] In the specific implementation process, see Figure 1 , Figure 4 The heating component 2 includes a heating profile 21 and a heating rod 22 coaxially disposed in the heating profile 21. The heating rod 22 is electrically connected to the circuit board 11, that is, the circuit board 11 causes the heating rod 22 to heat up after being powered on, and the heat of the heating rod 22 is transferred to the heating profile 21, causing the temperature of the heating profile 21 to rise.

[0044] The pipe 3 is disposed in the through groove of the heating profile 21, so that the heat of the heating profile 21 is transferred to the pipe 3. For example, the heating profile 21 has several through grooves (not labeled in the figure) along its axial direction for placing the pipe 3. (It can be noted that the pipe 3 here is composed of several segments connected end to end, and the segments of pipe 3 are arranged in parallel, so that the reagent is heated as it moves from the rigid pipe connector 31 on one side to the rigid pipe connector 31 on the other side. This structure can effectively save space.) For example, the heating profile 21 has several fins (not labeled in the figure) on the outside, and the fins are evenly spaced along the circumference of the heating profile 21 for easy cooling, while the heating rod 22 and the pipe 3 are located inside the fins for easy heating of the reagent.

[0045] To rapidly reduce the temperature of this heating device to meet the temperature requirements of different reagents, see [link / reference]. Figure 1 , Figure 4 The heating device of this utility model also includes a heat dissipation component 6 disposed in the housing 1. The heat dissipation component 6 is disposed between the circuit board 11 and the heating component 2. The circuit board 11 controls the heat dissipation component 6 to dissipate heat from the heating component 2. For example, the heat dissipation component 6 is electrically connected to the circuit board 11 to provide power to the heat dissipation component 6 so that it can be turned on.

[0046] For example, the heat sink 6 is a cooling fan, more specifically, a miniature brushless ducted fan.

[0047] In the specific implementation process, to monitor the temperature of the heating reagent in real time, please refer to... Figure 1 , Figure 4 The heating device in this embodiment also includes a temperature probe 7 disposed in the heating assembly 2. The temperature probe 7 is electrically connected to the circuit board 11. The temperature probe 7 monitors the temperature of the heating profile 21 in real time and feeds back the monitored signal to the circuit board 11 to achieve temperature control. In addition, the circuit board 11 can provide power to the temperature probe 7.

[0048] The heating profile 21 is provided with mounting holes for installing the temperature probe 7 (not shown in the figure);

[0049] In the specific implementation process, see Figure 1 , Figure 4 The heating device of this utility model also includes an end cover 8 and a baffle 9. The end cover 8, the circuit board 11, and the baffle 9 are sequentially arranged from the outside to the inside on one end of the housing 1 away from the pipe joint 12, and the end cover 8, the circuit board 11, and the baffle 9 are connected by studs 13. It can be noted that the end cover 8 prevents dust from entering the heating device, thereby improving the service life of the heating device, and at the same time protecting the internal structure of the housing 1.

[0050] For example, the baffle 9 has holes for cables to pass through (not shown in the figure), so that the cables on the circuit board 11 can pass through the holes on the baffle 9 and connect to various structures (such as heating rod 22, heat sink 6, temperature probe 7). It should be noted that each structure corresponds to at least one cable.

[0051] To improve aesthetics and facilitate installation and maintenance, please refer to... Figure 1 , Figure 2 , Figure 4 A cable connector 81 is connected to the side of the end cap 8 away from the circuit board 11 to fix the cables.

[0052] It should be noted that in the heating device of this embodiment, see... Figure 4 The housing 1 is a hollow housing 1, which is used to simultaneously house the heating component 2, the heat sink 6, the circuit board 11 and other components.

[0053] This embodiment is implemented as follows:

[0054] The heating rod 22 starts heating under the control of the circuit board 11, and then transfers the heat to the heating profile 21. Through the contact between the pipe 3 and the heating profile 21, the heat of the heating profile 21 is continuously transferred to the pipe 3 to heat the reagent in the pipe 3. The heated reagent flows out through the pipe connector 12 at the reagent outlet.

[0055] The temperature probe 7 transmits the temperature signal collected in the heating profile 21 to the circuit board 11 to realize temperature detection and control;

[0056] When the temperature of the reagent that needs to be preheated next is lower than that of the previous one, the heating rod 22 stops heating under the control of the circuit board 11, and the heat sink 6 is activated under the control of the circuit board 11 to cool down the heating component 2, so as to quickly control the reagent flowing through the pipeline 3 next to reach a suitable temperature.

[0057] The heating device of this invention has a simple structure, high integration, and is easy to install, facilitating production and subsequent maintenance. At the same time, the heating device effectively shortens the FISH testing time.

[0058] It should be noted that the descriptions of each embodiment in the above embodiments have different focuses. For parts that are not described in detail in a certain embodiment, please refer to the relevant descriptions in other embodiments.

[0059] Although preferred embodiments of the present invention have been described, those skilled in the art, upon learning the basic inventive concept, can make other changes and modifications to these embodiments. Therefore, the appended claims are intended to be interpreted as including the preferred embodiments as well as all changes and modifications falling within the scope of the present invention.

[0060] Obviously, those skilled in the art can make various modifications and variations to this utility model without departing from its spirit and scope. Therefore, if these modifications and variations fall within the scope of the claims of this utility model and their equivalents, this utility model also intends to include these modifications and variations.

Claims

1. A reagent heating device, characterized by, The device comprises a shell (1), a heating assembly (2), and a pipeline (3). The shell (1) is provided with a receiving cavity for receiving the heating assembly (2). The pipeline (3) is arranged in the heating assembly (2) and heated by the heating assembly (2).

2. The reagent heating device of claim 1, wherein One end of the shell (1) is provided with a circuit board (11), and the other end is provided with a pipeline connector (12). The circuit board (11) is electrically connected to the heating assembly (2) and used for controlling the heating assembly (2) to heat the pipeline (3). The pipeline connector (12) is in communication with the pipeline (3).

3. A reagent heating device according to claim 2, wherein The heating assembly (2) comprises a heating profile (21) and a heating rod (22) coaxially arranged in the heating profile (21). The heating rod (22) is electrically connected to the circuit board (11). The pipeline (3) is arranged in the through slot of the heating profile (21), so that the heat of the heating profile (21) is transferred to the pipeline (3).

4. The reagent heating device of claim 2, wherein A heat dissipation member (6) is arranged in the shell (1) and arranged between the circuit board (11) and the heating assembly (2). The heat dissipation member (6) is controlled by the circuit board (11) to dissipate heat from the heating assembly (2).

5. The reagent heating device of claim 2, wherein A temperature probe (7) is arranged in the heating assembly (2).

6. The reagent heating device of claim 2, wherein A hard pipe connector (31) is arranged on the pipeline (3) and connected to the pipeline connector (12).

7. A reagent heating device according to claim 6, wherein A connector seat (4) is further arranged, and the hard pipe connector (31) is in communication with the pipeline connector (12) after passing through the connector seat (4).

8. A reagent heating device according to claim 7, wherein A spacer (5) is arranged outside the hard pipe connector (31) and arranged in the shell (1) and abutting against the end surface of the connector seat (4) away from the pipeline connector (12).

9. The reagent heating device of claim 2, wherein, An end cover (8) and a baffle (9) are arranged on the end of the shell (1) away from the pipeline connector (12) from outside to inside in sequence and are connected by a stud (13).

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