Experimental fixing device for venous blood sampling of rats and mice

Abstract

The utility model discloses an experimental rat and mouse venous blood sampling fixing device which comprises a plane base and a slope base, four limb fixing devices are arranged on the upper surface of the front portion of the plane base, a drain hole is formed in the upper surface of the rear portion of the plane base, and each limb fixing device comprises a first inverted-T-shaped fixing groove, a first bolt and a bandage. The first bolt is connected with the first inverted-T-shaped fixing groove, the bandage is connected to the first bolt, a second inverted-T-shaped fixing groove is formed in the slope base, the head fixing device is connected to the second inverted-T-shaped fixing groove, the head fixing device comprises a clamping base and a conical barrel fixed to the clamping base, and the clamping base is fixedly connected with the slope base through a second bolt. A third inverted-T-shaped fixing groove perpendicular to the second inverted-T-shaped fixing groove is formed in the slope base, and the clamping base and the second bolt can slide in the third inverted-T-shaped fixing groove. The fixing device is suitable for rats and mice of different body types, can effectively fix the rats and the mice, and facilitates vein blood sampling.

Description

Technical Field

[0001] This utility model relates to the field of animal experimental device technology, specifically to an experimental rat and mouse venous blood collection and fixation device. Background Technology

[0002] Currently, blood collection from the submandibular jugular vein of laboratory mice is a commonly used experimental technique in research fields such as biology, medicine, and pharmacy. In non-clinical animal pharmacokinetic studies, continuous blood collection via the jugular vein is one of the most frequently used methods. During blood collection, laboratory mice often react violently, making control difficult. Therefore, animal restraint devices are used to first immobilize the animals to improve the success rate of blood collection and reduce the risk of injury to both the animal and the operator.

[0003] Most existing mouse restraint devices are cylindrical restraint devices. These devices insert the entire mouse into a roller and restrain the mouse by tightening the roller or reducing the space for movement in front of and behind the roller. The mouse wrapped in a cylindrical restraint device tends to curl up into a ball, making it difficult for researchers to locate the jugular vein and adjust the angle of needle insertion, making venous blood collection inconvenient. Utility Model Content

[0004] This invention provides a fixation device for venous blood collection from experimental mice and rats, which is adaptable to experimental mice of different sizes and can effectively fix them for convenient venous blood collection.

[0005] To achieve the above-mentioned technical objectives, the technical solution adopted by this utility model is as follows:

[0006] A device for fixing venous blood collection from mice and rats for laboratory use includes a flat base and an inclined base. The upper front surface of the flat base has four limb fixation devices, and the upper rear surface has an excretion hole. Each limb fixation device includes a first inverted T-shaped fixing groove, a first bolt, and a strap. The first inverted T-shaped fixing groove is inclined, and the first bolt connects to it. The strap is connected to the first bolt. A collection box is located below the excretion hole. The inclined base has a second inverted T-shaped fixing groove, and a head fixation device is connected to it. The head fixation device includes a retainer and a conical cylinder fixed to the retainer. The conical cylinder has a larger diameter at the front end and a smaller diameter at the rear end. The retainer is fixedly connected to the inclined base by a second bolt. The inclined base has a third inverted T-shaped fixing groove perpendicular to the second inverted T-shaped fixing groove. The retainer and the second bolt can slide within the third inverted T-shaped fixing groove.

[0007] Furthermore, the cross-section of the inclined base is a right-angled triangle, with the front end of the inclined base being lower than the rear end.

[0008] Furthermore, the upper surface of the rear end of the inclined base is hinged to the upper surface of the front end of the flat base by a metal hinge, the bottom of the front end of the inclined base is connected to a first support with adjustable height, and the four corners of the bottom of the flat base are connected to second supports.

[0009] Furthermore, the first support consists of a sleeve base and a telescopic rod. The telescopic rod is movably inserted into the sleeve base, and the side wall is provided with multiple positioning holes along the length direction. The side wall of the sleeve base is provided with positioning pins that are adapted to the positioning holes.

[0010] Furthermore, the conical cylinder is higher than the inclined base and is formed by the aggregation of fan-shaped pads, with the aggregation port connected by Velcro.

[0011] Furthermore, a flow guide ramp is provided on the side of the discharge hole near the limb fixation device.

[0012] Furthermore, the guide ramp is shaped like a funnel, extending from back to front.

[0013] Furthermore, the flat base has a drawer hole on the rear side, and a drain hole is connected above the drawer hole. The collection box is inserted into the drawer hole, and a handle is provided on the outside.

[0014] Furthermore, the first bolt is reversed, with the screw head located in the first inverted T-shaped fixing groove, and the screw rod passes upward through the first inverted T-shaped fixing groove to connect to the nut.

[0015] Furthermore, the card holder is provided with a fixing hole, the second bolt is reversed, the screw head is located in the second inverted T-shaped fixing groove below the card holder, and the screw rod passes through the fixing hole and the second inverted T-shaped fixing groove vertically upward to the inclined base and connects to the nut.

[0016] Compared with the prior art, the beneficial effects of this utility model are as follows:

[0017] This invention can easily fix laboratory mice of different sizes, fully expose the neck of the laboratory mice, facilitate venous blood collection, is suitable for jugular vein blood collection of laboratory mice in an conscious state, and can also reduce the risk of laboratory mice biting laboratory personnel. In addition, the excrement of laboratory mice during the experiment can flow into the collection box below through the excretion hole, which is easy to clean and keeps the operating table relatively clean. Attached Figure Description

[0018] To more clearly illustrate the technical solutions of the embodiments of this application, the accompanying drawings used in the embodiments will be briefly introduced below. It should be understood that the following drawings only show some embodiments of this application and should not be regarded as a limitation of the scope. For those skilled in the art, other related drawings can be obtained based on these drawings without creative effort.

[0019] Figure 1This is a schematic diagram of the overall structure of this utility model;

[0020] Figure 2 This is a schematic diagram of the structure of the card holder and the conical cylinder;

[0021] Figure 3 This is a schematic diagram of the structure of the first support;

[0022] Figure 4 This is a rear view of the present invention;

[0023] Figure 5 A sectional view of the limb fixation device;

[0024] Figure 6 A sectional view of the head fixation device;

[0025] In the diagram: 1-Flat base, 101-Drainage hole, 2-Sloping base, 201-Second inverted T-shaped fixing groove, 3-Head fixing device, 301-Hook and loop fastener, 302-Conical cylinder, 303-Fixing hole, 304-Card holder, 305-Second bolt, 4-Metal hinge, 5-Limb fixing device, 501-First bolt, 502-Strap, 503-First inverted T-shaped fixing groove, 6-Collection box, 601-Handle, 7-Second support, 8-First support, 801-Positioning pin, 802-Positioning hole, 803-Sleeve base, 804-Telescopic rod, 9-Third inverted T-shaped fixing groove. Detailed Implementation

[0026] To make the objectives, technical solutions, and advantages of the embodiments of this application clearer, the technical solutions of the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this application, and not all embodiments. The components of the embodiments of this application described and shown in the accompanying drawings can generally be arranged and designed in various different configurations.

[0027] In the description of the embodiments of this application, it should be noted that the indicated orientation or positional relationship is based on the orientation or positional relationship shown in the accompanying drawings, or the orientation or positional relationship that the product of this application is usually placed in when in use, or the orientation or positional relationship that is commonly understood by those skilled in the art. It is only for the convenience of describing this application and simplifying the description, and is not intended to indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, it should not be construed as a limitation of this application.

[0028] In the description of the embodiments of this application, it should also be noted that, unless otherwise expressly specified and limited, the terms "set," "install," and "connect" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a direct connection or an indirect connection through an intermediate medium. Those skilled in the art can understand the specific meaning of the above terms in this application based on the specific circumstances.

[0029] A fixation device for venous blood collection from mice and rats includes a flat base 1 and an inclined base 2. Four limb fixation devices 5 are provided on the upper front surface of the flat base 1, as shown in the figure. Figure 1 , Figure 5 As shown, the limb fixation device 5 includes a first inverted T-shaped fixing groove 503, a first bolt 501, and a strap 502. The first inverted T-shaped fixing groove 503 is obliquely arranged, and the strap is connected to the first bolt 501. The first bolt 501 is inverted, with the screw head located inside the first inverted T-shaped fixing groove 503. The screw rod passes upward through the first inverted T-shaped fixing groove 503 and connects to the nut. Preferably, one end of the strap 502 is connected to the screw head, and the other end is connected to the nut. During venous blood collection, the limbs of the experimental mouse are fixed one by one using the limb fixation device 5. The position of the first bolt 501 can be moved according to the size of the experimental mouse, and then the nut is tightened to effectively fix the limbs of the experimental mouse.

[0030] like Figure 1 , Figure 4 As shown, a drain hole 101 is provided on the upper rear surface of the flat base 1. A guide ramp is provided on the side of the drain hole 101 near the limb fixation device 5. The guide ramp is funnel-shaped from back to front, allowing the excrement produced by the experimental mouse during the experiment to flow smoothly into the drain hole 101. A collection box 6 is provided below the drain hole 101. A drawer hole is provided on the rear side of the flat base 1. The top of the drawer hole is connected to the drain hole 101. The collection box 6 is inserted into the drawer hole to collect the excrement of the experimental mouse flowing down from the drain hole 101. A handle 601 is provided on the outside.

[0031] like Figure 1 As shown, the inclined base 2 has a right-angled triangle cross-section, with the front end lower than the rear end. The upper surface of the rear end of the inclined base 2 is hinged to the upper surface of the front end of the flat base 1 via a metal hinge 4, allowing the inclination of the inclined base 2 to be adjusted according to the size of the experimental mouse and the required angle for the experiment. An adjustable-height first support 8 is connected to the bottom front end of the inclined base 2, and second supports 7 are connected to the four corners of the bottom of the flat base 1. The angle between the inclined base 2 and the flat base 1 is adjusted by adjusting the height of the first supports 8. In this embodiment, as... Figure 3As shown, the first support 8 consists of a sleeve base 803 and a telescopic rod 804. The telescopic rod 804 is movably inserted into the sleeve base 803. The side wall is provided with multiple positioning holes 802 along the length direction. The side wall of the sleeve base 803 is provided with positioning pins 801 that are adapted to the positioning holes 802. After the telescopic rod 804 is moved up and down to a suitable height, the positioning pins 801 are inserted to determine the height of the entire first support 8.

[0032] The inclined base 2 is provided with a second inverted T-shaped fixing groove 201 and a head fixing device 3, such as Figure 2 , Figure 6 As shown, the second inverted T-shaped fixing groove 201 is arranged front-to-back. The head fixing device 3 includes a card seat 304 that slides into the second inverted T-shaped fixing groove 201 and a conical cylinder 302 fixed on the card seat 304. The diameter of the conical cylinder 302 is larger at the front end and smaller at the rear end. The card seat 304 is fixedly connected to the inclined base 2 by a second bolt 305. The conical cylinder 302 is higher than the inclined base 2 and is formed by the aggregation of fan-shaped pads. The aggregation opening is connected by Velcro 301, and the bonding position of the Velcro 301 on both sides of the conical cylinder 302 can be adjusted according to the neck dimension of the experimental mouse. The card seat 304 is provided with a fixing hole 303. The second bolt 305 is inverted, with the screw head located inside the second inverted T-shaped fixing groove 201 and below the card seat 304. The screw rod passes vertically upward through the fixing hole 303 and the second inverted T-shaped fixing groove 201, and is connected to a nut. The head fixing device 3 is moved along the length of the second inverted T-shaped fixing groove 201 according to the body size of the experimental mouse to ensure that the neck of the experimental mouse is in an extended state.

[0033] The inclined base 2 has a third inverted T-shaped fixing groove 9 parallel to the inclined plane, perpendicular to the second inverted T-shaped fixing groove 201. The card holder 304 and the second bolt 305 can slide within the third inverted T-shaped fixing groove 9. During jugular vein blood collection, the head fixation device 3 can move left and right along the third inverted T-shaped fixing groove 9 to adjust the angle of the mouse's head offset from the body's central axis, that is, to offset the mouse's head to the left or right, thereby fully exposing the right or left scapula of the mouse, facilitating venous blood collection.

[0034] Preferably, multiple third inverted T-shaped fixing grooves 9 can be designed and distributed at intervals along the length direction of the second inverted T-shaped fixing groove 201. One third inverted T-shaped fixing groove 9 is selected according to the body size of the experimental mouse to allow the head fixing device 3 to move left and right.

[0035] Of course, there may be other embodiments of this utility model. Without departing from the spirit and essence of this utility model, those skilled in the art can make various corresponding changes and modifications based on this utility model, but these corresponding changes and modifications should all fall within the protection scope of the appended claims of this utility model.

Claims

1. A device for fixing venous blood collection from rats and mice for laboratory use, characterized in that: The utility model provides a kind of four limbs and head fixing device, including plane base (1), inclined plane base (2), plane base (1) upper surface is equipped with four four limbs fixing device (5) in front part, upper surface is equipped with drain hole (101) in rear part, four limbs fixing device (5) includes first inverted T type fixed groove (503), first bolt (501), bandage (502), first inverted T type fixed groove (503) is obliquely arranged, first bolt (501) is connected first inverted T type fixed groove (503), bandage (502) is connected on first bolt (501), drain hole (101) is equipped with collecting box (6) below, second inverted T type fixed groove (201) is equipped on inclined plane base (2), head fixing device (3) is connected in second inverted T type fixed groove (201), head fixing device (3) includes clamping seat (304), conical cylinder (302) fixed on clamping seat (304), the diameter of conical cylinder (302) is large in front end and small in rear end, clamping seat (304) is fixedly connected with inclined plane base (2) by second bolt (305), third inverted T type fixed groove (9) that is perpendicular to second inverted T type fixed groove (201) is equipped on inclined plane base (2), clamping seat (304) and second bolt (305) can slide in third inverted T type fixed groove (9).

2. The experimental mouse phlebotomy restraint device of claim 1, wherein: The inclined plane base (2) has a right-angled triangle cross section, and the front end of the inclined plane base (2) is lower than the rear end.

3. The experimental mouse phlebotomy restraint device of claim 2, wherein: The upper surface of the rear end of the inclined plane base (2) is hingedly connected with the upper surface of the front end of the plane base (1) by a metal hinge (4), and the front end of the inclined plane base (2) is connected with a first support (8) with adjustable height.

4. The experimental mouse phlebotomy restraint device of claim 3, wherein: The first support (8) is composed of a sleeve base (803) and a telescopic rod (804), the telescopic rod (804) is movably arranged in the sleeve base (803), a plurality of positioning holes (802) are arranged on the side wall along the length direction, and the side wall of the sleeve base (803) is provided with positioning pins (801) matched with the positioning holes (802).

5. The experimental mouse phlebotomy restraint device of claim 1, wherein: The conical cylinder (302) is composed of a plurality of fan-shaped pads, and the pads are connected by magic tapes (301).

6. The experimental mouse phlebotomy restraint device of claim 1, wherein: A guide slope is arranged on the side of the drain hole (101) close to the four limbs fixing device (5).

7. The experimental mouse phlebotomy restraint device of claim 6, wherein: The guide slope is in the shape of a horn mouth from back to front.

8. The experimental mouse phlebotomy restraint device of any one of claims 1, 6, 7, wherein: A drawer hole is arranged on the rear side of the plane base (1), the drain hole (101) is connected with the drawer hole, the collecting box (6) is inserted into the drawer hole, and a handle (601) is arranged on the outer side of the collecting box (6).

9. The experimental mouse phlebotomy restraint device of claim 1, wherein: The first bolt (501) is arranged in reverse, the screw head is arranged in the first inverted T type fixed groove (503), and the screw rod is connected with a nut by penetrating the first inverted T type fixed groove (503) upward.

10. The experimental mouse phlebotomy restraint device of claim 1, wherein: The clamping seat (304) is provided with a fixing hole (303), the second bolt (305) is arranged in reverse, the screw head is arranged below the clamping seat (304) in the second inverted T type fixed groove (201), the screw rod is connected with a nut by penetrating the fixing hole (303) and the second inverted T type fixed groove (201) upward, and the screw rod is perpendicular to the inclined plane base (2).

Images