Biological medicine fermentation device

Abstract

The utility model provides a biological medicine fermentation device, which relates to the technical field of biological medicine, and comprises a fermentation tank, two gas distributors are fixedly arranged in the fermentation tank; the temperature control assembly is arranged in the fermentation tank and comprises a threaded pipe, a heating pipe, a heating wire, a water injection pipe and a water outlet pipe; the oxygen supply assembly is arranged in the fermentation tank and comprises a cap hood, a breather pipe, a partition plate, a spring and an aeration pump. According to the biological medicine fermentation device, the temperature control assembly is arranged, a heating wire is heated, heat is transferred into the fermentation tank through water in a threaded pipe, the situation that the fermentation environment is damaged due to the too high temperature is avoided, flowing water takes away heat in the fermentation tank during cooling, oxygen can be evenly dispersed into fermentation liquid through the oxygen supply assembly, and the fermentation liquid is more uniform. The oxygen transmission efficiency is improved, microorganisms can obtain oxygen more sufficiently, the growth and metabolism requirements of the microorganisms are met, and fermentation liquor can make full contact with the oxygen through stirring.

Description

Technical Field

[0001] This utility model relates to the field of biomedical technology, specifically a biomedical fermentation device. Background Technology

[0002] Biomedicine utilizes biotechnology to develop and produce drugs and medical devices for the prevention, diagnosis, and treatment of human diseases. In biomedical research, fermentation devices are often used to ferment drugs in order to ensure their efficacy. Biomedical fermentation is a method of preparing compounds by utilizing the metabolic activities of microorganisms. The compound to be prepared is brought into contact with microorganisms. When the compound enters the microorganisms, the microorganisms change the compound in the body through their own metabolic pathways, ultimately forming the target product. Biomedical fermentation is an important biotechnology.

[0003] In the process of biopharmaceutical fermentation, it is usually necessary to raise or lower the temperature according to the specific situation to maintain suitable fermentation conditions. However, the existing fermentation equipment has poor heating and cooling effects. Excessive heating can easily lead to the death of microorganisms in the fermentation broth, while slow cooling can easily increase the fermentation time. Furthermore, during the fermentation process, it is necessary to introduce air or pure oxygen into the fermentation tank so that the oxygen dissolves in the fermentation broth for the respiration and metabolism of microorganisms. However, the solubility of oxygen is limited, especially when the viscosity of the fermentation broth is high, which may lead to insufficient local oxygen supply. Utility Model Content

[0004] The technical problem to be solved by this utility model is to provide a biomedical fermentation device. Through the setting of the temperature control component, the heating wire heats up and transfers the heat to the fermentation tank through the water in the threaded tube, so as to avoid the temperature being too high and damaging the fermentation environment. When cooling down, the flowing water takes away the heat inside the fermentation tank. Through the setting of the oxygen supply component, oxygen can be evenly dispersed into the fermentation liquid, improving the oxygen transfer efficiency, so that microorganisms can obtain oxygen more fully to meet their growth and metabolism needs, and the stirring can make the fermentation liquid fully contact with oxygen.

[0005] The technical problem to be solved by this utility model is achieved by the following technical solution:

[0006] A biopharmaceutical fermentation device includes: a fermenter, wherein two gas distributors are fixedly installed inside the fermenter; a temperature control component disposed inside the fermenter, the temperature control component including: a threaded pipe, a heating pipe, a heating wire, a water injection pipe and a water outlet pipe; and an oxygen supply component disposed inside the fermenter, the oxygen supply component including: a cap, a vent pipe, a baffle, a spring and an aeration pump.

[0007] Preferably, a feeding pipe is fixedly connected to the top of the fermentation tank, two fixed supports are fixedly installed on the inner wall of the fermentation tank, and a threaded pipe is fixedly installed on the inner wall of the fermentation tank. The threaded pipe is arranged around the inner wall of the fermentation tank, and both ends of the threaded pipe are fixedly connected to the two fixed supports respectively.

[0008] Preferably, a heating tube is fixedly installed inside the threaded tube, and a heating wire is fixedly installed inside the heating tube. A water injection pipe is fixedly connected to one side of one of the fixed brackets, a support plate is fixedly installed to one side of the fermentation tank, a heater is fixedly installed on the top of the support plate, and the top of the heater is fixedly connected to one end of the heating tube. A water outlet pipe is fixedly connected to one side of the other fixed bracket.

[0009] Preferably, a connecting block is fixedly installed on the top of the fermentation tank, a motor is fixedly installed on the top of the connecting block, a rotating shaft is driven and connected to the bottom of the motor, stirring rods are fixedly installed on both sides of the rotating shaft, and a temperature detector is fixedly installed on one side of the fermentation tank.

[0010] Preferably, the gas distributor has an oxygen chamber inside, and multiple caps are fixedly installed on one side of the gas distributor. A vent pipe is fixedly installed inside the cap. A partition is provided on one side of the vent pipe. Two springs are fixedly connected to one side of the partition. One end of the springs is fixedly connected to the gas distributor. Multiple vent holes are provided on the outer side of one end of the cap, and multiple connection holes are provided on one side of the gas distributor.

[0011] Preferably, a support frame is fixedly installed at the bottom of the fermenter, and two aeration pumps are fixedly installed at the top of the support frame. Each aeration pump is fixedly connected to an air pipe at its top, one end of which is fixedly connected to the gas distributor. A control valve is fixedly installed on the outside of the fermenter.

[0012] The beneficial effects of this utility model are:

[0013] The advantages of this invention are that, through the setting of the temperature control component, the heating wire heats up and transfers the heat to the fermentation tank through the water in the threaded tube, avoiding excessive temperature from damaging the fermentation environment. When cooling down, the flowing water carries away the heat inside the fermentation tank. The threaded tube structure design can expand the contact area between the fermentation liquid and the surface of the threaded tube, so that the fermentation liquid can be cooled down and heated up quickly.

[0014] Secondly, the oxygen supply components can evenly disperse oxygen into the fermentation broth, improving oxygen transfer efficiency and enabling microorganisms to obtain oxygen more fully to meet their growth and metabolic needs. Stirring also allows the fermentation broth to fully contact with oxygen. Attached Figure Description

[0015] Figure 1 This is a schematic diagram of the overall structure of this utility model.

[0016] Figure 2 This is a cross-sectional view of the overall structure of this utility model.

[0017] Figure 3 This is a schematic diagram of the gas distributor structure of this utility model.

[0018] Figure 4 This is a schematic diagram of the threaded pipe structure of this utility model.

[0019] Figure 5 For the present utility model Figure 2 Enlarged view of point A in the image.

[0020] Figure 6 For the present utility model Figure 2 Enlarged view of point B in the image.

[0021] Figures 1-6 In the middle: 1. Fermentation tank; 101. Feeding pipe; 102. Fixed bracket; 103. Threaded pipe; 104. Heating pipe; 105. Heating wire; 106. Water injection pipe; 107. Support plate; 108. Heater; 109. Water outlet pipe; 2. Connecting block; 201. Motor; 202. Rotating shaft; 203. Temperature detector; 3. Gas distributor; 301. Oxygen chamber; 302. Cap; 303. Vent pipe; 304. Baffle plate; 305. Spring; 306. Vent hole; 307. Connecting hole; 4. Support frame; 401. Aeration pump; 402. Gas pipe; 403. Control valve. Detailed Implementation

[0022] The technical solutions in the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this application, and not all embodiments. All other embodiments obtained by those skilled in the art based on the embodiments of this application without creative effort are within the scope of protection of this application.

[0023] The present application will now be described in detail with reference to the accompanying drawings and specific embodiments.

[0024] like Figures 1-6 As shown, a biopharmaceutical fermentation device includes: a fermenter 1, with two gas distributors 3 fixedly installed inside the fermenter 1; a temperature control component installed inside the fermenter 1, which includes: a threaded pipe 103, a heating pipe 104, a heating wire 105, a water injection pipe 106, and a water outlet pipe 109; and an oxygen supply component installed inside the fermenter 1, which includes: a cap 302, a vent pipe 303, a partition 304, a spring 305, and an aeration pump 401.

[0025] The temperature control component allows the heating wire 105 to heat the water through the threaded pipe 103 and transfer the heat to the fermenter 1, preventing excessive temperature from damaging the fermentation environment. During cooling, the flowing water carries away the heat inside the fermenter 1. The oxygen supply component ensures that oxygen is evenly distributed in the fermentation liquid, improving oxygen transfer efficiency and enabling microorganisms to obtain oxygen more fully to meet their growth and metabolic needs. Stirring also ensures that the fermentation liquid is in full contact with oxygen.

[0026] The fermenter 1 is equipped with a feeding pipe 101 fixedly connected to the top. Two fixed supports 102 are fixedly installed on the inner wall of the fermenter 1. A threaded pipe 103 is fixedly installed on the inner wall of the fermenter 1, and the threaded pipe 103 is arranged around the inner wall of the fermenter 1. Both ends of the threaded pipe 103 are fixedly connected to the two fixed supports 102 respectively. A heating pipe 104 is fixedly installed inside the threaded pipe 103. A heating wire 105 is fixedly installed inside the heating pipe 104. A water injection pipe 106 is fixedly connected to one side of one of the fixed supports 102. A support plate 107 is fixedly installed on one side of the fermenter 1. A heater 108 is fixedly installed on the top of the support plate 107. The top of the heater 108 is fixedly connected to one end of the heating pipe 104. A water outlet pipe 109 is fixedly connected to one side of the other fixed support 102.

[0027] When cooling is required inside fermenter 1, water is injected into the water injection pipe 106. The water flows inside the threaded pipe 103 and finally flows out through the water outlet pipe 109. The threaded structure of the threaded pipe 103 increases the contact area between the surface of the threaded pipe 103 and the fermentation liquid and drugs. When the water flows through the threaded pipe 103, it can carry away the heat generated by the fermentation of the fermentation liquid and drugs, so that the inside of fermenter 1 can be cooled down quickly. When heating is required inside fermenter 1, heater 108 heats heating wire 105. The heat is transferred to the water inside the threaded pipe 103 through heating pipe 104, so that the water temperature rises. Heat is transferred to the water through the threaded pipe 103. By heating the water, heat is transferred. While ensuring that the temperature inside fermenter 1 rises, local overheating is avoided, which may cause the death of microorganisms in biomedicine and reduce fermentation efficiency. The structure design of the threaded pipe 103 can effectively and quickly transfer the heat in the water to the fermentation liquid, accelerating the fermentation efficiency. Temperature detector 203 can detect the temperature inside fermenter 1 for easy temperature observation.

[0028] The fermenter 1 has a connecting block 2 fixedly installed on its top, a motor 201 fixedly installed on the top of the connecting block 2, a rotating shaft 202 driven by the bottom of the motor 201, stirring rods fixedly installed on both sides of the rotating shaft 202, a temperature detector 203 fixedly installed on one side of the fermenter 1, an oxygen chamber 301 inside the gas distributor 3, multiple caps 302 fixedly installed on one side of the gas distributor 3, a vent pipe 303 fixedly installed inside the cap 302, and a baffle 304 on one side of the vent pipe 303. Two springs 305 are fixedly connected to one side of the fermenter 1. One end of the springs 305 is fixedly connected to the gas distributor 3. Multiple vent holes 306 are opened on the outer side of one end of the cap 302. Multiple connection holes 307 are opened on one side of the gas distributor 3. A support frame 4 is fixedly installed at the bottom of the fermenter 1. Two aeration pumps 401 are fixedly installed on the top of the support frame 4. Each aeration pump 401 is fixedly connected to the top of the aeration pump 401. One end of the aeration pump 402 is fixedly connected to the gas distributor 3. A control valve 403 is fixedly installed on the outer side of the fermenter 1.

[0029] When oxygen needs to be added to fermenter 1, aeration pump 401 starts operating, and the generated oxygen is transported to oxygen chamber 301 through air pipe 402. The oxygen flows into vent pipe 303 through connection hole 307 and compresses baffle 304, causing baffle 304 to move. Gas flows out from vent pipe 303 and into fermenter 1 through vent hole 306. Motor 201 drives rotating shaft 202 to rotate, which in turn rotates stirring rod, causing the stirring rod to stir the biopharmaceuticals and fermentation broth in fermenter 1, so that oxygen can be fully dissolved in the fermentation broth, while simultaneously agitating the fermentation process. The liquid also increases the flow rate of the fermentation liquid on one side of the partition 304, and the pressure on the side of the partition 304 decreases relative to when the fermentation liquid is still. Oxygen can flow out from the vent pipe 303 more effectively. When there is sufficient oxygen in the fermenter 1, the motor 201 is turned off, causing the rotating shaft 202 and the stirring rod to stop rotating. The flow rate of the fermentation liquid in the fermenter 1 gradually decreases, the aeration pump 401 is turned off, the pressure on the oxygen side of the partition 304 decreases, and the elastic force generated by the stretching of the spring 305 pulls the partition 304, causing the partition 304 to block the vent pipe 303 and prevent the fermentation liquid from leaking into the vent pipe 303.

[0030] Working principle:

[0031] When cooling is required inside fermenter 1, water is injected into the water injection pipe 106. The water flows within the threaded pipe 103 and finally flows out through the outlet pipe 109. The threaded structure of the threaded pipe 103 increases the contact area between its surface and the fermentation liquid and the drug. As the water flows through the threaded pipe 103, it carries away the heat generated by the fermentation of the liquid and the drug, allowing for rapid cooling of fermenter 1. When heating is required inside fermenter 1, the heater 108 heats the heating wire 105. The heat is transferred to the water inside the threaded pipe 103 through the heating pipe 104, raising the water temperature. Heat is transferred to the water through the threaded pipe 103, ensuring a higher internal temperature while preventing localized overheating that could kill microorganisms and reduce fermentation efficiency. The threaded pipe 103 design allows heat to be effectively and quickly transferred from the water to the fermentation liquid, accelerating fermentation. The temperature sensor 203 detects the internal temperature of fermenter 1 for easy monitoring. Oxygen needs to be added to fermenter 1. At this time, the aeration pump 401 starts operating, and the generated oxygen is transported to the oxygen chamber 301 through the air pipe 402. The oxygen flows into the vent pipe 303 through the connection hole 307 and squeezes the baffle 304, causing the baffle 304 to move. The gas flows out from the vent pipe 303 and flows into the fermenter 1 through the vent hole 306. The motor 201 drives the rotating shaft 202 to rotate, which in turn rotates the stirring rod. The stirring rod stirs the biopharmaceuticals and fermentation broth in the fermenter 1, allowing the oxygen to fully dissolve in the fermentation broth. At the same time, stirring the fermentation broth also helps to separate the oxygen from the baffle. As the flow rate of the fermentation liquid on one side of plate 304 increases, the pressure on the side of plate 304 decreases relative to when the fermentation liquid is stationary, allowing oxygen to flow out more effectively from the vent pipe 303. When there is sufficient oxygen in the fermenter 1, the motor 201 is turned off, causing the rotating shaft 202 and the stirring rod to stop rotating. The flow rate of the fermentation liquid in the fermenter 1 gradually decreases, and the aeration pump 401 is turned off. The pressure on the oxygen side of plate 304 decreases, and the elastic force generated by the stretching of spring 305 pulls plate 304, causing plate 304 to block the vent pipe 303, preventing the fermentation liquid from leaking into the vent pipe 303.

[0032] In the above embodiments, the descriptions of each embodiment have different focuses. For parts not described in detail in a certain embodiment, please refer to the relevant descriptions in other embodiments.

[0033] The above provides a detailed description of a biopharmaceutical fermentation apparatus provided in the embodiments of this application. Specific examples have been used to illustrate the principles and implementation methods of this application. The descriptions of the above embodiments are only for the purpose of helping to understand the technical solutions and core ideas of this application. Those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some of the technical features. These modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of this application.

Claims

1. A biopharmaceutical fermentation apparatus, characterized in that, Include: The fermentation tank (1) is internally fixedly installed with two gas distributors (3); The temperature control assembly arranged in the fermentation tank (1) comprises a threaded pipe (103), a heating pipe (104), a heating wire (105), a water injection pipe (106) and a water outlet pipe (109); The oxygen supply assembly arranged in the fermentation tank (1) comprises a cap (302), a breather pipe (303), a baffle (304), a spring (305) and an aeration pump (401).

2. The bio-pharmaceutical fermentation device of claim 1, wherein, The fermentation tank (1) is fixedly connected with a feeding pipe (101) at the top, two fixed supports (102) are fixedly installed on the inner wall of the fermentation tank (1), and a threaded pipe (103) is fixedly installed on the inner wall of the fermentation tank (1). The threaded pipe (103) is arranged around the inner wall of the fermentation tank (1), and the two ends of the threaded pipe (103) are fixedly connected with the two fixed supports (102) respectively.

3. The bio-pharmaceutical fermentation apparatus as claimed in claim 2, wherein, The threaded pipe (103) is fixedly installed with a heating pipe (104) inside, the heating pipe (104) is fixedly installed with a heating wire (105) inside, one side of one of the fixed supports (102) is fixedly connected with a water injection pipe (106), one side of the fermentation tank (1) is fixedly installed with a support plate (107), the top of the support plate (107) is fixedly installed with a heater (108), and the top of the heater (108) is fixedly connected with one end of the heating pipe (104). The other side of the other fixed support (102) is fixedly connected with a water outlet pipe (109).

4. The biopharmaceutical fermentation device of claim 1, wherein, The fermentation tank (1) is fixedly installed with a connecting block (2) at the top, the connecting block (2) is fixedly installed with a motor (201) at the top, the bottom of the motor (201) is drivingly connected with a rotating shaft (202), the rotating shaft (202) is fixedly installed with stirring rods on both sides, and the fermentation tank (1) is fixedly installed with a temperature detector (203) on one side.

5. The biopharmaceutical fermentation device of claim 1, wherein, The gas distributor (3) is internally provided with an oxygen cavity (301), and a plurality of caps (302) are fixedly installed on one side of the gas distributor (3).

6. The biopharmaceutical fermentation device of claim 5, wherein, The cap (302) is internally fixedly installed with a breather pipe (303), the breather pipe (303) is provided with a baffle (304) on one side, the baffle (304) is fixedly connected with two springs (305) on one side, one end of the spring (305) is fixedly connected with the gas distributor (3), a plurality of air holes (306) are formed in the outer side of one end of the cap (302), and a plurality of connecting holes (307) are formed in one side of the gas distributor (3).

7. The bio-medical fermentation device according to claim 1, wherein, The fermentation tank (1) is fixedly installed with a support frame (4) at the bottom, the support frame (4) is fixedly installed with two aeration pumps (401) at the top, the aeration pumps (401) are fixedly connected with air pipes (402) at the top, one end of the air pipe (402) is fixedly connected with the gas distributor (3), and the fermentation tank (1) is fixedly installed with a control valve (403) on the outer side.

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