Mixer for dynamic gradient pressure compensation system of full-automatic liquid chromatograph

Abstract

The utility model relates to the field of liquid chromatographs, and discloses a mixer for a dynamic gradient pressure compensation system of a full-automatic liquid chromatograph, which comprises a mixing box, a compensation box is mounted at the top end of the right side of the mixing box, two groups of air bags are mounted in the compensation box, a breather pipe is fixedly connected to the top end of the compensation box, and a gas outlet pipe is fixedly connected to the top end of the breather pipe. A pressure compensation controller is installed at the top end of the right side of the compensation box, an inflation and deflation assembly is installed at the bottom end of the pressure compensation controller, and an inflation pipe is installed on the inflation and deflation assembly. According to the mixer for the dynamic gradient pressure compensation system of the full-automatic liquid chromatograph, dynamic compensation adjustment is carried out on the conveyed pressure through the pressure compensation controller, the pressure compensation controller can inflate and deflate the air bag in the compensation box through the inflation and deflation assembly during adjustment, and the conveyed pressure can be adjusted by changing the size of the air bag; therefore, dynamic pressure compensation is achieved, the dynamic pressure compensation function is achieved, and the problem that the pressure compensation effect is poor is solved.

Description

Technical Field

[0001] This utility model relates to the field of liquid chromatography technology, specifically to a mixer used in the dynamic gradient pressure compensation system of a fully automated liquid chromatograph. Background Technology

[0002] Liquid chromatography is an instrument that uses the difference in the distribution ratio of a mixture between a liquid and a solid or two immiscible liquids to separate the mixture first, and then analyze and identify it. Compared with the classic liquid column chromatography device, it has the characteristics of high efficiency, speed and sensitivity.

[0003] Automated liquid chromatographs (HPLC) require the use of a mixer during operation. The mixer thoroughly mixes the liquids to be mixed and then delivers them into the HPLC. However, common mixers suffer from unstable pressure during delivery and are not easily adjusted dynamically and flexibly, resulting in insufficient delivery stability and affecting the performance of the HPLC.

[0004] There is an urgent need for a mixer used in the dynamic gradient pressure compensation system of a fully automated liquid chromatograph to address the technical deficiencies mentioned above. Utility Model Content

[0005] The purpose of this invention is to provide a mixer for a dynamic gradient pressure compensation system of a fully automated liquid chromatograph, so as to solve the problem of poor pressure compensation effect mentioned in the background art.

[0006] To achieve the above objectives, this utility model provides the following technical solution: a mixer for a dynamic gradient pressure compensation system of a fully automated liquid chromatograph, comprising a mixing chamber, a compensation chamber mounted on the top right side of the mixing chamber, two sets of air bladders installed inside the compensation chamber, a vent pipe fixedly connected to the top of the compensation chamber, a pressure compensation controller mounted on the top right side of the compensation chamber, a gas filling / draining assembly mounted at the bottom of the pressure compensation controller, a gas filling pipe mounted on the gas filling / draining assembly, a feed inlet mounted on the left side of the top of the mixing chamber, a drive motor mounted at the middle position of the top of the mixing chamber, and an output end of the drive motor... The mixing chamber has a stirring shaft, an adjusting screw fixedly connected to its bottom end, second stirring rods fixedly connected to both sides of the stirring shaft, a screw sleeve installed on the outside of the adjusting screw, a limit ring fixedly connected to the top of the screw sleeve, first stirring rods fixedly connected to both sides of the screw sleeve, a discharge port fixedly connected to its bottom end, a discharge pipe installed at the bottom end of the discharge port, a pump body installed on the side of the mixing chamber, a connecting pipe installed at the output end of the pump body, a pressure compensation valve installed at the end of the connecting pipe, a conveying pipe installed on the left side of the pressure compensation valve, and a mounting flange fixedly connected to the pressure compensation valve.

[0007] As a further technical solution of this utility model, the vent pipe is connected to the top of the mixing box, and the inflation pipe is connected to the airbag.

[0008] As a further technical solution of this utility model, the pressure compensation controller is electrically connected to the inflation / deflation assembly.

[0009] As a further technical solution of this utility model, a pressure sensor is installed inside the compensation box, and the pressure compensation controller is electrically connected to the compensation box.

[0010] As a further technical solution of this utility model, the two sides of the limiting ring are movably hinged with connecting rods, the top of the connecting rod is movably hinged with a connecting sleeve, and the front end of the second stirring rod is provided with a limiting groove.

[0011] As a further technical solution of this utility model, the connecting sleeve is slidably connected to the outside of the second stirring rod, and the limiting ring is slidably connected to the outside of the adjusting screw.

[0012] As a further technical solution of this utility model, the lead screw sleeve is slidably connected to the outside of the adjusting lead screw.

[0013] As a further technical solution of this utility model, a control valve is installed on the discharge port and a sealing cap is installed on the inlet port.

[0014] Compared with the prior art, the beneficial effects of this utility model are: the mixer used in the dynamic gradient pressure compensation system of the fully automatic liquid chromatograph not only realizes the function of dynamic pressure compensation and facilitates thorough mixing, but also realizes the function of easy and flexible use.

[0015] By incorporating a compensation tank, an air bladder, a gas filling and defilling assembly, a pressure compensation controller, a vent pipe, a pressure compensation valve, and a gas filling pipe, the pump body delivers the liquid inside the mixing tank to the liquid chromatograph. During the process, the pressure compensation controller dynamically compensates and adjusts the delivery pressure. When adjusting, the pressure compensation controller can fill and defill the air bladder inside the compensation tank through the gas filling and defilling assembly. The change in the size of the air bladder can adjust the delivery pressure, thereby achieving dynamic pressure compensation. The pressure compensation valve can dually control the delivery pressure. This structure facilitates the implementation of dynamic pressure compensation.

[0016] By incorporating a first stirring rod, a connecting rod, a second stirring rod, a stirring shaft, a connecting sleeve, a limiting ring, a lead screw sleeve, and an adjusting lead screw, the drive motor can drive the stirring shaft to rotate and fully mix the internal liquid. During mixing, the drive motor drives the stirring shaft to repeatedly rotate forward and backward. During the mixing process, the lead screw sleeve moves up and down outside the adjusting lead screw, thereby flexibly adjusting the stirring position of the first stirring rod. This structure achieves the function of facilitating thorough mixing.

[0017] The mixing tank, equipped with a mixing chamber, drive motor, pressure compensation valve, pump body, and discharge pipe, is compact, simple to assemble, and easy to move and use. In use, the mixing tank is moved to a suitable position, and the liquid to be mixed is injected into the mixing tank through the inlet. The drive motor drives the stirring shaft to fully mix the liquid, and the pump body can deliver the mixed liquid inside. The pressure compensation valve can realize pressure compensation during delivery. This structure realizes the function of easy and flexible use. Attached Figure Description

[0018] Figure 1 This is a frontal cross-sectional view of the present invention.

[0019] Figure 2 This is a front view cross-sectional structural diagram of the compensation box of this utility model;

[0020] Figure 3 This is a partial front view of the stirring shaft of this utility model;

[0021] Figure 4 This is a front view structural diagram of the pressure compensation valve of this utility model.

[0022] In the diagram: 1. Mixing box; 2. First stirring rod; 3. Connecting rod; 4. Second stirring rod; 5. Stirring shaft; 6. Compensation box; 7. Airbag; 8. Inflation / depression assembly; 9. Pressure compensation controller; 10. Vent pipe; 11. Drive motor; 12. Feed inlet; 13. Connecting sleeve; 14. Limiting ring; 15. Screw sleeve; 16. Discharge port; 17. Pressure compensation valve; 18. Conveying pipe; 19. Connecting pipe; 20. Pump body; 21. Discharge pipe; 22. Inflation pipe; 23. Adjusting screw; 24. Mounting flange; 25. Limiting groove. Detailed Implementation

[0023] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0024] Please see Figure 1-4This utility model provides an embodiment of a mixer for a dynamic gradient pressure compensation system of a fully automated liquid chromatograph, comprising a mixing chamber 1, a compensation chamber 6 installed at the top right side of the mixing chamber 1, two sets of air bladders 7 installed inside the compensation chamber 6, a vent pipe 10 fixedly connected to the top of the compensation chamber 6, a pressure compensation controller 9 installed at the top right side of the compensation chamber 6, a gas filling / draining assembly 8 installed at the bottom of the pressure compensation controller 9, a gas filling pipe 22 installed on the gas filling / draining assembly 8, a feed inlet 12 installed on the left side of the top of the mixing chamber 1, and a drive motor 11 installed at the middle position of the top of the mixing chamber 1. A stirring shaft 5 is installed at the output end of the machine 11. An adjusting screw 23 is fixedly connected to the bottom end of the stirring shaft 5. Second stirring rods 4 are fixedly connected to both sides of the stirring shaft 5. A screw sleeve 15 is installed on the outside of the adjusting screw 23. A limit ring 14 is fixedly connected to the top end of the screw sleeve 15. First stirring rods 2 are fixedly connected to both sides of the screw sleeve 15. A discharge port 16 is fixedly connected to the bottom end of the mixing box 1. A discharge pipe 21 is installed at the bottom end of the discharge port 16. A pump body 20 is installed on the side of the mixing box 1. A connecting pipe 19 is installed at the output end of the pump body 20. A pressure compensation valve 17 is installed at the end of the connecting pipe 19.

[0025] The ventilation pipe 10 is connected to the top of the mixing box 1, the inflation pipe 22 is connected to the air bag 7, the pressure compensation controller 9 is electrically connected to the inflation / deflation assembly 8, and a pressure sensor is installed inside the compensation box 6. The pressure compensation controller 9 is electrically connected to the compensation box 6.

[0026] Specifically, such as Figure 1 and Figure 2 As shown, during the process of liquid being transported into the liquid chromatograph, the pressure compensation controller 9 dynamically compensates and adjusts the transport pressure. During adjustment, the pressure compensation controller 9 can charge and release the gas bag 7 inside the compensation box 6 through the gas charging and decharging assembly 8. The change in the size of the gas bag 7 can adjust the transport pressure, thereby achieving dynamic pressure compensation. The pressure compensation valve 17 can control the transport pressure in two ways.

[0027] The two sides of the limiting ring 14 are movably hinged with connecting rods 3, and the top of the connecting rods 3 is movably hinged with connecting sleeves 13. The front end of the second stirring rod 4 is provided with a limiting groove 25. The connecting sleeve 13 is slidably connected to the outside of the second stirring rod 4. The limiting ring 14 is slidably connected to the outside of the adjusting screw 23. The screw sleeve 15 is slidably connected to the outside of the adjusting screw 23.

[0028] Specifically, such as Figure 1 and Figure 3As shown, the drive motor 11 can drive the stirring shaft 5 to rotate and fully mix the internal liquid. During mixing, the drive motor 11 drives the stirring shaft 5 to rotate forward and backward repeatedly. During the stirring process, the lead screw sleeve 15 moves up and down outside the adjusting lead screw 23, thereby flexibly adjusting the stirring position of the first stirring rod 2. The limiting ring 14 can limit the position of the first stirring rod 2, improving the flexibility of stirring.

[0029] A conveying pipe 18 is installed on the left side of the pressure compensation valve 17. A mounting flange 24 is fixedly connected to the pressure compensation valve 17. A control valve is installed on the discharge port 16. A sealing cover is installed on the inlet port 12.

[0030] Specifically, such as Figure 1 and Figure 4 As shown, the mixing tank 1 has a compact structure and simple composition, making it easy to move and use. When in use, the mixing tank 1 is moved to a suitable position, and the liquid to be mixed is injected into the interior of the mixing tank 1 through the inlet 12. After the drive motor 11 drives the stirring shaft 5 to fully mix the liquid, the pump body 20 can transport the mixed liquid inside. The pressure compensation valve 17 can realize the pressure compensation of the transport.

[0031] Working principle: The liquid to be processed is injected into the mixing tank 1 through the inlet 12. The drive motor 11 drives the stirring shaft 5 to rotate and fully mix the liquid inside. During mixing, the drive motor 11 drives the stirring shaft 5 to rotate forward and backward repeatedly. During the mixing process, the lead screw sleeve 15 moves up and down outside the adjusting lead screw 23, thereby flexibly adjusting the stirring position of the first stirring rod 2. After the drive motor 11 drives the stirring shaft 5 to fully mix the liquid, the pump body 20 can transport the mixed liquid inside to the liquid chromatograph. The pressure compensation valve 17 can realize the pressure compensation of the transport. The pressure compensation controller 9 performs dynamic compensation adjustment of the transport pressure. During adjustment, the pressure compensation controller 9 can charge and depress the air bag 7 inside the compensation tank 6 through the gas charging and depressurization assembly 8. The change in the size of the air bag 7 can adjust the transport pressure, thereby realizing dynamic pressure compensation. This structure realizes the function of easy dynamic pressure compensation.

[0032] It will be apparent to those skilled in the art that this invention is not limited to the details of the exemplary embodiments described above, and that it can be implemented in other specific forms without departing from the spirit or essential characteristics of this invention. Therefore, the embodiments should be considered illustrative and non-limiting in all respects, and the scope of this invention is defined by the appended claims rather than the foregoing description. Thus, it is intended that all variations falling within the meaning and scope of equivalents of the claims be included within this invention. No reference numerals in the claims should be construed as limiting the scope of the claims.

Claims

1. Mixer for dynamic gradient pressure compensation systems of fully automated liquid chromatographs, comprising a mixing tank (1), characterized in that: The top end of the right side of the mixing box (1) is provided with a compensation box (6), two groups of air bags (7) are installed in the compensation box (6), a breather pipe (10) is fixedly connected to the top end of the compensation box (6), a pressure compensation controller (9) is installed on the top end of the right side of the compensation box (6), a gas charging and discharging assembly (8) is installed at the bottom end of the pressure compensation controller (9), a gas charging pipe (22) is installed on the gas charging and discharging assembly (8), an inlet (12) is installed on the left side of the top end of the mixing box (1), a driving motor (11) is installed at the middle position of the top end of the mixing box (1), a stirring shaft (5) is installed at the output end of the driving motor (11), an adjusting screw rod (23) is fixedly connected to the bottom end of the stirring shaft (5), second stirring rods (4) are fixedly connected to the two sides of the stirring shaft (5), a screw rod sliding sleeve (15) is installed on the outside of the adjusting screw rod (23), a limiting ring (14) is fixedly connected to the top end of the screw rod sliding sleeve (15), first stirring rods (2) are fixedly connected to the two sides of the screw rod sliding sleeve (15), an outlet (16) is fixedly connected to the bottom end of the mixing box (1), a discharge pipe (21) is installed at the bottom end of the outlet (16), a pump body (20) is installed on the side of the mixing box (1), a connecting pipe (19) is installed at the output end of the pump body (20), a pressure compensation valve (17) is installed at the end of the connecting pipe (19), a conveying pipe (18) is installed on the left side of the pressure compensation valve (17), and a mounting flange (24) is fixedly connected to the pressure compensation valve (17).

2. The mixer for use in a dynamic gradient pressure compensation system of a fully automated liquid chromatograph according to claim 1, characterized in that: The breather pipe (10) is connected with the top end of the mixing box (1), and the gas charging pipe (22) is connected with the air bag (7).

3. The mixer for use in a dynamic gradient pressure compensation system of a fully automated liquid chromatograph according to claim 1, characterized in that: The pressure compensation controller (9) is electrically connected with the gas charging and discharging assembly (8).

4. The mixer for use in a dynamic gradient pressure compensation system of a fully automated liquid chromatograph according to claim 1, characterized in that: A pressure sensor is installed in the compensation box (6), and the pressure compensation controller (9) is electrically connected with the compensation box (6).

5. The mixer for use in a dynamic gradient pressure compensation system of a fully automated liquid chromatograph according to claim 1, characterized in that: Limiting links (3) are movably hinged on the two sides of the limiting ring (14), and connecting sliding sleeves (13) are movably hinged at the top end of the limiting links (3).

6. The mixer for use in a dynamic gradient pressure compensation system of a fully automated liquid chromatograph according to claim 5, characterized in that: The connecting sliding sleeves (13) are slidably connected outside the second stirring rods (4), and the limiting ring (14) is slidably connected outside the adjusting screw rod (23).

7. The mixer for use in a dynamic gradient pressure compensation system of a fully automated liquid chromatograph according to claim 1, characterized in that: The screw rod sliding sleeve (15) is slidably connected outside the adjusting screw rod (23).

8. The mixer for use in a dynamic gradient pressure compensation system of a fully automated liquid chromatograph according to claim 1, characterized in that: A control valve is installed on the outlet (16), and a sealing cover is installed on the inlet (12).

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