Liquid chromatographic column with replaceable filler

Abstract

The liquid chromatographic column comprises a column tube, the packing is arranged in the column tube, tube heads are fixed to the two ends of the column tube, the inner diameter of each tube head is larger than that of the column tube, a detachable column head cover is fixedly connected to the surface of each tube head in a sleeved mode, and a clamping assembly used for fixing the column head cover is arranged on the outer side wall of each tube head. And a sieve plate and a blade ring are clamped in the pipe head, the sieve plate is located on the side close to the column pipe, and rubber protection plugs are clamped in the two column head covers. According to the utility model, the column tube, the two tube heads, the two column head covers, the clamping components, the sieve plates, the blade rings and the rubber protection plugs are arranged, the two tube heads are positioned at the two ends of the column tube and are integrated with the column tube, and the two column head covers can be quickly fixed on the surfaces of the two tube heads through the clamping components, so that the sieve plates and the blade rings in the tube heads can be taken out after the column head covers are detached; therefore, the filler in the column pipe can be conveniently and quickly replaced.

Description

Technical Field

[0001] This utility model relates to the field of chromatography column technology, and in particular to a liquid chromatography column with replaceable packing material. Background Technology

[0002] Liquid chromatography (LC) is a separation technique widely used in biology, chemistry, and environmental fields. Its principle is to separate mixtures using column packing material, achieving separation based on the differences in the partition coefficients (K values) of different components within the column packing. As the core component of a LC system, the LC column directly affects the sample separation effect and rate, making it a crucial part of LC separation. A LC column consists of two parts: the column shell and the column packing material. The column shell includes the column body and the column cap, and is filled with column packing material.

[0003] With the use of liquid chromatography columns, the performance of the packing material gradually declines over time and with increased use, leading to poorer separation. Furthermore, impurities in the mobile phase and sample can contaminate the packing material, further affecting column efficiency and separation. Additionally, existing columns use threaded connections between the column caps and the column body; frequent disassembly and replacement can easily lead to stripping of the threads, and rust can make disassembly and assembly difficult. Moreover, after removing the column caps, the sieve plates are located inside both ends of the column, and due to the relatively thin column, removing the sieve plates is difficult. Therefore, to address these shortcomings, this invention proposes a liquid chromatography column with replaceable packing material. Summary of the Invention

[0004] The purpose of this invention is to address the shortcomings of existing technologies by proposing a replaceable packing material liquid chromatography column.

[0005] To achieve the above objectives, the present invention adopts the following technical solution: a replaceable packing liquid chromatography column, comprising a column tube, wherein the column tube is filled with packing material, and both ends of the column tube are fixed with tube heads, the inner diameter of the tube head being larger than the inner diameter of the column tube, a detachable column head cap being fixedly sleeved on the surface of the tube head, a snap-fit ​​assembly for fixing the column head cap being provided on the outer wall of the tube head, a sieve plate and a blade ring being snapped inwards inside the tube head, the sieve plate being located on the side closer to the column tube, rubber protective plugs being snapped inwards on both column head caps, and ejection assemblies being provided on the side walls at both ends of the column tube.

[0006] Furthermore, a connector is fixedly connected to the end of the column cap away from the pipe head.

[0007] Furthermore, a snap hole is provided on the side wall of the column head cap near the snap-fit ​​assembly. The snap-fit ​​assembly includes a first groove on the outer side wall of the tube head, and a first spring is fixedly connected to the inner side wall of the first groove. A snap rod is fixedly connected to the other end of the first spring, and the end of the snap rod away from the first spring is snapped into the snap hole.

[0008] Furthermore, the inner wall of the column head cap is fixed with a protruding ridge, and the outer wall of the tube head is provided with a groove for engaging the protruding ridge.

[0009] Furthermore, a sealing ring is fixedly sleeved on the outer wall of the blade ring, and the sealing ring is in contact with the inner wall of the tube head.

[0010] Furthermore, the ejection assembly includes a second groove formed at the end of the column tube, a second spring fixedly connected to the inner wall of the second groove, and the other end of the second spring being in contact with the surface of the sieve plate.

[0011] The beneficial effects of this utility model are:

[0012] In use, this utility model provides a replaceable packing liquid chromatography column consisting of a column tube, two tube heads, two column head caps, a snap-fit ​​assembly, a sieve plate, a blade ring, and a rubber protective plug. The two tube heads are located at both ends of the column tube and are integral with the column tube. The two column head caps can be quickly fixed to the surfaces of the two tube heads via the snap-fit ​​assembly. Therefore, after removing the column head caps, the sieve plate and blade ring inside the tube head can be removed, facilitating the rapid replacement of the packing material inside the column tube.

[0013] In use, this utility model features a replaceable packing liquid chromatography column with a column tube. Both ends of the column tube are equipped with ejection components. When the column head cap is removed from the tube head surface at both ends of the column tube, the second spring of the ejection component can directly eject the sieve plate and blade ring from inside the tube head, making it more convenient and faster to remove the sieve plate and blade ring. Attached Figure Description

[0014] To more clearly illustrate the technical solution of this utility model, the drawings used in the description of the specific embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this utility model. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0015] Figure 1 : Overall sectional view of this utility model;

[0016] Figure 2 Partial perspective view of this utility model;

[0017] Figure 3 The present utility model Figure 1 Enlarged view of point A in the middle.

[0018] The attached figures are labeled as follows:

[0019] 1. Column tube; 2. Packing material; 3. Tube head; 31. Rib groove; 4. Column head cap; 41. Clip hole; 42. Raised rib; 5. Connector; 6. Clip assembly; 61. First groove; 62. First spring; 63. Clip rod; 7. Screen plate; 8. Blade ring; 9. Sealing ring; 10. Rubber protective plug; 11. Ejection assembly; 111. Second groove; 112. Second spring. Detailed Implementation

[0020] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those skilled in the art without creative effort are within the protection scope of the present utility model.

[0021] like Figures 1-3 As shown, a liquid chromatography column with replaceable packing material includes a column tube 1, with packing material 2 inside the column tube 1, and tube heads 3 fixed at both ends of the column tube 1. The inner diameter of the tube head 3 is larger than the inner diameter of the column tube 1. A removable column head cap 4 is fixedly sleeved on the surface of the tube head 3. A snap-fit ​​assembly 6 for fixing the column head cap 4 is provided on the outer wall of the tube head 3. A sieve plate 7 and a blade ring 8 are snapped inside the tube head 3. The sieve plate 7 is located on the side closer to the column tube 1. Rubber protective plugs 10 are snapped inside the two column head caps 4. Ejection assemblies 11 are provided on the side walls at both ends of the column tube 1.

[0022] The end of the column cap 4, away from the pipe head 3, is fixedly connected to a connector 5.

[0023] In this embodiment, the column tube 1, tube head 3, column head cap 4, and connector 5 are all made of stainless steel, and the surface of the connector 5 is threaded to facilitate the fixed installation of the chromatographic column.

[0024] The side wall of the column head cover 4 is provided with a locking hole 41 near the locking assembly 6. The locking assembly 6 includes a first groove 61 opened on the outer side wall of the tube head 3, and a first spring 62 is fixedly connected to the inner side wall of the first groove 61. The other end of the first spring 62 is fixedly connected to a locking rod 63, and the end of the locking rod 63 away from the first spring 62 is locked into the locking hole 41.

[0025] When installing the cap 4, first squeeze the locking rod 63 on the outer wall of the tube head 3 so that the locking rod 63 retracts into the first groove 61. Then, put the cap 4 onto the surface of the tube head 3 and align the locking hole 41 with the locking rod 63. When the cap 4 is fully fitted onto the surface of the tube head 3, the locking hole 41 and the locking rod 63 are aligned. At this time, the first spring 62 squeezes the locking rod 63 into the locking hole 41, thereby fixing the cap 4.

[0026] When disassembling the column head cover 4, first squeeze the locking rod 63 to retract it into the first groove 61. At this time, after the locking rod 63 disengages from the locking hole 41, the column head cover 4 can be pulled off the surface of the tube head 3, making the installation and disassembly of the column head cover 4 simple and quick.

[0027] The inner wall of the column head cap 4 is fixed with a protruding rib 42, and the outer wall of the tube head 3 is provided with a groove 31 for engaging the protruding rib 42.

[0028] When the cap 4 is fitted onto the surface of the pipe head 3, the protruding ridge 42 on the inner wall of the cap 4 can be aligned with the groove 31 on the outer wall of the pipe head 3 and inserted. In this way, when the cap 4 is fitted onto the surface of the pipe head 3, the positions of the locking rod 63 and the locking hole 41 can be aligned, which improves the ease of installation.

[0029] A sealing ring 9 is fixedly sleeved on the outer wall of the blade ring 8, and the sealing ring 9 is in contact with the inner wall of the tube head 3.

[0030] The sealing ring 9 can increase the sealing between the blade ring 8 and the tube head 3. When the column head cover 4 is fixed on the surface of the tube head 3, the column head cover 4 squeezes the blade ring 8, and the blade ring 8 then squeezes and fixes the screen plate 7 inside the tube head 3.

[0031] The ejection assembly 11 includes a second groove 111 opened at the end of the column tube 1. A second spring 112 is fixedly connected to the inner side wall of the second groove 111, and the other end of the second spring 112 is in contact with the surface of the sieve plate 7.

[0032] When the head cap 4 is removed, the blade ring 8 and the sieve plate 7 are no longer squeezed by the head cap 4, and the second spring 112 can push the blade ring 8 and the sieve plate 7 out of the tube head 3, thereby realizing the quick removal of the blade ring 8 and the sieve plate 7.

[0033] Working principle: When it is necessary to replace the packing 2, first squeeze the clamping rod 63, and then remove the column head cover 4 from the surface of the tube head 3. At this time, the second spring 112 pushes the blade ring 8 and the sieve plate 7 out of the tube head 3. Then remove the sieve plate 7 and the blade ring 8. After the column head covers 4, blade ring 8 and sieve plate 7 at both ends are removed, take out the original packing 2 inside the column tube 1. Then install the column head cover 4, blade ring 8 and sieve plate 7 at one end of the column tube 1. Then add the new packing 2 into the column tube 1 and compact the packing 2. Finally, install the column head cover 4, blade ring 8 and sieve plate 7 at the other end of the column tube 1.

[0034] The preferred embodiments of this utility model disclosed above are merely illustrative of the present utility model. These preferred embodiments do not exhaustively describe all details, nor do they limit the utility model to any specific implementation. Clearly, many modifications and variations can be made based on the content of this specification. This specification selects and specifically describes these embodiments to better explain the principles and practical applications of this utility model, thereby enabling those skilled in the art to better understand and utilize it. This utility model is limited only by the claims and their full scope and equivalents.

Claims

1. A replaceable-packed liquid chromatography column comprising a column tube (1), characterized in that: The column pipe (1) is internally provided with filler (2), and both ends of column pipe (1) are fixed with pipe head (3), the pipe head (3) inner diameter is greater than the inner diameter of column pipe (1), the pipe head (3) surface fixed sleeve has detachable head cover (4), the pipe head (3) outer wall is provided with the clamping assembly (6) for fixing head cover (4), the pipe head (3) internally clamped with sieve plate (7) and blade ring (8), the sieve plate (7) is located close to one side of column pipe (1), two the rubber protection plug (10) is clamped in the inside of the pipe head (3), the column pipe (1) both ends side wall is equipped with ejection assembly (11).

2. The replaceable packed liquid chromatography column of claim 1, wherein: The column head cover (4) is fixedly connected with a connecting head (5) away from one end of the pipe head (3).

3. The replaceable packed liquid chromatography column of claim 1, wherein: The column head cover (4) side wall is close to the clamping assembly (6) and is provided with a clamping hole (41), the clamping assembly (6) includes a first recess (61) provided on the outer side wall of the pipe head (3), and the first recess (61) is fixedly connected with a first spring (62) on the inner side wall, the other end of the first spring (62) is fixedly connected with a clamping rod (63), and the clamping rod (63) is clamped into the clamping hole (41) away from the first spring (62) one end.

4. The replaceable packed liquid chromatography column of claim 1, wherein: The inner side wall of the column head cover (4) is fixed with a convex rib (42), and the outer side wall of the pipe head (3) is provided with a rib groove (31) for clamping the convex rib (42).

5. The replaceable packed liquid chromatography column of claim 1, wherein: The outer side wall of the blade ring (8) is fixedly sleeved with a sealing ring (9), and the sealing ring (9) is attached to the inner side wall of the pipe head (3).

6. The replaceable packed liquid chromatography column of claim 1, wherein: The ejection assembly (11) includes a second recess (111) provided on the end of the column pipe (1), and the second recess (111) is fixedly connected with a second spring (112) on the inner side wall, and the other end of the second spring (112) is attached to the surface of the sieve plate (7).

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