Metabolism sample collection and cold insulation device for metabolism cage

Abstract

The metabolic sample collection and cold insulation device comprises a cold insulation barrel body, a middle layer, a sample tube fixing layer and a heat insulation cover, the cold insulation barrel body is used for vacuum heat insulation, and a mounting opening is formed in the top of the cold insulation barrel body; the middle layer is provided with a first cover plate and a containing cavity, the middle layer is detachably and rotatably mounted at the mounting opening through the first cover plate, the containing cavity is formed in the cold insulation barrel body, and a refrigerant is contained between the side wall of the containing cavity and the inner wall of the cold insulation barrel body; the sample tube fixing layer is arranged in the middle layer and is used for accommodating a metabolism sample tube; the heat preservation cover covers the installation opening. According to the metabolism sample collection and cold insulation device for the metabolism cage, the middle layer is rotated to adapt to different types of metabolism cages; the middle layer is convenient to clean; the cold insulation barrel body is good in cold insulation effect, and no condensate water is generated on the outer wall of the cold insulation barrel body; the thermal insulation cover further improves the cold insulation effect; the utility model has the advantages of simple structure and good adaptability, and is convenient for wide application.

Description

TECHNICAL FIELD

[0001] The utility model relates to experimental animal equipment technical field, especially a kind of metabolic sample collection cold-keeping device for metabolism cage. BACKGROUND

[0002] In the experimental study of drug metabolism and pharmacokinetics (DMPK), animal (such as rodents) bile, urine, feces and other metabolites are needed, therefore, the collection and storage of metabolic samples are very important.

[0003] The cold-keeping device in the prior art can only meet the cold-keeping condition of 0-8℃, but according to different experimental requirements, some samples need to be collected and stored at-78.5℃ (dry ice temperature), and the currently marketed cold-keeping device cannot meet this use requirement, and the cold-keeping effect cannot meet the expectation, which may affect the accuracy of the results of DMPK experimental research; in addition, the currently marketed cold-keeping device has poor adaptability to animal metabolism cages, and different metabolism cages need to be adapted to different cold-keeping devices. UTILITY MODEL CONTENTS

[0004] The utility model solves the technical problem to provide a kind of metabolic sample collection cold-keeping device for metabolism cage, and the adaptability to animal metabolism cage is good, and the cold-keeping effect is good.

[0005] To solve the above technical problems, the metabolic sample collection cold-keeping device for metabolism cage provided by the utility model comprises:

[0006] The cold-keeping barrel body comprises an inner container layer and an outer shell layer, and the inner container layer and the outer shell layer are vacuum insulated, and the top of the cold-keeping barrel body has a mounting port;

[0007] The intermediate layer has a first cover plate and a containing cavity, the first cover plate is circumferentially mounted to the outer peripheral surface of the top open position of the containing cavity, the intermediate layer is detachably and rotatably mounted to the mounting port through the first cover plate, the containing cavity is placed inside the cold-keeping barrel body, and the side wall of the containing cavity and the inner wall of the cold-keeping barrel body are used to hold the refrigerant;

[0008] The sample tube fixing layer is placed in the intermediate layer to accommodate the metabolic sample tube;

[0009] The heat preservation cover is provided on the mounting port.

[0010] Preferably, the first cover plate is provided with a refrigerant inlet.

[0011] Preferably, the sample tube fixing layer has a sample tube cavity and a second cover plate, the second cover plate is circumferentially mounted to the outer peripheral surface of the top open position of the sample tube cavity, and the metabolic sample tube is placed in the sample tube cavity.

[0012] Preferably, the second cover plate covers the first cover plate.

[0013] Preferably, the second cover plate is provided with a through hole corresponding to the refrigerant inlet.

[0014] Preferably, the heat preservation cover is provided with a metabolic sample inlet corresponding to the sample tube cavity position to make the metabolic sample in the metabolic cage flow into the sample tube placed in the sample tube cavity.

[0015] Preferably, the intermediate layer is sleeved at the mounting port.

[0016] Preferably, the inner container layer and the outer shell layer are both made of stainless steel material.

[0017] The containing cavity is made of aluminum alloy material or stainless steel material.

[0018] The sample tube cavity is made of aluminum alloy material or stainless steel material.

[0019] Preferably, a sealing ring is arranged between the heat preservation cover and the mounting port.

[0020] The utility model discloses a metabolic sample collection and cold preservation device for metabolic cage, through rotating the intermediate layer, drives metabolic sample pipe to rotate with sample pipe fixed layer to adapt to different models of metabolic cage, and the adaptability is strong, the intermediate layer can be dismantled and is installed, and it is convenient to clean, and the cold preservation barrel body is vacuum heat insulation, and the cold preservation effect is good, can ensure that metabolic sample pipe is in low temperature cold preservation state for a long time, and its outer wall does not produce condensate, simultaneously, the heat preservation cover plays further improve the role of cold preservation, prolongs the cold preservation duration of refrigerant, the utility model discloses simple structure, and the adaptability is good, and it is convenient to be widely used in the collection and storage field of rodent metabolic sample. BRIEF DESCRIPTION OF DRAWINGS

[0021] In order to more clearly illustrate the technical scheme of the utility model, the following briefly introduces the drawing needed to be used in the utility model, and obviously, the drawing in the following description is only some embodiments of the utility model, and for the ordinary skilled person in the art, other drawings can be obtained according to these drawings without paying creative labor.

[0022] Figure 1 It is the schematic diagram of one embodiment of the metabolic sample collection and cold preservation device for metabolic cage of the utility model,

[0023] Figure 2 It is the explosion drawing of one embodiment of the metabolic sample collection and cold preservation device for metabolic cage of the utility model,

[0024] In the figure, 1 - cold storage barrel body; 11 - mounting port; 2 - intermediate layer; 21 - first cover plate; 22 - containing cavity; 23 - refrigerant inlet; 3 - sample tube fixing layer; 31 - sample tube cavity; 32 - second cover plate; 33 - through hole; 4 - heat preservation cover; 41 - metabolic sample inlet. DETAILED DESCRIPTION

[0025] The technical solutions in the present application will be described clearly and completely below in conjunction with the drawings. Obviously, the described embodiments are only a part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative work are within the scope of protection of the present application.

[0026] Reference Figure 1 and Figure 2 , a metabolic sample collection cold storage device for metabolic cages is shown, comprising:

[0027] The cold storage barrel body comprises an inner container layer and an outer shell layer, and the inner container layer and the outer shell layer are vacuum insulated. The top of the cold storage barrel body has a mounting port;

[0028] The intermediate layer has a first cover plate and a containing cavity. The first cover plate is circumferentially mounted to the outer circumferential surface at the top open position of the containing cavity. The intermediate layer is detachably and rotatably mounted to the mounting port through the first cover plate. The containing cavity is arranged inside the cold storage barrel body, and the side wall of the containing cavity and the inner wall of the cold storage barrel body are used to hold refrigerant;

[0029] The sample tube fixing layer is arranged in the intermediate layer to hold metabolic sample tubes;

[0030] The heat preservation cover is arranged on the mounting port.

[0031] The utility model discloses a cold -keeping barrel body is vacuum heat -insulation, and the cold -keeping effect is good, and the outer wall of cold -keeping barrel body can not have condensed water to produce, and the intermediate layer is isolated to the coolant (such as dry ice or ice block etc.) between its outer wall and the inner bag layer of cold -keeping barrel body, further improve the cold -keeping effect, and the intermediate layer can rotate and adapt to the metabolism cage of different models, increased the adaptability of the utility model, the intermediate layer can be dismantled and install, and the convenient cleaning is placed in the containing chamber of the intermediate layer, and the temperature of coolant is passed through the intermediate layer, sample tube fixed layer and is transferred to the metabolism sample tube, and the temperature in the metabolism sample tube keeps with the temperature of coolant consistent, because the cold -keeping effect of cold -keeping barrel body is good, therefore, can ensure that the metabolism sample tube is in low temperature cold -keeping state for a long time, in addition, the heat preservation cover is covered in the installation mouth, plays the role of further improving the cold -keeping, prolongs the cold -keeping duration of coolant, the utility model discloses when dry ice as coolant, after single addition dry ice, the time that the metabolism sample tube keeps temperature at -78.5 DEG C can be at least 16 hours, when wet ice as coolant, after single addition wet ice, the time that the metabolism sample tube keeps temperature at 0-8 DEG C can be at least 16 hours.

[0032] In a specific embodiment, the first cover plate is provided with a coolant inlet. It can be understood that although the cold -keeping device of the utility model has a long cold -keeping time after single addition of coolant, it can still not meet the collection and storage requirements, therefore, the first cover plate of the intermediate layer is provided with a coolant inlet, which can add coolant to the cold -keeping barrel multiple times, further prolonging the cold -keeping time. The coolant inlet is, for example, a round hole, a square hole, etc., which is convenient for adding coolant. In addition, by providing the coolant inlet, the coolant can be added without disassembling the intermediate layer, which is conducive to improving the cold -keeping effect and prolonging the cold -keeping time.

[0033] In a specific embodiment, the sample tube fixed layer has a sample tube cavity and a second cover plate, the second cover plate is circumferentially mounted to the outer periphery of the top open position of the sample tube cavity, and the metabolism sample tube is placed in the sample tube cavity. Preferably, the second cover plate covers the first cover plate. More preferably, the second cover plate is provided with a through hole corresponding to the coolant inlet. In this specific embodiment, the second cover plate of the sample fixed layer covers the first cover plate, and the first cover plate provides support to the sample tube fixed layer (the mounting port provides support to the first cover plate). The through hole in the second cover plate facilitates the addition of coolant, which can be added without removing the sample tube fixed layer, so that the metabolism sample can be kept at a cooling temperature while adding coolant. At the same time, the area of contact between the coolant and the external environment is also limited, which is conducive to improving the cold -keeping effect and prolonging the cold -keeping time.

[0034] In a specific embodiment, the heat preservation cover is provided with a metabolic sample inlet, which corresponds to the sample tube cavity position to make the metabolic sample in the metabolic cage flow into the sample tube placed in the sample tube cavity.

[0035] In a specific embodiment, the intermediate layer is sleeved at the mounting port.

[0036] In a specific embodiment, the inner container layer and the outer shell layer are both made of stainless steel; the containing cavity is made of aluminum alloy or stainless steel; and the sample tube cavity is made of aluminum alloy or stainless steel. In this specific embodiment, the material of the inner container layer and the outer shell layer is preferably stainless steel considering the strength and other factors; the containing cavity and the sample tube cavity are preferably made of aluminum alloy or stainless steel considering the heat transfer, strength and other factors; in addition, it should be noted that the first cover plate and the second cover plate are preferably made of a material with good heat insulation performance, such as nylon, which are assembled with the containing cavity and the sample tube cavity respectively by fastening and mounting, etc., and have good cold insulation effect and are easy to disassemble.

[0037] In a specific embodiment, a sealing ring is arranged between the heat preservation cover and the mounting port. It can be understood that the sealing ring can further improve the cold insulation effect.

[0038] The above description is only a preferred embodiment of the present application and is not intended to limit the protection scope of the present application. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present application shall be included in the protection scope of the present application.

Claims

1. A metabolic sample collection and cooling device for a metabolic cage, characterized in that, include: A cold insulation container includes an inner liner layer and an outer shell layer, with vacuum insulation between the inner liner layer and the outer shell layer, and an installation port on the top of the cold insulation container. The intermediate layer has a first cover plate and a receiving cavity. The first cover plate is circumferentially mounted on the outer peripheral surface of the top open position of the receiving cavity. The intermediate layer is detachably and rotatably mounted to the mounting port via the first cover plate. The receiving cavity is placed inside the cold insulation barrel body, and the space between the side wall of the receiving cavity and the inner wall of the cold insulation barrel body is used to hold refrigerant. A sample tube fixing layer is placed within the intermediate layer to accommodate metabolic sample tubes; An insulation cover is provided at the mounting port.

2. The metabolic sample collection and cooling device for a metabolic cage as described in claim 1, characterized in that, The first cover plate has a refrigerant inlet.

3. The metabolic sample collection and cooling device for a metabolic cage as described in claim 2, characterized in that, The sample tube fixing layer has a sample tube cavity and a second cover plate. The second cover plate is circumferentially installed on the outer circumferential surface of the top open position of the sample tube cavity, and the metabolic sample tube is placed inside the sample tube cavity.

4. The metabolic sample collection and cooling device for a metabolic cage as described in claim 3, characterized in that, The second cover plate covers the first cover plate.

5. The metabolic sample collection and cooling device for a metabolic cage as described in claim 4, characterized in that, The second cover plate has a through hole, which corresponds to the refrigerant inlet.

6. The metabolic sample collection and cooling device for a metabolic cage as described in claim 3, characterized in that, The heat-insulating cover has a metabolic sample inlet, which corresponds to the position of the sample lumen so that the metabolic sample in the metabolic cage flows into the sample tube placed in the sample lumen.

7. The metabolic sample collection and cooling device for a metabolic cage as described in claim 1, characterized in that, The intermediate layer is fitted onto the mounting port.

8. The metabolic sample collection and cooling device for a metabolic cage as described in claim 3, characterized in that, Both the inner liner and the outer shell are made of stainless steel. The cavity is made of aluminum alloy or stainless steel; The sample cavity is made of aluminum alloy or stainless steel.

9. The metabolic sample collection and cooling device for a metabolic cage as described in claim 1, characterized in that, A sealing ring is provided between the heat insulation cover and the installation port.

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