Cooling device for medical intermediate production

Abstract

The utility model discloses a cooling device for production of medical intermediates, which belongs to the technical field of medicine preparation and is characterized by comprising a tank body, an inlet pipe is fixedly connected to the top of the tank body, an interlayer is arranged inside the inner wall of the tank body, a turning assembly is fixedly connected to the inside of the tank body, and the turning assembly is fixedly connected to the top of the tank body. The top of the right side of the tank body is fixedly connected with a cooling assembly, the overturning assembly comprises a storage barrel, the right side of the storage barrel is provided with a gas conveying pipe, and the surface of the storage barrel is fixedly connected with a plurality of spray heads. The problems that the contact area of a cooling cylinder and an intermediate is small, when the cooling cylinder rolls, only limited contact of partial areas can be achieved, full contact with the intermediate in an all-dimensional and large-area mode cannot be achieved, the heat transfer efficiency is low, the cooling efficiency of the medical intermediate is greatly affected, and the practicability of the device is reduced are solved.

Description

Technical Field

[0001] This utility model relates to the field of drug preparation technology, and in particular to a cooling device for the production of pharmaceutical intermediates. Background Technology

[0002] In the production of pharmaceutical intermediates, chemical reactions are often accompanied by the release of a large amount of heat. Many reactions need to be carried out within a specific temperature range to ensure the efficiency, selectivity and quality of the reaction. If the temperature of the reaction system is too high, it may not only lead to an increase in side reactions and a decrease in product yield, but may also cause safety risks, such as material boiling and decomposition. Therefore, efficient and reliable cooling devices are crucial in the production of pharmaceutical intermediates.

[0003] Most existing cooling devices directly sprinkle high-temperature pharmaceutical intermediates onto cooling plates for cooling. However, both the pharmaceutical intermediates and the cooling plates are in a static state, which makes it difficult to dissipate heat from the accumulated pharmaceutical intermediates.

[0004] An existing patent (publication number: CN216409501U) discloses a cooling device for the production of pharmaceutical intermediates. The high-temperature pharmaceutical intermediates produced can be evenly spread in the processing box through the feeding mechanism. Then, the cooling cylinder in the cooling mechanism can roll back and forth on the pharmaceutical intermediates, and the turning mechanism can turn the pharmaceutical intermediates. This allows the cooling cylinder and the high-temperature pharmaceutical intermediates in various positions in the processing box to be in contact and in constant motion, which facilitates the uniform cooling of the high-temperature pharmaceutical intermediates.

[0005] To address the aforementioned problems, existing patents have provided solutions, but their cooling effects are unsatisfactory. In actual production, due to poor cooling structure design, the contact area between the cooling cylinder and the pharmaceutical intermediate is small. When the cooling cylinder rolls, it can only achieve limited contact in some areas, failing to achieve full, comprehensive, and large-area contact with the intermediate. This results in low heat transfer efficiency, greatly affecting the cooling efficiency of the pharmaceutical intermediate and reducing the practicality of the device.

[0006] Therefore, a cooling device for the production of pharmaceutical intermediates is proposed. Utility Model Content

[0007] The purpose of this invention is to provide a cooling device for the production of pharmaceutical intermediates, which can solve the problems of poor cooling effect of existing cooling devices. In actual production, due to poor cooling structure design, the contact area between the cooling cylinder and the intermediate is small. When the cooling cylinder rolls, it can only achieve limited contact in some areas and cannot fully contact the intermediate in all directions and over a large area, resulting in low heat transfer efficiency, which greatly affects the cooling efficiency of pharmaceutical intermediates and reduces the practicality of the device.

[0008] To achieve the above objectives, the present invention provides the following technical solution: a cooling device for the production of pharmaceutical intermediates, comprising a tank, an inlet pipe fixedly connected to the top of the tank, a partition provided inside the inner wall of the tank, a turning assembly fixedly connected inside the tank, and a cooling assembly fixedly connected to the top of the right side of the tank, the turning assembly comprising a storage cylinder, a gas supply pipe provided on the right side of the storage cylinder, and a plurality of nozzles fixedly connected to the surface of the storage cylinder;

[0009] The cooling assembly includes a liquid storage tank, a liquid pump is fixedly connected to the bottom of the front side of the liquid storage tank, and heat conduction plates are fixedly connected to the front and rear sides of the top of the liquid storage tank. A delivery pipe is fixedly connected to the output end of the liquid pump, and the side of the delivery pipe away from the liquid pump extends into the interior of the partition. A return pipe is fixedly connected to the top of the rear side of the liquid storage tank, and the side of the return pipe away from the liquid storage tank extends into the interior of the partition.

[0010] Preferably, a pressurizing fan is fixedly connected to the side of the gas supply pipe away from the storage cylinder, and the pressurizing fan is located on the rear side of the right side of the tank.

[0011] Preferably, a spiral blade is fixedly connected to the surface of the storage cylinder, and a rotating motor is fixedly connected to the left side of the storage cylinder.

[0012] Preferably, an air inlet pipe is fixedly connected to the right side of the pressurizing fan, and a filter screen is fixedly connected inside the air inlet pipe.

[0013] Preferably, an observation glass is embedded inside the right side of the liquid storage tank, and an inlet valve is fixedly connected to the top of the liquid storage tank.

[0014] Preferably, a temperature sensor is fixedly connected to the right side of the top of the inner wall of the tank.

[0015] Preferably, a controller is fixedly connected to the front side of the tank, and the controller is electrically connected to the tilting assembly, the cooling assembly, and the temperature sensor.

[0016] Preferably, an electric discharge valve is fixedly connected to the bottom of the right side of the tank, and the electric discharge valve is electrically connected to the controller.

[0017] Compared with the prior art, the beneficial effects of this utility model are:

[0018] 1. By setting up a tumbling component, this application can drive the pharmaceutical intermediate to flow smoothly along the spiral blades, and can also blow gas onto it to promote heat dissipation in all directions and improve the cooling effect of the pharmaceutical intermediate.

[0019] 2. By setting up a cooling component, this application can continuously cool the inside of the tank, keeping the tank at a suitable temperature at all times. This allows for the cooling of pharmaceutical intermediates, achieving efficient and comprehensive cooling and improving the ease of use of the device. Attached Figure Description

[0020] Figure 1 This is an overall structural diagram of the cooling device for the production of pharmaceutical intermediates according to this utility model;

[0021] Figure 2 This is a schematic diagram showing the connection between the tank body, the tilting assembly, and the cooling assembly of this utility model;

[0022] Figure 3 This is a schematic diagram of the structure of the tank body of this utility model;

[0023] Figure 4 This is a schematic diagram of the structure of the flipping component of this utility model;

[0024] Figure 5 This is a schematic diagram of the cooling component of this utility model.

[0025] In the diagram, 1. Tank; 2. Inlet pipe; 3. Divider; 4. Tilting assembly; 401. Storage cylinder; 402. Gas supply pipe; 403. Nozzle; 404. Pressurizing fan; 405. Spiral blades; 406. Rotary motor; 5. Cooling assembly; 501. Liquid storage tank; 502. Liquid pump; 503. Heat conduction plate; 504. Delivery pipe; 505. Return pipe; 6. Air inlet pipe; 7. Filter screen; 8. Observation glass; 9. Liquid inlet valve; 10. Temperature sensor; 11. Controller; 12. Electric discharge valve. Detailed Implementation

[0026] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0027] Please see Figure 1-5 The present invention provides the following technical solution:

[0028] A cooling device for the production of pharmaceutical intermediates includes a tank 1, an inlet pipe 2 fixedly connected to the top of the tank 1, a partition 3 provided inside the inner wall of the tank 1, a tilting assembly 4 fixedly connected inside the tank 1, and a cooling assembly 5 fixedly connected to the top of the right side of the tank 1. The tilting assembly 4 includes a storage cylinder 401, a gas supply pipe 402 provided on the right side of the storage cylinder 401, and a plurality of nozzles 403 fixedly connected to the surface of the storage cylinder 401.

[0029] The cooling assembly 5 includes a liquid storage tank 501. A liquid pump 502 is fixedly connected to the bottom front side of the liquid storage tank 501. Heat conduction plates 503 are fixedly connected to the front and rear sides of the top of the liquid storage tank 501. A delivery pipe 504 is fixedly connected to the output end of the liquid pump 502. The side of the delivery pipe 504 away from the liquid pump 502 extends into the interior of the partition 3. A return pipe 505 is fixedly connected to the top rear side of the liquid storage tank 501. The side of the return pipe 505 away from the liquid storage tank 501 extends into the interior of the partition 3.

[0030] In this embodiment: the infusion pump 502 allows the coolant in the storage tank 501 to flow smoothly into the partition 3, cooling the inside of the tank 1. Simultaneously, the return pipe 505 allows the coolant in the partition 3 to flow smoothly back into the storage tank 501, achieving coolant recycling. This continuously cools the inside of the tank 1, ensuring it remains at a suitable temperature for cooling pharmaceutical intermediates, thus improving the cooling effect. Furthermore, the heat-conducting plate 503 efficiently removes heat from the coolant in the storage tank 501, reducing the cooling effect in the storage tank 501 in real time. The temperature of the liquid is maintained, thus ensuring the normal operation of the cooling component 5 and improving its ease of use. Then, under the action of the rotating motor 406, the storage cylinder 401 can be rotated smoothly, synchronously driving the spiral blades 405 to rotate. This allows the pharmaceutical intermediate to flow smoothly along the spiral blades 405. At the same time, under the action of the pressurizing fan 404, the outside air can be pressurized and smoothly transported to the inside of the storage cylinder 401 through the air supply pipe 402. Finally, it is sprayed onto the surface of the pharmaceutical intermediate through the nozzle 403, thereby promoting heat dissipation in all directions and improving the ease of use of the turning component 4.

[0031] Specifically, such as Figure 4 As shown, a pressurizing fan 404 is fixedly connected to the side of the gas pipeline 402 away from the storage cylinder 401, and the pressurizing fan 404 is located on the rear side of the right side of the tank body 1.

[0032] Specifically, such as Figure 4 As shown, a spiral blade 405 is fixedly connected to the surface of the storage cylinder 401, and a rotating motor 406 is fixedly connected to the left side of the storage cylinder 401.

[0033] Specifically, such as Figure 1 , Figure 2 , Figure 4 As shown, an air inlet pipe 6 is fixedly connected to the right side of the pressurizing fan 404, and a filter screen 7 is fixedly connected inside the air inlet pipe 6.

[0034] In this embodiment, the combined use of the air intake pipe 6 and the filter screen 7 not only increases the air intake range, allowing outside air to flow smoothly into the pressurizing fan 404, but also filters impurities in the air, preventing impurities from affecting the normal operation of the pressurizing fan 404, ensuring that the pressurizing fan 404 is always in a stable operating state, and improving the ease of use of the flipping component 4.

[0035] Specifically, such as Figure 5 As shown, an observation glass 8 is embedded inside the right side of the liquid storage tank 501, and an inlet valve 9 is fixedly connected to the top of the liquid storage tank 501.

[0036] Specifically, such as Figure 2 , Figure 3 As shown, a temperature sensor 10 is fixedly connected to the right side of the top of the inner wall of tank 1.

[0037] In this embodiment: by observing the combined use of glass 8 and liquid inlet valve 9, not only can the condition of the coolant inside the liquid storage tank 501 be observed in real time, but the coolant can also be added or replaced through liquid inlet valve 9, ensuring the normal operation of cooling component 5. At the same time, under the action of temperature sensor 10, the temperature inside tank 1 can be monitored in real time and the data is transmitted to controller 11, providing data support for the operation of cooling component 5 and tilting component 4, thereby enabling precise and comprehensive cooling of pharmaceutical intermediates and improving the ease of use of cooling component 5.

[0038] Specifically, such as Figure 1 , Figure 2 , Figure 3 As shown, a controller 11 is fixedly connected to the front side of the tank 1, and the controller 11 is electrically connected to the tilting assembly 4, the cooling assembly 5 and the temperature sensor 10.

[0039] Specifically, such as Figure 1 , Figure 2 , Figure 3 As shown, an electric discharge valve 12 is fixedly connected to the bottom right side of the tank body 1, and the electric discharge valve 12 is electrically connected to the controller 11.

[0040] In this embodiment: the controller 11 can receive data transmitted by the temperature sensor 10 in real time and precisely control the flipping component 4 and the cooling component 5 based on the data. This not only continuously cools the inside of the tank 1, ensuring that the inside of the tank 1 is always maintained at a suitable temperature for cooling the pharmaceutical intermediate, but also drives the pharmaceutical intermediate to flow smoothly along the spiral blades 405 while blowing gas onto it, thereby promoting heat dissipation in all directions and improving the cooling effect of the pharmaceutical intermediate. After processing is completed, the controller 11 activates the electric discharge valve 12 to connect the tank 1 to the outside, so that the processed pharmaceutical intermediate is smoothly pushed out by the spiral blades 405, thus completing the cooling process of the pharmaceutical intermediate and improving the ease of use of the device.

[0041] Working Principle: During the cooling operation of pharmaceutical intermediates, the intermediates first flow smoothly into tank 1 through inlet pipe 2. Then, temperature sensor 10 monitors the internal temperature of tank 1 in real time and transmits the data to controller 11. Operators operate controller 11 based on the data to precisely control the agitation component 4 and cooling component 5. After the initial preparation is complete, infusion pump 502 is started, allowing the coolant in storage tank 501 to flow smoothly into partition 3, and then back into storage tank 501 through return pipe 505, achieving coolant recycling. This continuously cools the inside of tank 1. Simultaneously, heat conduction plate 503 efficiently removes heat from the coolant in storage tank 501, reducing the coolant temperature in real time and maintaining the normal operation of cooling component 5, ensuring that the inside of tank 1 is always maintained at a suitable temperature for pharmaceutical intermediates. Once the temperature inside tank 1 is adjusted, the rotating motor 406 is started, which drives the storage cylinder 401 to rotate smoothly, simultaneously driving the spiral blades 405 to rotate. This allows the pharmaceutical intermediate to flow smoothly along the spiral blades 405, achieving the tumbling of the pharmaceutical intermediate and preventing uneven cooling caused by material accumulation. At the same time, the pressurizing fan 404 is started, which pressurizes the outside air and smoothly delivers it to the inside of the storage cylinder 401 through the air supply pipe 402. Finally, the air is sprayed onto the surface of the pharmaceutical intermediate through the nozzle 403, thereby promoting heat dissipation in all directions. After the pharmaceutical intermediate has cooled, the electric discharge valve 12 is activated by the controller 11 to connect tank 1 to the outside. At the same time, the rotating motor 406 drives the spiral blades 405 to rotate, thereby smoothly discharging the processed pharmaceutical intermediate from tank 1, thus completing the cooling process of the pharmaceutical intermediate.

[0042] The above are merely preferred embodiments of the present utility model and are not intended to limit the present utility model. Any modifications, equivalent substitutions, and improvements made within the spirit and principles of the present utility model should be included within the protection scope of the present utility model.

Claims

1. A cooling device for the production of pharmaceutical intermediates, comprising a tank (1), characterized in that: An inlet pipe (2) is fixedly connected to the top of the tank (1), and a partition (3) is provided inside the inner wall of the tank (1). A flipping assembly (4) is fixedly connected inside the tank (1), and a cooling assembly (5) is fixedly connected to the top of the right side of the tank (1). The flipping assembly (4) includes a storage cylinder (401), and a gas supply pipe (402) is provided on the right side of the storage cylinder (401). Several nozzles (403) are fixedly connected to the surface of the storage cylinder (401). The cooling assembly (5) includes a liquid storage tank (501), a liquid pump (502) is fixedly connected to the bottom of the front side of the liquid storage tank (501), and heat conduction plates (503) are fixedly connected to the front and rear sides of the top of the liquid storage tank (501). A delivery pipe (504) is fixedly connected to the output end of the liquid pump (502), and the delivery pipe (504) extends into the interior of the partition (3) on the side away from the liquid pump (502). A return pipe (505) is fixedly connected to the top of the rear side of the liquid storage tank (501), and the return pipe (505) extends into the interior of the partition (3) on the side away from the liquid storage tank (501).

2. The cooling device for producing pharmaceutical intermediates according to claim 1, characterized in that: A pressurizing fan (404) is fixedly connected to the side of the gas pipeline (402) away from the storage cylinder (401), and the pressurizing fan (404) is located on the rear side of the right side of the tank body (1).

3. The cooling device for pharmaceutical intermediate production according to claim 1, characterized in that: The surface of the storage cylinder (401) is fixedly connected with a spiral blade (405), and a rotating motor (406) is fixedly connected to the left side of the storage cylinder (401).

4. A cooling device for the production of pharmaceutical intermediates according to claim 2, characterized in that: An air inlet pipe (6) is fixedly connected to the right side of the pressurizing fan (404), and a filter screen (7) is fixedly connected inside the air inlet pipe (6).

5. A cooling device for the production of pharmaceutical intermediates according to claim 1, characterized in that: An observation glass (8) is embedded inside the right side of the liquid storage tank (501), and an inlet valve (9) is fixedly connected to the top of the liquid storage tank (501).

6. A cooling device for the production of pharmaceutical intermediates according to claim 1, characterized in that: A temperature sensor (10) is fixedly connected to the right side of the top of the inner wall of the tank (1).

7. A cooling device for the production of pharmaceutical intermediates according to claim 6, characterized in that: A controller (11) is fixedly connected to the front side of the tank (1), and the controller (11) is electrically connected to the overturning assembly (4), the cooling assembly (5) and the temperature sensor (10).

8. A cooling device for the production of pharmaceutical intermediates according to claim 7, characterized in that: An electric discharge valve (12) is fixedly connected to the bottom right side of the tank (1), and the electric discharge valve (12) is electrically connected to the controller (11).

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