Novel high-precision purification device for apixaban intermediate

Abstract

The utility model discloses a novel high-precision purification device for an apixaban intermediate, and relates to the technical field of medicine preparation. The device comprises a base, a purification tank is fixedly mounted on the base, a mounting cover is mounted at the top of the purification tank, a vertically-arranged rotating shaft is rotatably arranged at the middle end of the mounting cover, and a plurality of stirring pieces distributed at equal intervals are fixedly mounted at the end, located in the purification tank, of the rotating shaft. A horizontally-arranged cross rod is fixedly arranged at the top of the rotating shaft, a vertically-arranged first scraping plate is fixedly arranged at the end, away from the rotating shaft, of the cross rod, and an obliquely-arranged second scraping plate is fixedly arranged at the bottom of the first scraping plate; high-pressure water flow flushing of the fancy spraying head is combined with mechanical scraping of the first scraping plate and the second scraping plate, the double functions of spraying flushing and physical stripping are achieved, compared with a traditional single spraying mode, medicine impurities attached to the inner wall can be more thoroughly removed, and the cleaning efficiency is improved.

Description

TECHNICAL FIELD

[0001] The utility model relates to the technical field of medicine preparation, specifically to a high-precision novel purification device for apixaban intermediate. BACKGROUND

[0002] Apixaban is a kind of oral selective activated factor Xa inhibitor after dabigatran and rivaroxaban, is used to prevent the occurrence of venous in adult patients receiving elective hip or knee replacement surgery, apixaban needs to be purified by extraction and other intermediates during preparation, the obtained intermediate is taken out, the inner wall of the purification tank needs to be cleaned, and the stirring part of the extraction and purification also needs to be cleaned to avoid residues and affect the purification accuracy of subsequent reuse.

[0003] Application number: "CN201921037795.8" a kind of apixaban intermediate high-precision novel purification device, the vibrating element is fixedly connected with the elastic component, the feed pipe and the discharge pipe are communicated with the purification container, the water storage tank is fixedly connected with the purification container, the output end of the driving element is fixedly connected with one end of the water jet pipe, the other end of the water jet pipe is sequentially penetrated through the water storage tank and the purification container, the water jet pipe in the water storage tank has water inlet hole, the water jet pipe in the purification container has the water jet component, one end of the water supply pipe is communicated with the water storage tank, the other end of the water supply pipe is communicated with water pump. The cleaning of the purification container is more thorough, avoids the impurities remaining on the inner wall of the purification container, and affects the purity of apixaban intermediate high-precision novel purification device for apixaban intermediate prepared next time.

[0004] When the purification container after the above-mentioned patent of apixaban intermediate purification preparation is cleaned, the inside is cleaned by spray pipe and spring vibration, but the attachment of drug solution impurities relies on spraying cleaning, the effect is very small, and the vibration frequency of spring is very limited, the cleaning is not comprehensive enough, which will affect the accuracy of subsequent purification. Utility model content

[0005] In order to solve the above problems, the utility model aims at providing a high-precision novel purification device for apixaban intermediate.

[0006] To solve the above technical problems, the utility model discloses the following technical scheme: A high-precision novel purifier for apixaban intermediate, comprising a base, a purifying tank is fixedly installed on the base, a mounting cover is installed on the top of the purifying tank, a rotating shaft is vertically arranged on the middle end of the mounting cover, a plurality of stirring parts are fixedly installed at equal intervals on the end of the rotating shaft in the purifying tank, a horizontal crossbar is fixedly arranged on the top of the rotating shaft, a first scraper is fixedly arranged on the end of the crossbar away from the rotating shaft, a second scraper is fixedly arranged on the bottom of the first scraper, a fixing plate is fixedly arranged on the purifying tank, a rotating rod is rotatably inserted into the end of the fixing plate close to the purifying tank, a rotating plate is fixedly arranged on the top of the rotating rod, an eccentric shaft is rotatably inserted into the eccentric position of the rotating plate, an eccentric sleeve is fixedly arranged on the top of the eccentric shaft, two vertical standing plates are fixedly arranged on the upper and lower surfaces of the fixing plate, a fixed rod is rotatably inserted between the two adjacent standing plates, a swing plate is arranged in a U-shaped mode on the fixed rod, the eccentric sleeve is arranged on the swing plate, and a knocking plate is fixedly arranged on the end of the swing plate away from the eccentric sleeve.

[0007] Preferably, a drive gear is fixedly arranged on the middle of the outer wall of the purifying tank close to the rotating rod, a first gear is fixedly arranged on the middle end of the rotating rod in a ring-shaped mode and is meshed with the drive gear, a transmission shaft is rotatably arranged on the outer wall of the purifying tank close to the drive gear, a second gear is fixedly arranged on the transmission shaft and is meshed with the drive gear, a second motor is fixedly arranged below the second gear on the outer wall of the purifying tank, and the output end of the second motor is coaxially fixedly arranged on the transmission shaft.

[0008] Compared with the prior art, the utility model has the beneficial effects that:

[0009] 1. The high-pressure water flow of the fancy spray head is combined with the mechanical scraping of the first scraper and the second scraper to realize the dual effects of "spray flushing + physical stripping", so that the drug impurities attached to the inner wall can be more completely removed than in the traditional single spray mode, and the cleaning efficiency is improved.

[0010] 2. The unique mechanical vibration structure is adopted to replace the spring vibration, and the knocking is more effective and the vibration frequency is faster, so that the impurities attached to the inner wall can be more completely removed under the combined action of the scraping of the scraper and the vibration effect, the subsequent impurity attachment can be prevented, and the precision of the subsequent purification is ensured. BRIEF DESCRIPTION OF DRAWINGS

[0011] In order to more clearly illustrate the technical solutions in the embodiments of the present application or the prior art, the drawings needed to be used in the embodiments or prior art description will be briefly introduced as follows. Obviously, the drawings described in the following are only some of the embodiments of the present application, and not all the embodiments. Based on the embodiments in the present application, all the other embodiments obtained by those skilled in the art without creative labor are within the protection scope of the present application.

[0012] Figure 1 It is a schematic view of the overall structure of the present application.

[0013] Figure 2 It is a schematic view of the mounting cover structure of the present application.

[0014] Figure 3 It is a schematic view of the fixed plate structure of the present application

[0015] Figure 4 It is the present application Figure 3 It is a schematic view of the enlarged structure at A

[0016] Figure 5 It is the present application Figure 3 It is a schematic view of the enlarged structure at B.

[0017] In the figure: 1, base; 11, purification tank; 12, mounting cover; 13, feed pipe; 131, discharge pipe; 14, rotating shaft; 15, stirring part; 16, cross rod; 17, first scraper; 18, second scraper; 19, first motor; 2, fixed plate; 21, vertical plate; 22, fixed rod; 23, swing plate; 24, knocking plate; 25, rotating rod; 26, rotating plate; 27, movable rod; 28, movable sleeve; 3, water inlet pipe; 31, water delivery pipe; 32, fancy spray head; 4, driving gear; 41, first gear; 43, second gear; 44, second motor; 45, transmission shaft; 46, support plate; 47, support. DETAILED DESCRIPTION

[0018] The technical solutions in the embodiments of the present application will be described clearly and completely in combination with the drawings in the embodiments of the present application. Obviously, the described embodiments are only some of the embodiments of the present application, and not all the embodiments. Based on the embodiments in the present application, all the other embodiments obtained by those skilled in the art without creative labor are within the protection scope of the present application.

[0019] Embodiment: as Figures 1-5The utility model provides a kind of high-precision novel purifying device of apixaban intermediate, including base 1, base 1 is fixedly installed with purifying tank 11, the top of purifying tank 11 is installed with installation cover 12, the intermediate end of installation cover 12 is rotatably equipped with vertical setting pivot 14, pivot 14 is fixedly installed with multiple equidistant distribution settings stirring piece 15 in one end inside purifying tank 11, raw material required to be purified is put into purifying tank 11, then first motor 19 is started to drive pivot 14 to make stirring piece 15 rotate, so that raw material and extractant are more fully mixed, subsequent in purifying tank 11 waits extraction purification separation, the top of pivot 14 is fixedly equipped with horizontal setting cross bar 16, the end of cross bar 16 away from pivot 14 is fixedly equipped with vertical setting first scraper 17, the bottom of first scraper 17 is fixedly equipped with second scraper 18 of inclined setting, purifying tank 11 is fixedly equipped with annular distribution setting fixed plate 2, one end of fixed plate 2 close to purifying tank 11 is rotatably inserted with vertical setting pivot 25, the top of pivot 25 is fixedly equipped with turn plate 26, eccentricity of turn plate 26 is movably inserted with movable rod 27, the top of movable rod 27 is fixedly equipped with movable sleeve 28, the upper and lower surfaces of fixed plate 2 are fixedly equipped with two vertical settings riser 21, common rotation is inserted with fixed rod 22 between adjacent two risers 21, fixed rod 22 is equipped with swing plate 23 of U type setting, movable sleeve 28 is equipped on swing plate 23, one end of swing plate 23 away from movable sleeve 28 is fixedly equipped with knock plate 24, the knock plate 24 shown in the figure is rectangle, can be set to arc according to actual demand, more fit tank body.

[0020] Three annularly arranged water inlets 3 are fixedly installed on the installation cover 12, and a fancy shower head 32 is fixedly arranged at the bottom of the water inlet 3. A water delivery pipe 31 is connected to the top of the water inlet 3. The water source is connected to the water delivery pipe 31, so that the water in the water delivery pipe 31 is delivered to the fancy shower head 32 through the water inlet 3, and the fancy shower head 32 can clean the inner wall of the purifying tank 11.

[0021] A first motor 19 is fixedly installed on the top of the installation cover 12, and the output end of the first motor 19 is coaxially fixed on the pivot 14. The first motor 19 is arranged to provide power for the rotation of the pivot 14, so that the pivot 14 drives the stirring piece 15 to rotate, improves the extraction efficiency, and at the same time, when the pivot 14 rotates, the cross bar 16 drives the first scraper 17 and the second scraper 18 to scrape and clean the inner wall of the purifying tank 11.

[0022] The outer wall of the purification tank 11 is fixed with a drive gear 4 near the middle of the rotating rod 25, and the middle end of the annular rotating rod 25 is fixed with a first gear 41 engaged with the drive gear 4. When the drive gear 4 is driven to rotate, a plurality of first gears 41 can be driven to rotate at one time, so that a plurality of rotating rods 25 can work at the same time, improving the convenience of operation of the device. The outer wall of the purification tank 11 is rotatably provided with a transmission shaft 45 near the drive gear 4, and the transmission shaft 45 is fixedly provided with a second gear 43 engaged with the drive gear 4. The second motor 44 is fixedly arranged on the transmission shaft 45. The second motor 44 is used to provide power for the rotation of the second gear 43, the first gear 41 and the drive gear 4, which is convenient for the operator to control. The support plate 46 is fixedly arranged on the bottom of the base 1 below the second motor 44. The second motor 44 is fixedly arranged on the support plate 46. The support plate 46 is fixedly provided with a bracket 47 arranged in an L shape. The top of the transmission shaft 45 is rotatably inserted into the bracket 47. The bracket 47 can provide power for the rotation of the transmission shaft 45, so as to ensure the stable rotation of the transmission shaft 45 and prevent the second gear 43 from being driven away from the drive gear 4. The support plate 46 is fixed between the base 1 and the second motor 44 for supporting the second motor 44.

[0023] A partition plate is fixed below the mounting cover 12. The upper surface of the partition plate is fixedly connected with the lower surface of the mounting cover 12 through three annular connecting blocks, and the rotating shaft 14 penetrates the partition plate. The mounting cover 12 and the partition plate are jointly fixed with the feed pipe 13. The bottom of the purification tank 11 is provided with a discharge pipe 131, and the discharge pipe 131 is provided with a switch valve. The feed pipe 13 is used to put the preparation raw materials needed for purification. The discharge pipe 131 is used to discharge the impurities after purification and cleaning.

[0024] Working principle: when it is necessary to effectively clean the inside of the purification tank 11, first, the water source is connected to the water supply pipe 31, so that the water is transmitted to the fancy spray head 32 through the water inlet pipe 3, so that the fancy spray head 32 can spray the inner wall of the purification tank 11. Then the first motor 19 can be driven to rotate the rotating shaft 14, and the horizontal rod 16 fixed on the rotating shaft 14 can drive the first scraper 17 and the second scraper 18 to rotate. At this time, the first scraper 17 and the second scraper 18 can conveniently remove the impurities attached to the inner wall of the purification tank 11. In this way, the impurities can be removed and treated at the same time as the spray cleaning water, so that the inner wall of the purification tank 11 can be effectively cleaned.

[0025] At this time, the staff can directly drive the second motor 44, the second motor 44 is provided to drive the second gear 43 to rotate, the second gear 43 drives the driving gear 4 connected with it to rotate, the driving gear 4 drives a plurality of first gears 41 to rotate at one time when rotating, so that a plurality of rotating rods 25 work at the same time, the rotating rod 25 rotates, the rotating plate 26 fixedly arranged at the end of the rotating rod 25 rotates at the same time, the movable rod 27 arranged at the eccentric position of the rotating plate 26 rotates with the rotating plate 26, the movable sleeve 28 fixedly arranged at the end of the movable rod 27 moves the swing plate 23 sleeved with it by chance, since the swing plate 23 is sleeved on the fixed rod 22, at this time, with the rotating plate 26 driving the movable rod 27 to rotate continuously, the movable sleeve 28 fixedly arranged at the top of the movable rod 27 drives the swing plate 23 to swing back and forth with the fixed rod 22 as the center continuously, at this time, the knocking plate 24 fixedly arranged at the end of the swing plate 23 continuously knocks the surface of the purification tank 11, through the above-mentioned way, the knocking is more effective and the vibration frequency is faster, so that the impurities attached to the inner wall are cleaned more comprehensively under the effect of the scraper cleaning and vibration, so that the subsequent impurities can be prevented from adhering after cleaning, affecting the accuracy of subsequent purification again.

[0026] Obviously, those skilled in the art can make various modifications and variations to the present application without departing from the spirit and scope of the present application. Thus, if these modifications and variations of the present application belong to the scope of the claims of the present application and their equivalent technologies, the present application also intends to include these modifications and variations.

Claims

1. A novel high-precision purification device for apixaban intermediates, comprising a base (1), characterized in that: A purification tank (11) is fixedly installed on the base (1). A mounting cover (12) is installed on the top of the purification tank (11). A vertically arranged rotating shaft (14) is rotatably mounted on the middle end of the mounting cover (12). A plurality of equally spaced stirring pieces (15) are fixedly installed on one end of the rotating shaft (14) inside the purification tank (11). A horizontally arranged crossbar (16) is fixedly mounted on the top of the rotating shaft (14). A vertically arranged first scraper (17) is fixedly mounted on the end of the crossbar (16) away from the rotating shaft (14). A second scraper (18) is fixedly mounted at an angle on the bottom of the first scraper (17). A ring-shaped fixing plate (2) is fixedly mounted on the purification tank (11). A vertically arranged rotating rod (25) is rotatably inserted into one end of the fixed plate (2) near the purification tank (11). A rotating plate (26) is fixedly installed on the top of the rotating rod (25). A movable rod (27) is movably inserted into the eccentric part of the rotating plate (26). A movable sleeve (28) is fixedly installed on the top of the movable rod (27). Two vertically arranged upright plates (21) are fixedly installed on the upper and lower surfaces of the fixed plate (2). A fixed rod (22) is rotatably inserted between two adjacent upright plates (21). A U-shaped swing plate (23) is sleeved on the fixed rod (22). The movable sleeve (28) is sleeved on the swing plate (23). A striking plate (24) is fixedly installed at the end of the swing plate (23) away from the movable sleeve (28).

2. The novel high-precision purification device for apixaban intermediates as described in claim 1, characterized in that, The mounting cover (12) is fixedly installed with three annularly arranged water inlet pipes (3), the bottom of the water inlet pipes (3) is fixedly provided with a fancy spray head (32), and the top of the water inlet pipes (3) is connected to a water supply pipe (31).

3. The novel high-precision purification device for apixaban intermediates as described in claim 2, characterized in that, The top of the mounting cover (12) is fixedly mounted with a first motor (19), and the output end of the first motor (19) is coaxially fixed on the rotating shaft (14).

4. The novel high-precision purification device for apixaban intermediates as described in claim 3, characterized in that, The outer wall of the purification tank (11) is fixedly provided with a drive gear (4) near the middle of the rotating rod (25), and the middle end of the rotating rod (25) arranged in a ring is fixedly provided with a first gear (41) that meshes with the drive gear (4).

5. The novel high-precision purification device for apixaban intermediates as described in claim 4, characterized in that, The outer wall of the purification tank (11) is provided with a drive shaft (45) near the drive gear (4). A second gear (43) that meshes with the drive gear (4) is fixed on the drive shaft (45). A second motor (44) is fixed on the outer wall of the purification tank (11) below the second gear (43). The output end of the second motor (44) is coaxially fixed on the drive shaft (45).

6. The novel high-precision purification device for apixaban intermediates as described in claim 5, characterized in that, A support plate (46) is fixedly installed on the base (1) directly below the second motor (44). The second motor (44) is fixedly installed on the support plate (46). An L-shaped bracket (47) is fixedly installed on the support plate (46). The top of the transmission shaft (45) is rotatably inserted into the bracket (47).

7. The novel high-precision purification device for apixaban intermediates as described in claim 6, characterized in that, A partition is fixedly provided directly below the mounting cover (12). The upper surface of the partition is fixedly connected to the lower surface of the top mounting cover (12) by three connecting blocks arranged in a ring. The rotating shaft (14) passes through the partition. A feed pipe (13) is fixedly provided between the mounting cover (12) and the partition. A discharge pipe (131) is provided at the bottom of the purification tank (11), and a switch valve is installed on the discharge pipe (131).

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