Magnetic frame capable of integrally centrifuging

Abstract

The utility model discloses a magnetic frame capable of integrated centrifugation, which comprises a magnetic suction unit and a centrifugation unit, the magnetic suction unit comprises a base, a magnetic stripe fixing plate is arranged on the base, one or more magnetic stripes are mounted on the magnetic stripe fixing plate, and the centrifugation unit comprises a centrifugation disc. The magnetic strips are attached to the EP pipes in the storage racks, so that magnetic beads in the EP pipes can be conveniently attracted to the pipe walls by the magnetic strips, then the EP pipes in other storage racks can be magnetically attracted by the magnetic strips by rotating the centrifugal disc, compared with the prior art that the EP pipes are replaced one by one, more convenience is achieved, the working efficiency is improved, the centrifugal disc can be directly taken down, and the labor intensity of workers is reduced. By shaking or vibrating the centrifugal disc, a sample in the EP tube in the centrifugal disc is rapidly and uniformly mixed, then the centrifugal disc is directly placed on the base again for centrifugation, magnetic attraction is directly carried out after centrifugation, the EP tube does not need to be taken out in the whole process, the operation process is simplified, and the working efficiency is further improved.

Description

TECHNICAL FIELD

[0001] The utility model relates to magnetic force frame technical field especially relates to a kind of magnetism frame capable of integration centrifugation. BACKGROUND

[0002] Magnetic force frame is mainly widely applied to molecular biology and medical diagnosis field. It is used with nucleic acid extraction reagent and nanometer micrometer magnetic bead, can be preprocessed to different types of samples such as whole blood, tissue, cell culture etc., and sample pretreatment is the prerequisite for gene amplification, sequencing, its process includes gene separation, extraction, purification etc., and nucleic acid extraction, purification is often carried out using magnetic bead method, such as the process is completed by manual operation, the magnetic force frame involved in this patent plays an indispensable role.

[0003] The magnetism frame disclosed in publication No. CN216972491U includes a support, an adapter ring and an EP tube, the adapter ring is provided with a plurality of matrix distribution on the support, the EP tube is detachably arranged in the inner ring of the adapter ring, further including a magnet fixing strip and a magnet, the magnet fixing strip is in long strip shape, a plurality of magnets are equidistantly distributed on the magnet fixing strip along the length direction of the magnet fixing strip, and the magnet fixing strip is detachably connected with the support, solving the technical problem of how to facilitate the disassembly and installation of the magnet by the staff.

[0004] The above prior art when using, when needing to use magnetic force frame to sample is magnetically attracted, is needed to place centrifugal tube in corresponding adapter ring one by one, and after magnetically attracting, still needs to take out centrifugal tube from corresponding adapter ring one by one, low efficiency, in addition, sample before magnetically attracting still needs to carry out mixing and centrifugation process, and the above prior art can only carry out magnetically attracting process, mixing and centrifugation need separate operation, and after mixing and centrifugation, still need to take out centrifugal tube one by one and then place on the magnetic force frame one by one to magnetically attract, many and complicated procedures, affect work efficiency. UTILITY MODEL CONTENTS

[0005] The utility model aims at providing a kind of magnetism frame capable of integration centrifugation, and the technical problems to be solved are that the existing centrifugal tube needs to be placed in corresponding adapter ring one by one, and after magnetically attracting, still needs to take out centrifugal tube from corresponding adapter ring one by one, low efficiency. In addition, sample before magnetically attracting still needs to carry out mixing and centrifugation process, and the existing magnetic force frame can only carry out magnetically attracting process, mixing and centrifugation need separate operation, and after mixing and centrifugation, still need to take out centrifugal tube one by one and then place on the magnetic force frame one by one to magnetically attract, many and complicated procedures, affect work efficiency.

[0006] To achieve the above technical purpose, the utility model provides a kind of magnetism frame capable of integration centrifugation:

[0007] It includes a magnetic unit and a centrifugal unit, the magnetic unit includes a base, a magnetic strip fixing plate is arranged on the base, one or more magnetic strips are installed on the magnetic strip fixing plate, the centrifugal unit includes a centrifugal disc, first notches are arranged at four corners of the centrifugal disc, second notches are arranged at four edges of the centrifugal disc, a storage rack is arranged in the second notches, a plurality of storage grooves are arranged at equal intervals in the storage rack, EP tubes are placed in the storage grooves, and a driving assembly for driving the EP tubes to centrifuge is arranged on the base.

[0008] Preferably, the distance between the axes of adjacent EP tubes in each storage rack is 13-23 mm.

[0009] Preferably, a baffle and two guide plates are fixed on the top of the base, one end of each of the two guide plates is fixed with the baffle, the magnetic strip fixing plate is slidingly fitted between the two guide plates, and a handle is fixed on one side of the magnetic strip fixing plate.

[0010] Preferably, a foldable connecting strip is fixed at the neck of the EP tube, a tube cap is fixed on the side of the connecting strip away from the neck of the EP tube, a plurality of partition strips are fixed on the storage rack, a gap for the connecting strip to pass through is formed between two adjacent partition strips, rubber strips are fixed on both sides of the partition strip, and the rubber strips can be deformed correspondingly when the connecting strip is folded and pressed against the rubber strips.

[0011] Preferably, the four first notches and the four second notches divide the centrifugal disc into eight installation strips, a circular hole is arranged in each installation strip, a cylindrical rod penetrates through the circular hole, the cylindrical rod can rotate in the circular hole, a stop block is fixed on one end of the cylindrical rod, a screw rod is fixed on the other end of the cylindrical rod, two ear plates are fixed on the top of the storage rack, screw holes are arranged in the ear plates, and the screw rod is threadedly connected with the screw holes.

[0012] Preferably, the driving assembly includes a motor installed on the top of the base, a rotating shaft is fixed on the output end of the motor, a rotating disc is fixed on the outer side of the rotating shaft, a plurality of columns are fixed on the rotating disc, a second through groove is arranged in the centrifugal disc, a plurality of first through grooves are arranged in the centrifugal disc, the rotating shaft can penetrate through the second through groove, and the columns can penetrate through the first through grooves.

[0013] Preferably, an external thread is arranged on the top of the rotating shaft, a nut is threadedly connected with the rotating shaft, and the diameter of the outer side of the nut is greater than the diameter of the second through groove.

[0014] From the above technical solutions, the application has the following beneficial effects:

[0015] 1、 through shaking the centrifugal disc to drive multiple EP tubes to shake simultaneously, the sample in the EP tube can be conveniently mixed, and the motor is started to drive the shaft, the disc, and the column to rotate, thereby driving the centrifugal disc to rotate, and the sample in the EP tube can be centrifuged, when the centrifugation of the EP tube is completed, the magnetic strip fixing plate is moved between the two guide plates, at this time, the magnetic strip is attached to the multiple EP tubes in one of the holders, so that the magnetic strip can adsorb the magnetic beads in the EP tube, then the centrifugal disc is rotated, so that the EP tubes in the other holders can be magnetically attracted by the magnetic strip, compared with the prior art of replacing the EP tubes one by one, the working efficiency is improved, and the centrifugal disc can be directly taken off, the EP tubes in the centrifugal disc are quickly mixed by shaking or vibrating the centrifugal disc, then the centrifugal disc is directly placed on the base again for centrifugation, and the magnetic attraction is directly performed after centrifugation, and the whole process does not need to take out the EP tubes again, the operation process is simplified, and the working efficiency is further improved.

[0016] 2、 Since the distance between the axes of the adjacent EP tubes in each holder is 13-23mm, the distance is suitable for the row gun, and after the multiple EP tubes are sequentially placed in the corresponding storage grooves, the row gun can be used to suck or add liquid.

[0017] 3、 After the EP tube is placed in the storage groove, the connecting strip is folded to press the rubber strip, the rubber strip is deformed under pressure, and when the connecting strip is embedded into the gap between the adjacent partition strips through the rubber strip, the rubber strip restores to the original state, so that the rubber strip clamps the connecting strip in the gap between the adjacent partition strips, avoiding that the cap blocks the EP tube and affecting the suction or liquid addition of the EP tube. BRIEF DESCRIPTION OF DRAWINGS

[0018] In order to more clearly illustrate the technical solutions in the embodiments of the present application or the prior art, the following will briefly introduce the drawings needed to be used in the embodiment or prior art description. Obviously, the drawings in the following description are only embodiments of the present application, and other drawings can be obtained by those skilled in the art without creative labor on the basis of the provided drawings.

[0019] Figure 1 A structure diagram of a magnetic force frame capable of integrated centrifugation is provided.

[0020] Figure 2 A split structure diagram of a magnetic force frame capable of integrated centrifugation is provided.

[0021] Figure 3 A split structure diagram of a centrifugal disc and a holder is provided.

[0022] Figure 4The utility model provides a partial structure split schematic drawing of EP pipe and storage rack.

[0023] BRIEF DESCRIPTION OF DRAWINGS: 100, magnetic attraction unit;101, base;102, magnetic strip fixed plate;103, magnetic strip;104, baffle;105, guide plate;106, handle;200, centrifugal unit;201, centrifugal disc;202, first notch;203, second notch;204, storage rack;205, storage groove;206, EP pipe;207, connecting strip;208, pipe cap;209, partition strip;210, rubber strip;211, motor;212, rotating shaft;213, rotating disc;214, column;215, first through groove;216, second through groove;217, nut;218, mounting strip;219, round hole;220, cylindrical rod;221, stop block;222, screw;223, ear plate;224, screw hole. DETAILED DESCRIPTION

[0024] The following description is merely exemplary in nature and is not intended to limit the present disclosure, application and uses. It should be understood that throughout the drawings, the same or similar reference numerals can be used to depict the same or similar components as throughout the specification. The various drawings can schematically represent the concepts and principles of embodiments of the present disclosure, and do not necessarily show the specific dimensions and ratios thereof. Certain parts in certain drawings can be exaggerated to illustrate the relevant details or structures of the embodiments of the present disclosure.

[0025] REFERENCE Figures 1-4 : for an embodiment of the utility model, provide a kind of magnetic force frame capable of integration centrifugation, including magnetic attraction unit 100 and centrifugal unit 200, magnetic attraction unit 100 includes base 101, base 101 is provided with magnetic strip fixed plate 102, one or more magnetic strips 103 are installed on magnetic strip fixed plate 102, centrifugal unit 200 includes centrifugal disc 201, first notch 202 is all set up in the four corners of centrifugal disc 201, second notch 203 is all set up in the four edges of centrifugal disc 201, storage rack 204 is provided in second notch 203, multiple storage grooves 205 are equidistantly set up in storage rack 204, EP pipe 206 is placed in storage groove 205, the spacing between the axis of adjacent EP pipe 206 in each storage rack 204 is 13-23mm, base 101 is provided with the drive assembly for driving EP pipe 206 to carry out centrifugation.

[0026] The base 101 is fixed with a baffle 104 and two guide plates 105 on the top, one end of the two guide plates 105 is fixed with the baffle 104, the magnetic strip fixing plate 102 is slidingly fitted between the two guide plates 105, the magnetic strip fixing plate 102 is fixed with a handle 106 on one side, the EP tube 206 is fixed with a foldable connecting strip 207 at the tube neck, the connecting strip 207 is fixed with a tube cap 208 away from the tube neck of the EP tube 206, the storage rack 204 is fixed with a plurality of partition strips 209, there is a gap between the two adjacent partition strips 209 for the connecting strip 207 to pass through, the two sides of the partition strip 209 are fixed with rubber strips 210, when the connecting strip 207 is folded and pressed against the rubber strip 210, the rubber strip 210 will deform under pressure, and the rubber strip 210 can clamp the connecting strip 207 in the gap between the two partition strips 209.

[0027] In use, after the EP tube 206 is placed in the storage groove 205, the connecting strip 207 is folded to press the rubber strip 210, the rubber strip 210 deforms under pressure, and when the connecting strip 207 is embedded in the gap between the adjacent partition strips 209 through the rubber strip 210, the rubber strip 210 returns to its original shape, so that the rubber strip 210 clamps the connecting strip 207 in the gap between the adjacent partition strips 209, avoiding the tube cap 208 from blocking the EP tube 206 and affecting the suction or liquid addition of the EP tube 206.

[0028] In addition, the driving assembly includes a motor 211 mounted on the top of the base 101, the output end of the motor 211 is fixed with a rotating shaft 212, the outer side of the rotating shaft 212 is fixed with a rotating disc 213, the rotating disc 213 is fixed with a plurality of column bodies 214, the centrifugal disc 201 is provided with a second through groove 216 and a plurality of first through grooves 215, the rotating shaft 212 can penetrate through the second through groove 216, the column body 214 can penetrate through the first through groove 215, the rotating shaft 212 is provided with an external thread on the top, the rotating shaft 212 is threadedly connected with a nut 217, and the diameter of the outer side of the nut 217 is greater than the diameter of the second through groove 216.

[0029] It should be noted that, since the spacing between the axes of adjacent EP tubes 206 in each shelf 204 is 13-23 mm, which is just suitable for the row gun, after sequentially placing multiple EP tubes 206 into the corresponding receiving grooves 205, the row gun can be used to suck or add liquid. After the sample is added, the tube cap 208 is covered, and then the centrifuge disc 201 is removed. By shaking the centrifuge disc 201, multiple EP tubes 206 are shaken at the same time, which facilitates the mixing of the sample in the EP tube 206. After the sample is mixed, the centrifuge disc 201 is placed on the base 101, so that the column 214 is embedded into the corresponding first through groove 215, and the shaft 212 is embedded into the second through groove 216. Then the nut 217 is threadedly connected with the shaft 212. At this time, the motor 211 is started to drive the shaft 212, the turntable 213, and the column 214 to rotate, thereby driving the centrifuge disc 201 to rotate, which can centrifuge the sample in the EP tube 206.

[0030] In addition, the four first notches 202 and the four second notches 203 divide the centrifuge disc 201 into eight installation strips 218. The installation strip 218 is provided with a round hole 219. A cylindrical rod 220 penetrates through the round hole 219. The cylindrical rod 220 can rotate in the round hole 219. The one end of the cylindrical rod 220 is fixed with a stop block 221. The other end of the cylindrical rod 220 is fixed with a screw rod 222. The top of the shelf 204 is fixed with two ear plates 223. The ear plate 223 is provided with a screw hole 224. The screw rod 222 is threadedly connected with the screw hole 224.

[0031] In use, after the EP tube 206 is centrifuged, the magnetic strip fixing plate 102 is moved between the two guide plates 105 by holding the handle 106. At this time, the magnetic strip 103 is attached to the multiple EP tubes 206 in one of the shelves 204, so that the magnetic strip 103 can adsorb the magnetic beads in the EP tube 206. Then the magnetic strip fixing plate 102 and the magnetic strip 103 are removed. The centrifuge disc 201 is rotated by ninety degrees, so that the other shelf 204 is rotated to be parallel to the guide plate 105. Then the magnetic strip fixing plate 102 and the magnetic strip 103 are placed between the two guide plates 105, so that the magnetic strip 103 can magnetically attract the sample in the multiple EP tubes 206 in the shelf 204. In this way, the sample in the multiple EP tubes 206 in the four shelves 204 can be magnetically attracted. Compared with the prior art, the EP tubes 206 are replaced one by one, which is more convenient and improves the work efficiency. Moreover, the centrifuge disc 201 can be directly removed. By shaking or vibrating the centrifuge disc 201, the sample in the EP tube 206 in the centrifuge disc 201 can be quickly mixed. Then the centrifuge disc 201 is directly placed on the base 101 again for centrifugation. After centrifugation, magnetic attraction is directly performed. The whole process does not need to take out the EP tube 206 again, which simplifies the operation process and further improves the work efficiency.

[0032] The exemplary embodiments of the solutions proposed by the present disclosure are described in detail above with reference to the preferred embodiments, however, it can be understood by those skilled in the art that various modifications and changes can be made to the above specific embodiments, and various technical features and structures proposed by the present disclosure can be combined without departing from the concept of the present disclosure, and the protection scope of the present disclosure is determined by the appended claims.

Claims

1. A magnetic stand capable of integrated centrifugation, characterized by, include: A magnetic unit (100) includes a base (101) on which a magnetic strip fixing plate (102) is provided, and one or more magnetic strips (103) are installed on the magnetic strip fixing plate (102); Centrifuge unit (200) includes centrifuge plate (201), with first slots (202) at each of the four corners of the centrifuge plate (201) and second slots (203) at each of the four sides of the centrifuge plate (201). A shelf (204) is provided in the second slot (203), and multiple storage slots (205) are provided at equal intervals in the shelf (204). An EP tube (206) is placed in the storage slot (205). A drive assembly for driving the EP tube (206) to centrifuge is provided on the base (101).

2. The integratable centrifugable magnetic stand of claim 1, wherein, The distance between the axes of adjacent EP tubes (206) within each of the aforementioned shelves (204) is 13-23 mm.

3. The integrally centrifugable magnetic stand of claim 1, wherein, The base (101) is fixed with a baffle (104) and two guide plates (105) at the top. One end of each of the two guide plates (105) is fixed to the baffle (104). The magnetic strip fixing plate (102) is slidably fitted between the two guide plates (105). A handle (106) is fixed on one side of the magnetic strip fixing plate (102).

4. The integrally centrifugable magnetic stand of claim 1, wherein, A foldable connecting strip (207) is fixed at the neck of the EP tube (206). A tube cap (208) is fixed on the side of the connecting strip (207) away from the neck of the EP tube (206). Multiple partitions (209) are fixed on the shelf (204). There is a gap between two connected partitions (209) for the connecting strip (207) to pass through. Rubber strips (210) are fixed on both sides of the partitions (209). When the connecting strip (207) is folded and squeezed, the rubber strip (210) will deform accordingly under pressure. The rubber strip (210) can hold the connecting strip (207) in the gap between the two partitions (209).

5. The integrally centrifugable magnetic stand of claim 1, wherein, Four first slots (202) and four second slots (203) divide the centrifugal disc (201) into eight mounting strips (218). Each mounting strip (218) has a circular hole (219) through which a cylindrical rod (220) passes. The cylindrical rod (220) can rotate within the circular hole (219). One end of the cylindrical rod (220) is fixed with a stop block (221), and the other end of the cylindrical rod (220) is fixed with a screw (222). The top of the shelf (204) is fixed with two ear plates (223). Each ear plate (223) has a screw hole (224) inside it. The screw (222) and the screw hole (224) are threaded together.

6. The integrally centrifugable magnetic stand of claim 1, wherein, Said driving assembly includes motor (211) installed on the top of base (101), the output end of motor (211) is fixed with rotating shaft (212), the outside of rotating shaft (212) is fixed with rotating disc (213), a plurality of columns (214) are fixed on rotating disc (213), the inside of centrifugal disc (201) is provided with second through groove (216), a plurality of first through grooves (215) are also set in centrifugal disc (201), rotating shaft (212) can penetrate from second through groove (216), column (214) can penetrate from first through groove (215).

7. The integrally centrifugable magnetic stand of claim 6, wherein, The top of rotating shaft (212) is provided with external thread, nut (217) is threadedly connected on rotating shaft (212), the diameter of the outside of nut (217) is greater than the diameter of second through groove (216).

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