Drug synthesis reaction experimental device with temperature and pressure interlocking protection function

Abstract

The utility model relates to a drug synthesis reaction experimental device with a temperature and pressure interlocking protection function, which comprises a base, a support frame and a reaction bottle, and has the technical key points that the upper part of the reaction bottle is provided with a straight-through pipe, the upper end of the straight-through pipe is provided with a functional gland, and the top of the functional gland is provided with an annular outer edge; a clamping and positioning mechanism is arranged between the annular outer edge and the base, a communicating hole connected with the interior of the reaction bottle is formed in the outer side wall of the functional gland, the outer end of the communicating hole is connected with a transition pipe, one end of the transition pipe is connected with the communicating hole, and the other end of the transition pipe is connected with a pressure release valve; a temperature sensor is embedded in the inner surface of the functional gland, the signal output end of the temperature sensor is fixed to the outer side wall of the functional gland, a lifting cylinder is arranged on the upper surface of the base, and a heater matched with the bottom face of the reaction bottle is arranged on the upper surface of the lifting cylinder. The device monitors the temperature and pressure of the synthetic reaction in real time, ensures the safe proceeding of the synthetic reaction, and ensures the personal safety of experimenters.

Description

TECHNICAL FIELD

[0001] The utility model relates to the technical field of drug synthesis experiment, specifically to a drug synthesis reaction experiment device with temperature and pressure interlocking protection function. BACKGROUND

[0002] Drug synthesis reaction experiment can be used for teaching, also can be used by drug chemists to develop new compounds, further improve the curative effect of drug, also can be used to try new drug production method, reach reduce production cost or environmental protection etc.

[0003] Drug synthesis reaction experiment is usually carried out in the laboratory, and the traditional experimental device mainly comprises a support, a reaction container, a heating assembly, a stirring assembly and the like. For example, CN 206701280 U discloses a synthesis experiment device, which comprises an electric heating jacket, a box body is arranged below the electric heating jacket, a frequency converter is embedded on the box body, a support column is arranged above the electric heating jacket, a lower connecting arm and an upper connecting arm are movably connected to the support column, a fixed clamp is arranged on the lower connecting arm, a reaction bottle is clamped on the fixed clamp, the reaction bottle corresponds to the electric heating jacket, a motor is arranged on the upper connecting arm, the motor is electrically connected with the frequency converter, one end of a stirring rod is connected with the motor, and the other end of the stirring rod extends into the interior of the reaction bottle. The synthesis experiment device enhances the stability in physical structure, but still has the following problems: lack of monitoring and protection for the chemical synthesis reaction process, especially for the synthesis reaction with violent reaction, and poor safety. UTILITY MODEL CONTENT

[0004] The utility model aims at providing a drug synthesis reaction experiment device with temperature and pressure interlocking protection function, which has reasonable structure and reliable use, can monitor the temperature and pressure of the synthesis reaction in real time, ensure the safe performance of the synthesis reaction, and ensure the personal safety of the experiment personnel.

[0005] The technical scheme of the utility model is as follows:

[0006] A drug synthesis reaction experiment device with temperature and pressure interlocking protection function comprises a base, a support frame and a reaction bottle arranged on the support frame, and the technical key points are as follows: a straight-through pipe is arranged on the upper portion of the reaction bottle, a functional gland is arranged on the upper end of the straight-through pipe, an annular outer edge is arranged on the top of the functional gland, a clamping and positioning mechanism is arranged between the annular outer edge and the base, a communication hole connected with the reaction bottle is arranged on the outer side wall of the functional gland, a transition pipe is connected to the outer end of the communication hole, one end of the transition pipe is connected with the communication hole, and the other end of the transition pipe is connected with a pressure relief valve, a pressure sensor is arranged on the transition pipe, a temperature sensor is additionally embedded in the inner surface of the functional gland, the signal output end of the temperature sensor is fixed to the outer side wall of the functional gland, a lifting cylinder is additionally arranged on the upper surface of the base, and a heater matched with the bottom surface of the reaction bottle is arranged on the upper surface of the lifting cylinder.

[0007] The drug synthesis reaction experiment device with temperature and pressure interlocking protection function, the clamping and positioning mechanism comprises a fixed clamp matched with the annular outer edge, a movable clamp connected with the fixed clamp, a horizontal positioning plate connected with the other side of the fixed clamp, a support arranged on the base, and a positioning nut arranged on the upper part of the support, the horizontal positioning plate is provided with a through hole corresponding to the support, the support is connected and fixed by the positioning nut after penetrating through the through hole, and the center line of the fixed clamp and the movable clamp is coincident with the center line of the support frame.

[0008] The drug synthesis reaction experiment device with temperature and pressure interlocking protection function, the heater comprises a heat-conducting shell and heating resistance wires arranged in the heat-conducting shell, the lower surface of the heat-conducting shell is connected and fixed with the top of the telescopic part of the lifting cylinder, and the upper surface of the heat-conducting shell is provided with a spherical recess matched with the spherical bottom surface of the reaction bottle.

[0009] The drug synthesis reaction experiment device with temperature and pressure interlocking protection function, the support frame is composed of a support ring matched with the reaction bottle and a plurality of support columns connected between the support ring and the base.

[0010] The drug synthesis reaction experiment device with temperature and pressure interlocking protection function, the upper end of the functional gland is fixed with a stirring motor, and the inside of the reaction bottle is provided with a stirring paddle connected with the output end of the stirring motor.

[0011] The drug synthesis reaction experiment device with temperature and pressure interlocking protection function, the upper surface of the base is further fixed with a controller, and the controller is connected with the lifting cylinder, the heater, the pressure sensor, the temperature sensor and the pressure relief valve.

[0012] The drug synthesis reaction experiment device with temperature and pressure interlocking protection function, the side wall of the straight-through pipe is further provided with a feeding branch pipe, and the upper end of the feeding branch pipe is provided with a fixed cap.

[0013] The drug synthesis reaction experiment device with temperature and pressure interlocking protection function, the lower surface of the base is embedded with a counterweight.

[0014] The drug synthesis reaction experiment device with temperature and pressure interlocking protection function, the lower surface of the base is embedded with a counterweight.

[0015] Before conducting the drug synthesis reaction experiment, the reaction flask is supported and positioned using a clamping and positioning mechanism and a support frame to achieve stable physical support. Other reaction solvents are then added, and the reaction is rapidly promoted under the combined effects of heating and stirring. During this process, pressure and temperature sensors are used to monitor the pressure and temperature inside the reaction flask in real time. When the reaction becomes vigorous and causes a sharp rise in pressure and temperature inside the flask, the pressure relief valve opens to release pressure, and simultaneously, a lifting cylinder lowers the heater to detach it from the reaction flask, cutting off the heating source and preventing further heat conduction. By jointly suppressing temperature and pressure, the safe operation of the synthesis reaction is ensured, thereby guaranteeing the personal safety of the experimental personnel. Attached Figure Description

[0016] Figure 1 This is a schematic diagram of the structure of this utility model;

[0017] Figure 2 This is a top view of the fixed and movable clamps of the clamping and positioning mechanism.

[0018] In the diagram: 1. Support column, 2. Positioning nut, 3. Horizontal positioning plate, 4. Controller, 5. Counterweight, 6. Base, 7. Lifting cylinder, 8. Heat-conducting shell, 9. Temperature sensor, 10. Support column, 11. Support ring, 12. Reaction flask, 13. Stirring paddle, 14. Straight pipe, 15. Feeding branch pipe, 16. Fixing cap, 17. Pressure relief valve, 18. Transition pipe, 19. Temperature sensor, 20. Pressure sensor, 21. Moving clamp, 22. Functional pressure cap, 23. Stirring motor, 24. Annular outer edge, 25. Fixed clamp. Detailed Implementation

[0019] The present invention will be described in detail with reference to the accompanying drawings.

[0020] like Figure 1 , Figure 2 As shown, the experimental apparatus for drug synthesis reaction with temperature and pressure interlock protection includes a base 6, a support frame, and a reaction flask 12 mounted on the support frame.

[0021] The reaction flask 12 has a straight pipe 14 at its upper part, and a functional cap 22 at its upper end. The top of the functional cap 22 has an annular outer edge 24, and a clamping and positioning mechanism is provided between the annular outer edge 24 and the base 6. In this embodiment, the clamping and positioning mechanism includes a fixed clamp 25 that cooperates with the annular outer edge 24, a movable clamp 21 that is opposite to and connected to the fixed clamp 25, a horizontal positioning plate 3 connected to the other side of the fixed clamp 25, a support column 1 on the base 6, and a positioning nut 2 on the upper part of the support column 1. The horizontal positioning plate 3 has a through hole corresponding to the support column 1, and the support column 1 passes through the through hole and is fixed by the positioning nut 2. The support frame consists of a support ring 11 that cooperates with the reaction flask 12 and a plurality of support columns 10 connected between the support ring 11 and the base 6. The center line of symmetry of the fixed clamp 25 and the movable clamp 21 coincides with the center line of the support ring 11.

[0022] The outer wall of the functional cap 22 has a connecting hole that connects to the inside of the reaction flask 12, and the outer end of the connecting hole is connected to a transition pipe 18. One end of the transition pipe 18 is connected to the connecting hole, and the other end is connected to a pressure relief valve 17. A pressure sensor 20 is provided on the transition pipe 18. A temperature sensor 19 is also embedded in the inner surface of the functional cap 22, and the signal output end of the temperature sensor 19 is fixed to the outer wall of the functional cap 22. A lifting cylinder 7 is provided on the upper surface of the base 6, and a heater that mates with the bottom surface of the reaction flask 12 is provided on the upper surface of the lifting cylinder 7. In this embodiment, the heater includes a heat-conducting shell 8 and a heating resistance wire 9 disposed in the heat-conducting shell 8. The lower surface of the heat-conducting shell 8 is connected and fixed to the top of the telescopic part of the lifting cylinder 7, and the upper surface of the heat-conducting shell 8 has a spherical groove that mates with the spherical bottom surface of the reaction flask 12. A stirring motor 23 is fixed to the upper end of the functional cap 22, and a stirring paddle 13 connected to the output end of the stirring motor 23 is provided inside the reaction flask 12. A controller 4 is also fixed on the upper surface of the base 6. The controller 4 is connected to the lifting cylinder 7, the heater, the pressure sensor 20, the temperature sensor 19, and the pressure relief valve 17.

[0023] A feeding branch pipe 15 is provided on the side wall of the straight pipe 14, and a fixing cap 16 is provided at the upper end of the feeding branch pipe 15. A counterweight 5 is embedded in the lower surface of the base 6.

[0024] Working principle:

[0025] 1. Add the drug raw materials into the reaction bottle 12 and fasten the functional pressure cap 22. Support the reaction bottle 12 above the support ring 11 and then lock it in place using the clamping and positioning mechanism.

[0026] 2. Add catalyst or other additives to reaction flask 12 through feeding branch pipe 15, and then fasten the fixing cap 16. Start the heater and stirring motor 23 to promote rapid reaction under the dual action of heating and stirring. During this process, the pressure sensor 20 and temperature sensor 19 are used to monitor the pressure and temperature inside reaction flask 12 in real time.

[0027] 3. When the reaction is vigorous and causes a rapid increase in pressure and temperature inside reaction flask 12, pressure relief valve 17 opens to release pressure. At the same time, lifting cylinder 7 drives the heater downward to disengage the heater from reaction flask 12, cutting off the heating source and preventing further heat conduction. By jointly suppressing temperature and pressure, the safe operation of the synthesis reaction is ensured, thereby guaranteeing the personal safety of the experimental personnel.

[0028] The embodiments of this utility model have been described in detail above, but the content described is only a preferred embodiment of this utility model and should not be considered as limiting the scope of implementation of this utility model. All equivalent changes and improvements made within the scope of this utility model should still fall within the scope of this utility model.

Claims

1. A drug synthesis reaction experimental apparatus with temperature and pressure interlock protection function, comprising a base, a support frame, and a reaction flask disposed on the support frame, characterized in that: The reaction flask is provided with a straight pipe at the top and a functional cap at the top end of the straight pipe. The top of the functional cap has an annular outer edge, and a clamping and positioning mechanism is provided between the annular outer edge and the base. The outer wall of the functional cap has a connecting hole that connects to the inside of the reaction flask, and the outer end of the connecting hole is connected to a transition pipe. One end of the transition pipe is connected to the connecting hole, and the other end is connected to a pressure relief valve. A pressure sensor is provided on the transition pipe. A temperature sensor is also embedded in the inner surface of the functional cap. The signal output end of the temperature sensor is fixed to the outer wall of the functional cap. A lifting cylinder is provided on the upper surface of the base, and a heater that mates with the bottom surface of the reaction flask is provided on the upper surface of the lifting cylinder.

2. The experimental apparatus for drug synthesis reaction with temperature and pressure interlock protection function according to claim 1, characterized in that: The clamping and positioning mechanism includes a fixed clamp that mates with the outer edge of the ring, a movable clamp that is opposite to and connected to the fixed clamp, a horizontal positioning plate connected to the other side of the fixed clamp, a support column on the base, and a positioning nut on the upper part of the support column. The horizontal positioning plate has a through hole corresponding to the support column. The support column passes through the through hole and is fixed by the positioning nut. The center line of symmetry of the fixed clamp and the movable clamp coincides with the center line of the support frame.

3. The experimental apparatus for drug synthesis reaction with temperature and pressure interlock protection function according to claim 1, characterized in that: The heater includes a heat-conducting shell and a heating resistance wire disposed in the heat-conducting shell. The lower surface of the heat-conducting shell is connected and fixed to the top of the telescopic part of the lifting cylinder. The upper surface of the heat-conducting shell is provided with a spherical groove that matches the spherical bottom surface of the reaction flask.

4. The experimental apparatus for drug synthesis reaction with temperature and pressure interlock protection function according to claim 1, characterized in that: The support frame consists of a support ring that mates with the reaction flask and multiple support columns connecting the support ring and the base.

5. The experimental apparatus for drug synthesis reaction with temperature and pressure interlock protection function according to claim 1, characterized in that: The upper end of the functional cap is fixed with a stirring motor, and the inside of the reaction flask is equipped with a stirring paddle connected to the output end of the stirring motor.

6. The experimental apparatus for drug synthesis reaction with temperature and pressure interlock protection function according to claim 1, characterized in that: A controller is also fixed on the upper surface of the base, and the controller is connected to the lifting cylinder, heater, pressure sensor, temperature sensor and pressure relief valve.

7. The experimental apparatus for drug synthesis reaction with temperature and pressure interlock protection function according to claim 1, characterized in that: A feeding branch pipe is provided on the side wall of the straight pipe, and a fixing cap is provided at the upper end of the feeding branch pipe.

8. The experimental apparatus for drug synthesis reaction with temperature and pressure interlock protection function according to claim 1, characterized in that: The lower surface of the base is fitted with a counterweight.

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