Organ chip perfusion control equipment

Abstract

The utility model relates to the technical field of biomedical engineering, in particular to organ chip perfusion control equipment which comprises a controller, a protective shell is arranged on one side of the controller, a peristaltic pump is fixedly installed in the protective shell, a culture device is rotatably installed on one side of the peristaltic pump, and a control device is installed on the other side of the culture device. The utility model aims to provide the organ chip perfusion control equipment, a magnet block is arranged above a chip clamp base, a magnet is arranged at the bottom of a chip clamp, the chip clamp base is fixedly provided with a peristaltic pump, and the other side of the peristaltic pump is fixedly provided with a chip placing area. When the chip clamp needs to be used, the chip clamp can be rapidly fixed to the chip clamp base through the magnetic force of the magnet and can be continuously used, the pressure change in the perfusion process can be monitored in real time by installing and pressing the first sensor in the peristaltic pump, and when it is found that the flow and the pressure change in the perfusion process, the chip clamp is fixed to the chip clamp base through the first sensor. And the perfusion pressure can be timely fed back to the controller for adjustment, so that stable perfusion pressure is maintained, and continuous and effective operation can be ensured.

Description

TECHNICAL FIELD

[0001] The utility model relates to biomedical engineering technical field, concretely is a kind of organ chip perfusion control equipment. BACKGROUND

[0002] Organ chip is a kind of in vitro organ model constructed on microfluidic chip, it can simulate the microenvironment and physiological function of human organ, provide new platform for drug research and development, disease research etc. Through integrating cell culture, microfluidic channel etc. Structure on chip, realize the accurate control of intercellular interaction, material transport etc. Process.

[0003] The existing organ chip perfusion control equipment does not have fixing clamp, they are consumables directly screwed to organ chip with two screws, and the verticality cannot be maintained or coaxiality is poor during assembling process, which can cause uneven force on screw thread, cause some screw threads to be damaged due to excessive force, and as the use time is long, the stability effect of base thread will be weakened, so that the whole base cannot be used and needs to be replaced, and the replacement is expensive and inconvenient, which can additionally increase cost, and is not conducive to long-term use.

[0004] Therefore, the existing problems are researched and improved, and an organ chip perfusion control equipment is provided, which has reasonable structure design, high stability, and considers the use of all aspects, so as to solve the problems and improve the practical value through the technology. UTILITY MODEL CONTENTS

[0005] The utility model discloses a kind of organ chip perfusion control equipment, magnet block is installed above chip clamp base, magnet is installed at the bottom of chip clamp, the magnetic force of magnet can quickly fix chip clamp to chip clamp base when needing to use, and it can be used continuously, and by installing pressing first inductor in peristaltic pump, the pressure change in perfusion process can be monitored in real time, when finding that flow and pressure change in perfusion process, it can be fed back to controller in time to adjust, to maintain stable perfusion pressure, guarantee that can continue to effectively operate.

[0006] To achieve the above object, the utility model provides the following technical scheme: an organ chip perfusion control equipment, including controller, the side of the controller has protective shell, the inside of the protective shell is fixedly installed with peristaltic pump, the side of the peristaltic pump is rotatably installed with culture device, the other side of the peristaltic pump is fixedly installed with chip placement area;

[0007] The protective shell includes outer frame, the upper side of the outer frame is fixedly installed with anti-collision strip, the lower side of the outer frame is fixedly installed with a plurality of anti-skid blocks;

[0008] The culture device includes a culture medium fixing frame, a plurality of culture mediums are installed in the culture medium fixing frame, a clamping block is installed on one side of the culture medium fixing frame, a rotating damping shaft is installed in the clamping block, bolts are installed on one side of the rotating damping shaft, and a plurality of bolts are installed on the outer surface of the bolts.

[0009] The peristaltic pump includes a fixing block, and a first sensor is installed in the fixing block.

[0010] The chip placement area includes a chip clamp base, a magnet block is fixedly installed above the chip clamp base, a chip clamp is installed above the magnet block, an organ chip is in the chip clamp, a plurality of sealing openings are arranged above the organ chip, transparent plastic covers are arranged above the sealing openings, and hand screws are installed on the transparent plastic covers.

[0011] Preferably, the rotating damping shaft penetrates the outer frame.

[0012] Preferably, the hand screws penetrate the transparent plastic covers and the chip clamp and are installed.

[0013] Preferably, the clamping block penetrates the auxiliary block and is installed.

[0014] Preferably, the magnet block is opposite to the lower position of the chip clamp.

[0015] Compared with the prior art, the beneficial effects of the utility model are as follows: the magnet block is installed above the chip clamp base, the magnet is installed at the bottom of the chip clamp, the magnetic force of the magnet can quickly fix the chip clamp to the chip clamp base when the chip clamp is needed to be used, and the chip clamp can be continuously used, the first sensor is installed in the peristaltic pump, the pressure change in the perfusion process can be monitored in real time, when the flow and the pressure in the perfusion process are found to change, the controller can be adjusted in time to maintain stable perfusion pressure and ensure that the organ chip can continue to effectively operate, the second sensor is installed on the chip clamp base, the second sensor is installed on the base, whether the flow path leaks liquid can be determined, when the flow path is found to leak liquid, the control box can give an alarm sound prompt, and the display screen of the controller can also appear a prompt, and the flow path leak can be processed in time. BRIEF DESCRIPTION OF DRAWINGS

[0016] Figure 1 It is an overall structure schematic view of the organ chip perfusion control equipment.

[0017] Figure 2 It is a structure schematic view of the organ chip perfusion control equipment.

[0018] Figure 3 It is a parts view of the organ chip perfusion control equipment.

[0019] Figure 4 Parts drawing of the organ chip perfusion control equipment;

[0020] Figure 5 Parts drawing of the organ chip perfusion control equipment Figure 4 Partial enlarged view of part A;

[0021] Figure 6 Parts layout drawing of the organ chip perfusion control equipment;

[0022] Figure 7 Parts layout drawing of the organ chip perfusion control equipment Figure 6 Partial enlarged view of part B.

[0023] In the figure: 1, controller; 2, protective shell; 3, culture device; 4, peristaltic pump; 5, chip placement area; 201, outer frame; 202, anti-collision strip; 203, anti-skid block; 301, culture medium fixing frame; 302, culture medium; 303, auxiliary block; 304, bolt; 305, rotary damping shaft; 306, clamping block; 401, fixed block; 402, first sensor; 501, chip clamp base; 502, magnet block; 503, chip clamp; 504, organ chip; 505, hand screw; 506, transparent plastic cover; 507, sealing port; 508, second sensor. DETAILED DESCRIPTION

[0024] The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative labor fall within the scope of protection of the present application.

[0025] Please refer to Figures 1 to 7 The present application provides an organ chip perfusion control equipment, which comprises a controller 1, the controller 1 has a protective shell 2 on one side, the protective shell 2 is internally fixedly installed with a peristaltic pump 4, the peristaltic pump 4 is rotatably installed with a culture device 3 on one side, and the peristaltic pump 4 is fixedly installed with a chip placement area 5 on the other side.

[0026] The protective shell 2 comprises an outer frame 201, the outer frame 201 is fixedly installed with an anti-collision strip 202 above, and the outer frame 201 is fixedly installed with a plurality of anti-skid blocks 203 below.

[0027] The culture device 3 comprises a culture medium fixing frame 301, a plurality of culture media 302 are installed in the culture medium fixing frame 301, a clamping block 306 is installed on one side of the culture medium fixing frame 301, a rotating damping shaft 305 is installed in the clamping block 306, a plurality of bolts 304 are installed on one side of the rotating damping shaft 305, and the outer surface of the bolt 304 is installed with a plurality of bolts 304;

[0028] The peristaltic pump 4 comprises a fixing block 401, and a first sensor 402 is installed in the fixing block 401;

[0029] The chip placement area 5 comprises a chip clamp base 501, a magnet block 502 is fixedly installed above the chip clamp base 501, a chip clamp 503 is installed above the magnet block 502, an organ chip 504 is in the chip clamp 503, a plurality of sealing openings 507 are arranged above the organ chip 504, a transparent plastic cover 506 is arranged above the sealing openings 507, and a hand screw 505 is installed on the transparent plastic cover 506.

[0030] The organ chip 504 is placed on the chip clamp 503, the transparent plastic cover 506 is covered at this time, the pipe penetrating through the transparent chip cover 506 is in contact with the sealing opening on the chip clamp 503 due to the smooth back surface of the transparent plastic cover 506, and is in a tightly fitted state, so that the liquid is not leaked during transportation, the hand screw 505 is screwed at this time to press the transparent plastic cover 506, and the organ chip 504 is ensured to be stably installed, a magnet is arranged below the 503, the magnet block 502 is arranged on the chip clamp base 501 and below the chip clamp base 501, the chip clamp base 501 is quickly and stably installed due to the magnetic force between the magnets when the chip clamp base 501 is installed, the second sensor 508 is arranged on the chip clamp base 501, and the chip clamp base 501 is installed on the base, whether the flow path leaks liquid can be determined, when the flow path leaks liquid is found, the controller 1 emits an alarm sound prompt, and a prompt also appears on the display screen of the controller 1, so that the flow path leakage can be treated in time.

[0031] In an optional embodiment, the rotating damping shaft 305 penetrates through the outer frame 201, and the linkage between devices is increased.

[0032] In an optional embodiment, the hand screw 505 penetrates through the transparent plastic cover 506 and the chip clamp 503 to be installed, so that the device is more stable when rotating.

[0033] In an optional embodiment, the clamping block 306 penetrates through the auxiliary block 303 to be installed, so that the device is more smooth when operating.

[0034] In an alternative embodiment, the magnet block 502 is opposite to the lower position of the chip clamp 503, so that the device is more stable when in operation.

[0035] Working principle: after the device is placed, the circuit is connected, the organ chip 504 is placed on the chip clamp 503, and the transparent plastic cover 506 is covered, because the back of the transparent plastic cover 506 is smooth, the tube penetrating the transparent chip cover 506 will be in contact with the sealing port on the chip clamp 503, and belongs to the state of close contact, so that the liquid during transportation will not leak, at this time, the hand screw 505 is twisted to press the transparent plastic cover 506, and the organ chip 504 is installed stably, the magnet is arranged below the 503, the magnet block 502 is arranged on the chip clamp base 501, and the magnet block 502 is arranged below the chip clamp base 501, when the chip clamp base 501 is installed, the chip clamp base 501 is quickly and stably installed due to the magnetic force between the magnets, the second sensor 508 is arranged on the chip clamp base 501, and the chip clamp base 501 is arranged on the base, whether the flow path leaks liquid can be determined, and when the flow path leaks liquid is found, the controller 1 will issue an alarm sound prompt, and at the same time, the display screen of the controller 1 will also appear a prompt, so that the flow path leakage can be treated in time.

[0036] After the organ chip 504 is placed in the chip clamp 503, the controller 1 is started, when the controller 1 is started, the pump in the fluid delivery system can install the preset parameter, the liquid in the culture medium 302 is extracted, so as to be delivered to the organ chip 504, the first sensor 402 is installed in the peristaltic pump 4, the first sensor 402 can monitor the pressure change in the perfusion process in real time, when the flow and pressure change in the perfusion process are found, the controller can be fed back in time to adjust, so as to maintain stable perfusion pressure, and ensure that the device can continue to operate effectively.

[0037] Although the embodiments of the utility model have been shown and described, it can be understood by those skilled in the art that various changes, modifications, replacements and variations can be made to these embodiments without departing from the principles and spirits of the utility model, the scope of the utility model is defined by the appended claims and its equivalents.

Claims

1. An organ-chip perfusion control device comprising a controller (1), characterized in that, One side of the controller (1) has a protective shell (2), the inside of the protective shell (2) is fixedly installed with a peristaltic pump (4), one side of the peristaltic pump (4) is rotatably installed with a culture device (3), the other side of the peristaltic pump (4) is fixedly installed with a chip placement area (5); The protective shell (2) comprises an outer frame (201), the upper portion of the outer frame (201) is fixedly installed with an anti-collision strip (202), and the lower portion of the outer frame (201) is fixedly installed with a plurality of anti-skid blocks (203); The culture device (3) comprises a culture medium fixing frame (301), a plurality of culture media (302) are installed in the culture medium fixing frame (301), a clamping block (306) is installed on one side of the culture medium fixing frame (301), a rotary damping shaft (305) is installed in the clamping block (306), a bolt (304) is installed on one side of the rotary damping shaft (305), and a plurality of bolts (304) are installed on the outer surface of the bolt (304); The peristaltic pump (4) comprises a fixed block (401), and the fixed block (401) is installed with a first sensor (402); The chip placement area (5) comprises a chip clamp base (501), a magnet block (502) is fixedly installed on the upper portion of the chip clamp base (501), a chip clamp (503) is installed on the upper portion of the magnet block (502), an organ chip (504) is arranged in the chip clamp (503), a plurality of sealing openings (507) are arranged on the upper portion of the organ chip (504), a transparent plastic cover (506) is arranged on the upper portion of the sealing opening (507), and a hand screw (505) is installed on the transparent plastic cover (506).

2. The organ-chip perfusion control device according to claim 1, characterized in that The rotary damping shaft (305) penetrates the outer frame (201).

3. The organ-chip perfusion control device according to claim 1, wherein, The hand screw (505) penetrates the transparent plastic cover (506) and the chip clamp (503) and is installed.

4. The organ-chip perfusion control device according to claim 1, wherein, The clamping block (306) penetrates the auxiliary block (303) and is installed.

5. The organ-chip perfusion control device according to claim 1, wherein, The magnet block (502) is opposite to the lower portion of the chip clamp (503).

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