Kit for exosome extraction

Abstract

The utility model belongs to the technical field of medical equipment, and particularly relates to an exosome extraction kit which comprises a kit body, through grooves are formed in the left side and the right side of the kit body, two first reagent racks matched with the through grooves are arranged on the upper side of the kit body in a sliding mode, and a second reagent rack located in the middle is arranged on the lower side of the kit body. A gear is rotationally assembled in the middle of the box body, racks meshed with the gear are fixed to the two first reagent racks, the two racks are located on the upper side and the lower side of the gear respectively, a first spring is arranged between the bottom of the second reagent rack and the box body, and the upper end of the second reagent rack abuts against the bottoms of the two first reagent racks; two layers of reagent racks can be conveniently displayed at the same time, a worker can conveniently store and take reagent tubes, and the operation efficiency is greatly improved.

Description

TECHNICAL FIELD

[0001] The utility model belongs to the technical field of medical equipment, specifically relates to a kit for exosome extraction. BACKGROUND

[0002] As a kind of important biological function extracellular vesicle of cell, exosome shows tremendous application potential in disease diagnosis, drug research and development and basic biology research etc. With the continuous deepening of exosome research, the requirement of exosome extraction process is increasingly improved, and efficient, convenient and can guarantee the extraction tool of exosome activity and purity becomes the key requirement of research.

[0003] In the exosome extraction process, reagent is properly stored, suitable reagent storage device can not only ensure the quality and stability of reagent, but also improve the convenience and efficiency of experimental operation, however, there are some limitations in the structure design of existing reagent box, part reagent box structure is simple, reagent rack is fixed, and the operation space is limited when storing and taking reagent tube, it is difficult to simultaneously display multiple reagent racks, so that it is not convenient for operator to store and take reagent tube. UTILITY MODEL CONTENT

[0004] The utility model aims at providing a kind of kit for exosome extraction, to solve the problems presented in background art.

[0005] To achieve the above technical purpose, the technical scheme adopted by the utility model is as follows:

[0006] A kind of kit for exosome extraction, including box body, the left and right sides of the box body are provided with through slot, the upper side of the box body is slidably provided with two first reagent racks matched with through slot, the lower side of the box body is provided with second reagent rack located in middle part;

[0007] Gear is rotatably assembled in the middle part of the box body, two first reagent racks are fixed with rack engaged with gear, two rack are located on the upper and lower sides of gear respectively, first spring is arranged between the bottom of second reagent rack and the box body, and the upper end of second reagent rack is in abutment with the bottom of two first reagent racks.

[0008] Two first reagent rack outer sides are provided with pull groove.

[0009] The upper side wall of the first reagent rack is provided with sliding slot, and the box body is fixed with sliding block in the sliding slot.

[0010] Multi-stage telescopic rod is further arranged between the second reagent rack and the box body.

[0011] A positioning assembly is arranged between the second reagent rack and the box body, the positioning assembly comprises a mounting slot formed in the second reagent rack, a positioning block is slidably arranged in the mounting slot, a second spring is arranged between the positioning block and the mounting slot, the end of the positioning block is semicircular, and the box body is provided with a positioning groove matched with the positioning block.

[0012] A box cover is hingedly arranged at the upper end of the box body, the box cover and the box body are connected with each other through a lock buckle, and a handle is arranged at the upper end of the box cover.

[0013] Lock holes are formed in the upper ends of the two first reagent racks, and the box cover is provided with lock blocks matched with the lock holes.

[0014] The first reagent rack is fixedly provided with a mounting frame, a plurality of mounting holes are formed in the mounting frame, and a plurality of first elastic sheets are arranged on the outside of the mounting holes.

[0015] The first reagent rack is fixedly provided with a cylinder corresponding to the mounting hole, and a plurality of second elastic sheets are arranged in the cylinder.

[0016] The utility model discloses a gear is assembled in the middle part of box body, and the two first reagent racks are fixed with the rack engaged with the gear, when one of the first reagent racks is pulled to move to the outside, the other first reagent rack is driven to move to the outside synchronously through the gear, realizes that the two first reagent racks are away from each other, simultaneously, the second reagent rack at the bottom moves up under the first spring elasticity effect, and is in the same plane with the first reagent rack, and the two layers of reagent racks are conveniently displayed simultaneously, and the reagent pipe is convenient for staff to store and take, greatly improves operating efficiency. BRIEF DESCRIPTION OF DRAWINGS

[0017] The utility model can be further illustrated by the non-limiting embodiments shown in the drawings.

[0018] Figure 1 For the structure diagram of the utility model discloses a kind of exosome extraction kit embodiment Figure 1 ;

[0019] Figure 2 For the structure diagram of the utility model discloses a kind of exosome extraction kit embodiment Figure 2 ;

[0020] Figure 3 For the internal structure diagram of the utility model discloses a kind of exosome extraction kit embodiment;

[0021] Figure 4 For the sectional structure diagram of the utility model discloses a kind of exosome extraction kit embodiment;

[0022] Figure 5It is the structure schematic view of the first reagent frame of the utility model;

[0023] Figure 6 It is the section structure schematic view of the second reagent frame of the utility model;

[0024] Figure 7 It is Figure 6 The structure enlarged schematic view of A in the middle.

[0025] The main element symbol explanation is as follows:

[0026] Box body 1, slider 101, positioning groove 102, first reagent frame 11, pull groove 111, sliding groove 112, lock hole 113, second reagent frame 12, multistage telescopic rod 121, installation groove 122, positioning block 123, second spring 124, gear 13, rack 14, first spring 15, box cover 2, handle 21, lock block 22, mounting frame 3, mounting hole 31, first spring 32, cylinder 33, second spring 34. Specific implementation

[0027] In order to make the person skilled in the art can better understand the utility model, the utility model technical scheme is further explained below in conjunction with the drawings and examples.

[0028] As Figures 1-7 The utility model discloses a reagent box for exosome extraction, which comprises a box body 1, and the left and right sides of the box body 1 are provided with through grooves.

[0029] The gear 13 is rotationally assembled in the middle of the box body 1, the two first reagent frames 11 are fixedly provided with the rack 14 engaged with the gear 13, the two racks 14 are located on the upper and lower sides of the gear 13 respectively, the first spring 15 is arranged between the bottom of the second reagent frame 12 and the box body 1, and the upper end of the second reagent frame 12 abuts against the bottom of the two first reagent frames 11.

[0030] In the initial state, the two first reagent frames 11 abut against each other and are located on the upper side of the second reagent frame 12, the upper end of the second reagent frame 12 abuts against the bottom of the two first reagent frames 11, the side walls of the two first reagent frames 11 block the through grooves of the box body 1 and form a same plane, and the two first reagent frames 11 are used to constitute the outer side wall of the box body 1, so as to ensure that the product appearance is neat and can prevent foreign matters from entering the box body 1 through the through grooves of the box body 1.

[0031] The first reagent rack 11 and the second reagent rack 12 are rack bodies for storing reagent tubes, in actual use, one of the first reagent racks 11 can be pulled to move outward, since the two first reagent racks 11 are both fixed with the gear racks 14 engaged with the gear 13, and the two gear racks 14 are located on the upper and lower sides of the gear 13 respectively, when one of the first reagent racks 11 moves outward, the other first reagent rack 11 can be driven to move outward synchronously through the gear 13, then the two first reagent racks 11 will move away from each other until the bottoms of the two first reagent racks 11 are not in contact with the second reagent rack 12, so the distance between the two first reagent racks 11 is greater than the length of the second reagent rack 12, therefore the second reagent rack 12 can move upward to extend into the space between the two first reagent racks 11 under the elastic force of the first spring 15, and the second reagent rack 12 is kept in the same horizontal plane with the two first reagent racks 11, so that the reagent tubes with excretory bodies can be conveniently stored on the first reagent rack 11 and the second reagent rack 12;

[0032] When resetting, the second reagent rack 12 in the middle is first pressed downward so that its upper end is lower than the bottom of the first reagent rack 11, then the first reagent rack 11 in the middle is pushed, the two first reagent racks 11 move relative to each other to block the upper end of the second reagent rack 12 so that it cannot move upward, until the two first reagent racks 11 abut against each other, then the elastic force of the first spring 15 pushes the second reagent rack 12 upward to form a pushing force on the first reagent rack 11, so that the two first reagent racks 11 cannot slide randomly;

[0033] Such design can move the two first reagent racks 11 away from each other, the second reagent rack 12 at the bottom can move upward to be in the same plane with the first reagent rack 11, which facilitates the operation of storing and taking reagent tubes from the second reagent rack 12, that is, two layers of reagent racks can be displayed at the same time, which improves the practicability of the device under the condition of the volume of the box body 1.

[0034] The outer side of each of the two first reagent racks 11 is provided with a pull slot 111, so that the operator can put his fingers into the pull slot 111 to pull the first reagent rack 11 to move, which is convenient for the operator to use.

[0035] The upper side wall of the first reagent rack 11 is provided with a sliding groove 112, and the box body 1 is fixed with a sliding block 101 located in the sliding groove 112; the first reagent rack 11 slides in the sliding groove 112 through the sliding block 101, realizing the sliding connection between the first reagent rack 11 and the box body 1, which can limit the first reagent rack 11 and prevent it from completely leaving the box body 1.

[0036] The second reagent rack 12 is further provided with a plurality of telescopic rods 121 between the second reagent rack 12 and the box body 1; the plurality of telescopic rods 121 are arranged to limit the second reagent rack 12, and the maximum position of upward movement of the second reagent rack 12 is the position where the second reagent rack 12 is at the same horizontal position as the first reagent rack 11.

[0037] The second reagent rack 12 is further provided with a positioning assembly between the second reagent rack 12 and the box body 1, the positioning assembly comprising a mounting groove 122 arranged on the second reagent rack 12, a positioning block 123 slidingly arranged in the mounting groove 122, a second spring 124 arranged between the positioning block 122 and the mounting groove 122, the end of the positioning block 122 being semicircular, and the box body 1 being provided with a positioning groove 102 matched with the positioning block 122; when the second reagent rack 12 is located at the bottom of the box body 1, the positioning block 123 abuts against the sidewall of the box body 1, so that the second spring 124 is compressed; when the second reagent rack 12 moves upward to the same horizontal position as the first reagent rack 11, the positioning block 123 is aligned with the positioning groove 102, and the elastic force of the second spring 124 pushes the positioning block 123 to extend into the positioning groove 102; only the semicircular end of the positioning block 123 extends into the positioning groove 102, so as to position the second reagent rack 12 and keep it at the position; when the second reagent rack 12 is pushed downward to reset, the operator only needs to force the semicircular end of the positioning block 123 to move away from the positioning groove 102 and overcome the elastic force of the first spring 15.

[0038] The box cover 2 is hingedly connected to the upper end of the box body 1, the box cover 2 and the box body 1 are connected to each other through a lock catch, and the box cover 2 is provided with a handle 21 at the upper end; the box cover 2 is used for covering the upper end of the box body 1, so as to facilitate storage of the reagent tubes; the box cover 2 and the box body 1 are connected through the lock catch, so that the operator needs to contact the connection of the lock catch to turn and open the box cover 2, and the handle 21 arranged at the upper end of the box cover 2 facilitates the operator to transport the box body 1.

[0039] The two first reagent racks 11 are provided with lock holes 113 at the upper ends, and the box cover 2 is provided with lock blocks 22 matched with the lock holes; when the two first reagent racks 11 abut against each other, the box cover 2 covers the upper end of the box body 1 downward, and the lock blocks 22 arranged on the box cover 2 extend into the lock holes 113 of the first reagent racks 11, so as to lock the first reagent racks 11; when the box cover 2 is in the covering state, the first reagent racks 11 cannot be pulled to move, and the first reagent racks 11 will not be automatically opened during the transportation process, so that the structure design is reasonable.

[0040] The middle part of the first reagent rack 11 is fixed with a mounting rack 3, the mounting rack 3 is provided with a plurality of mounting holes 31 which are uniformly distributed, and the bottom of the mounting rack 3 is provided with a plurality of first elastic sheets 32 which are uniformly distributed outside the mounting holes 31; the first reagent rack 11 and the second reagent rack 12 are the same in structure, when the reagent tube is installed, the reagent tube extends into the bottom of the first reagent rack 11 through the mounting hole 31, and the bottom of the mounting rack 3 is provided with a plurality of first elastic sheets 32 which are uniformly distributed outside the mounting hole 31. When the reagent tube extends into the mounting hole 31 downwards, the first elastic sheet 32 will be forced to open outward and be deformed, then the elastic force of the plurality of first elastic sheets 32 can clamp the reagent tube and fix the reagent tube on the mounting rack 3, so that the installation of the reagent tube is facilitated.

[0041] The bottom of the first reagent rack 11 is fixed with a cylinder 33 corresponding to the mounting hole 31, and the cylinder 33 is provided with a plurality of second elastic sheets 34 which are uniformly distributed; the bottom of the reagent tube extends into the cylinder 33, and the bottom of the reagent tube is clamped by the plurality of second elastic sheets 34 in the cylinder 33. Such a design can clamp the middle part and the bottom of the reagent tube at the same time, prevent the reagent tube from being tilted, and be suitable for reagent tubes of different sizes, and the practicability is higher.

[0042] The above embodiments only exemplarily illustrate the principle and effect of the present application, and are not used to limit the present application. Any person skilled in the art can modify or change the above embodiments without departing from the spirit and scope of the present application. Therefore, all equivalent modifications or changes completed by those skilled in the art without departing from the spirit and technical thought of the present application should be covered by the claims of the present application.

Claims

1. A kit for exosome extraction, comprising a case, characterized by: Both sides of the box are provided with through grooves, the upper side of the box is slidably provided with two first reagent racks matched with the through grooves, and the lower side of the box is provided with a second reagent rack located at the middle part; The middle part of the box is rotationally provided with a gear, both the first reagent racks are fixedly provided with a rack engaged with the gear, both the racks are located at the upper and lower sides of the gear, a first spring is arranged between the bottom of the second reagent rack and the box, and the upper end of the second reagent rack abuts against the bottom of the two first reagent racks.

2. The kit for exosome extraction according to claim 1, characterized by: Both sides of the two first reagent racks are provided with pull grooves.

3. The kit for exosome extraction according to claim 2, characterized in that: The upper side wall of the first reagent rack is provided with a sliding groove, and the box is fixedly provided with a sliding block located in the sliding groove.

4. The kit for exosome extraction according to claim 3, characterized by: The second reagent rack and the box are further provided with a multi-stage telescopic rod.

5. The kit for exosome extraction according to claim 4, characterized in that: The second reagent rack and the box are provided with a positioning assembly, the positioning assembly comprises a mounting groove provided in the second reagent rack, a positioning block slidably arranged in the mounting groove, a second spring arranged between the positioning block and the mounting groove, a semicircular end of the positioning block, and a positioning groove matched with the positioning block and arranged in the middle part of the box.

6. The kit for exosome extraction according to claim 5, characterized in that: The upper end of the box is hingedly connected with a box cover, the box cover and the box are connected with each other through a lock buckle, and the upper end of the box cover is provided with a handle.

7. The kit for exosome extraction according to claim 6, characterized in that: The upper end of the two first reagent racks is provided with a lock hole, and the box cover is provided with a lock block matched with the lock hole.

8. The kit for exosome extraction according to claim 7, characterized in that: The middle part of the first reagent rack is fixedly provided with a mounting rack, the mounting rack is provided with a plurality of uniformly distributed mounting holes, and the bottom of the mounting rack is provided with a plurality of first elastic sheets uniformly distributed outside the mounting holes.

9. The kit for exosome extraction according to claim 8, characterized in that: The bottom of the first reagent rack is fixedly provided with a cylinder corresponding to the mounting hole, and the cylinder is provided with a plurality of uniformly distributed second elastic sheets.

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