Chromatographic column parallel connection structure for chromatographic instrument

Abstract

The utility model relates to the technical field of chromatographic columns, in particular to a chromatographic column parallel connection structure for a chromatographic instrument, which comprises a first guide pipe and a second guide pipe which are oppositely arranged, connecting rods are fixed on opposite side walls of the first guide pipe and the second guide pipe, a detector is fixedly arranged at the bottom end of the second guide pipe in a penetrating manner, and the bottom end of the second guide pipe is provided with a connecting rod. The connecting rod is fixedly connected with a concave seat, and the concave seat is provided with a pair of fixing plates for fixing a chromatographic column; the device further comprises a driving structure, the driving structure is arranged on the concave base, and the driving structure is used for driving the two fixing plates to synchronously and horizontally move. Through the arrangement of the driving structure and the fixing plate, compared with the use of the chromatographic columns, mechanical linkage clamping and valve shunt control in the prior art, independent replacement and parallel work of the chromatographic columns are realized, the installation stability of the chromatographic columns is ensured, the interruption of the detection process is avoided, and the detection efficiency and the equipment utilization rate are improved.

Description

Technical Field

[0001] This utility model relates to the field of chromatography column technology, and in particular to a parallel structure of chromatography columns for chromatography instruments. Background Technology

[0002] In the field of drug development and quality control, high-performance liquid chromatography (HPLC) is an important tool in modern analytical chemistry. Its analytical efficiency and quality directly determine the new drug development cycle and the level of production quality control.

[0003] Current chromatographic analysis systems generally adopt a single-column direct-connection design, which achieves quick connection through threaded connectors. This design offers advantages such as simple structure, low cost, and convenient operation. However, because the column is fixed solely by a simple threaded connection, leakage is prone to occur under high-pressure mobile phase, affecting detection accuracy and potentially distorting experimental data. Furthermore, the single-column structure requires a complete interruption of the detection process when replacing the column, causing equipment downtime and significantly reducing work efficiency. Utility Model Content

[0004] The purpose of this invention is to solve the problems in the prior art where chromatographic columns are fixed by simple threaded connections, which are prone to leakage under high-pressure mobile phase, affecting detection accuracy and potentially causing data distortion. In addition, the single-column structure requires a complete interruption of the detection process when changing the column, causing equipment downtime and significantly reducing work efficiency. Therefore, this invention proposes a parallel structure for chromatographic columns.

[0005] To achieve the above objectives, the present invention adopts the following technical solution:

[0006] A parallel structure for a chromatographic column includes a guide tube one and a guide tube two arranged opposite to each other. A connecting rod is fixed on the opposite sidewall of the guide tube one and the guide tube two. A detector is fixedly passed through the bottom end of the guide tube two. A concave seat is fixedly connected to the connecting rod. A pair of fixing plates for fixing the chromatographic column are provided on the concave seat.

[0007] Also includes:

[0008] A driving structure is provided on the concave seat, and the driving structure is used to drive the two fixed plates to move horizontally synchronously.

[0009] Preferably, the drive structure includes a bidirectional lead screw rotatably connected to the concave seat, a pair of movable plates threaded onto the bidirectional lead screw, one end of the bidirectional lead screw extending to the outside of the concave seat and fixedly connected to a transmission rod, one end of the transmission rod fixedly connected to a wheel, a horizontal plate fixedly connected to the concave seat, a set screw threaded onto the horizontal plate and in contact with the transmission rod, and short shafts fixedly connected to the opposite sidewalls of the two movable plates, the short shafts being fixedly connected to the fixed plate.

[0010] Preferably, the guide pipe includes a first branch pipe, a tee pipe and a second branch pipe that are connected to each other in sequence. A rubber plug is installed on the top of the tee pipe, and two valves are installed on the tee pipe respectively. The valves are used to control the flow direction.

[0011] Preferably, the connecting rods are arranged in pairs, and the concave seat is arranged on the opposite sides of the two connecting rods.

[0012] Preferably, the concave seat has a sliding groove, and the moving plate and the sliding groove are horizontally slidably connected.

[0013] Preferably, a pair of support legs are fixedly connected to the bottom of the second guide tube.

[0014] Compared with the prior art, the advantages of this utility model are as follows:

[0015] This invention, through the configuration of a drive structure and fixing plates, allows the rotating wheels to move the two fixing plates synchronously towards each other, clamping the chromatographic column between guide tube one and guide tube two. When a column needs to be replaced, simply adjust the corresponding valve on the three-way valve to cut off the mobile phase in that path, allowing for the individual removal and replacement of the target column while the other column continues to operate normally. Through mechanical linkage clamping and valve diversion control, independent replacement and parallel operation of the chromatographic column are achieved, ensuring the stability of the column installation, avoiding interruptions in the detection process, and improving detection efficiency and equipment utilization. Attached Figure Description

[0016] Figure 1 This is a schematic diagram of the overall structure of a parallel chromatographic column for a chromatograph proposed in this utility model;

[0017] Figure 2 This is a schematic diagram of the fixed structure in the parallel structure of a chromatographic column for a chromatographic instrument proposed in this utility model;

[0018] Figure 3 for Figure 1 Enlarged view of point A in the middle.

[0019] In the picture:

[0020] 1. Guide tube one; 101. Diverter tube one; 102. Diverter tube two; 103. T-connector; 104. Rubber plug; 105. Valve; 2. Guide tube two; 3. Connecting rod; 4. Detector; 5. Support leg; 6. Concave seat; 61. Two-way lead screw; 62. Moving plate; 63. Transmission rod; 64. Horizontal plate; 65. Top screw; 66. Rotary wheel; 67. Short shaft; 68. Slide groove; 7. Fixed plate. Detailed Implementation

[0021] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments of the present utility model. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments.

[0022] Reference Figures 1-3 A parallel chromatographic column structure for a chromatogram includes a guide tube 1 and a guide tube 2 arranged opposite to each other. The symmetrical guide tube design (guide tube 1 and guide tube 2) is secured by a rigid connecting rod 3, effectively ensuring the coaxiality of the chromatographic column installation. Connecting rods 3 are fixed to the opposite sidewalls of guide tube 1 and guide tube 2. A detector 4 is fixedly connected to the bottom end of guide tube 2. The detector 4 detects the separated components of the chromatographic column in real time, converting the chemical signal into an electrical signal to achieve highly sensitive and rapid qualitative and quantitative analysis. The detector 4 is typically a high-performance liquid chromatography (HPLC) detector, including but not limited to: UV-VIS (ultraviolet-visible detector), DAD (diode array detector), and RID (refractive index detector), which are existing and mature technologies and will not be described in detail here. A concave seat 6 is fixedly connected to the connecting rod 3, and a pair of fixing plates 7 for fixing the chromatographic column are provided on the concave seat 6. The adjustable spacing of the fixing plates 7, combined with the short shaft 67 connection method, allows for the rapid clamping of chromatographic columns of different specifications.

[0023] Also includes:

[0024] The drive structure is mounted on the concave seat 6 and is used to drive the two fixed plates 7 to move horizontally synchronously.

[0025] The drive structure includes a bidirectional lead screw 61 rotatably connected to a concave seat 6. A movable plate 62 is threaded onto the bidirectional lead screw 61. One end of the bidirectional lead screw 61 extends to the outside of the concave seat 6 and is fixedly connected to a transmission rod 63. One end of the transmission rod 63 is fixedly connected to a rotating wheel 66. The relative movement of the two fixed plates 7 can be achieved by operating the rotating wheel 66, ensuring the fixed clamping of the chromatographic column. A horizontal plate 64 is fixedly connected to the concave seat 6. A set screw 65 is threaded onto the horizontal plate 64 and contacts the transmission rod 63. The set screw 65 is provided to lock the transmission rod 63, thereby preventing the bidirectional lead screw 61 from rotating on its own. Short shafts 67 are fixed to the opposite side walls of the two movable plates 62, and the short shafts 67 are fixedly connected to the fixed plates 7.

[0026] The guide pipe 1 includes a first branch pipe 101, a tee pipe 103, and a second branch pipe 102 that are sequentially connected to each other. A rubber plug 104 is installed on the top of the tee pipe 103, and two valves 105 are installed on the tee pipe 103. The valves 105 are used to control the flow direction. The three-section flow-dividing structure (first branch pipe 101 + tee pipe 103 + second branch pipe 102), combined with the top rubber plug 104 and the double valves 105, can realize fluid diversion control and facilitate system sealing and maintenance.

[0027] The connecting rods 3 are arranged in pairs, and the concave seat 6 is arranged on the opposite sides of the two connecting rods 3.

[0028] The concave seat 6 has a sliding groove 68, and the movable plate 62 is horizontally slidably connected to the sliding groove 68. The sliding groove 68 ensures the smooth movement and positioning accuracy of the movable plate 62.

[0029] The bottom of the guide tube 2 is fixedly connected to a pair of support legs 5.

[0030] The functional principle of this utility model can be explained through the following operation methods:

[0031] First, insert guide tube 1 and guide tube 2 into both ends of the chromatographic column, respectively.

[0032] The rotating wheel 66 drives the transmission rod 63 to rotate the bidirectional lead screw 61, which in turn drives the two moving plates 62 to move synchronously towards each other along the slide groove 68. The short shaft 67 pushes the fixed plate 7 to clamp the chromatographic column, and the set screw 65 is tightened to hold the transmission rod 63 in place to achieve locking.

[0033] Then, the rubber stopper 104 is removed, and the sample is injected into the top of the three-way tube 103. The split ratio is controlled by adjusting the two valves 105, so that the sample is evenly distributed to the parallel chromatographic column through the first split tube 101 and the second split tube 102. The separated components are collected through the second guide tube 2 and enter the detector 4 for analysis. The support leg 5 ensures the stability of the device.

[0034] When changing the chromatographic column, loosen the set screw 65 and rotate the wheel 66 in the opposite direction to release the fixation. The symmetrical design of the connecting rod 3 and the concave seat 6 ensures structural rigidity, keeps the two chromatographic columns parallel and aligned, and ensures split accuracy.

[0035] The entire operation process achieves rapid clamping and precise positioning of the chromatographic column through mechanical linkage, and valve 105 can flexibly adjust the split mode to meet different separation needs.

[0036] The above description is only a preferred embodiment of the present utility model, but the protection scope of the present utility model is not limited thereto. Any equivalent substitutions or changes made by those skilled in the art within the technical scope disclosed in the present utility model, based on the technical solution and the inventive concept of the present utility model, should be included within the protection scope of the present utility model.

Claims

1. A parallel connection structure of chromatographic columns for chromatographs, comprising oppositely arranged guide pipe one (1) and guide pipe two (2), characterized in that, The connecting rod (3) is fixed on the opposite side walls of the guide pipe one (1) and the guide pipe two (2), the detector (4) is fixed through the bottom end of the guide pipe two (2), the concave seat (6) is fixedly connected on the connecting rod (3), a pair of fixing plates (7) for fixing the chromatographic column are arranged on the concave seat (6); Also include: The driving structure is arranged on the concave seat (6), and the driving structure is used for driving two fixing plates (7) to move horizontally synchronously.

2. The parallel connection structure of chromatographic columns for chromatographs according to claim 1, characterized in that, The driving structure includes a bidirectional screw rod (61) rotatably connected on the concave seat (6), a pair of moving plates (62) are threadedly connected on the bidirectional screw rod (61), one end of the bidirectional screw rod (61) extends to the outside of the concave seat (6) and is fixedly connected with a transmission rod (63), one end of the transmission rod (63) is fixedly connected with a rotating wheel (66), a cross plate (64) is fixedly connected on the concave seat (6), a jackscrew (65) is threadedly connected on the cross plate (64), and the jackscrew (65) and the transmission rod (63) are in contact, short shafts (67) are fixedly connected on the opposite side walls of the two moving plates (62), and the short shafts (67) and the fixing plates (7) are fixedly connected.

3. The parallel connection structure of chromatographic columns for chromatographs according to claim 1, characterized in that, The guide pipe one (1) includes a shunt pipe one (101), a three-way pipe (103) and a shunt pipe two (102) which are sequentially and mutually penetrated, the rubber plug (104) is installed on the top of the three-way pipe (103), two valves (105) are respectively installed on the three-way pipe (103), and the valves (105) are used for controlling the flow direction.

4. The parallel connection structure of chromatographic columns for chromatographs according to claim 1, characterized in that, The connecting rod (3) is arranged in pairs, and the concave seat (6) is arranged on the opposite sides of the two connecting rods (3).

5. The parallel connection structure of chromatographic columns for chromatographs according to claim 2, characterized in that, The sliding groove (68) is arranged on the concave seat (6), and the moving plate (62) and the sliding groove (68) are horizontally and slidably connected.

6. The parallel connection structure of chromatographic columns for chromatographs according to claim 1, characterized in that, The pair of supporting legs (5) are fixedly connected to the bottom of the guide pipe two (2).

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