Biological sample library tube picking equipment

Abstract

The utility model provides biological sample library tube picking equipment, and relates to the field of biological medical equipment, and the biological sample library tube picking equipment comprises a box body, a cryopreservation box bracket, a positioning slide rail system, a tube picking mechanism and a power system. According to the equipment, a positioning slide rail system consisting of orthogonal slide rails is arranged in the box body, so that a frozen storage tube sample is accurately positioned, and a target sample frozen storage tube is picked and taken out in cooperation with jacking of the tube picking mechanism. The storage cavity and the temperature detection element of the box body are beneficial to keeping the low-temperature environment of the box body and ensuring the sample safety. The tube picking equipment is simple in structure, convenient to operate and accurate in positioning, the biological sample taking efficiency can be improved, and the manual operation cost is reduced.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of biological medical equipment, in particular to a biological sample bank tube picking device. BACKGROUND

[0002] The biological sample bank is an important infrastructure for modern medical research and drug development, and the biological samples stored therein need to be preserved and used in a low-temperature environment. The traditional sample (cryopreservation tube) taking method mainly relies on manual operation, which is not only low in efficiency, but also easy to affect the sample quality due to the change of environmental temperature. The existing automatic equipment is often complex in structure and high in cost, which is not conducive to popularization and use. Therefore, it is of great significance to develop a biological sample bank tube picking device which is simple in structure, convenient in operation and moderate in cost. CONTENT OF THE INVENTION

[0003] The present application provides a biological sample bank tube picking device which is simple in structure and convenient in operation, and can accurately position and quickly take out the target sample in a low-temperature environment. The technical scheme is as follows:

[0004] A biological sample bank tube picking device, comprising: a box body, a cryopreservation box holder, a positioning sliding rail system, a tube picking mechanism and a power system;

[0005] The box body is provided with an openable box cover at the top;

[0006] The cryopreservation box holder is arranged in the upper space in the box body and is used for supporting the sample cryopreservation box; the sample cryopreservation box has a plurality of rows and columns of sample tube placement grids;

[0007] The positioning sliding rail system is installed below the cryopreservation box holder and comprises:

[0008] An X-axis sliding rail is horizontally arranged and slidably connected to the first pair of side walls of the box body at both ends;

[0009] A Y-axis sliding rail is arranged perpendicularly to the X-axis sliding rail and slidably connected to the second pair of side walls of the box body at both ends;

[0010] A first through-hole sliding groove is arranged on the X-axis sliding rail in the transverse direction to guide the movement of the tube picking mechanism in the transverse direction; a second through-hole sliding groove is arranged on the Y-axis sliding rail in the longitudinal direction to guide the movement of the tube picking mechanism in the longitudinal direction; and the positioning sliding rail system is used for accurately positioning the position of the target sample;

[0011] The tube picking mechanism is arranged on the positioning sliding rail system and is used for picking out the target sample from the cryopreservation box;

[0012] The power system is used for driving the tube picking mechanism to move in the X-axis and Y-axis directions.

[0013] Further, the tube picking mechanism comprises a top rod, a lifting bottom plate and an operating rod.

[0014] The top rod penetrates the X-axis slide rail and the Y-axis slide rail along the vertical direction and is arranged on the through-hole sliding groove at the intersection of the X-axis slide rail and the Y-axis slide rail; the top of the top rod is provided with a top head for lifting the target sample;

[0015] The lifting bottom plate is arranged below the positioning slide rail system, and in the state of not lifting the tube, the lifting bottom plate is separated from the bottom of the top rod and does not contact; in the state of lifting the tube, the lifting bottom plate contacts the bottom of the top rod;

[0016] The operating rod is connected to the lifting bottom plate at one end and extends to the outside of the box body at the other end, and is used for controlling the lifting and lowering of the top rod.

[0017] Further, the operating rod is movably connected to the box body through a hinge point, and the operating rod extending to the end of the outer wall of the box body is provided as an operating handle for manual operation by an operator; the outer wall of the box body is provided with a guide groove for reciprocating movement of the operating handle.

[0018] Further, the power system comprises a first driver and a second driver, the first driver is used for driving the top rod to move in the transverse direction of the X-axis slide rail, and the second driver is used for driving the top rod to move in the longitudinal direction of the Y-axis slide rail.

[0019] Further, the first driver and the second driver are both linear drivers.

[0020] Further, the size of the top head is greater than the width of the through-hole sliding groove, so that the top rod can be moved to the position of the target sample along the through-hole sliding groove without falling off.

[0021] Further, a reset spring member is further arranged between the top rod and the lifting bottom plate, one end of the reset spring member is connected to the inner wall of the box body, and the other end of the reset spring member is connected to the lifting bottom plate; preferably connected to the side of the lifting bottom plate; the reset spring member is used for automatically resetting the lifting bottom plate and the operating rod after the tube lifting mechanism operates to lift the tube.

[0022] Further, the X-axis slide rail is provided with a sliding block at both ends; the Y-axis slide rail is provided with a sliding block at both ends; and the sliding blocks are in sliding fit with the inner wall of the box body.

[0023] Further, the box body is further provided with a storage cavity for placing dry ice; and the storage cavity is provided with a sealing cover to prevent the dry ice in the storage cavity from evaporating too quickly.

[0024] Further, the box body is further provided with a temperature detection element, and the outer wall of the box body is further provided with a display control panel, and the display control panel is electrically connected to the temperature detection element.

[0025] The application relates to a biological sample bank tube picking device, which comprises a box body, a cryopreservation box bracket, a positioning slide rail system, a tube picking mechanism and a power system. The device realizes accurate positioning of a frozen storage tube sample (a cryopreservation tube sample) by arranging the positioning slide rail system composed of orthogonal slide rails in the box body, and realizes picking and taking out of a target sample cryopreservation tube by cooperating with the jacking of the tube picking mechanism. The storage cavity of the box body and the temperature detection element are beneficial to maintaining a low-temperature environment of the box body and ensuring the safety of the sample. The tube picking device is simple in structure, convenient to operate and accurate in positioning, can improve the biological sample taking efficiency and reduce the labor operation cost. BRIEF DESCRIPTION OF DRAWINGS

[0026] In order to more clearly illustrate the technical solutions in the embodiments of the present application or the prior art, the drawings needed to be used in the embodiments or the prior art description will be briefly introduced. Obviously, the drawings in the following description are only some embodiments described in the present application, and other drawings can be obtained by those skilled in the art without creative labor.

[0027] Figure 1 It is an appearance schematic view of the biological sample bank tube picking device of the present application.

[0028] Figure 2 It is an appearance schematic view of the biological sample bank tube picking device of the present application. Figure 1 It is a schematic view of the internal structure of the tube picking device (tube picking state).

[0029] Figure 3 It is a schematic view of the internal structure of the tube picking device (tube picking state). Figure 1 It is a schematic view of the internal structure of the tube picking device (tube picking state).

[0030] Figure 4 It is a top view of the tube picking device. Figure 3

[0031] It is a top view of the internal structure of the tube picking device. Figure 5 Figure 4

[0032] Among them, 10, the box body, 11, the box cover, 20, the positioning slide rail system, 21, the X-axis slide rail, 22, the Y-axis slide rail, 30, the tube picking mechanism, 31, the jacking rod, 32, the jacking bottom plate, 33, the operating rod, 34, the operating handle, 35, the hinge point, 36, the reset spring piece, 40, the cryopreservation tube. DETAILED DESCRIPTION

[0033] ​​In order for those skilled in the art to better understand the technical solutions in the present application, the technical solutions in the embodiments of the present application will be clearly and completely described below. Obviously, the described embodiments are only part of the embodiments of the present application, not all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative labor fall within the scope of protection of the present application.

[0034] It should be noted that when an element is referred to as being "fixed to" or "disposed on" another element, it can be directly on the other element or indirectly disposed on the other element; when an element is referred to as being "connected to" another element, it can be directly connected to the other element or indirectly connected to the other element.

[0035] It should be understood that the terms "length", "width", "upper", "lower", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", and the like indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings, and are only for the convenience of describing the present application and simplifying the description, and do not indicate or imply that the indicated biological sample bank pipette device or element must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as limiting the present application.

[0036] In addition, the terms "first", "second", "third", etc. are only used for descriptive purposes and cannot be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features defined with "first", "second", etc. can explicitly or implicitly include one or more of the features. In the description of the present application, the meaning of "a plurality of" or "several" is two or more, unless otherwise explicitly specified.

[0037] It should be understood that the structures, proportions, sizes, etc. shown in the drawings of the present specification are only used to cooperate with the content disclosed in the specification, to enable those skilled in the art to understand and read, and are not used to limit the conditions that can be implemented by the present application, and therefore do not have technical significance. Any modification of structure, change of proportion relationship or adjustment of size, which does not affect the effects that can be produced by the present application and the purposes that can be achieved, should still fall within the scope of the technical content disclosed by the present application.

[0038] The embodiments of the present application are written in a progressive manner.

[0039] Referring to Figures 1 to 5 As shown in the drawings, a biological sample bank pipette device comprises a box body, a cryopreservation box holder, a positioning slide rail system, a pipette mechanism and a power system.

[0040] The box body is provided with an openable box cover on the top;

[0041] The cryotube holder is arranged in the upper space of the box body and used for supporting the sample cryotube; the sample cryotube has a plurality of rows and columns of sample tube placement grids.

[0042] The positioning slide rail system is arranged below the cryotube holder and comprises:

[0043] The X-axis slide rail is horizontally arranged and slidably connected to the first pair of side walls of the box body at both ends.

[0044] The Y-axis slide rail is arranged perpendicularly to the X-axis slide rail and slidably connected to the second pair of side walls of the box body at both ends.

[0045] The X-axis slide rail is provided with a transverse first through-hole sliding groove for guiding the movement of the pipetting mechanism in the transverse direction; the Y-axis slide rail is provided with a longitudinal second through-hole sliding groove for guiding the movement of the pipetting mechanism in the longitudinal direction; and the positioning slide rail system is used for accurately positioning the position of the target sample.

[0046] The pipetting mechanism is arranged on the positioning slide rail system and used for picking out the target sample from the cryotube.

[0047] The power system is used for driving the pipetting mechanism to move in the X-axis and Y-axis directions.

[0048] The cryotube holder has a relatively simple structure, and as a feasible way, the cryotube holder comprises a frame structure holder main body, the frame structure holder main body is provided with a positioning groove for limiting and fixing the position of the sample cryotube; and the edge of the holder main body is provided with a connecting lug plate connected to the wall plate of the box body.

[0049] The pipetting mechanism comprises a top rod, a lifting bottom plate and an operating rod.

[0050] The top rod penetrates the X-axis slide rail and the Y-axis slide rail along the vertical direction (Z-axis direction) and is arranged on the through-hole sliding groove at the intersection of the X-axis slide rail and the Y-axis slide rail; the top of the top rod is provided with a top head for picking up the target sample.

[0051] The lifting bottom plate is arranged below the positioning slide rail system, and in the state of not picking up the tube, the lifting bottom plate is separated from the bottom of the top rod and does not contact; in the state of picking up the tube, the lifting bottom plate contacts the bottom of the top rod.

[0052] The operating rod is connected to the lifting bottom plate at one end and extends to the outside of the box body at the other end, and is used for controlling the lifting of the top rod.

[0053] The power system comprises a first driver and a second driver, the first driver is used for driving the top rod to move in the transverse direction of the X-axis slide rail; and the second driver is used for driving the top rod to move in the longitudinal direction of the Y-axis slide rail. The first driver and the second driver are both linear drivers.

[0054] The size of the top head is larger than the width of the through hole sliding groove, so that the top rod can move along the through hole sliding groove to the target sample position without falling. The operating rod is movably connected to the box body through a hinge point, and the operating rod extending to the end of the outer wall of the box body is provided as an operating handle for manual operation by an operator; the outer wall of the box body is provided with a guide groove for reciprocating movement of the operating handle.

[0055] A reset spring element is further arranged between the top rod and the lifting bottom plate, one end of the reset spring element is connected to the inner wall of the box body, and the other end of the reset spring element is connected to the lifting bottom plate; preferably, the reset spring element is connected to the side of the lifting bottom plate; the reset spring element is used to automatically reset the lifting bottom plate and the operating rod after the tube picking mechanism operates to pick the tube. More preferably, a limiting clamping plate is arranged between the top rod and the lifting bottom plate, one end of the reset spring element is arranged on the limiting clamping plate, and the other end of the reset spring element is connected to the lifting bottom plate.

[0056] The X-axis sliding rail is provided with a sliding block at both ends; the Y-axis sliding rail is provided with a sliding block at both ends; the sliding block is in sliding cooperation with the inner wall of the box body, and the inner wall of the box body preferably has a sliding groove structure matched with the sliding block.

[0057] Further, the X-axis sliding rail and the Y-axis sliding rail are respectively used as X-axis and Y-axis to construct a rectangular coordinate system to coordinate the sample placement grid of the sample cryopreservation box; the coordinate scale can be arranged on the X-axis sliding rail and the Y-axis sliding rail, or the coordinate scale can be arranged on the wall of the box body; one cryopreservation tube placement grid is a unit of the coordinate scale; by constructing the coordinate system to coordinate the sample placement grid of the sample cryopreservation box, the coordinates of each sample cryopreservation tube on the sample placement grid can be known, which helps to position the top rod of the tube picking mechanism on the sliding rail system to the target sample cryopreservation tube and operate the tube picking to take out the target sample cryopreservation tube. As a feasible way, the X-axis coordinate scale is represented by numbers, and the Y-axis coordinate scale is represented by letters; it can be understood that the X-axis sliding rail and the Y-axis sliding rail of the present application can also be designed according to the conventional rectangular coordinate system, and the symmetrical intersection of the X-axis sliding rail and the Y-axis sliding rail is taken as the initial zero point of the coordinate.

[0058] Further, the box body is further provided with a storage cavity for placing dry ice; the storage cavity is provided with a sealing cover to prevent the dry ice in the storage cavity from evaporating too fast.

[0059] The box body is further provided with a temperature detection element, and the outer wall of the box body is further provided with a display control panel, which is electrically connected with the temperature detection element. The temperature detection element is preferably a temperature probe, and the temperature information of the box body detected by the temperature detection element is displayed on the display control panel. According to the above design scheme, the control of the environment of the box body is facilitated.

[0060] The pick tube device components of the present application mainly include: 10, box body, 11, box cover, 20, positioning slide rail system, 21, X-axis slide rail, 22, Y-axis slide rail, 30, pick tube mechanism, 31, top rod, 32, lifting bottom plate, 33, operating lever, 34, operating handle, 35, hinge point, 36, reset spring piece, 40, cryopreserved tube.

[0061] The scheme points of the pick tube device of the present application are:

[0062] Box body: as the main structure of the device, the top is provided with an openable box cover, which is convenient for the operator to place and take out the sample.

[0063] Positioning slide rail system: provided in the box body, including X-axis slide rail and Y-axis slide rail, used for accurate positioning of the position of the target sample. The slide rail is respectively provided with a transverse first through hole sliding groove and a longitudinal second through hole sliding groove, used for guiding the movement of the pick tube mechanism.

[0064] Pick tube mechanism: provided on the positioning slide rail system, including top rod, operating lever and lifting bottom plate. The top end of the top rod is provided with a top head, used for picking up the target sample. The operating lever is movably connected with the box body through the hinge point, and the outer end is an operating handle, used for manual operation of the operator to drive the top rod to rise and fall. The lifting bottom plate is connected with the bottom of the top rod, used for supporting the lifting of the top rod, and can be automatically reset under the action of the reset spring piece.

[0065] Power device: including first driver and second driver, respectively used for driving the top rod of the pick tube mechanism to move in the transverse and longitudinal directions, to realize accurate positioning of the target sample.

[0066] Low-temperature environment control: the box body is also provided with a storage cavity for placing dry ice to maintain the low-temperature environment inside the box body. The storage cavity is provided with a sealing cover to prevent the dry ice from evaporating too fast. The design of the temperature detection element and the display control panel can know the temperature information of the box body.

[0067] The pick tube device of the present application can accurately position the position of the target sample through the positioning slide rail system, using the coordinate system constructed by the X-axis slide rail and the Y-axis slide rail, and cooperating with the coordinate scale display. In the pick tube operation, the operator manually controls the operating handle to drive the top rod to rise, and the top rod head picks up the target sample to pick it out from the cryopreserved box. It can be understood that the bottom of the cryopreserved box where the sample cryopreserved tube is placed has a through hole through which the top rod head rises. After the pick tube operation is completed, the reset spring piece automatically resets the lifting bottom plate and the operating lever, and the top rod falls by gravity to reset, preparing for the next operation. The dry ice in the low-temperature storage cavity is sealed by the sealing cover to maintain the low-temperature environment inside the box body.

[0068] The pick tube device of the present application has:

[0069] Efficiency: The positioning slide rail system and the tube picking mechanism enable fast and accurate sample picking, greatly improving work efficiency.

[0070] Accuracy: The positioning slide rail system and the coordinate system design ensure accurate positioning of the target sample.

[0071] Safety: Low-temperature environment control effectively protects the stability of the sample.

[0072] Low cost: The device structure is simple, and the main components of the tube picking device are common mechanical structures, reducing the manufacturing and maintenance costs of the device.

[0073] Ease of use: Simple operation, the sample can be picked by manual operation of the handle, without the need for complex operation skills.

[0074] The tube picking device of the present application provides an efficient, accurate and low-cost solution for the management of biological sample libraries, which can effectively improve the efficiency of tube picking in biological sample libraries.

[0075] The above description of the disclosed embodiments enables those skilled in the art to implement or use the present application. Various modifications to these embodiments will be apparent to those skilled in the art, and the general principles defined herein can be implemented in other embodiments without departing from the spirit or scope of the present application. Therefore, the present application will not be limited to these embodiments shown herein, but will conform to the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. A biological sample bank tube-picking apparatus, characterized by, The application relates to a sample freezing box. The sample freezing box comprises a box body, a freezing box support, a positioning sliding rail system, a tube picking mechanism and a power system. The box body is provided with an openable box cover. The freezing box support is arranged in the upper space of the box body and used for supporting sample freezing boxes. The sample freezing box has a plurality of sample tube placing grids. The positioning sliding rail system is installed below the freezing box support and comprises an X-axis sliding rail, an X-axis sliding rail and a Y-axis sliding rail. The X-axis sliding rail is horizontally arranged and slidably connected with the first pair of side walls of the box body. The Y-axis sliding rail is arranged perpendicularly to the X-axis sliding rail and slidably connected with the second pair of side walls of the box body. A first through-hole sliding groove is arranged on the X-axis sliding rail and used for guiding the movement of the tube picking mechanism in the transverse direction. A second through-hole sliding groove is arranged on the Y-axis sliding rail and used for guiding the movement of the tube picking mechanism in the longitudinal direction. The positioning sliding rail system is used for accurately positioning the position of a target sample.

2. The biological sample bank tube-picking apparatus of claim 1, wherein, The tube picking mechanism is arranged on the positioning sliding rail system and used for picking the target sample from the freezing box. The power system is used for driving the tube picking mechanism to move in the X-axis and Y-axis directions. The tube picking mechanism comprises a top rod, a lifting bottom plate and an operating rod. The top rod penetrates the X-axis sliding rail and the Y-axis sliding rail along the vertical direction and is arranged on the through-hole sliding groove at the intersection of the X-axis sliding rail and the Y-axis sliding rail.

3. The biological sample bank tube-picking apparatus of claim 2, wherein, The top of the top rod is provided with a top head used for picking the target sample.

4. The biological sample bank tube-picking apparatus of claim 2, wherein, The lifting bottom plate is arranged below the positioning sliding rail system.

5. The biological sample bank tube-picking apparatus of claim 4, wherein, In the state of not picking the tube, the lifting bottom plate is separated from the bottom of the top rod and does not contact the bottom of the top rod.

6. The biobank tube picking device according to any one of claims 2-5, characterized in that, In the state of picking the tube, the lifting bottom plate contacts the bottom of the top rod.

7. The biological sample bank tube-picking apparatus of claim 6, wherein, One end of the operating rod is connected with the lifting bottom plate, and the other end of the operating rod extends to the outside of the box body and is used for controlling the lifting of the top rod.

8. The biological sample bank pipette apparatus of any one of claims 1-5, 7, wherein, The operating rod is movably connected with the box body through a hinge point.

9. The biological sample bank tube-picking apparatus of claim 8, wherein, The operating rod extending to the end of the outer wall of the box body is provided with an operating handle used for manual operation.

10. The biological sample bank tube-picking apparatus of claim 9, wherein, The outer wall of the box body is provided with a guide groove used for the reciprocating movement of the operating handle. The power system comprises a first driver and a second driver. The first driver is used for driving the top rod to move in the transverse direction of the X-axis sliding rail. The second driver is used for driving the top rod to move in the longitudinal direction of the Y-axis sliding rail. The first driver and the second driver are linear drivers. The size of the top head is larger than the width of the through-hole sliding groove, so that the top rod can move to the position of the target sample along the through-hole sliding groove without falling. A reset spring is arranged between the top rod and the lifting bottom plate. One end of the reset spring is connected with the inner wall of the box body, and the other end of the reset spring is connected with the lifting bottom plate. The reset spring is used for automatically resetting the lifting bottom plate and the operating rod after the tube picking mechanism finishes the operation of picking the tube. The X-axis sliding rail is provided with a sliding block at two ends. The Y-axis sliding rail is provided with a sliding block at two ends. The sliding block is slidably connected with the inner wall of the box body. The box body is further provided with a storage cavity used for placing dry ice. The storage cavity is provided with a sealing cover to prevent the dry ice in the storage cavity from evaporating too fast. The box body is further provided with a temperature detection element and a display control panel. The display control panel is electrically connected with the temperature detection element.

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