Cell suction device for immune cell detection
By introducing a sealing ring and a pipette tip replacement mechanism into the cell aspiration device, the problems of fixed pipette tip specifications and insufficient sealing are solved, achieving effective sealing and flexible replacement of the pipette tip and syringe interface, improving aspiration accuracy and operational flexibility, and making it suitable for primary hospitals and field testing.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- SHANXI JUNNUO KANGYUAN BIOTECHNOLOGY CO LTD
- Filing Date
- 2025-04-23
- Publication Date
- 2026-04-10
AI Technical Summary
Existing cell aspiration devices for immune cell detection have fixed pipette tip specifications, making it difficult to quickly change to different capacities according to experimental needs. Furthermore, the lack of an effective sealing structure at the interface between the pipette tip and the syringe results in poor operational flexibility and insufficient aspiration accuracy.
A cell aspiration device comprising a sealing ring and a tip replacement mechanism was designed. The sealing ring seals the interface between the tip and the syringe to prevent leakage or insufficient airtightness. The tip can be quickly replaced through a friction rod and a stud mechanism, supporting the replacement of different sizes of tips from 10μl to 1ml.
It improves aspiration accuracy and operational flexibility, ensures effective sealing between the pipette tip and syringe interface to prevent leakage and insufficient air tightness, supports quick replacement of different pipette tip sizes, and is suitable for primary hospitals and field testing.
Smart Images
Figure CN224105820U_ABST
Abstract
Description
TECHNICAL FIELD
[0001] The utility model relates to cell detection technical field, concretely is cell sucking device of immune cell detection. BACKGROUND
[0002] The cell sucking device of immune cell detection is the precision operation tool specially designed for immune cell separation, transfer and detection, is widely used in clinical diagnosis (such as flow cytometry, immune typing) and cell therapy (such as CAR-T preparation), the device adopts medical grade syringe structure, combines high-precision piston drive and disposable sterile suction head, ensures the safety and repeatability of operation, and its core advantage lies in that gentle sucking is realized through mechanical-fluid collaborative optimization, for example: the nanometer hydrophobic coating of the inner wall of the suction head reduces cell adhesion and improves recovery rate (>85%); some models integrate micro pressure sensors, real-time monitoring of the plugging state is carried out and the LED is prompted to be abnormal, at the same time, the anti-slip handle and scale amplification window of ergonomic design facilitate one-handed operation and volume calibration (error ±2%), and the modular interface can be adapted to different specifications filter screen (such as 40 μm screen for removing cell clumps), compared with the electric pipetting system, the device does not need power supply and the cost is reduced by 60%, and it is especially suitable for primary hospitals or field detection, and in the future, through the integration of intelligent chips (such as RFID records batch information) or pre-installed anticoagulants (such as EDTA), the application potential in point-of-care testing (POCT) will be further expanded, and it is especially suitable for high-throughput screening or single-cell sequencing and other precision scenes, in the future, with the deep integration of microfluidic and AI technology, such devices will further develop towards automation and miniaturization, and become one of the core tools of immunotherapy and precision medicine.
[0003] The existing cell sucking device of immune cell detection has fixed suction head specifications, it is difficult to quickly replace different capacities, such as 10 μl to 1 ml suction head according to experimental requirements, leading to poor operation flexibility, and the existing cell sucking device of immune cell detection lacks effective sealing structure at the interface between the suction head and the needle cylinder, liquid leakage or insufficient airtightness is easy to occur, affecting the sucking precision, therefore, new technical solutions need to be designed to solve the problem. UTILITY MODEL CONTENTS
[0004] The technical solutions in the embodiments of the utility model will be clearly and completely described below with reference to the drawings in the embodiments of the utility model, and obviously, the described embodiments are only part of the embodiments of the utility model, not all the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by those skilled in the art without creative labor belong to the scope of protection of the utility model.
[0005] In order to achieve the above object, the utility model provides the following technical scheme: cell suction device of immune cell detection, including needle cylinder body, the inside slide connection of needle cylinder body has extraction piston, the top of extraction piston is screwed with piston rod, the outside fixed connection of needle cylinder body has installation ring, the inside of installation ring is equipped with two installation slot, the inner chamber slide connection of installation slot has stake, through the sealing mechanism of junction, the effective sealing of suction head and needle cylinder interface is carried out, prevents the leakage or gas tightness of suction head and needle cylinder interface is insufficient, influences suction precision, thereby can effectively seal the gap of suction head and needle cylinder interface, improves suction precision, through suction head replacement mechanism, can according to the experiment demand quick dismounting of suction head to different specifications suction head, such as 10ul to 1ml suction head, improve the use flexibility of cell suction device.
[0006] Preferably, the inside of the needle cylinder body is integrally formed with a sealing ring below, and the bottom end of the needle cylinder body is integrally formed with two clamping rings.
[0007] Preferably, the needle cylinder body is provided below with a needle seat, and the bottom of the needle seat is fixedly connected with an extraction needle.
[0008] Preferably, the top end of the needle seat is integrally formed with an inclined seat, the inner side of the inclined seat is fitted with the sealing ring, and the top of the inclined seat is provided with two clamping grooves, the clamping grooves are inserted with the clamping rings, and the sealing ring seals the gap at the connection between the needle cylinder body and the needle seat.
[0009] Preferably, one end of the stake penetrates through the installation ring and the needle cylinder body and extends to the inside of the needle seat, and the stake is used to quickly fix the needle seat.
[0010] Preferably, the outside of the installation ring is fixedly connected with two friction sleeves, and the inside of the friction sleeves is slidably connected with a friction rod, the friction sleeves cooperate with the friction rod to generate damping force through friction, preventing the friction rod from moving easily.
[0011] Preferably, one end of the friction rod penetrates through the installation ring and extends to the inner chamber of the installation slot, one end of the friction rod is fixedly connected with the stake, and a compression spring is sleeved on the outside of the friction rod, and the stake is compressed by the compression spring.
[0012] Compared with the prior art, the utility model has the beneficial effects that:
[0013] 1. The immune cell detection cell suction device, through the sealing mechanism of the connection, the sealing ring installed below the inner side of the needle cylinder body is tightly fitted with the gap of the connection between the needle seat and the needle cylinder body, effectively seals the interface between the suction head and the needle cylinder, prevents liquid leakage or insufficient air tightness at the interface between the suction head and the needle cylinder, and affects the suction precision, so that the gap between the suction head and the needle cylinder can be effectively sealed, and the suction precision is improved.
[0014] 2. The immune cell detection cell suction device, through the suction head replacement mechanism, the friction rod is pulled to drive the plug to extrude the compression spring, and then the plug is removed to the installation groove, and then the needle seat can be removed, the suction head can be quickly disassembled according to the experimental requirements, and different specifications of suction heads such as 10 μl to 1 ml suction heads can be replaced, and the use flexibility of the cell suction device is improved. BRIEF DESCRIPTION OF DRAWINGS
[0015] Figure 1 It is a front view of the immune cell detection cell suction device provided by the utility model;
[0016] Figure 2 It is a front view of the immune cell detection cell suction device provided by the utility model;
[0017] Figure 3 It is a front view of the immune cell detection cell suction device provided by the utility model;
[0018] Figure 4 It is a front view of the immune cell detection cell suction device provided by the utility model; Figure 3 It is a front view of the immune cell detection cell suction device provided by the utility model;
[0019] In the figure: 100, the needle cylinder body; 110, the extraction piston; 120, the piston rod; 130, the sealing ring; 140, the snap ring; 150, the needle seat; 151, the extraction needle; 160, the inclined seat; 161, the clamping groove; 200, the mounting ring; 210, the installation groove; 220, the plug; 230, the friction sleeve; 240, the friction rod; 241, the compression spring. DETAILED DESCRIPTION
[0020] The technical solutions in the embodiments of the utility model will be clearly and completely described below with reference to the drawings in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by those skilled in the art without creative labor belong to the scope of protection of the utility model.
[0021] Embodiment 1: Please refer to againFigures 1-4 The utility model provides immune cell detection's cell sucking device, including needle cylinder body 100, the inside slide connection of needle cylinder body 100 has the extraction piston 110, the top screw of extraction piston 110 has piston rod 120, the inside below of needle cylinder body 100 is integrally formed with sealing ring 130, the bottom of needle cylinder body 100 is integrally formed with two snap rings 140, the below of needle cylinder body 100 is provided with needle seat 150, the bottom fixed connection of needle seat 150 has extraction needle 151, the top of needle seat 150 is integrally formed with inclined seat 160, the inside of inclined seat 160 and sealing ring 130 are pasted, the top of inclined seat 160 is opened with two clamping grooves 161, and clamping groove 161 is inserted with snap ring 140, and one end of stake 220 passes through mounting ring 200 and extends to the inside of needle seat 150 with needle cylinder body 100.
[0022] Specifically, when needle cylinder body 100 and needle seat 150 are combined, sealing ring 130 installed inside the needle cylinder will closely fit the gap between needle seat 150 and needle cylinder body 100, sealing the gap between needle seat 150 and needle cylinder body 100. At the same time, the two snap rings 140 installed at the bottom of the needle cylinder body 100 also extend into the two clamping grooves 161 at the top of the inclined seat 160, so that the snap ring 140 cooperates with the clamping groove 161 to form a sealed partition, sealing the gap between the needle seat 150 and the needle cylinder body 100. At the same time, due to the inclination angle of the inclined seat 160, it can further prevent the cell fluid from leaking through the gap between the needle seat 150 and the needle cylinder body 100.
[0023] For example: the existing immune cell detection cell suction device suction head specification is fixed, it is difficult to quickly replace different capacity according to experimental demand, such as 10ul to 1ml suction head, leading to poor operation flexibility, but the application can quickly disassemble and replace different specifications of suction head, such as 10ul to 1ml suction head, through the suction head replacement mechanism, improve the use flexibility of cell suction device.
[0024] Example 2: please refer to Figures 1-4 The outside of the needle cylinder body 100 is fixedly connected with the mounting ring 200, two installation grooves 210 are formed in the inside of the mounting ring 200, the stake 220 is slidably connected in the inner cavity of the installation groove 210, two friction sleeves 230 are fixedly connected to the outside of the mounting ring 200, the friction rod 240 is slidably connected to the inside of the friction sleeve 230, one end of the friction rod 240 penetrates through the mounting ring 200 and extends to the inner cavity of the installation groove 210, and the other end of the friction rod 240 is fixedly connected with the stake 220, and the outside of the friction rod 240 is sleeved with the compression spring 241.
[0025] Specifically, by pulling the friction rod 240, the friction rod 240 drives the stake 220 to extrude the compression spring 241, and then the stake 220 is removed from the fixed needle seat 150 to the installation groove 210, and then the needle seat 150 is removed, and then the required needle seat 150 is installed in the needle cylinder body 100, and then the friction rod 240 is loosened, the compression spring 241 extruded by the stake 220 is reset and extended to push the stake 220 to move, the stake 220 is inserted into the replaced needle seat 150, and the replaced needle seat 150 is fixed, and the outside is replaced with the extracted needle 151.
[0026] For example, the existing immune cell detection cell suction device lacks effective sealing structure at the interface between the suction head and the needle cylinder, which is easy to cause liquid leakage or insufficient air tightness, affecting the suction accuracy. However, the sealing mechanism at the connection can effectively seal the gap between the suction head and the needle cylinder, improve the suction accuracy.
[0027] Working principle: by pulling the friction rod 240, the friction rod 240 drives the stake 220 to extrude the compression spring 241, and then the stake 220 is removed from the fixed needle seat 150 to the installation groove 210, and then the needle seat 150 is removed, and then the required needle seat 150 is installed in the needle cylinder body 100, and then the friction rod 240 is loosened, the compression spring 241 extruded by the stake 220 is reset and extended to push the stake 220 to move, the stake 220 is inserted into the replaced needle seat 150, and the replaced needle seat 150 is fixed, and the outside is replaced with the extracted needle 151.
[0028] When the needle cylinder body 100 and the needle seat 150 are combined, the sealing ring 130 installed inside the needle cylinder will tightly fit the gap between the connection of the needle seat 150 and the needle cylinder body 100, and the two clamping rings 140 installed at the bottom of the needle cylinder body 100 will also extend into the two clamping grooves 161 at the top of the inclined seat 160, so that the clamping ring 140 cooperates with the clamping groove 161 to form a sealed partition, and the connection gap between the needle seat 150 and the needle cylinder body 100 is sealed. At the same time, since the inclined seat 160 has a certain inclination angle, it can further prevent the cell fluid from leaking through the connection gap between the needle seat 150 and the needle cylinder body 100.
[0029] It is apparent for a person skilled in the art that the present application is not restricted to the details of the above exemplary embodiments, but that it can be implemented in other concrete forms without departing from the spirit or the essential characteristics of the present application. Therefore, the embodiments should be considered as exemplary only, and not limiting, the scope of the present application being defined by the appended claims rather than the above description, and all changes coming within the meaning and range of equivalency of the claims are therefore intended to be embraced therein. Any reference signs in the claims should not be construed as limiting the claims concerned.
Claims
1. A cell suction device for immune cell detection, comprising a syringe body (100), characterized in that, The inside of the needle cylinder body (100) is slidably connected with a drawing piston (110), and the top of the drawing piston (110) is screwed with a piston rod (120); The outside of the needle cylinder body (100) is fixedly connected with a mounting ring (200), the inside of the mounting ring (200) is provided with two mounting grooves (210), and the inner cavity of the mounting groove (210) is slidably connected with a plug (220).
2. The cell suction device for immune cell detection according to claim 1, wherein The inside of the needle cylinder body (100) is integrally formed with a sealing ring (130) below, and the bottom end of the needle cylinder body (100) is integrally formed with two clamping rings (140).
3. The cell suction device for immune cell detection according to claim 2, wherein The bottom of the needle cylinder body (100) is provided with a needle seat (150), and the bottom of the needle seat (150) is fixedly connected with a drawing needle (151).
4. The cell suction device for immune cell detection according to claim 3, wherein The top of the needle seat (150) is integrally formed with an inclined seat (160), the inside of the inclined seat (160) is matched with the sealing ring (130), the top of the inclined seat (160) is provided with two clamping grooves (161), and the clamping groove (161) is inserted with the clamping ring (140).
5. The cell suction device for immune cell detection according to claim 3, wherein One end of the plug (220) penetrates the mounting ring (200) and the needle cylinder body (100) and extends to the inside of the needle seat (150).
6. The cell suction device for immune cell detection according to claim 5, wherein The outside of the mounting ring (200) is fixedly connected with two friction sleeves (230), and the inside of the friction sleeve (230) is slidably connected with a friction rod (240).
7. The cell suction device for immune cell detection according to claim 6, wherein One end of the friction rod (240) penetrates the mounting ring (200) and extends to the inner cavity of the mounting groove (210), one end of the friction rod (240) is fixedly connected with the plug (220), and the outside of the friction rod (240) is sleeved with a compression spring (241).