Full-automatic sheet making machine for liquid-based cells

Abstract

The utility model provides a full-automatic liquid-based cell pelleter, which comprises a pelleter main body, a transfer assembly, a placing plate and a glass slide, the pelleter main body is rotatably connected with an opening and closing door, the opening and closing door is provided with an observation window, the inner wall of the pelleter main body is fixedly connected with an extension plate, the extension plate is provided with a moving assembly, and the moving assembly is provided with a slide. A lifting table is slidably connected to the moving assembly, a sampling part is arranged on the lifting table, a first sealing door and a second sealing door are arranged on the two sides of the pelleter body respectively, and a sample area is arranged on the side, close to the first sealing door, of the inner wall of the pelleter body. According to the full-automatic slide making machine for the liquid-based cells provided by the utility model, by virtue of the moving assembly, a sample is conveniently taken out from a sample area by the sampling part and accurately drips on glass slides on the two groups of transfer assemblies, and when the sample is titrated by the auxiliary positioning assembly, the placing plate is clamped and lifted to a proper height; the quality reduction of the sample caused by deviation or sample splashing is prevented.

Description

Technical Field

[0001] This utility model relates to the field of cell slide preparation technology, and in particular to a fully automated liquid-based cell slide preparation machine. Background Technology

[0002] In the existing technology, liquid-based cytology testing uses liquid-based cytology slide preparation and staining techniques to detect exfoliated cells from the cervix and other sites for cytological diagnosis. It is currently one of the most advanced cytology testing technologies internationally. In the field of cervical exfoliated cells, this technology has significantly improved specimen quality and the detection rate of abnormal cervical cells compared with traditional cervical smears and Pap smears.

[0003] Traditional slide preparation equipment relies heavily on manual operation for sample transfer, leading to the following problems: insufficient precision in slide positioning during manual sample dispensing, resulting in uneven cell distribution; and a lack of height self-adaptive adjustment during liquid sample titration, often causing sample splashing due to mechanical vibration or platform displacement.

[0004] Therefore, it is necessary to provide a fully automated liquid-based cell slide preparation machine to solve the above-mentioned technical problems. Utility Model Content

[0005] This invention provides a fully automated liquid-based cell slide preparation machine, which solves the problems of insufficient slide positioning accuracy and uneven cell distribution during manual sample titration, as well as the easy splashing of samples during the titration process.

[0006] To solve the above-mentioned technical problems, this utility model provides a fully automated liquid-based cell slide preparation machine, comprising: a slide preparation machine body, a transfer assembly, a placement plate, and glass slides. The slide preparation machine body is rotatably connected to an opening and closing door, which has an observation window. An extension plate is fixedly connected to the inner wall of the slide preparation machine body, and a moving assembly is provided on the extension plate. A lifting platform is slidably connected to the moving assembly, and a sampling section is provided on the lifting platform. A first closed door and a second closed door are respectively provided on both sides of the slide preparation machine body. A sample area is provided on the inner wall of the slide preparation machine body near the first closed door. Two sets of transfer assemblies are provided. The glass slides are placed on the placement plate, and an auxiliary positioning assembly is provided inside the slide preparation machine body.

[0007] Preferably, the moving component includes a first sliding rail, a crossbar slidably connected to the first sliding rail, a second sliding rail provided on the crossbar, a mounting plate slidably connected to the second sliding rail, a third sliding rail provided on the mounting plate, and the lifting platform slidably connected to the third sliding rail.

[0008] Preferably, the sampling unit includes a fixed base, on which multiple sets of extraction needles are provided, with an extraction needle tip at the lower part of the extraction needle and a micro extraction pump at the upper part of the extraction needle.

[0009] Preferably, the sample area includes a sliding frame with a support plate slidably connected to it. Multiple sets of sample tubes are arranged equidistantly on the support plate, and the positions of the sample tubes correspond to the extraction needles.

[0010] Preferably, the transfer assembly includes a base plate, on which a drive component and a transfer track are provided. A sliding seat is slidably connected to the transfer track, and a support block is provided on the sliding seat. The placement plate is placed on the support block, and the side of the support block that contacts the placement plate is provided with anti-slip texture.

[0011] Preferably, the auxiliary positioning component includes a lifting push rod and a moving block. The end of the lifting push rod is fixedly connected to a mounting plate. The mounting plate is provided with a drive motor, a lead screw, and a sliding rod. The moving block is sleeved on the lead screw and the sliding rod. An L-shaped clamp is fixedly connected to the moving block, and the L-shaped clamp corresponds to the placement plate.

[0012] Compared with related technologies, the fully automated liquid-based cell slide preparation machine provided by this utility model has the following beneficial effects:

[0013] This invention provides a fully automated liquid-based cell slide preparation machine. Through a moving component, the sampling unit can easily take out the sample from the sample area and accurately drop it onto the glass slides on two sets of transfer components. When the sample is being titrated, the auxiliary positioning component clamps the placement plate and raises it to a suitable height to prevent displacement or sample splashing, which would lead to a decrease in sample quality. Attached Figure Description

[0014] Figure 1 This is a schematic diagram of a preferred embodiment of a fully automated liquid-based cell slide preparation machine provided by this utility model;

[0015] Figure 2 This is a schematic diagram of the internal structure of the main body of the film-making machine in this utility model;

[0016] Figure 3 This is a schematic diagram of the sampling section and transfer assembly in this utility model;

[0017] Figure 4 This is a schematic diagram of the auxiliary positioning component in this utility model.

[0018] Numbered components in the diagram: 1. Main body of the film-making machine; 2. Opening door; 3. Extension plate; 4. Moving assembly; 41. First sliding rail; 42. Crossbar; 43. Second sliding rail; 44. Mounting plate; 45. Third sliding rail; 5. Lifting platform; 6. Sampling section; 61. Fixed base; 62. Extraction needle; 63. Extraction needle tip; 64. Miniature extraction pump; 7. First sealing door; 8. Sample area; 81. Sliding frame; 82. Support plate; 83. Sample... This test tube, 9. Transfer assembly, 91. Base plate, 92. Drive unit, 93. Transfer track, 94. Sliding seat, 95. Support block, 96. Anti-slip texture, 10. Placement plate, 11. Glass slide, 12. Auxiliary positioning assembly, 121. Lifting push rod, 122. Mounting plate, 123. Drive motor, 124. Lead screw, 125. Sliding rod, 126. Moving block, 127. L-shaped clamp, 13. Second sealing door, 14. Observation window. Detailed Implementation

[0019] The present invention will be further described below with reference to the accompanying drawings and embodiments.

[0020] Please refer to the following: Figure 1 , Figure 2 , Figure 3 , Figure 4 ,in, Figure 1 This is a schematic diagram of a preferred embodiment of a fully automated liquid-based cell slide preparation machine provided by this utility model;

[0021] Figure 2 This is a schematic diagram of the internal structure of the main body of the film-making machine in this utility model;

[0022] Figure 3 This is a schematic diagram of the sampling section and transfer assembly in this utility model;

[0023] Figure 4 This is a schematic diagram of the auxiliary positioning component in this utility model.

[0024] An automated liquid-based cell slide preparation machine includes: a slide preparation machine body 1, a transfer assembly 9, a placement plate 10, and glass slides 11. The slide preparation machine body 1 is rotatably connected to an opening and closing door 2, which has an observation window 14. An extension plate 3 is fixedly connected to the inner wall of the slide preparation machine body 1, and a moving assembly 4 is provided on the extension plate 3. A lifting platform 5 is slidably connected to the moving assembly 4, and a sampling section 6 is provided on the lifting platform 5. A first closed door 7 and a second closed door 13 are respectively provided on both sides of the slide preparation machine body 1. A sample area 8 is provided on the inner wall of the slide preparation machine body 1 near the first closed door 7. Two sets of transfer assemblies 9 are provided. The glass slides 11 are placed on the placement plate 10. An auxiliary positioning assembly 12 is provided inside the slide preparation machine body 1.

[0025] Open the opening and closing door 2, fix the corresponding number of glass slides 11 on the placement plate 10, and finally place them on the transfer assembly 9. Close the opening and closing door 2. After the first closed door 7 is opened, the sample in the sample area 8 can be replaced. After the moving assembly 4 controls the sampling unit 6 to take a sample in the sample area 8, the auxiliary positioning assembly 12 fixes the placement plate 10 and raises it to a suitable height. The sampling unit 6 drops the sample onto the glass slide 11. Then the auxiliary positioning assembly 12 descends and places the placement plate 10 back on the transfer assembly 9. When it is transferred to the second closed door 13, open the second closed door 13 and take it away. The observation window 14 allows the operator to observe the internal working status in real time during the operation of the equipment, which not only ensures the sealing of the equipment operating environment, but also avoids temperature or cleanliness fluctuations caused by frequent opening of the door.

[0026] The moving component 4 includes a first sliding rail 41, a crossbar 42 slidably connected to the first sliding rail 41, a second sliding rail 43 provided on the crossbar 42, a mounting plate 44 slidably connected to the second sliding rail 43, a third sliding rail 45 provided on the mounting plate 44, and the lifting platform 5 slidably connected to the third sliding rail 45.

[0027] The combined structure of the extension plate 3 and the moving component 4 provides a flexible three-axis motion path for the lifting platform 5 and the sampling unit 6 through a multi-dimensional sliding connection method (first sliding rail 41, second sliding rail 43, and third sliding rail 45), enabling the sampling unit 6 to accurately cover the entire space from the sample area to the slide placement area.

[0028] The sampling unit 6 includes a fixed base 61, on which multiple sets of extraction needles 62 are provided. The lower part of the extraction needle 62 is provided with an extraction needle 63, and the upper part of the extraction needle 62 is provided with a micro extraction pump 64.

[0029] The sampling unit 6, through the combination of multiple sets of extraction needles 62 and micro extraction pumps 64 integrated by the fixed base 61, can complete the parallel processing of multiple samples in a single operation, achieving highly repeatable transfer of micro-samples.

[0030] The sample area 8 includes a sliding frame 81, on which a support plate 82 is slidably connected. Multiple sets of sample tubes 83 are arranged on the support plate 82 at equal intervals, and the positions of the sample tubes 83 correspond to the extraction needle tubes 62.

[0031] The sample area 8 adopts a sliding fit design between the sliding frame 81 and the support plate 82, which allows the sample tube 83 to be quickly loaded or removed as a whole from the first closed door 7.

[0032] The transfer assembly 9 includes a base plate 91, on which a drive component 92 and a transfer track 93 are provided. A sliding seat 94 is slidably connected to the transfer track 93. A support block 95 is provided on the sliding seat 94. The placement plate 10 is placed on the support block 95. The side of the support block 95 that contacts the placement plate 10 is provided with anti-slip texture 96.

[0033] The transfer assembly 9, through the coordinated action of the drive component 92 and the transfer track 93, realizes the automated transfer of the placement plate 10 inside and outside the equipment. The dual protection mechanism of the sliding seat 94 and the anti-slip texture 96 of the transfer assembly 9 not only enhances the stability of the glass slide placement plate 10 during movement, but also avoids the glass slide 11 from shifting due to vibration.

[0034] The auxiliary positioning component 12 includes a lifting push rod 121 and a moving block 126. The end of the lifting push rod 121 is fixedly connected to a mounting plate 122. The mounting plate 122 is provided with a drive motor 123, a lead screw 124 and a sliding rod 125. The moving block 126 is sleeved on the lead screw 124 and the sliding rod 125. An L-shaped clamping plate 127 is fixedly connected to the moving block 126. The L-shaped clamping plate 127 corresponds to the placement plate 10.

[0035] The auxiliary positioning component 12 adopts a combined drive method of lead screw transmission and lifting push rod. The L-shaped clamping plate 127 clamps and raises and lowers the placement plate 10, while correcting the position of the placement plate 10 to prevent the sample from being displaced when the sampling part 6 drops the sample. Its structure, based on the longitudinal height adjustment of the lifting push rod 121, combined with the lateral fine adjustment capability driven by the lead screw 124, can adapt to the precise positioning requirements of glass slides 11 of different specifications.

[0036] The working principle of the fully automated liquid-based cell slide preparation machine provided by this utility model is as follows:

[0037] Open the opening and closing door 2, fix the corresponding number of glass slides 11 on the placement plate 10, and finally place them on the transfer assembly 9. Close the opening and closing door 2. After the first closed door 7 is opened, the sample in the sample area 8 can be replaced. After the moving assembly 4 controls the sampling unit 6 to take a sample in the sample area 8, the auxiliary positioning assembly 12 fixes the placement plate 10 and raises it to a suitable height. The sampling unit 6 drops the sample onto the glass slide 11. Then the auxiliary positioning assembly 12 descends and places the placement plate 10 back on the transfer assembly 9. When it is transferred to the second closed door 13, open the second closed door 13 and take it away. The observation window 14 allows the operator to observe the internal working status in real time during the operation of the equipment, which not only ensures the sealing of the equipment operating environment, but also avoids temperature or cleanliness fluctuations caused by frequent opening of the door.

[0038] Compared with related technologies, the fully automated liquid-based cell slide preparation machine provided by this utility model has the following beneficial effects:

[0039] The moving component 4 facilitates the sampling unit 6 to take out the sample from the sample area 8 and accurately drop it onto the glass slide 11 on the two sets of transfer components 9. When the sample is being titrated, the auxiliary positioning component 12 clamps the placement plate 10 and lifts it to a suitable height to prevent deviation or sample splashing, which would lead to a decrease in sample quality.

[0040] The above description is merely an embodiment of this utility model and does not limit the patent scope of this utility model. Any equivalent structural or procedural transformations made based on the content of this utility model specification and drawings, or direct or indirect applications in other related technical fields, are similarly included within the patent protection scope of this utility model.

Claims

1. A fully automated liquid-based cell slide preparation machine, characterized in that, include: The slide preparation machine includes a main body, a transfer assembly, a placement plate, and glass slides. The main body is rotatably connected to an opening and closing door with an observation window. An extension plate is fixedly connected to the inner wall of the main body, and a moving assembly is mounted on the extension plate. A lifting platform is slidably connected to the moving assembly, and a sampling section is mounted on the lifting platform. A first closed door and a second closed door are respectively located on both sides of the main body. A sample area is located on the inner wall of the main body near the first closed door. Two sets of transfer assemblies are provided. The glass slides are placed on the placement plate, and an auxiliary positioning assembly is located inside the main body.

2. The fully automated liquid-based cell slide preparation machine according to claim 1, characterized in that, The moving component includes a first sliding rail, a crossbar slidably connected to the first sliding rail, a second sliding rail provided on the crossbar, a mounting plate slidably connected to the second sliding rail, a third sliding rail provided on the mounting plate, and the lifting platform slidably connected to the third sliding rail.

3. The fully automated liquid-based cell slide preparation machine according to claim 1, characterized in that, The sampling unit includes a fixed base, on which multiple sets of extraction needles are provided. The lower part of the extraction needle is provided with an extraction needle tip, and the upper part of the extraction needle is provided with a micro extraction pump.

4. The fully automated liquid-based cell slide preparation machine according to claim 3, characterized in that, The sample area includes a sliding frame with a support plate slidably connected to it. Multiple sets of sample tubes are arranged equidistantly on the support plate, and the positions of the sample tubes correspond to the extraction needles.

5. The fully automated liquid-based cell slide preparation machine according to claim 1, characterized in that, The transfer assembly includes a base plate, on which a drive component and a transfer track are provided. A sliding seat is slidably connected to the transfer track, and a support block is provided on the sliding seat. The placement plate is placed on the support block, and the side of the support block that contacts the placement plate is provided with anti-slip texture.

6. The fully automated liquid-based cell slide preparation machine according to claim 1, characterized in that, The auxiliary positioning component includes a lifting push rod and a moving block. The end of the lifting push rod is fixedly connected to a mounting plate. The mounting plate is provided with a drive motor, a lead screw, and a sliding rod. The moving block is sleeved on the lead screw and the sliding rod. An L-shaped clamp is fixedly connected to the moving block, and the L-shaped clamp corresponds to the placement plate.

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