Miniature separation equipment

Abstract

The utility model discloses miniature separation equipment which comprises a rack, a stock solution tank, a filter pump, a hollow fiber membrane column, a flat sheet membrane bag, a collecting tank and a disposable filter assembly are arranged on the rack, and the stock solution tank is connected with an inlet of the filter pump through a pipeline; an outlet of the filter pump is respectively connected with inlets of the hollow fiber membrane column, the flat sheet membrane bag and the disposable filter assembly through pipelines with first switching valves, and outlets of the hollow fiber membrane column, the flat sheet membrane bag and the disposable filter assembly are respectively connected with the collecting tank through pipelines with second switching valves; the disposable filter assembly comprises one or more of a deep membrane bag, a sterilization filter and a virus removal filter. The device has the advantages of being simple in structure, diversified in function, beneficial to test cost reduction and the like.

Description

Technical Field

[0001] This utility model relates to the field of food and pharmaceutical production equipment technology, and in particular to a micro separation device. Background Technology

[0002] In large-scale pharmaceutical manufacturing, new production processes require pilot-scale and intermediate-scale trials before large-scale production to optimize process parameters and evaluate product quality and costs. Laboratory filtration equipment can simulate the filtration process in industrial production, providing data support for process optimization. Currently, commercially available laboratory filtration equipment has relatively limited applications; typically, a single device can only perform one specific filtration process. If other types of filtration process experiments are required, additional laboratory equipment is needed, increasing costs. Utility Model Content

[0003] The technical problem to be solved by this utility model is to overcome the shortcomings of the existing technology and provide a micro separation device with simple structure, diversified functions, and the ability to reduce test costs.

[0004] To solve the above-mentioned technical problems, the present invention adopts the following technical solution:

[0005] A miniature separation device includes a frame on which a raw liquid tank, a filter pump, a hollow fiber membrane column, a flat sheet membrane pack, a collection tank, and a disposable filter assembly are mounted. The raw liquid tank is connected to the inlet of the filter pump via a pipe. The outlet of the filter pump is connected to the inlets of the hollow fiber membrane column, the flat sheet membrane pack, and the disposable filter assembly via pipes equipped with a first switching valve. The outlets of the hollow fiber membrane column, the flat sheet membrane pack, and the disposable filter assembly are connected to the collection tank via pipes equipped with a second switching valve. The disposable filter assembly includes one or more of a deep membrane pack, a sterilizing filter, and a virus-removing filter.

[0006] As a further improvement to the above technical solution: the frame is provided with a first mounting platform and a foldable second mounting platform, the raw liquid tank, the filter pump, the hollow fiber membrane column, the flat membrane pack and the collection tank are located on the first mounting platform, and the disposable filter assembly is located on the second mounting platform.

[0007] As a further improvement to the above technical solution: the second mounting platform is hinged to the first mounting platform, or the second mounting platform is hinged to the frame, and the frame is provided with a support swing rod, which is detachably connected to the second mounting platform.

[0008] As a further improvement to the above technical solution: the second mounting platform is provided with an L-shaped slot, and the support swing rod is provided with a locking pin that cooperates with the slot.

[0009] As a further improvement to the above technical solution: the first installation platform is provided with a fixing rod, and the fixing rod is provided with a first fixing component. The first fixing component includes a slide that can move along the fixing rod and a pair of clamping blocks provided on the slide. The hollow fiber membrane column is provided between the pair of clamping blocks.

[0010] As a further improvement to the above technical solution: the fixing rod passes through the slide block, the slide block is fixed to the fixing rod by a set screw, a pair of clamping blocks are sleeved on the support and fixed by set screws, the support is provided with a connecting rod, the connecting rod passes through the slide block and is fixed by a set screw.

[0011] As a further improvement to the above technical solution: the fixed rod is connected to the extension rod, and the extension rod is also provided with the first fixing component.

[0012] As a further improvement to the above technical solution: the first installation platform is provided with a second fixing component, the second fixing component includes a first clamping plate and a second clamping plate, the first clamping plate and the second clamping plate are detachably connected, and the flat film is wrapped between the first clamping plate and the second clamping plate.

[0013] As a further improvement to the above technical solution: the hollow fiber membrane column and the flat membrane package are arranged on one side edge of the frame.

[0014] As a further improvement to the above technical solution: the frame is also provided with a rotating arm, the rotating arm is provided with a display screen, the rotating arm is a hollow structure, and the cables of the filter pump, the first switching valve and the second switching valve are passed through the rotating arm.

[0015] Compared with the prior art, the advantages of this utility model are:

[0016] The micro-separation device disclosed in this utility model combines three types of laboratory filters—hollow fiber membrane columns, flat sheet membrane packs, and disposable filter components—on a frame, along with matching filter pumps, pipelines, and switching valves. This allows for the parallel connection of the hollow fiber membrane columns, flat sheet membrane packs, and disposable filter components. Different types of filtration process experiments can be conducted by controlling the opening and closing of the corresponding switching valves. Furthermore, the disposable filter components include one or more of the following: deep membrane packs, sterilization filters, and virus removal filters. The device features a simple structure, diverse functions, and helps reduce experimental costs.

[0017] Other features and advantages of this invention will be described in detail in the following detailed description section. Attached Figure Description

[0018] Figure 1This is a three-dimensional structural diagram of the front of the micro separation device of this utility model.

[0019] Figure 2 This is a three-dimensional structural diagram of the back of the micro separation device of this utility model.

[0020] Figure 3 This is an exploded view of the first fixing component in this utility model.

[0021] Figure 4 yes Figure 1 Enlarged view of point A in the middle.

[0022] Figure 5 yes Figure 1 Enlarged view of point B in the middle.

[0023] Figure 6 This is a schematic diagram illustrating the principle of this utility model.

[0024] The labels in the diagram represent:

[0025] 1. Frame; 11. First mounting platform; 12. Second mounting platform; 121. Slot; 13. Support swing arm; 131. Locking pin; 14. Rotating arm; 2. Raw material tank; 21. Magnetic stirring device; 22. First weighing sensor; 23. First gas filter; 3. Filter pump; 31. Replenishment pump; 4. Hollow fiber membrane column; 41. Fixing rod; 42. Slide; 43. Clamping block; 44. Set screw; 45. Support; 46. Connecting rod; 4 7. Extension rod; 48. First clamping plate; 49. Second clamping plate; 5. Flat membrane pack; 51. Pinch valve; 6. Collection tank; 61. Second weighing sensor; 62. Second gas filter; 7. Disposable filter assembly; 71. Deep membrane pack; 72. Sterilization filter; 73. Virus removal filter; 81. First switching valve; 82. Second switching valve; 83. Pressure sensor; 84. pH sensor; 85. Conductivity sensor; 9. Display screen. Detailed Implementation

[0026] In the description of this utility model, it should be understood that the terms "length", "width", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this utility model.

[0027] Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of this utility model, "a plurality of" means two or more, unless otherwise explicitly specified.

[0028] In this utility model, unless otherwise explicitly specified and limited, the terms "assembly," "connection," "joining," and "fixing" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral part; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; they can refer to the internal communication of two components or the interaction between two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model according to the specific circumstances.

[0029] The present invention will be further described in detail below with reference to the accompanying drawings and specific embodiments.

[0030] Figures 1 to 6 This illustration shows an embodiment of the micro-separation device of the present invention. The micro-separation device of this embodiment includes a frame 1, on which a raw liquid tank 2, a filter pump 3, a hollow fiber membrane column 4, a flat membrane pack 5, a collection tank 6, and a disposable filter assembly 7 are mounted. The raw liquid tank 2 is connected to the inlet of the filter pump 3 through a pipe. The outlet of the filter pump 3 is connected to the inlets of the hollow fiber membrane column 4, the flat membrane pack 5, and the disposable filter assembly 7 through pipes equipped with a first switching valve 81. The outlets of the hollow fiber membrane column 4, the flat membrane pack 5, and the disposable filter assembly 7 are connected to the collection tank 6 through pipes equipped with a second switching valve 82. The disposable filter assembly 7 includes one or more of the following in this embodiment: a deep membrane pack 71, a sterilization filter 72, and a virus removal filter 73. Preferably, the frame 1 is a cabinet structure. The raw material tank 2, filter pump 3, hollow fiber membrane column 4, flat membrane pack 5, collection tank 6, and disposable filter assembly 7 are located on the top of the cabinet. The control system of the equipment is installed inside the cabinet. The bottom of the cabinet is equipped with braked casters (including omnidirectional casters and / or directional casters) to facilitate the movement of the equipment without manual handling. The piping is mainly rigid pipe to facilitate control of the pipe shape, and flexible pipes are used where bending is required (e.g., flexible tubing). Figure 6 (As shown by the wavy lines); the first switching valve 81 and the second switching valve 82 are diaphragm valves; a replenishment pump 31 is also provided on the frame 1. The outlet of the replenishment pump 31 is connected to the filter pump 3 through a pipe, which can replenish the original liquid for the filter pump 3. The outlet of the replenishment pump 31 is also connected to the hollow fiber membrane column 4 and the flat membrane pack 5 through pipes respectively.

[0031] The micro separation device of this embodiment combines three types of laboratory filters on the frame 1: hollow fiber membrane column 4, flat sheet membrane pack 5, and disposable filter assembly 7, as well as matching filter pump 3, pipelines, and first switching valve 81 and second switching valve 82. This allows the hollow fiber membrane column 4, flat sheet membrane pack 5, and disposable filter assembly 7 to be connected in parallel (i.e., the raw solution can be filtered through the hollow fiber membrane 4, or through the flat sheet membrane pack 5, or through the disposable filter assembly 7). Different types of filtration process experiments can be carried out by controlling the opening and closing of the corresponding switching valves. Furthermore, the disposable filter assembly 7 includes one or more of the following: deep membrane pack 71, sterilization filter 72, and virus removal filter 73. The device has a simple structure, diverse functions, and helps to reduce experimental costs.

[0032] Furthermore, in this embodiment, the frame 1 is provided with a first mounting platform 11 and a foldable second mounting platform 12. The raw material tank 2, filter pump 3, hollow fiber membrane column 4, flat membrane pack 5, and collection tank 6 are mounted on the first mounting platform 11, and the disposable filter assembly 7 is mounted on the second mounting platform 12. Since the filter screens of disposable filters such as the deep membrane pack 71, sterilization filter 72, and virus removal filter 73 are already encapsulated into an integrated filter, they do not need to be clamped and can be directly placed on the second mounting platform 12. When the equipment is not equipped with the disposable filter assembly 7, the second mounting platform 12 can be folded to reduce the space occupied by the equipment, making the structure reasonable and effective.

[0033] See details Figure 1 and Figure 2 In this embodiment, the second mounting platform 12 is hinged to the first mounting platform 11 (in other embodiments, the second mounting platform 12 may also be hinged to the frame 1). The frame 1 is provided with a support swing rod 13, which is detachably connected to the second mounting platform 12. When it is necessary to fold the second mounting platform 12, the connection between the support swing rod 13 and the second mounting platform 12 is first disconnected, and then both the support swing rod 13 and the second mounting platform 12 rotate downwards. The structure is simple and reliable.

[0034] See details Figure 4 Furthermore, in this embodiment, the second mounting platform 12 is provided with an L-shaped slot 121, and the support swing rod 13 is provided with a locking pin 131 that cooperates with the slot 121. When the locking pin 131 is located in the horizontal section of the L-shape, the support swing rod 13 can provide support for the second mounting platform 12. When the support swing rod 13 swings clockwise, so that the locking pin 131 is located in the vertical section of the L-shape, the second mounting platform 12 can rotate upward, realizing the separation of the slot 121 and the locking pin 131, that is, the connection between the support swing rod 13 and the second mounting platform 12 is broken. The structure is reasonable and effective.

[0035] See details Figure 3In this embodiment, a fixing rod 41 is provided on the first mounting platform 11, and a first fixing component is provided on the fixing rod 41. The first fixing component includes a slide 42 that can move along the fixing rod 41 and a pair of clamping blocks 43 disposed on the slide 42. The hollow fiber membrane column 4 is disposed between the pair of clamping blocks 43. The hollow fiber membrane column 4 has various specifications in terms of length and diameter. The slide 42 in the first fixing component can move along the fixing rod 41 to adjust the clamping position of the pair of clamping blocks 43. At the same time, as the distance between the pair of clamping blocks 43 changes, the clamping diameter can be adjusted to accommodate hollow fiber membrane columns 4 of different specifications.

[0036] Furthermore, in this embodiment, the fixing rod 41 passes through the slide 42, and the slide 42 is fixed to the fixing rod 41 by the set screw 44. After loosening the set screw 44, the position of the slide 42 on the fixing rod 41 can be easily adjusted, thereby adjusting the vertical clamping position of the pair of clamping blocks 43. The pair of clamping blocks 43 are sleeved on the support 45 and fixed by the set screw 44. After loosening the set screw 44, the distance between the pair of clamping blocks 43 can be easily adjusted, thereby adjusting the clamping diameter. The support 45 is provided with a connecting rod 46, which passes through the slide 42 and is fixed by the set screw 44. After loosening the set screw 44, the distance between the support 45, the pair of clamping blocks 43 and the slide 42 can be adjusted by pushing and pulling the connecting rod 46, thereby adjusting the horizontal clamping position of the pair of clamping blocks 43. The overall structure is simple, reliable and easy to adjust.

[0037] Furthermore, in this embodiment, the fixing rod 41 and the extension rod 47 are connected (e.g., by threaded connection, clamp connection, etc.), and the extension rod 47 is also provided with a first fixing component. For hollow fiber membrane columns 4 with a relatively long length, the fixing rod 41 and the extension rod 47 are connected for use, and the two sets of first fixing components can reliably clamp and fix the hollow fiber membrane column 4.

[0038] See details Figure 5 In this embodiment, a second fixing component is provided on the first mounting platform 11. The second fixing component includes a first clamping plate 48 and a second clamping plate 49, which are detachably connected. A flat film package 5 is disposed between the first clamping plate 48 and the second clamping plate 49. This structure is suitable for areas of 0.1 to 0.5 m². 2 The flat film package 5 is clamped and fixed inside. Preferably, the first clamping plate 48 and the second clamping plate 49 are connected by screws, which has a simple structure and good reliability.

[0039] In this embodiment, the hollow fiber membrane column 4 and the flat membrane package 5 are arranged near the edge of the frame 1. See details. Figure 1 The display screen 9 faces forward (or towards the operator), and the hollow fiber membrane column 4 and flat membrane package 5 are arranged on the front side of the frame 1 to facilitate replacement and maintenance by the operator and avoid interference from other pipes, pumps, valves, etc.

[0040] Furthermore, in this embodiment, the frame 1 is also provided with a rotating arm 14, and the rotating arm 14 is provided with a display screen 9. The position and orientation of the display screen 9 can be easily adjusted through the rotating arm 14. The rotating arm 14 has a hollow structure, and the cables of the filter pump 3, the first switching valve 81 and the second switching valve 82 are passed through the rotating arm 14. This facilitates the connection of the cables of the pumps (filter pump 3 and replenishment pump 31), valves, and sensors (pressure sensor 83, pH sensor 84 and conductivity sensor 85, etc.) into the cabinet, reducing the space occupied and improving the convenience of replacing the filter.

[0041] Although the present invention has been disclosed above with reference to preferred embodiments, it is not intended to limit the present invention. Any person skilled in the art can make many possible variations and modifications to the present invention, or modify it into equivalent embodiments, without departing from the scope of the present invention. Therefore, any simple modifications, equivalent changes, and modifications made to the above embodiments based on the technical essence of the present invention, without departing from the content of the present invention, should fall within the protection scope of the present invention.

Claims

1. A micro-separation device, characterized by: The system includes a frame (1), on which are mounted a raw material tank (2), a filter pump (3), a hollow fiber membrane column (4), a flat membrane pack (5), a collection tank (6), and a disposable filter assembly (7). The raw material tank (2) is connected to the inlet of the filter pump (3) via a pipe. The outlet of the filter pump (3) is connected to the inlets of the hollow fiber membrane column (4), the flat membrane pack (5), and the disposable filter assembly (7) via pipes with a first switching valve (81). The outlets of the hollow fiber membrane column (4), the flat membrane pack (5), and the disposable filter assembly (7) are connected to the collection tank (6) via pipes with a second switching valve (82). The disposable filter assembly (7) includes one or more of a deep membrane pack (71), a sterilizing filter (72), and a virus-removing filter (73).

2. The micro-separation device of claim 1, wherein: The frame (1) is provided with a first mounting platform (11) and a foldable second mounting platform (12). The raw liquid tank (2), the filter pump (3), the hollow fiber membrane column (4), the flat membrane pack (5) and the collection tank (6) are located on the first mounting platform (11), and the disposable filter assembly (7) is located on the second mounting platform (12).

3. The micro-separation device of claim 2, wherein: The second mounting platform (12) is hinged to the first mounting platform (11), or the second mounting platform (12) is hinged to the frame (1). The frame (1) is provided with a support swing rod (13), and the support swing rod (13) is detachably connected to the second mounting platform (12).

4. The micro-separation device of claim 3, wherein: The second mounting platform (12) is provided with an L-shaped slot (121), and the support swing rod (13) is provided with a locking pin (131) that cooperates with the slot (121).

5. The micro-separation device of claim 2, wherein: The first installation platform (11) is provided with a fixing rod (41), and the fixing rod (41) is provided with a first fixing component. The first fixing component includes a slide (42) that can move along the fixing rod (41) and a pair of clamping blocks (43) provided on the slide (42). The hollow fiber membrane column (4) is located between the pair of clamping blocks (43).

6. The micro-separation device of claim 5, wherein: The fixing rod (41) passes through the slide (42), and the slide (42) is fixed to the fixing rod (41) by a set screw (44). A pair of clamping blocks (43) are sleeved on the support (45) and fixed by a set screw (44). A connecting rod (46) is provided on the support (45), and the connecting rod (46) passes through the slide (42) and is fixed by a set screw (44).

7. The micro-separation device of claim 5, wherein: The fixing rod (41) is connected to the extension rod (47), and the extension rod (47) is also provided with the first fixing component.

8. The micro-separation device of claim 2, wherein: The first installation platform (11) is provided with a second fixing component, which includes a first clamping plate (48) and a second clamping plate (49). The first clamping plate (48) and the second clamping plate (49) are detachably connected, and the flat film package (5) is disposed between the first clamping plate (48) and the second clamping plate (49).

9. The micro-separation device according to any one of claims 1 to 8, characterized in that: The hollow fiber membrane column (4) and the flat sheet membrane package (5) are arranged close to one side edge of the rack (1).

10. The micro-separation device according to any one of claims 1 to 8, characterized in that: The rack (1) is further provided with a rotating arm (14), and a display screen (9) is arranged on the rotating arm (14). The rotating arm (14) is a hollow structure, and the cables of the filter pump (3), the first switch valve (81) and the second switch valve (82) are arranged in the rotating arm (14).

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