Constant temperature device for menstrual blood stem cell culture
By introducing a flexible clamping structure and a heating plate design into the thermostat, the problem of test tube damage was solved, achieving efficient clamping and convenient handling, thus improving the clamping efficiency and practicality of the thermostat for hematopoietic stem cell culture.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- SHANGHAI SINOBAY BIOTECH CO LTD
- Filing Date
- 2025-03-25
- Publication Date
- 2026-04-21
AI Technical Summary
In existing technologies, the constant temperature device used for hematopoietic stem cell culture is prone to damage to the culture tube during clamping, making it impossible to clamp flexibly, resulting in stem cell leakage and reducing clamping efficiency.
The design incorporates a constant temperature chamber, a fixing block, a pressing rod, a spring, a clamping plate, and an anti-slip pad. Through the cooperation of knobs and screws, the test tubes are flexibly clamped, and a heating plate is used for constant temperature treatment.
It achieves flexible clamping of test tubes, improving clamping efficiency, and prevents test tubes from sliding through anti-slip pads, enhancing the practicality of the device.
Smart Images
Figure CN224148057U_ABST
Abstract
Description
Technical Field
[0001] This utility model relates to the field of menstrual blood stem cell culture technology, and in particular to a constant temperature device for menstrual blood stem cell culture. Background Technology
[0002] Menstrual blood stem cells refer to a type of stem cell isolated from menstrual blood. Studies have shown that menstrual blood is rich in various types of stem cells, which have certain self-renewal, differentiation potential and regenerative capacity. These stem cells are considered to have the potential to be used in regenerative medicine and tissue repair. Compared with stem cells from other sources such as bone marrow stem cells and embryonic stem cells, menstrual blood stem cells have a more convenient way of obtaining them and do not involve ethical issues, thus becoming an important research direction in the scientific research field.
[0003] In the prior art, such as Chinese Patent No. CN215757396U, a constant temperature device for culturing menstrual stem cells relates to the technical field of menstrual stem cell culture equipment. This constant temperature device for culturing menstrual stem cells includes a constant temperature chamber, the interior of which has a placement groove. A retaining ring is disposed inside the placement groove. A limiting plate is fixedly connected to the outer wall of the retaining ring to restrict its single-degree-of-freedom sliding movement within the placement groove. The limiting plate has four annularly distributed sliding grooves extending into the retaining ring. A culture tube located inside the placement groove is inserted into the retaining ring. A support base is disposed at the bottom of the culture tube. The top of the support base has four annularly distributed arc-shaped grooves, and a connecting shaft is slidably connected inside the arc-shaped grooves. Through the cooperation of an adjustment mechanism and a drive mechanism, the device can be easily adjusted to place and remove the culture tube, and the culture tube can be well fixed during storage, making the culture tube and the device an integral unit, preventing slippage.
[0004] While the above-mentioned solution has the advantages mentioned above, its disadvantage is that the device is extremely prone to damaging the culture tubes during clamping, making it impossible to perform flexible clamping. This results in the leakage of stem cells due to tube damage, reducing the clamping efficiency of the constant temperature device for menstrual stem cell culture. Utility Model Content
[0005] The purpose of this invention is to solve the problem that in the prior art, the culture tube is easily damaged during clamping, making it impossible to perform flexible clamping treatment, resulting in the leakage of stem cells from the damaged tube, and reducing the clamping efficiency of the constant temperature device for blood stem cell culture.
[0006] To achieve the above objectives, the present invention adopts the following technical solution: a constant temperature device for hematopoietic stem cell culture: comprising a constant temperature chamber, wherein multiple fixing blocks are fixedly connected to both sides of the inner wall of the constant temperature chamber, and a placement groove is opened on the top of the multiple fixing blocks; two vertical plates are fixedly connected inside the fixing blocks, and a pressing rod is movably embedded inside each of the two vertical plates; a spring is fixedly connected to one end of the pressing rod, and a telescopic column is fixedly connected to one end of the pressing rod; a wedge is fixedly connected to the other end of the pressing rod, and a wedge is movably embedded inside the wedge; a push rod is fixedly connected to the outer surface of the wedge, and the outer surface of the push rod is movably embedded inside the fixing block; a clamping plate is fixedly connected to one end of the telescopic column, and the outer surface of the clamping plate is fixedly connected to one end of the spring; multiple anti-slip pads are fixedly connected to the inner wall of the clamping plate; a connecting plate is fixedly connected to one end of each of the two push rods; a screw is movably connected to the outer surface of the fixing block, and the outer surface of the screw is threadedly connected to the inside of the connecting plate; a knob is fixedly connected to one end of the screw.
[0007] In a preferred embodiment, two heating plates are fixedly installed on both sides of the inner wall of the constant temperature chamber, and a thermostat is fixedly installed on the outer surface of the constant temperature chamber.
[0008] The technical effect of adopting the above-mentioned further solution is: turn on the thermostat, use the thermostat to control two electric heating plates, and use the two electric heating plates to perform constant temperature treatment on the test tube.
[0009] In a preferred embodiment, the interior of the thermostat is electrically connected to the interior of the heating plate.
[0010] The technical advantage of adopting the above-mentioned further solution is that the thermostat makes it easier to control the heating plate.
[0011] In a preferred embodiment, a screw rod is movably connected to the inner wall of the constant temperature chamber, and a knob is fixedly connected to the top end of the screw rod.
[0012] The technical effect of adopting the above-mentioned further solution is that the second knob will drive the second screw to rotate, and the second screw will drive the slider to rise gradually.
[0013] In a preferred embodiment, the outer surface of the screw two is threaded with a slider.
[0014] The technical effect of adopting the above-mentioned further solution is that the slider drives the pallet to rise.
[0015] In a preferred embodiment, a support plate is fixedly connected to the outer surface of the slider.
[0016] The technical effect of adopting the above-mentioned further solution is that multiple test tubes can be lifted by raising the tray.
[0017] In a preferred embodiment, a limiting post is fixedly connected to the inner wall of the constant temperature chamber, and the outer surface of the limiting post is movably embedded inside the slider.
[0018] The technical effect of adopting the above-mentioned further solution is that the limiting post is easy to limit.
[0019] In a preferred embodiment, the top of the constant temperature chamber is connected to a sealing cover via a hinge.
[0020] The technical effect of adopting the above-mentioned further solution is that the sealed cover prevents heat loss.
[0021] Compared with the prior art, the advantages and positive effects of this utility model are as follows:
[0022] In use, this invention begins by opening the sealing cap and then sequentially placing multiple blood stem cells stored in test tubes into the placement slots. Next, knob one is manually rotated, causing screw one to rotate clockwise. This continuous clockwise rotation of screw one gradually moves the connecting plate towards the outer surface of the fixed block. The connecting plate then pushes two push rods horizontally towards the interior of the fixed block. Simultaneously, the two push rods move two wedge blocks two, which in turn gradually move two wedge blocks one horizontally, thus pushing the pressing rod to move. The spring and telescopic column 2, along with the clamping plate, are moved towards the outer surface of the test tube by the pressing rod. The spring force of spring 2 pushes the clamping plate, which flexibly holds the test tube. Anti-slip pads are used to prevent the test tube from slipping. Wedge 2 and wedge 1 are in a meshing state, so when screw 1 reverses, wedge 1 also resets with wedge 2. After installation, the sealing cover is closed, the thermostat is turned on, and the thermostat controls the two heating plates to maintain a constant temperature for the test tube, thus achieving flexible clamping and improving the clamping efficiency of the thermostat device for hematopoietic stem cell culture.
[0023] In this invention, when test tubes are needed, the operator manually rotates knob two, which in turn drives screw two to rotate. Screw two causes the slider to gradually rise, which in turn causes the tray to rise. The rising of the tray lifts multiple test tubes, and the operator can then remove the test tubes as needed. This makes it easier to handle the test tubes and improves the practicality of the constant temperature device for hematopoietic stem cell culture. Attached Figure Description
[0024] Figure 1 A schematic diagram of the main structure of a constant temperature device for culturing menstrual blood stem cells provided by this utility model;
[0025] Figure 2A schematic diagram of the internal structure of a constant temperature device for culturing menstrual blood stem cells provided by this utility model;
[0026] Figure 3 A vertical cross-sectional view of a constant temperature device for culturing menstrual stem cells provided by this utility model;
[0027] Figure 4 A cross-sectional schematic diagram of a constant temperature device for culturing blood stem cells provided by this utility model.
[0028] Legend:
[0029] 1. Constant temperature chamber body; 101. Sealing cover; 102. Thermostat; 103. Fixing block; 104. Placement slot; 105. Screw one; 106. Push rod; 107. Connecting plate; 108. Knob one; 109. Vertical plate; 110. Press-in rod; 111. Wedge one; 112. Wedge two; 113. Clamping plate; 114. Anti-slip pad; 115. Telescopic column two; 116. Spring two; 117. Heating plate; 2. Screw two; 201. Limiting column; 202. Knob two; 203. Sliding block; 204. Support plate. Detailed Implementation
[0030] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.
[0031] Example 1, please refer to Figures 1-4This utility model provides a technical solution: a constant temperature device for hematopoietic stem cell culture, including a constant temperature chamber 1. Multiple fixing blocks 103 are fixedly connected to both sides of the inner wall of the constant temperature chamber 1. Placement slots 104 are opened on the top of the multiple fixing blocks 103. Two vertical plates 109 are fixedly connected inside the fixing blocks 103. A pressing rod 110 is movably embedded inside each of the two vertical plates 109. A spring 116 is fixedly connected to one end of the pressing rod 110, and a telescopic column 115 is fixedly connected to the other end of the pressing rod 110. A wedge 111 is fixedly connected to the other end of the pressing rod 110. A wedge 112 is movably embedded inside the wedge 111. A push rod 106 is fixedly connected to the outer surface of the wedge 112. The surface is movably embedded inside the fixed block 103. One end of the telescopic column 115 is fixedly connected to the clamping plate 113. The outer surface of the clamping plate 113 is fixedly connected to one end of the spring 116. Multiple anti-slip pads 114 are fixedly connected to the inner wall of the clamping plate 113. One end of the two push rods 106 is fixedly connected to the connecting plate 107. The outer surface of the fixed block 103 is movably connected to the screw 105. The outer surface of the screw 105 is threadedly connected to the inside of the connecting plate 107. One end of the screw 105 is fixedly connected to the knob 108. Two electric heating plates 117 are fixedly installed on both sides of the inner wall of the constant temperature chamber 1. A thermostat 102 is fixedly installed on the outer surface of the constant temperature chamber 1. The interior of the thermostat 102 is electrically connected to the interior of the electric heating plate 117.
[0032] In this embodiment, during use, the sealing cap 101 is first opened, and then multiple hematopoietic stem cells stored in test tubes are sequentially placed into multiple placement slots 104. Then, the knob 108 is manually rotated sequentially. The knob 108 drives the screw 105 to rotate forward. Through the continuous forward rotation of the screw 105, the screw 105 gradually moves the connecting plate 107 towards the outer surface of the fixing block 103. The connecting plate 107 then pushes the two push rods 106 to move horizontally towards the interior of the fixing block 103. Simultaneously, the two push rods 106 gradually push the two wedge blocks 112 to move. As the two wedge blocks 112 move, they gradually push the two wedge blocks 111 to move horizontally. The wedge blocks 111 gradually push the pressing rod 110 to move. The spring 116, telescopic column 115, and clamping plate 113 are moved towards the outer surface of the test tube by the pressing rod 110. The spring 116 pushes the clamping plate 113, and the two clamping plates 113 flexibly hold the test tube. The anti-slip pad 114 is used to prevent the test tube from slipping. The wedge 112 and wedge 111 are in a meshing state. So when the screw 105 reverses, the wedge 111 also resets with the wedge 112. After installation, the sealing cover 101 is closed and the thermostat 102 is turned on. The thermostat 102 controls the two heating plates 117 to keep the test tube at a constant temperature, thereby achieving flexible clamping and improving the clamping efficiency of the thermostat for hematopoietic stem cell culture.
[0033] Example 2, as Figure 1 - Figure 4 As shown, a screw 2 is movably connected to the inner wall of the constant temperature chamber 1. A knob 202 is fixedly connected to the top of the screw 2. A slider 203 is threadedly connected to the outer surface of the screw 2. A support plate 204 is fixedly connected to the outer surface of the slider 203. A limit post 201 is fixedly connected to the inner wall of the constant temperature chamber 1. The outer surface of the limit post 201 is movably embedded in the inside of the slider 203. A sealing cover 101 is connected to the top of the constant temperature chamber 1 via a hinge.
[0034] In this embodiment, when test tubes are needed, the staff manually rotates knob 202, which in turn drives screw 22 to rotate. Screw 22 drives slider 203 to gradually rise, and slider 203 drives tray 204 to rise. The rise of tray 204 lifts multiple test tubes, and then the staff takes out the test tubes as needed, thereby making it easier to take out the test tubes and improving the practicality of the constant temperature device for hematopoietic stem cell culture.
[0035] Working Principle: In use, first open the sealing cap 101, then place multiple blood stem cells stored in test tubes into multiple placement slots 104. Next, manually rotate knob 108. Knob 108 drives screw 105 to rotate forward. Through the continuous forward rotation of screw 105, screw 105 gradually moves connecting plate 107 towards the outer surface of fixing block 103. Connecting plate 107 then pushes two push rods 106 horizontally towards the interior of fixing block 103. Simultaneously, the two push rods 106 gradually push two wedge blocks 112. As wedge blocks 112 move, they gradually push two wedge blocks 111 horizontally. Wedge blocks 111 gradually push the pressing rod 110, which in turn pushes spring 116, telescopic column 115, and clamping plate 113 towards the outer surface of the test tube. The elastic force of spring 116 pushes clamping plate 113, utilizing the two clamping... Plate 113 flexibly clamps the test tube and provides anti-slip treatment with anti-slip pad 114. Wedge 112 and wedge 111 are in a mutually meshing state, so when screw 105 reverses, wedge 111 also resets with wedge 112. After installation, the sealing cover 101 is closed and the thermostat 102 is turned on. The thermostat 102 controls two heating plates 117 to maintain the temperature of the test tube, thereby achieving flexible clamping and improving the clamping efficiency of the thermostat for hematopoietic stem cell culture. When test tubes are needed, the operator manually rotates knob 202, which in turn drives screw 22 to rotate. Screw 22 drives slider 203 to gradually rise, and slider 203 drives tray 204 to rise. The rise of tray 204 lifts multiple test tubes, and then the operator takes out the test tubes as needed, thus facilitating the handling of test tubes and improving the practicality of the thermostat for hematopoietic stem cell culture.
[0036] The above description is merely a preferred embodiment of the present utility model and is not intended to limit the present utility model in any other way. Any person skilled in the art may make changes or modifications to the above-disclosed technical content to create equivalent embodiments for application in other fields. However, any simple modifications, equivalent changes, and modifications made to the above embodiments based on the technical essence of the present utility model without departing from the technical solution of the present utility model shall still fall within the protection scope of the technical solution of the present utility model.
Claims
1. A thermostatic device for blood stem cell culture, comprising a thermostat body (1), characterized in that: Multiple fixing blocks (103) are fixedly connected to both sides of the inner wall of the constant temperature chamber (1). The top of the multiple fixing blocks (103) is provided with a placement groove (104). Two vertical plates (109) are fixedly connected inside the fixing blocks (103). Press-in rods (110) are movably embedded inside the two vertical plates (109). A spring (116) is fixedly connected to one end of the press-in rod (110). A telescopic column (115) is fixedly connected to one end of the press-in rod (110). A wedge (111) is fixedly connected to the other end of the press-in rod (110). A wedge (112) is movably embedded inside the wedge (111). The outer surface of the wedge (112) is fixed. A push rod (106) is connected, and the outer surface of the push rod (106) is movably embedded inside the fixed block (103). One end of the telescopic column (115) is fixedly connected to a clamping plate (113). The outer surface of the clamping plate (113) is fixedly connected to one end of the spring (116). Multiple anti-slip pads (114) are fixedly connected to the inner wall of the clamping plate (113). One end of the two push rods (106) is fixedly connected to a connecting plate (107). The outer surface of the fixed block (103) is movably connected to a screw (105). The outer surface of the screw (105) is threadedly connected to the inside of the connecting plate (107). One end of the screw (105) is fixedly connected to a knob (108).
2. The constant temperature device for blood stem cell culture according to claim 1, wherein: Two electric heating plates (117) are fixedly installed on both sides of the inner wall of the constant temperature chamber (1), and a thermostat (102) is fixedly installed on the outer surface of the constant temperature chamber (1).
3. The constant temperature device for blood stem cell culture according to claim 2, wherein: The thermostat (102) is electrically connected to the heating plate (117).
4. The constant temperature device for blood stem cell culture according to claim 1, wherein: The inner wall of the constant temperature chamber (1) is movably connected to a screw rod (2), and the top of the screw rod (2) is fixedly connected to a knob (202).
5. The constant temperature device for blood stem cell culture according to claim 4, wherein: The outer surface of the screw (2) is threaded with a slider (203).
6. The constant temperature device for blood stem cell culture according to claim 5, wherein: The outer surface of the slider (203) is fixedly connected to the support plate (204).
7. The constant temperature device for blood stem cell culture according to claim 1, wherein: The inner wall of the constant temperature chamber (1) is fixedly connected to a limiting post (201), and the outer surface of the limiting post (201) is movably embedded in the inside of the slider (203).
8. The constant temperature device for blood stem cell culture according to claim 1, wherein: The top of the constant temperature chamber (1) is connected to a sealing cover (101) by a hinge.