Modularized chromatographic solvent preparation mixer

Abstract

The utility model relates to a modular preparative chromatography solvent mixer, which belongs to the technical field of liquid chromatography and comprises a base and supporting rods fixed at the top of the base in a circumferential array, the tops of the supporting rods are fixedly connected with a solvent mixing barrel with an upward opening, and a stirring component is connected in the solvent mixing barrel. The stirring assembly is used for stirring and mixing a solvent, a rotary feeding assembly is arranged at the top of the solvent mixing barrel, the rotary feeding assembly is used for guiding the solvent into the solvent mixing barrel in a rotary feeding mode, a material supply assembly is arranged at the top of the rotary feeding assembly, and the material supply assembly is used for providing the solvent for the rotary feeding assembly; according to the mixer for modular preparation of the chromatographic solvent, a rotary feeding mode is adopted, the solvent is put into the mixing barrel, and compared with a vertical feeding mode, the problem that the solvent is concentrated and accumulated in a local area is effectively avoided, and the mixing efficiency and uniformity of the stirring assembly to the solvent are remarkably improved.

Description

Technical Field

[0001] This utility model relates to the field of liquid chromatography technology, and in particular to a modular preparative chromatographic solvent mixer. Background Technology

[0002] In modern chemistry, pharmaceuticals, and bioengineering, preparative chromatography is a core technique for obtaining high-purity target compounds. It plays a crucial role in separating and purifying samples from complex mixtures, providing indispensable raw material support for subsequent product development, quality testing, and industrial production. In a preparative chromatography system, the solvent mixer, as the core device for mobile phase preparation, directly determines the homogeneity of the mobile phase, thus affecting the efficiency and accuracy of chromatographic separation. A precise and homogeneous mobile phase not only improves the separation purity of the target compound but also ensures the reliability of analytical results and the repeatability of experimental data, playing a vital, bridging role in the entire preparative chromatography process.

[0003] However, the vertical feeding method commonly used in traditional preparative chromatography solvent mixers has revealed significant drawbacks in practical applications. In this method, the solvent is vertically injected from the top of the mixing tank via a pipe, and the high-speed impact of the solvent flow creates strong eddies within the tank, making it difficult for the solvent to diffuse and become uniform quickly. Especially when mixing multiple solvents with different properties and significantly different viscosities, this feeding method easily creates significant concentration gradients in localized areas of the mixing tank, resulting in excessively high solvent concentrations in some areas and low concentrations in others. When the unevenly mixed mobile phase enters the chromatographic column, it causes peak broadening and tailing in sample separation, severely reducing chromatographic resolution and making it difficult to effectively separate and purify target compounds. Simultaneously, the uneven concentration of the mobile phase also affects the repeatability of chromatographic analysis, leading to significant differences in results between different batches, increasing experimental errors and data processing difficulties. Furthermore, extending the mixing time to improve mixing efficiency reduces the overall efficiency of preparative chromatography and increases production costs. Therefore, developing new solvent mixing methods and equipment to overcome the technical bottlenecks of traditional vertical feeding has become an urgent task for improving preparative chromatography technology and meeting the ever-increasing demand for high-purity sample preparation. Utility Model Content

[0004] To overcome the technical defects of the existing technology, this utility model provides a modular preparative chromatography solvent mixer, which has the advantages of uniform feeding and effectively avoids the problem of solvent accumulation in local areas.

[0005] The technical solution adopted by this utility model is as follows: it includes a base and support rods fixed in a circumferential array on the top of the base. A solvent mixing tank with an upward opening is fixedly connected to the top of the support rods. A stirring assembly is connected inside the solvent mixing tank. The stirring assembly is used to stir and mix the solvent. A rotary feeding assembly is provided on the top of the solvent mixing tank. The rotary feeding assembly is used to introduce the solvent into the solvent mixing tank in a rotary feeding manner. A feeding assembly is provided on the top of the rotary feeding assembly. The feeding assembly is used to supply solvent to the rotary feeding assembly.

[0006] Preferably, in order to rotate the stirring rod, the stirring assembly includes a stirring rod disposed inside the solvent mixing tank, and a stirring motor is fixedly connected to the bottom of the solvent mixing tank, with the output shaft of the stirring motor fixed to one end of the stirring rod.

[0007] Preferably, in order to connect the end cap and the rotating ring as a whole, the rotating feed assembly includes an end cap disposed on the top of the solvent mixing tank, a rotating ring fixedly connected to the bottom of the end cap, and a limit ring installed on the outer side wall of the solvent mixing tank near the opening.

[0008] Preferably, in order to make the drive gear rotate, the rotating ring is rotatably mounted on the limiting ring, a gear ring is fixed to the top of the end cap, a drive motor is fixedly connected to the outer wall of the solvent mixing tank, and a drive gear is fixed to the output shaft of the drive motor.

[0009] Preferably, in order to enable the drive gear to cooperate with the gear ring, the drive gear meshes with the gear ring, and the end cover is provided with mounting holes arranged in a circumferential array. A solvent storage tank is installed in the mounting holes, and a solenoid valve is installed at the bottom of the solvent storage tank.

[0010] Preferably, in order to extract external solvent by means of the extraction pump, the feeding assembly includes stabilizing rods fixed on both sides of the top of the base, a circular top plate is installed on one end of the stabilizing rod, and the extraction pump is fixed in a circumferential array on the top of the circular top plate.

[0011] Preferably, in order to protect the internal components by means of the protective glass, the bottom of the circular top plate is fixedly connected to the protective glass, and the bottom end of the protective glass extends to the top of the end cap.

[0012] The beneficial effects of this utility model are as follows: by providing a rotary feeding component and a feeding component, the feeding component can supply solvent to the rotary feeding component before stirring the solvent. After the rotary feeding component starts working, the solvent is placed into the solvent mixing tank in a rotating manner. Compared with the vertical feeding method, it effectively avoids the problem of solvent accumulation in local areas, significantly improves the mixing efficiency and uniformity of the stirring component, and has a simple structure and strong practicality. Attached Figure Description

[0013] Figure 1 This is a schematic diagram of the structure of this utility model.

[0014] Figure 2 This is a schematic diagram of the solvent mixing tank in this utility model.

[0015] Figure 3 This is a cross-sectional structural diagram of the solvent mixing tank in this utility model.

[0016] Figure 4 for Figure 3 A magnified structural diagram of point A in the middle.

[0017] Figure 5 This is a schematic diagram of the feeding component in this utility model.

[0018] Explanation of reference numerals in the attached drawings: 1. Base; 2. Support rod; 3. Solvent mixing tank; 4. Stirring assembly; 401. Stirring rod; 402. Stirring motor; 5. Rotary feeding assembly; 501. End cap; 502. Rotating ring; 503. Limiting ring; 504. Gear ring; 505. Drive motor; 506. Drive gear; 507. Solvent storage tank; 6. Feeding assembly; 601. Stabilizing rod; 602. Circular top plate; 603. Extraction pump; 604. Protective glass. Detailed Implementation

[0019] The present invention will be further described below with reference to the accompanying drawings:

[0020] like Figures 1-5 As shown, this embodiment provides a modular preparative chromatography solvent mixer, including a base 1 and support rods 2 fixed in a circumferential array on the top of the base 1. The top of the support rods 2 is fixedly connected to an upward-opening solvent mixing tank 3. A stirring assembly 4 is connected inside the solvent mixing tank 3. The stirring assembly 4 is used to stir and mix the solvent. A rotary feed assembly 5 is provided on the top of the solvent mixing tank 3. The rotary feed assembly 5 is used to introduce the solvent into the solvent mixing tank 3 in a rotary feeding manner. A feeding assembly 6 is provided on the top of the rotary feed assembly 5. The feeding assembly 6 is used to supply solvent to the rotary feed assembly 5.

[0021] Before mixing the solvent, the feeding component 6 can supply the solvent to the rotary feeding component 5. After the rotary feeding component 5 is working, the solvent is placed into the solvent mixing tank 3 in a rotating manner. Compared with the vertical feeding method, this effectively avoids the problem of solvent accumulation in a local area. When the solvent is placed into the solvent mixing tank 3, the stirring component 4 works and can stir and mix the solvent. The bottom of the solvent mixing tank 3 is provided with a discharge pipe, and a switch valve is connected to the discharge pipe. The mixed solvent can be discharged through the discharge pipe.

[0022] The stirring assembly 4 includes a stirring rod 401 disposed inside the solvent mixing tank 3. A stirring motor 402 is fixedly connected to the bottom of the solvent mixing tank 3. The output shaft of the stirring motor 402 is fixed to one end of the stirring rod 401. After the solvent is placed inside the solvent mixing tank 3, the stirring motor 402 fixed to the bottom of the solvent mixing tank 3 is powered on, and its output shaft begins to rotate, driving the stirring rod 401 fixedly connected to it to rotate synchronously. The stirring rod 401 stirs the solvent in the solvent mixing tank 3, further mixing the solvent that was initially evenly distributed. Compared with the traditional feeding and stirring method, the stirring rod 401 can act on the solvent more efficiently, avoiding uneven mixing due to excessively high local concentration, and enabling the solvent to reach a highly uniform state in a short time.

[0023] The rotary feed assembly 5 includes an end cap 501 mounted on top of the solvent mixing tank 3. A rotating ring 502 is fixedly connected to the bottom of the end cap 501. A limiting ring 503 is installed on the outer side wall of the solvent mixing tank 3 near the opening. The rotating ring 502 is rotatably mounted on the limiting ring 503. A gear ring 504 is fixed to the top of the end cap 501. A drive motor 505 is fixedly connected to the outer side wall of the solvent mixing tank 3. A drive gear 506 is fixed to the output shaft of the drive motor 505. The drive gear 506 meshes with the gear ring 504. Mounting holes are arranged in a circumferential array on the end cap 501, and solvent storage containers are installed in the mounting holes. The solvent storage tank 507 is equipped with a solenoid valve at its bottom. When in use, different solvents are loaded into the solvent storage tank 507 in the mounting hole of the end cap 501 and the solenoid valve is closed. After the equipment is started, the drive motor 505 drives the drive gear 506 to rotate, which in turn drives the gear ring 504 to rotate, thereby driving the end cap 501 and the bottom rotating ring 502 to rotate stably within the limiting ring 503. When adding solvent, the solenoid valve is opened, and the solvent enters the solvent mixing tank 3 in a rotating manner under the action of centrifugal force and gravity. Compared with traditional vertical feeding, it avoids local accumulation and achieves preliminary uniform distribution.

[0024] The feeding assembly 6 includes a stabilizing rod 601 fixed on both sides of the top of the base 1. A circular top plate 602 is installed on one end of the stabilizing rod 601. A pump 603 is fixed in a circumferential array on the top of the circular top plate 602. A protective glass 604 is fixedly connected to the bottom of the circular top plate 602. The bottom end of the protective glass 604 extends to the top of the end cap 501. In use, the pump 603 on the top of the circular top plate 602 accurately extracts multi-component solvent from the external container according to a preset program or real-time demand and delivers it to the solvent storage tank 507. During this process, the solvent storage tank 507 remains fixed to ensure stable solvent injection and avoid splashing or injection deviation caused by rotation. The protective glass 604 extending from the bottom of the circular top plate 602 to the top of the end cap 501 can not only observe the solvent delivery status in real time, but also effectively block external dust and impurities.

[0025] The foregoing has shown and described the basic principles and main features of this invention, as well as its advantages. Those skilled in the art should understand that this invention is not limited to the above embodiments. The embodiments and descriptions in the specification are merely illustrative of the principles of this invention. Various changes and modifications can be made to this invention without departing from its spirit and scope. All such changes and modifications fall within the scope of this invention as defined by the appended claims and their equivalents.

Claims

1. A modular preparative chromatographic solvent mixer, comprising a base (1) and support rods (2) arranged in a circumferential array and fixed on the top of the base (1), wherein the top of the support rods (2) is fixedly connected to an upward-opening solvent mixing tank (3), characterized in that: The solvent mixing tank (3) is connected to a stirring assembly (4), which is used to stir and mix the solvent. A rotary feed assembly (5) is provided on the top of the solvent mixing tank (3), which is used to introduce the solvent into the solvent mixing tank (3) by rotary feeding. A feeding assembly (6) is provided on the top of the rotary feed assembly (5), which is used to supply the solvent to the rotary feed assembly (5).

2. The modular preparative chromatographic solvent mixer according to claim 1, characterized in that: The stirring assembly (4) includes a stirring rod (401) disposed in the solvent mixing tank (3), and a stirring motor (402) is fixedly connected to the bottom of the solvent mixing tank (3). The output shaft of the stirring motor (402) is fixed to one end of the stirring rod (401).

3. The modular preparative chromatographic solvent mixer according to claim 1, characterized in that: The rotary feed assembly (5) includes an end cap (501) disposed on the top of the solvent mixing tank (3), a rotating ring (502) fixedly connected to the bottom of the end cap (501), and a limiting ring (503) installed on the outer side wall of the solvent mixing tank (3) near the opening.

4. The modular preparative chromatographic solvent mixer according to claim 3, characterized in that: The rotating ring (502) is rotatably mounted on the limiting ring (503), the top of the end cap (501) is fixed with a gear ring (504), the outer wall of the solvent mixing tank (3) is fixedly connected with a drive motor (505), and the output shaft of the drive motor (505) is fixed with a drive gear (506).

5. The modular preparative chromatographic solvent mixer according to claim 4, characterized in that: The drive gear (506) meshes with the gear ring (504). The end cap (501) is provided with mounting holes in a circumferential array. A solvent storage tank (507) is installed in the mounting holes. A solenoid valve is installed at the bottom of the solvent storage tank (507).

6. The modular preparative chromatographic solvent mixer according to claim 3, characterized in that: The feeding assembly (6) includes a stabilizing rod (601) fixed on both sides of the top of the base (1). A circular top plate (602) is installed on one end of the stabilizing rod (601), and a pump (603) is fixed in a circumferential array on the top of the circular top plate (602).

7. The modular preparative chromatographic solvent mixer according to claim 6, characterized in that: The bottom of the circular top plate (602) is fixedly connected to a protective glass (604), and the bottom end of the protective glass (604) extends to the top of the end cap (501).

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