Concentration device for pharmaceutical production

Abstract

The utility model discloses a concentration device for pharmaceutical production, which comprises a concentrator rack, two evaporation concentration tanks are fixedly connected to the left side in the concentrator rack, a separation tank is fixed to the right side in the concentrator rack, and a concentration driving component is fixedly connected to the lower part of the right side of an inner cavity of the concentrator rack, 4-6 groups of tank wall residual dirt cleaning mechanisms are arranged in an inner cavity of each evaporation concentration tank; the evaporation concentration tank comprises a tank body, a liquid inlet pipe fixed at the bottom of the tank body and a liquid outlet pipe fixed at the top of the tank body. According to the technical scheme of the concentration device, an evaporation concentration tank is matched with a concentration driving assembly to achieve agent evaporation concentration and steam condensation, a high-temperature-resistant motor in a tank wall residual scale cleaning mechanism drives a transmission shaft to rotate, an expansion rod and a brush plate are driven to rotate to brush the tank wall, and residual scale accumulation is prevented. The tank wall residual scale cleaning mechanism can clean tank wall residual scales in time, so that the inner wall of the evaporation concentration tank is kept clean, and the residual scales are prevented from influencing the medicament quality and the subsequent concentration effect.

Description

A pharmaceutical concentration device Technical Field

[0001] This utility model relates to the field of evaporation and concentrator technology, specifically to a concentration device for pharmaceutical production. Background Technology

[0002] In the pharmaceutical manufacturing industry, the concentration process is a crucial step in many drug preparation processes. Its purpose is to remove excess solvent from the drug and increase the concentration of the active ingredient to meet the quality standards and usage requirements of the drug. Most existing drug concentration devices employ evaporation concentration technology, which involves heating the solvent in the drug to vaporize it, and then condensing and recovering the vapor to achieve drug concentration.

[0003] However, in actual production processes, existing concentration devices have some problems that urgently need to be solved. On the one hand, during the evaporation and concentration process, some components of the reagent tend to crystallize or deposit on the walls of the concentration tank, forming scale. This scale not only gradually reduces the effective volume of the concentration tank and lowers the concentration efficiency, but may also mix into subsequent pharmaceutical products, affecting the quality and purity of the drug. Therefore, developing a pharmaceutical concentration device that can effectively clean scale from the tank walls is of significant practical importance. Summary of the Invention

[0004] The purpose of this utility model is to provide a technical solution for a concentration device in pharmaceutical production, thereby addressing the shortcomings mentioned in the background art. To overcome the drawbacks and defects described in the background art, this technical solution includes the following:

[0005] It includes a concentrator frame, with two evaporation and concentration tanks fixedly connected to the left side of the concentrator frame, a separation tank fixedly connected to the right side of the concentrator frame, and a concentration drive assembly fixedly connected to the lower right side of the inner cavity of the concentrator frame. Each of the evaporation and concentration tanks is equipped with 4-6 sets of tank wall residue cleaning mechanisms.

[0006] The evaporation and concentration tank includes a tank body, an inlet pipe fixed to the bottom of the tank body, and an outlet pipe fixed to the top of the tank body.

[0007] The tank wall residue cleaning mechanism includes a high-temperature resistant motor, multiple drive shafts connected to the output end of the high-temperature resistant motor via couplings, and expansion rods hinged to the left and right sides of the drive shafts. Two pull rods are hinged to the lower left and right sides of the drive shafts. The top of the pull rods is hinged to the middle section of the bottom surface of the expansion rods. The ends of the expansion rods are all hinged to brush plates that contact the inner cavity sidewall of the tank.

[0008] As a preferred embodiment of this utility model: the concentration drive assembly consists of a heater, an evaporator, a condenser, a compressor, and pipelines, wherein the heater is used to evaporate and concentrate the liquid inside the evaporation and concentration tank, and the evaporator, condenser, and compressor are used to condense the steam inside the tank.

[0009] As a preferred embodiment of this utility model: the inlet pipe is connected to the pharmaceutical raw material to be concentrated, and the outlet pipe is connected to the inlet of the separator through a pipeline.

[0010] As a preferred embodiment of this utility model: the outer shell sidewall of the high-temperature resistant motor is fixedly connected to the inner cavity top sidewall of the tank through a bracket, and the transmission shafts are fixedly connected to each other through a coupling.

[0011] As a preferred embodiment of this utility model, the high-temperature resistant motor is an HSV series high and low temperature servo motor or a YGF series high-temperature resistant three-phase asynchronous motor.

[0012] As a preferred embodiment of this utility model: a fixed ring is fixedly connected to the top of the outer ring of the transmission shaft, and a movable ring is movably arranged in the middle section of the outer ring of the transmission shaft. A cylindrical spring is fixed between the fixed ring and the movable ring and is looped on the transmission shaft to provide a downward pushing force for the expansion rod, forcing the expansion rod to open to both sides.

[0013] As a preferred embodiment of this utility model, the top end of the expansion rod is hinged to the left and right side walls of the movable ring via a pivot pin.

[0014] The technical effects and advantages provided by this utility model in the above technical solution are as follows:

[0015] In this concentration device technical solution, the evaporation and concentration tank, together with the concentration drive assembly, realizes the evaporation and concentration of the reagent and the condensation of the steam. The tank wall residue cleaning mechanism uses a high-temperature resistant motor to drive the transmission shaft to rotate, causing the expansion rod and brush plate to rotate and scrub the tank wall, preventing residue accumulation. This tank wall residue cleaning mechanism can promptly remove residue from the tank wall, ensuring the cleanliness of the inner wall of the evaporation and concentration tank and preventing residue from affecting the quality of the reagent and the subsequent concentration effect. Attached Figure Description

[0016] To more clearly illustrate the technical solutions in the embodiments of this application or the prior art, the drawings used in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments recorded in this utility model. For those skilled in the art, other drawings can be obtained based on these drawings.

[0017] Figure 1 is a schematic diagram of the overall structure of the evaporation and concentration mechanism;

[0018] Figure 2 is a schematic diagram of the interior of the evaporation and concentration tank;

[0019] Figure 3 is a schematic diagram of the tank wall residue cleaning mechanism inside the concentration tank.

[0020] Explanation of reference numerals in the attached figures:

[0021] 1. Concentrator frame; 2. Evaporation and concentration tank; 21. Tank body; 22. Inlet pipe; 23. Outlet pipe; 3. Tank wall residue cleaning mechanism; 31. High temperature resistant motor; 32. Drive shaft; 33. Fixed ring; 34. Moving ring; 35. Expansion rod; 36. Pulling rod; 37. Brush plate; 38. Cylindrical spring; 4. Separation tank; 5. Concentration drive assembly. Detailed Implementation

[0022] To provide a clearer explanation and description of the technical solution and implementation of this utility model, several preferred specific embodiments for implementing the technical solution of this utility model are introduced below.

[0023] The following description is exemplary in nature and is not intended to limit the scope, application, or use of this disclosure. It should be understood that in all these figures, the same or similar reference numerals indicate the same or similar parts and features. The figures are merely schematic representations of the concept and principles of embodiments of this disclosure and do not necessarily show the specific dimensions and scale of each embodiment. Specific details or structures of embodiments of this disclosure may be exaggerated in particular portions of certain figures. The disclosures of various publications, patents, and published patent specifications cited herein are incorporated herein by reference in their entirety. The technical solutions of this utility model will be clearly and completely described below in conjunction with embodiments of this utility model. Obviously, the described embodiments are only a part of the embodiments of this utility model.

[0024] Example 1: This pharmaceutical production concentration device includes a concentration machine frame 1, which is a stainless steel frame structure. Two evaporation and concentration tanks 2 are bolted to the left side of the frame, and a separation tank 4 is welded to the right side. A concentration drive assembly 5 is bolted to the lower right side of the inner cavity of the concentration machine frame 1. The tank body 21 of the evaporation and concentration tank 2 is made of 316L stainless steel. A liquid inlet pipe 22 is welded to the bottom and connected to the raw material delivery pipeline of the pharmaceutical agent to be concentrated. A liquid outlet pipe 23 is welded to the top and connected to the liquid inlet of the separation tank 4 via a high-temperature resistant hose. Four to six sets of tank wall residue cleaning mechanisms 3 are symmetrically arranged inside the tank body 21. The high-temperature resistant motor 31 in each mechanism is welded to the inner top wall of the tank body 21 via a bracket. Its output end is connected to the first drive shaft 32 via a coupling. Adjacent drive shafts 32 are connected in series via couplings.

[0025] A fixed ring 33 is welded to the top of the drive shaft 32, and a movable ring 34 that can slide axially is fitted in the middle section. A cylindrical spring 38 is fitted between the two, and the two ends of the spring are welded and fixed to the fixed ring 33 and the movable ring 34 respectively. The top of the expansion rod 35 is hinged to the movable ring 34 through a shaft pin, and the bottom middle section is hinged to the top of the pull rod 36. The bottom end of the pull rod 36 is connected to the hinge seat at the bottom of the drive shaft 32. The brush plate 37 is installed at the end of the expansion rod 35 through the hinge seat. Its bristles are made of corrosion-resistant silicone material and maintain elastic contact with the inner wall of the tank 21. The concentration drive assembly 5 consists of a heater, evaporator, condenser, compressor and connecting pipelines. The heater is connected to the jacket of the evaporation and concentration tank 2 through a coil structure. The evaporator, condenser and compressor are connected in series through pipelines to form a steam condensation circulation system. The high-temperature resistant motor 31 is selected from the HSV series high and low temperature servo motor or the YGF series high-temperature resistant three-phase asynchronous motor, and its protection level reaches the IP67 standard. When the equipment is running, the raw materials of the reagent enter the tank 21 through the liquid inlet pipe 22. The concentration drive component 5 starts the heating and evaporation process. The high temperature motor 31 drives the transmission shaft 32 to rotate. Under the action of the cylindrical spring 38, the movable ring 34 drives the expansion rod 35 to unfold outward, so that the brush plate 37 always adheres to the tank wall and rotates to clean. The concentrated liquid is transported to the separation tank 4 through the liquid outlet pipe 23 for subsequent processing.

[0026] Example 2: The pharmaceutical concentration device in this example also includes a concentrator frame 1, an evaporation and concentration tank 2, a separation tank 4, a concentration drive assembly 5, and a tank wall residue cleaning mechanism 3. The connection method of each component in the tank wall residue cleaning mechanism 3 is consistent with the aforementioned example. To address the cleaning issue of the tank wall residue cleaning mechanism 3 itself, a combination of backwashing and mechanical cleaning is used. During device operation, the backwashing system is periodically activated. The backwashing system uses a backwashing pipe installed at a specific location in the evaporation and concentration tank 2 to flush cleaning water back into the tank at a certain pressure. At this time, the high-temperature resistant motor 31 maintains a low speed, causing the tank wall residue cleaning mechanism 3 to rotate slowly. The backwash water forms a vortex inside the tank, flushing the various components of the tank wall residue cleaning mechanism 3 and removing some of the dirt. Simultaneously, the brush plate 37 brushes its own surface during rotation, further removing residual dirt. After backwashing is completed, the backwashing system is shut off, and the device continues to operate normally. By combining periodic backwashing with mechanical cleaning, the cleaning problem of the tank wall residue cleaning mechanism 3 itself is effectively solved.

[0027] Based on the above-described preferred technical solution, the workflow of this technical solution is explained as follows: The inlet pipe 22 is connected to the raw material to be concentrated, and the outlet tank 23 is connected to the inlet of the separator 4 via a pipeline. Simultaneously, it is ensured that all components of the concentration drive assembly 5 are properly connected and ready for operation. The high-temperature resistant motor 31 in the tank wall residue cleaning mechanism 3 is in an startable state. At this time, under the elastic force of the cylindrical spring 38, the fixed ring 33 and the movable ring 34 cooperate to open the expansion rod 35 to both sides, and the brush plate 37 is tightly attached to the inner wall of the tank body 21. After the device is started, the raw material enters the tank body 21 of the evaporation and concentration tank 2 through the inlet pipe 22. The concentration drive assembly 5 begins to work, and the heater heats, evaporates, and concentrates the liquid inside the tank body 21. The generated steam enters the system composed of the evaporator, condenser, compressor, and pipelines for condensation treatment. During the evaporation and concentration process, the high-temperature resistant motor 31 starts, and its output end drives multiple drive shafts 32 to rotate via a coupling. Since the drive shafts 32 are fixedly connected to each other via couplings, all drive shafts 32 rotate synchronously, thereby driving the expansion rods 35 hinged to the left and right sides of the drive shafts 32 to rotate. The brush plates 37 at the ends of the expansion rods 35 scrub the inner wall of the tank 21 to prevent the accumulation of chemical residues on the tank wall. At the same time, the pull rods 36 on the left and right sides below the drive shafts 32 move accordingly with the rotation of the drive shafts 32 and the movement of the expansion rods 35, playing a role in assisting support and guiding the movement of the expansion rods 35. As the evaporation and concentration proceeds, the liquid in the tank 21 gradually concentrates. The concentrated liquid enters the inlet of the separator 4 through the outlet tank 23 and the pipeline connected to it, where it undergoes further separation processing to obtain the desired concentrated chemical product.

[0028] After the device has been running for a period of time, the tank wall residue cleaning mechanism 3 needs to be cleaned. At this time, the feeding of reagent raw materials into the evaporation and concentration tank 2 should be stopped. If using a cleaning solvent, inject an appropriate amount of cleaning solvent into the tank, and restart the high-temperature motor 31 to start the tank wall residue cleaning mechanism 3. During rotation, the cleaning solvent continuously washes over the various parts of the tank wall residue cleaning mechanism 3, dissolving and removing the attached dirt. If using a periodic disassembly and cleaning method, during device shutdown maintenance, first close the relevant valves, disconnect from the reagent raw materials and separation tank 4, and use professional tools to remove the tank wall residue cleaning mechanism 3 from the evaporation and concentration tank 2. Soak it in a container of cleaning agent for a period of time to soften the dirt, and then use... Soft brushes and other tools are used to carefully clean all parts, especially the drive shaft 32, expansion rod 35, pull rod 36, and brush plate 37. After cleaning, the parts are dried and then reinstalled into the evaporation and concentration tank 2. If a combination of backwashing and mechanical cleaning is used, the backwashing system is turned on periodically during the operation of the device. Clean water is flushed into the tank at a certain pressure through the backwashing pipe set at a specific position in the evaporation and concentration tank 2. At this time, the high-temperature motor 31 keeps running at a low speed, causing the tank wall residue cleaning mechanism 3 to rotate slowly. The backwash water forms a vortex in the tank to flush all parts of the tank wall residue cleaning mechanism 3. At the same time, the brush plate 37 brushes its own surface during rotation. After the backwashing is completed, the backwashing system is turned off and the device continues to operate normally.

[0029] The foregoing description only illustrates certain exemplary embodiments of the present invention. Undoubtedly, those skilled in the art can modify the described embodiments in various ways without departing from the spirit and scope of the present invention. Therefore, the above drawings and descriptions are illustrative in nature and should not be construed as limiting the scope of protection of the claims of the present invention.

Claims

1. A concentration apparatus for pharmaceutical production, comprising a concentration frame (1), characterized in that: Two evaporation and concentration tanks (2) are fixedly connected to the left side of the inside of the concentrator frame (1), and a separation tank (4) is fixedly connected to the right side of the inside of the concentrator frame (1). A concentration drive assembly (5) is fixedly connected to the lower right side of the inner cavity of the concentrator frame (1). Each of the evaporation and concentration tanks (2) is equipped with 4-6 sets of tank wall residue cleaning mechanisms (3). The evaporation and concentration tank (2) includes a tank body (21), an inlet pipe (22) fixed to the bottom of the tank body (21), and an outlet pipe fixed to the top of the tank body (21). (23); The tank wall residue cleaning mechanism (3) includes a high-temperature resistant motor (31), multiple transmission shafts (32) connected to the output end of the high-temperature resistant motor (31) via a coupling, and expansion rods (35) hinged on the left and right sides of the transmission shafts (32). Two pull rods (36) are hinged to the lower left and right sides of the transmission shafts (32). The top of the pull rods (36) is hinged to the middle section of the bottom surface of the expansion rods (35). The ends of the expansion rods (35) are all hinged to a brush plate (37) that contacts the inner wall of the tank body (21).

2. The concentration apparatus for pharmaceutical production according to claim 1, characterized in that: The concentration drive assembly (5) consists of a heater, an evaporator, a condenser, a compressor, and pipelines. The heater is used to evaporate and concentrate the liquid inside the evaporation and concentration tank (2), while the evaporator, condenser, and compressor are used to condense the steam inside the tank (21).

3. A concentration device for pharmaceutical production according to claim 1, characterized in that: The inlet pipe (22) is connected to the pharmaceutical raw material to be concentrated, and the outlet pipe (23) is connected to the inlet of the separator (4) through a pipeline.

4. A concentration apparatus for pharmaceutical production according to claim 1, characterized in that: The outer shell sidewall of the high-temperature motor (31) is fixedly connected to the inner cavity top sidewall of the tank (21) by a bracket, and the drive shafts (32) are fixedly connected to each other by a coupling.

5. A concentration apparatus for pharmaceutical production according to claim 1, characterized in that: The high-temperature resistant motor (31) is an HSV series high and low temperature servo motor or a YGF series high-temperature resistant three-phase asynchronous motor.

6. A concentration apparatus for pharmaceutical production according to claim 1, characterized in that: A fixed ring (33) is fixedly connected to the top of the outer ring of the drive shaft (32), and a movable ring (34) is movably arranged in the middle section of the outer ring of the drive shaft (32). A cylindrical spring (38) is fixed between the fixed ring (33) and the movable ring (34) and is looped on the drive shaft (32) to provide a downward pushing force for the expansion rod (35) and force the expansion rod (35) to open to both sides.

7. A concentration apparatus for pharmaceutical production according to claim 1, characterized in that: The top end of the expansion rod (35) is hinged to the left and right side walls of the movable ring (34) by a pivot pin.

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