Derivative interface for liquid chromatography-mass spectrometry

Abstract

The utility model relates to the technical field of mass spectrometers, and discloses a liquid chromatography-mass spectrometry derivative interface which comprises a liquid chromatograph, an interface seat is fixedly mounted on the right side of the liquid chromatograph, a threaded groove is formed in the right side of the interface seat, two functional cavities are formed in the interface seat, and the threaded groove is located between the two functional cavities. A column hole is formed between the functional cavity and the threaded groove; the right side of the interface seat is provided with a connecting cylinder, the connecting cylinder is provided with a connecting mechanism, the functional cavity is internally provided with a screw mechanism, the threaded groove is internally provided with a limiting mechanism, the right side of the interface seat is provided with a plate hole, the plate hole is communicated with the corresponding functional cavity, and the left side of the interface seat is provided with a through hole. Compared with the prior art, the device has the following advantages and effects that by arranging the limiting mechanism, the purpose of fixing and limiting the chromatographic column through the two arc-shaped pads can be achieved, and then the purposes of conveniently installing the chromatographic column and improving the working efficiency can be achieved.

Description

Technical Field

[0001] This application relates to the field of mass spectrometry technology, and in particular to a derivative interface for liquid chromatography-mass spectrometry. Background Technology

[0002] Liquid chromatography-mass spectrometry (LC-MS) is an instrument that combines liquid chromatography and mass spectrometry. It combines the ability of liquid chromatography to effectively separate thermally unstable and high-boiling-point compounds with the strong component identification capability of mass spectrometry, making it an effective means of separating and analyzing complex organic mixtures.

[0003] In practical use, it was found that the existing equipment is not convenient for changing the chromatographic column, which makes column replacement time-consuming and laborious, affecting work efficiency. Therefore, we proposed a liquid chromatography-mass spectrometry derivation interface to solve the above problems. Utility Model Content

[0004] The purpose of this application is to address the shortcomings of existing technologies, such as the inconvenience of changing chromatographic columns, which leads to time-consuming and laborious column replacement and affects work efficiency, and to propose a derivative interface for liquid chromatography-mass spectrometry.

[0005] The above-mentioned technical objective of this application is achieved through the following technical solution: a liquid chromatography-mass spectrometry derivation interface, including a liquid chromatograph, an interface seat fixedly installed on the right side of the liquid chromatograph, a threaded groove opened on the right side of the interface seat, two functional cavities opened inside the interface seat, the threaded groove being located between the two functional cavities, and a column hole opened between the functional cavities and the threaded groove; a connecting cylinder is provided on the right side of the interface seat, a connecting mechanism is provided on the connecting cylinder, a wire moving mechanism is provided inside the functional cavity, a limit mechanism is provided inside the threaded groove, a plate hole is opened on the right side of the interface seat, the plate hole is connected to the corresponding functional cavity, and a through hole is opened on the left side of the interface seat.

[0006] A further configuration of this application is as follows: the lead screw mechanism includes a lead screw and a lead screw seat. The same lead screw is rotatably installed on the top inner wall and the bottom inner wall of the functional cavity. The lead screw is located on the right side of the corresponding column hole. The lead screw seat is threaded on the lead screw. The left side of the lead screw seat is slidably connected to the left inner wall of the functional cavity. A gear mechanism is provided between the lead screw seat and the plate hole.

[0007] By adopting the above technical solution and by setting up a lead screw mechanism, the lead screw can drive the lead screw seat to move closer to the thread groove, thereby achieving the purpose of driving the connecting column to move closer to the chromatographic column.

[0008] A further configuration of this application is as follows: the limiting mechanism includes a connecting column, an arc-shaped block and an arc-shaped pad. The connecting column is fixedly installed on the side of the lead screw seat near the threaded groove. The connecting column is slidably connected to the corresponding column hole. An arc-shaped block is fixedly installed on the other end of the connecting column. The arc-shaped block is located in the threaded groove, and an arc-shaped pad is provided on the inner wall of the arc-shaped block.

[0009] By adopting the above technical solution and setting a limiting mechanism, the connecting column can drive the arc-shaped pad to move closer to the chromatographic column, thereby achieving the purpose of limiting and fixing the chromatographic column through the arc-shaped pad.

[0010] A further feature of this application is that the connecting mechanism includes a rotating seat and a chromatographic column, the rotating seat is fixedly sleeved on the outside of the connecting cylinder, the chromatographic column is inserted into the connecting cylinder, and the arc-shaped pad is adapted to the chromatographic column.

[0011] By adopting the above technical solution and by setting a connecting mechanism, the rotating seat can drive the connecting cylinder to be installed with the threaded groove.

[0012] A further configuration of this application is as follows: the gear mechanism includes a rack plate and a gear, the same rack plate is slidably installed on the top inner wall and bottom inner wall of the plate hole, a gear is fixedly sleeved on the lead screw, the gear is located outside the corresponding lead screw seat, the gear meshes with the corresponding rack plate, and a sealing mechanism and a reset mechanism are provided on the rack plate.

[0013] By adopting the above technical solution and by setting up a gear mechanism, the push ring can drive the lead screw to rotate.

[0014] A further configuration of this application is as follows: the sealing mechanism includes a push ring and a sealing ring, the push ring is fixedly installed on the right side of the rack plate, the sealing ring is provided on the left side of the push ring, the push ring and the sealing ring are sleeved on the connecting cylinder, and the right side of the push ring is adapted to the left side of the rotating seat.

[0015] By adopting the above technical solution and by setting a sealing mechanism, the push ring can drive the sealing ring to fit tightly against the right side of the interface seat, thereby achieving the purpose of sealing the connection seam between the threaded groove and the connecting cylinder.

[0016] A further feature of this application is that the reset mechanism includes a reset plate and a spring, the reset plate is fixedly installed on the rear side of the rack plate, and the same spring is fixedly installed on the left side of the reset plate and the left inner wall of the functional cavity.

[0017] By adopting the above technical solution and by setting a reset mechanism, when the connecting cylinder is disassembled, the spring can drive the reset plate to reset through the rebound force, thereby achieving the purpose of driving the rack plate to move to the right and reset.

[0018] A further feature of this application is that the outer side of the connecting cylinder is provided with an external thread, which is adapted to the internal thread of the threaded groove.

[0019] By adopting the above technical solution and by providing external threads, the connecting cylinder can be easily assembled and disassembled from the threaded groove.

[0020] The beneficial effects of this application are:

[0021] 1. By cooperating with the connecting cylinder, rotating seat and threaded groove, the connecting cylinder and threaded groove can be threadedly installed, the connecting cylinder can be fixed on the interface seat, and the chromatographic column can be initially connected. By cooperating with the sealing ring and the interface seat, the sealing ring can be tightly attached to the right side of the interface seat, and the connection seam between the threaded groove and the connecting cylinder can be sealed.

[0022] 2. Through the cooperation of the push ring, rack plate, gear, lead screw, lead screw seat, connecting column, arc block and arc pad, the push ring can drive the arc pad to move closer to the chromatographic column, and the two arc pads can fix and limit the chromatographic column, thereby facilitating the convenient installation of the chromatographic column and improving work efficiency. Attached Figure Description

[0023] To more clearly illustrate the technical solutions in the embodiments of this application, the accompanying drawings used in the description of the embodiments will be briefly introduced below. Obviously, the accompanying drawings described below are only some embodiments of this application. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0024] Figure 1 This is a three-dimensional structural schematic diagram of a liquid chromatography-mass spectrometry derivation interface according to this application;

[0025] Figure 2 This is a schematic cross-sectional view of the interface seat structure of a liquid chromatography-mass spectrometry derivation interface according to this application;

[0026] Figure 3 This is a schematic diagram of the internal structure of the interface socket of a liquid chromatography-mass spectrometry derivation interface according to this application;

[0027] Figure 4 This is a schematic diagram of the A-structure of a liquid chromatography-mass spectrometry derivation interface according to this application.

[0028] In the diagram: 1. Liquid chromatograph; 2. Interface seat; 3. Threaded groove; 4. Functional chamber; 401. Lead screw; 402. Lead screw seat; 403. Connecting column; 404. Arc block; 405. Arc pad; 5. Connecting cylinder; 501. Rotating seat; 502. Chromatographic column; 6. Plate hole; 601. Rack plate; 602. Gear; 603. Push ring; 604. Sealing ring; 7. Reset plate; 701. Spring; 8. Through hole. Detailed Implementation

[0029] The technical solution of this application will be clearly and completely described below with reference to specific embodiments. Obviously, the described embodiments are only a part of the embodiments of this application, and not all of them. All other embodiments obtained by those skilled in the art based on the embodiments of this application without creative effort are within the scope of protection of this application.

[0030] See Figures 1-4 This application provides a derivatization interface for liquid chromatography-mass spectrometry, including a liquid chromatograph 1. An interface seat 2 is fixedly installed on the right side of the liquid chromatograph 1. A threaded groove 3 is opened on the right side of the interface seat 2. Two functional cavities 4 are opened inside the interface seat 2. The threaded groove 3 is located between the two functional cavities 4. A column hole is opened between the functional cavities 4 and the threaded groove 3. A connecting cylinder 5 is provided on the right side of the interface seat 2. A connecting mechanism is provided on the connecting cylinder 5. A wire moving mechanism is provided inside the functional cavity 4. A limit mechanism is provided inside the threaded groove 3. A plate hole 6 is opened on the right side of the interface seat 2, which is connected to the corresponding functional cavity 4. A through hole 8 is opened on the left side of the interface seat 2.

[0031] Specifically, the lead screw mechanism includes a lead screw 401 and a lead screw seat 402. The same lead screw 401 is rotatably installed on the top inner wall and the bottom inner wall of the functional cavity 4. The lead screw 401 is located on the right side of the corresponding column hole. The lead screw seat 402 is threaded on the lead screw 401. The left side of the lead screw seat 402 is slidably connected to the left inner wall of the functional cavity 4. A gear mechanism is provided between the lead screw seat 402 and the plate hole.

[0032] Specifically, the limiting mechanism includes a connecting column 403, an arc-shaped block 404, and an arc-shaped pad 405. The connecting column 403 is fixedly installed on the side of the lead screw seat 402 near the threaded groove 3. The connecting column 403 is slidably connected to the corresponding column hole. The arc-shaped block 404 is fixedly installed on the other end of the connecting column 403. The arc-shaped block 404 is located in the threaded groove 3, and an arc-shaped pad 405 is provided on the inner wall of the arc-shaped block 404.

[0033] Specifically, the connecting mechanism includes a rotating seat 501 and a chromatographic column 502. The rotating seat 501 is fixedly sleeved on the outside of the connecting cylinder 5, and the chromatographic column 502 is inserted into the connecting cylinder 5. The arc-shaped pad 405 is adapted to the chromatographic column 502.

[0034] Specifically, the gear mechanism includes a rack plate 601 and a gear 602. The same rack plate 601 is slidably installed on the top inner wall and bottom inner wall of the plate hole 6. The gear 602 is fixedly sleeved on the lead screw 401. The gear 602 is located outside the corresponding lead screw seat 402. The gear 602 meshes with the corresponding rack plate 601. The rack plate 601 is provided with a sealing mechanism and a reset mechanism.

[0035] Specifically, the sealing mechanism includes a push ring 603 and a sealing ring 604. The push ring 603 is fixedly installed on the right side of the rack plate 601, and the sealing ring 604 is provided on the left side of the push ring 603. The push ring 603 and the sealing ring 604 are sleeved on the connecting cylinder 5, and the right side of the push ring 603 is adapted to the left side of the rotating seat 501.

[0036] Specifically, the reset mechanism includes a reset plate 7 and a spring 701. The reset plate 7 is fixedly installed on the rear side of the rack plate 601, and the same spring 701 is fixedly installed on the left side of the reset plate 7 and the left inner wall of the functional cavity 4.

[0037] Specifically, the outer side of the connecting cylinder 5 is provided with an external thread, which is compatible with the internal thread of the threaded groove 3.

[0038] In this application, when installing the chromatographic column 502, the column 502 is first inserted into the connecting sleeve 5. The left end of the column 502 is connected to the liquid chromatograph 1 through the through hole 8. By rotating the rotating seat 501 clockwise, the connecting sleeve 5 and the threaded groove 3 are threaded together, thus fixing the connecting sleeve 5 onto the interface seat 2 and achieving the initial connection of the chromatographic column 502. At the same time, the rotating seat 501 pushes the push ring 603 and the sealing ring 604 to the left. The push ring 603 can drive the rack plate 601 to move to the left, which can drive the gear 602 to rotate. The rotation of the lead screw 401 causes the lead screw seat 402 to move closer to the threaded groove 3, allowing it to move closer to the chromatographic column 502 via the connecting column 403, the arc-shaped block 404, and the arc-shaped pad 405. This allows the chromatographic column 502 to be fixed and limited by the two arc-shaped pads 405, thus facilitating convenient installation of the chromatographic column 502 and improving work efficiency. The push ring 603 pushes the sealing ring 604 to the left, allowing the sealing ring 604 to fit tightly against the right side of the interface seat 2, thus sealing the connection between the threaded groove 3 and the connecting cylinder 5.

Claims

1. A derivatization interface for liquid chromatography-mass spectrometry, characterized in that, The system includes a liquid chromatograph (1), an interface seat (2) is fixedly installed on the right side of the liquid chromatograph (1), a threaded groove (3) is provided on the right side of the interface seat (2), two functional cavities (4) are provided in the interface seat (2), the threaded groove (3) is located between the two functional cavities (4), and a column hole is provided between the functional cavity (4) and the threaded groove (3). A connecting cylinder (5) is provided on the right side of the interface seat (2), a connecting mechanism is provided on the connecting cylinder (5), a threading mechanism is provided in the functional cavity (4), a limit mechanism is provided in the threaded groove (3), a plate hole (6) is opened on the right side of the interface seat (2), the plate hole (6) is connected to the corresponding functional cavity (4), and a through hole (8) is opened on the left side of the interface seat (2).

2. The liquid chromatography-mass spectrometry derivatization interface of claim 1, wherein: The threaded mechanism includes a lead screw (401) and a lead screw seat (402). The same lead screw (401) is rotatably installed on the top inner wall and the bottom inner wall of the functional cavity (4). The lead screw (401) is located on the right side of the corresponding column hole. The lead screw seat (402) is threaded on the lead screw (401). The left side of the lead screw seat (402) is slidably connected to the left inner wall of the functional cavity (4). A geared mechanism is provided between the lead screw seat (402) and the plate hole.

3. The derivatization interface for liquid chromatography-mass spectrometry according to claim 2, characterized in that: The limiting mechanism includes a connecting column (403), an arc block (404), and an arc pad (405). The connecting column (403) is fixedly installed on the side of the lead screw seat (402) near the thread groove (3). The connecting column (403) is slidably connected to the corresponding column hole. An arc block (404) is fixedly installed on the other end of the connecting column (403). The arc block (404) is located in the thread groove (3). An arc pad (405) is provided on the inner wall of the arc block (404).

4. The liquid chromatography-mass spectrometry derivatization interface of claim 3, wherein: The connecting mechanism includes a rotating seat (501) and a chromatographic column (502). The rotating seat (501) is fixedly sleeved on the outside of the connecting cylinder (5). The chromatographic column (502) is inserted into the connecting cylinder (5). The arc-shaped pad (405) is adapted to the chromatographic column (502).

5. The liquid chromatography-mass spectrometry derivatization interface of claim 2, wherein: The gear mechanism includes a rack plate (601) and a gear (602). The same rack plate (601) is slidably installed on the top inner wall and bottom inner wall of the plate hole (6). The gear (602) is fixedly sleeved on the lead screw (401). The gear (602) is located outside the corresponding lead screw seat (402). The gear (602) meshes with the corresponding rack plate (601). The rack plate (601) is provided with a sealing mechanism and a reset mechanism.

6. The liquid chromatography-mass spectrometry derivatization interface of claim 5, wherein: The sealing mechanism includes a push ring (603) and a sealing ring (604). The push ring (603) is fixedly installed on the right side of the rack plate (601), and the sealing ring (604) is provided on the left side of the push ring (603). The push ring (603) and the sealing ring (604) are sleeved on the connecting cylinder (5). The right side of the push ring (603) is adapted to the left side of the rotating seat (501).

7. The derivatization interface for liquid chromatography-mass spectrometry according to claim 5, characterized in that: The reset mechanism includes a reset plate (7) and a spring (701). The reset plate (7) is fixedly installed on the rear side of the rack plate (601). The same spring (701) is fixedly installed on the left side of the reset plate (7) and the left inner wall of the functional cavity (4).

8. The liquid chromatography-mass spectrometry derivatization interface of claim 1, wherein: The outer side of the connecting cylinder (5) is provided with an external thread, which is adapted to the internal thread of the threaded groove (3).

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