Composite liquid drop synthesis device
By designing a composite droplet synthesis device, the shearing action of the main pipe, inlet pipe, and outlet pipe is utilized to solve the problems of uneven preparation and complex operation in existing technologies for composite droplets. This enables the rapid preparation of composite droplets with uniform particle size, meeting diverse product requirements.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- CHEM & CHEM ENG GUANGDONG LAB
- Filing Date
- 2025-05-28
- Publication Date
- 2026-05-05
AI Technical Summary
Existing technologies are difficult to rapidly prepare uniform simple or composite droplets, especially bilayer or multilayer composite droplets, and the operation is complex, which cannot meet the diverse product requirements.
A composite droplet synthesis device is used, including a main pipe, an inlet pipe and an outlet pipe arranged coaxially. By controlling the flow rate and the input method of the liquid phase, composite droplets are formed under the shearing action between the inlet pipe and the outlet pipe. The device has a simple structure and can quickly prepare composite droplets with uniform particle size.
It enables the rapid and convenient preparation of composite droplets with uniform particle size, especially water-in-oil or oil-in-water-in-oil droplets, enriching the diversity and application range of droplet products.
Smart Images
Figure CN224194473U_ABST
Abstract
Description
Technical Field
[0001] This invention belongs to the field of composite droplet synthesis technology, specifically relating to a composite droplet synthesis device. Background Technology
[0002] Droplets serve as templates for many microbead products; microbeads can be obtained by solidifying droplets. Microbeads are gel particles ranging in size from hundreds of micrometers to several millimeters. They have a wide range of applications, especially in the cosmetics industry, where they are used to encapsulate easily precipitated active ingredients, stabilize emulsion systems, and improve the appearance of products.
[0003] Currently, the main method for producing microbeads is the droplet template method, which involves dissolving polymers at high temperatures in an oil phase, then mixing the oil phase with an aqueous phase. Stirring is used to obtain an oil-in-water emulsion. The oil phase is then broken into droplets and dispersed in the aqueous phase. After obtaining the emulsion, the oil phase is solidified, usually by cooling or adding a cross-linking agent. Microbeads are then obtained through separation, such as centrifugation. This method is difficult to control the uniformity of the droplets, and vigorous stirring cannot be avoided as it can result in excessively small droplets. The operation is also very complex. Furthermore, this method can only be used to produce simple droplets and cannot be used to produce bilayer composite droplets, i.e., water-in-oil-in-water or oil-in-water-in-oil droplets. Therefore, developing a device for rapidly preparing controllable composite droplets would significantly contribute to enriching droplet-derived products. Utility Model Content
[0004] To address the aforementioned technical problems, the present invention aims to provide a composite droplet synthesis device with a simple structure that can rapidly prepare composite droplets with uniform and controllable particle size.
[0005] To achieve the above-mentioned objectives, the technical solution adopted by this utility model is as follows:
[0006] A composite droplet synthesis device includes a main pipe, an inlet pipe, and an outlet pipe arranged coaxially;
[0007] The cross-sectional area of the inlet pipe is smaller than that of the outlet pipe, and the cross-sectional area of the outlet pipe is smaller than that of the main pipe.
[0008] The inlet pipe and outlet pipe are located at both ends of the main pipe. The discharge end of the inlet pipe is located inside the main pipe, and the feed end of the outlet pipe is located inside the main pipe. There is a gap between the outlet end of the inlet pipe and the inlet end of the outlet pipe.
[0009] The main pipe is closed at both ends, and a first feed inlet and a second feed inlet are provided on the side of the main pipe. The first feed inlet is located outside the inlet pipe, and the second feed inlet is located outside the outlet pipe.
[0010] Preferably, the inlet pipe includes a central pipe and side pipes, the central pipe and the outlet pipe are coaxially arranged, and multiple side pipes are evenly arranged around the central pipe, with the outlet end face of the side pipes flush with that of the central pipe.
[0011] Preferably, the distance between the outlet end of the inlet pipe and the inlet end of the outlet pipe is 1 to 5 mm.
[0012] More preferably, the distance between the outlet end of the inlet pipe and the inlet end of the outlet pipe is 2 to 4 mm.
[0013] Preferably, the inner diameter of the outlet pipe is 3 to 6 mm.
[0014] Preferably, the inner diameter of the main pipe is 5-9 mm.
[0015] Preferably, the inner diameter of the first feed inlet is 1-5 mm, and the inner diameter of the second feed inlet is 1-5 mm.
[0016] Preferably, the inner diameter of the central tube is 0.5 to 1.5 mm.
[0017] Preferably, the inner diameter of the side tube is 0.5 to 1.5 mm.
[0018] More preferably, the inner diameters of the central tube and the side tubes are the same.
[0019] Beneficial effects:
[0020] In this invention, an aqueous phase and an oil phase are introduced into the main pipe, and an oil phase or an aqueous phase is introduced into the inlet pipe accordingly. A complex flow is formed at the outlet end of the inlet pipe. During the process of the complex flow entering the outlet pipe, it is sheared to form complex droplets. The device structure of this invention is simple and can quickly prepare complex droplets with uniform and controllable particle size, which has a positive effect on enriching droplet-derived products. Attached Figure Description
[0021] Figure 1 The diagram shown is a structural schematic of this invention and a shearing principle diagram for preparing W / O / W type composite droplets.
[0022] Figure 2 The diagram shows the central pipe and side pipes of the inlet pipe, where pipe A represents the central pipe and pipe BG represents the side pipes.
[0023] Figure 3 The diagram shown is a schematic diagram of the preparation of W / O / W single-particle composite droplets according to Embodiment 1 of this utility model.
[0024] Figure 4 The diagram shown is a schematic diagram of the preparation of W / O / W dual-particle composite droplets according to Embodiment 2 of this utility model.
[0025] Figure 5 The diagram shown is a schematic diagram of the preparation of W / O / W three-particle composite droplets according to Embodiment 3 of this utility model.
[0026] Attached label: 1-Main pipe, 2-Inlet pipe, 3-Outlet pipe, 4-First liquid phase zone, 5-Second liquid phase zone;
[0027] 11-First feed inlet, 12-Second feed inlet, 21-Central tube, 22-Side tube. Detailed Implementation
[0028] To more clearly illustrate the technical solutions in the embodiments of this utility model or the prior art, the specific implementation methods of this utility model will be described below with reference to the accompanying drawings. Obviously, the drawings described below are merely some embodiments of this utility model. For those skilled in the art, other drawings and other implementation methods can be obtained based on these drawings without any creative effort.
[0029] like Figure 1-5 As shown, this utility model proposes a composite droplet synthesis device, including a main pipe 1, an inlet pipe 2, and an outlet pipe 3 arranged coaxially. The cross-sectional area of the inlet pipe 2 is smaller than that of the outlet pipe 3, and the cross-sectional area of the outlet pipe 3 is smaller than that of the main pipe 1. The inlet pipe 2 and the outlet pipe 3 are located at both ends of the main pipe 1. The discharge end of the inlet pipe 2 is located inside the main pipe 1, and the feed end of the outlet pipe 3 is located inside the main pipe 1. There is a gap between the outlet end of the inlet pipe 2 and the inlet end of the outlet pipe 3. The main pipe 1 is closed at both ends. A first feed port 11 and a second feed port 12 are provided on the side of the main pipe 1. The first feed port 11 is located outside the inlet pipe 2, and the second feed port 12 is located outside the outlet pipe 3.
[0030] like Figure 1 As shown, taking the example where the outlet pipe 3, main pipe 1, and inlet pipe 2 are all circular pipes, the outlet pipe 3, main pipe 1, and central pipe 21 are coaxially arranged, and multiple side pipes 22 are evenly arranged around the central pipe 21. The outer diameter of the outlet pipe 3 is smaller than the inner diameter of the main pipe 1. Along the radial direction of the central pipe 21, the sum of the outer diameters of the central pipe 21 and the side pipes 22 is smaller than the inner diameter of the outlet pipe 3, ensuring that all the material output from the inlet pipe 2 can enter the outlet pipe 3. A first liquid phase zone 4 is formed between the outer wall of the discharge end of the inlet pipe 2 and the inner wall of the main pipe 1, and a second liquid phase zone 5 is formed between the feed end of the outlet pipe 3 and the inner wall of the main pipe 1.
[0031] The working principle of this utility model is as follows: Figure 1As shown, taking the preparation of water-in-oil-in-water composite droplets (W / O / W type composite droplets) as an example, the first inlet 11 of the main pipe 1 introduces the oil phase, and the second inlet 12 introduces the first aqueous phase. That is, the first liquid phase region 4 contains the oil phase, and the second liquid phase region 5 contains the first aqueous phase. The interface between the two phases is located between the outlet end of the inlet pipe 2 and the inlet end of the outlet pipe 3. The first aqueous phase is discharged through the outlet pipe 3, and the oil phase covers the outlet end of the inlet pipe 2. At the same time, the second aqueous phase is introduced into the inlet pipe 2. During the outflow process, the second aqueous phase is enveloped by the oil phase, forming an oil-in-water composite flow. The composite flow and the first aqueous phase enter the outlet pipe 3 together. During the entry into the outlet pipe 3, the first aqueous phase has a shearing effect on the composite flow, causing the composite flow to focus and thus undergo shearing and fracture, forming a double-layer droplet, thereby completing the preparation of the water-in-oil-in-water composite droplet.
[0032] In some embodiments, the distance between the outlet end of the inlet pipe 2 and the inlet end of the outlet pipe 3 is 1–5 mm. Preferably, the distance between the outlet end of the inlet pipe 2 and the inlet end of the outlet pipe 3 is 2–4 mm. More preferably, the distance between the outlet end of the inlet pipe 2 and the inlet end of the outlet pipe 3 is 2 mm.
[0033] In some embodiments, the inner diameter of the outlet pipe 3 is 3-6 mm. Preferably, the inner diameter of the outlet pipe 3 is 4-5 mm. More preferably, the inner diameter of the outlet pipe 3 is 4 mm.
[0034] In some embodiments, the inner diameter of the main pipe 1 is 5-9 mm. Preferably, the inner diameter of the main pipe 1 is 6-9 mm. More preferably, the inner diameter of the main pipe 1 is 6 mm.
[0035] In some embodiments, the inner diameter of the first feed inlet 11 of the main pipe 1 is 1-5 mm, and the inner diameter of the second feed inlet 12 is 1-5 mm. Preferably, the inner diameter of the first feed inlet 11 of the main pipe 1 is 1-3 mm, and the inner diameter of the second feed inlet 12 is 1-3 mm. More preferably, the inner diameter of the first feed inlet 11 of the main pipe 1 is 2 mm, and the inner diameter of the second feed inlet 12 is 2 mm.
[0036] This invention can control the particle size by controlling the flow rate. For example, if the flow rates at the second inlet 12 and the inlet pipe 2 remain constant, increasing the flow rate at the first inlet 11 will enhance the shearing efficiency, thereby obtaining small-diameter composite droplets; or decreasing the flow rate at the first inlet 11 will reduce the shearing efficiency, thereby obtaining large-diameter composite droplets.
[0037] In some embodiments, the inlet pipe 2 includes a central pipe 21 and side pipes 22. The central pipe 21 is coaxially arranged with the outlet pipe 3, and a plurality of side pipes 22 are evenly arranged around the central pipe 21. The outlet end face of the side pipes 22 is flush with the outlet end face of the central pipe 21.
[0038] Preferably, the number of side tubes 22 is ≥2. In the figure, the number of side tubes 22 is six.
[0039] This invention can also control the types of droplets inside the composite droplet. Taking the preparation of water-in-oil-in-water composite droplets as an example, for instance... Figure 2 As shown, there are six side tubes 22, which are evenly arranged around the central tube 21. The central tube 21 is called tube A, and the six side tubes 22 are named tubes B, C, D, E, F, and G in sequence.
[0040] Example 1: As Figure 3 As shown, to prepare W / O / W single-particle composite droplets, the first inlet 11 introduces the oil phase, the second inlet 12 introduces the first aqueous phase, the central tube 21 introduces the second aqueous phase, and the side tubes 22 do not introduce any material. Droplets encapsulating single particles can be obtained in the outlet tube 3. It is easy to understand that even if one side tube 22 introduces the second aqueous phase, and the central tube 21 and the other side tubes 22 do not introduce any material, droplets encapsulating single particles can still be prepared.
[0041] Example 2: Figure 4 As shown, to prepare W / O / W dual-particle composite droplets, the first inlet 11 introduces the oil phase, the second inlet 12 introduces the first aqueous phase, and the central tube 21 introduces the oil phase. Two opposing side tubes 22, arranged radially along the central tube 21, each introduce the second aqueous phase; for example, tubes B and G, C and F, or D and E each introduce the aqueous phase. Droplets encapsulating the dual particles are then obtained in the outlet tube 3. The oil phase is introduced into the central tube 21A to prevent the aqueous phases from merging at the diagonal side tubes 22, thus preventing the formation of dual particles. It is easy to understand that the two side tubes 22 can be filled with the same aqueous phase or different aqueous phases.
[0042] Example 3: Figure 5 As shown, to prepare W / O / W three-particle composite droplets, the first inlet 11 introduces the oil phase, the second inlet 12 introduces the first aqueous phase, and three non-adjacent side pipes 22 introduce the second aqueous phase (e.g., pipes C, D, and G). Droplets encapsulating the three particles are obtained in the outlet pipe 3. The central pipe 21 and the other side pipes 22 introduce the oil phase to prevent the aqueous phases output from the side pipes 22 from merging and failing to form three particles. By controlling the type of aqueous phase input into the side pipes 22, three-particle two-component composite droplets and three-particle three-component composite droplets can be prepared.
[0043] In some embodiments, the inner diameter of the central tube 21 is 0.5 to 1.5 mm. Preferably, the inner diameter of the central tube 21 is 0.5 to 1 mm. More preferably, the inner diameter of the central tube 21 is 0.7 mm.
[0044] In some embodiments, the inner diameter of the side tube 22 is 0.5 to 1.5 mm. Preferably, the inner diameter of the side tube 22 is 0.5 to 1 mm. More preferably, the inner diameter of the side tube 22 is 0.7 mm.
[0045] Preferably, the inner diameters of the central tube 21 and the side tube 22 are the same.
[0046] The embodiments provided by this utility model have been described in detail above. Specific examples have been used to illustrate the principles and implementation methods of this utility model. The descriptions of the embodiments above are only for the purpose of helping to understand the core ideas of this utility model. It should be noted that those skilled in the art can make several improvements and modifications to this utility model without departing from the principles of this utility model, and these improvements and modifications also fall within the protection scope of the claims of this utility model.
Claims
1. A composite droplet synthesis device, characterized in that, It includes a main pipe (1), an inlet pipe (2), and an outlet pipe (3) that are coaxially arranged; The cross-sectional area of the inlet pipe (2) is smaller than that of the outlet pipe (3), and the cross-sectional area of the outlet pipe (3) is smaller than that of the main pipe (1). The inlet pipe (2) and the outlet pipe (3) are located at both ends of the main pipe (1). The discharge end of the inlet pipe (2) is located inside the main pipe (1), and the feed end of the outlet pipe (3) is located inside the main pipe (1). There is a gap between the outlet end of the inlet pipe (2) and the inlet end of the outlet pipe (3). The main pipe (1) is closed at both ends. The side of the main pipe (1) is provided with a first feed port (11) and a second feed port (12). The first feed port (11) is located outside the inlet pipe (2), and the second feed port (12) is located outside the outlet pipe (3).
2. The composite droplet synthesis apparatus according to claim 1, characterized in that, The distance between the outlet end of the inlet pipe (2) and the inlet end of the outlet pipe (3) is 1-5 mm.
3. The composite droplet synthesis apparatus according to claim 2, characterized in that, The distance between the outlet end of the inlet pipe (2) and the inlet end of the outlet pipe (3) is 2-4 mm.
4. The composite droplet synthesis apparatus according to claim 1, characterized in that, The inner diameter of the outlet pipe (3) is 3-6 mm.
5. The composite droplet synthesis apparatus according to claim 1, characterized in that, The inner diameter of the main tube (1) is 5-9 mm.
6. The composite droplet synthesis apparatus according to claim 5, characterized in that, The inner diameter of the first feed inlet (11) is 1-5 mm, and the inner diameter of the second feed inlet (12) is 1-5 mm.
7. The composite droplet synthesis apparatus according to any one of claims 1-6, characterized in that, The inlet pipe (2) includes a central pipe (21) and a side pipe (22). The central pipe (21) is coaxially arranged with the outlet pipe (3). Multiple side pipes (22) are evenly arranged around the central pipe (21). The outlet end face of the side pipes (22) is flush with the outlet end face of the central pipe (21).
8. The composite droplet synthesis apparatus according to claim 7, characterized in that, The inner diameters of the central tube (21) and the side tube (22) are the same.
9. The composite droplet synthesis apparatus according to claim 8, characterized in that, The inner diameter of the central tube (21) is 0.5 to 1.5 mm.
10. The composite droplet synthesis apparatus according to claim 8, characterized in that, The inner diameter of the side tube (22) is 0.5 to 1.5 mm.