Emulsifying kettle for preparing vitamin K1 microcapsules

Abstract

The utility model relates to the technical field of medicine preparation, in particular to an emulsifying kettle for preparing vitamin K1 micro-capsules, which not only accelerates the emulsification of raw materials by utilizing ultrasonic waves, but also destroys the surface tension of bubbles by utilizing the cavitation effect of the ultrasonic waves to promote the breakage of the bubbles, and filters the discharged emulsified materials by utilizing a hydrophobic microporous membrane to improve the quality of the emulsified materials. Bubbles are intercepted and discharged due to surface tension when passing through; comprising an emulsifying kettle; the device further comprises a driving mechanism, a stirring mechanism, a dispersing mechanism and a filtering mechanism, the driving mechanism is installed on the emulsifying kettle and drives the stirring mechanism to rotate, the stirring mechanism is installed on the driving mechanism and stirs raw materials, and the dispersing mechanism is installed on the emulsifying kettle and adds the raw materials for emulsification through ultrasonic waves. The filtering mechanism is mounted on the emulsifying kettle and is used for filtering discharged materials.

Description

Technical Field

[0001] This utility model relates to the technical field of drug preparation, and in particular to an emulsification vessel for preparing vitamin K1 microcapsules. Background Technology

[0002] Vitamin K1 (phyllotone) microencapsulation is a common drug delivery technique that encapsulates vitamin K1 to improve its stability, control the release rate, or enhance bioavailability.

[0003] Existing vitamin K1 microcapsule preparation emulsification kettles, such as the bidirectional stirring emulsification kettle for microparticle production disclosed in utility model patent application number 202222827754.7, mainly include a kettle body with a detachable kettle cover on top, an auxiliary stirring mechanism, a motor on top of the kettle body, a rotating rod at the motor output end, the rotating rod extending through the kettle cover into the kettle body, and several first stirring rods on the rotating rod. In use, the guide ring and the fixed ring are designed to allow rotation while ensuring sufficient support for the mounting frame and the limiting ring. Furthermore, the arc-shaped groove design prevents the liquid scraped off the inner wall of the kettle body by the scraper from falling and accumulating on the limiting ring, thus preventing the liquid from accumulating and solidifying, which would affect the quality of vitamin microparticle emulsification.

[0004] However, most existing emulsification vessels only emulsify by stirring, which results in a slow emulsification rate and the easy generation of bubbles during the emulsification process. These bubbles can easily cause the microcapsule structure to become loose or rupture when mixed into the emulsion. Utility Model Content

[0005] To solve the above-mentioned technical problems, this utility model provides a vitamin K1 microcapsule preparation emulsification kettle that not only uses ultrasound to accelerate the emulsification of raw materials and the ultrasonic cavitation effect to destroy the surface tension of bubbles and cause them to break, but also uses a hydrophobic microporous membrane to filter the discharged emulsified material, so that the bubbles are intercepted and discharged due to surface tension when they pass through.

[0006] This invention relates to a vitamin K1 microcapsule preparation emulsification vessel, comprising an emulsification vessel, a driving mechanism, a stirring mechanism, a dispersing mechanism, and a filtering mechanism. The driving mechanism is mounted on the emulsification vessel and drives the stirring mechanism to rotate. The stirring mechanism is mounted on the driving mechanism and stirs the raw materials. The dispersing mechanism is mounted on the emulsification vessel and uses ultrasound to add the raw materials for emulsification. The filtering mechanism is mounted on the emulsification vessel and filters the discharged material. The operator delivers the raw materials into the emulsification vessel, starts the driving mechanism, which drives the stirring mechanism to rotate and stir the material. Simultaneously, the dispersing mechanism is activated to use ultrasound to accelerate the emulsification of the raw materials and eliminate bubbles generated during the emulsification process. After emulsification, the material is discharged through the filtering mechanism, which filters the material, intercepting and expelling bubbles due to surface tension.

[0007] Preferably, the emulsification vessel includes a vessel body, a feed pipe, a hinge, a sealing cap, and a handle. The bottom end of the vessel body is connected to the ground, and the interior of the vessel body is provided with a cavity. The bottom end of the feed pipe is connected to the top end of the vessel body. The hinge is installed on the feed pipe, the sealing cap is installed on the hinge, and the handle is installed on the sealing cap. The operator operates the handle to open the sealing cap, feeds the raw materials for preparing vitamin K1 microcapsules into the cavity of the vessel body through the feed pipe, and then closes the sealing cap to prevent outside air from entering and ensure the airtightness of the device.

[0008] Preferably, the drive mechanism includes a motor, a reducer, a transmission shaft, and a support plate. The motor is mounted on the vessel body, the reducer is mounted on the vessel body, the transmission shaft is rotatably mounted in the cavity of the vessel body and longitudinally connected to the reducer, and the bottom end of the support plate is connected to the top end of the transmission shaft. When the motor is started, the motor drives the support plate and the support plate to rotate through the reducer.

[0009] Preferably, the stirring mechanism includes two sets of support rods, a positioning ring plate, four sets of stirring rods, two sets of connecting plates, and two sets of scrapers. The bottom ends of the two sets of support rods are connected to the top ends of the support plates. The cavity inside the vessel body has a groove. The positioning ring plate is rotatably installed in the groove of the vessel body, and the bottom end of the positioning ring plate is connected to the top ends of the two sets of support rods. The top ends of the four sets of stirring rods are all connected to the bottom ends of the positioning ring plate. The connecting plates are connected and installed between two adjacent sets of stirring rods. The two sets of scrapers are respectively installed on the two sets of support rods. The support plates drive the two sets of support rods to rotate, and the two sets of support rods drive the positioning ring plate and the two sets of scrapers to rotate. The positioning ring plate rotates in the groove to maintain the stability of the stirring mechanism during rotation. The positioning ring plate drives the four sets of stirring rods and the two sets of connecting plates to rotate to stir the raw materials and accelerate the emulsification of the raw materials. The two sets of scrapers rotate to scrape off the emulsion adhering to the inner wall of the vessel body.

[0010] Preferably, the dispersion mechanism includes an ultrasonic generator, an extension rod, and a dispersion disc. The ultrasonic generator is mounted on the vessel body, the extension rod is mounted inside the cavity of the vessel body, and the dispersion disc is mounted on the extension rod. When the ultrasonic generator is started, it drives the dispersion disc to rotate through the extension rod. The dispersion disc uses the ultrasonic cavitation effect to break the surface tension of the bubbles, causing them to break down, and at the same time accelerates the dispersion of the raw materials into an emulsion.

[0011] Preferably, the filtration mechanism includes a feed pipe, a valve, a filter box, a hydrophobic microporous membrane, and a discharge pipe. The top end of the feed pipe is connected to the bottom end of the vessel body, the valve is installed on the feed pipe, the top end of the filter box is connected to the bottom end of the feed pipe, the hydrophobic microporous membrane is slidably installed on the filter box, and the discharge pipe is connected to the inside of the filter box. When the raw material is completely emulsified, the valve is opened, and the emulsion is transported to the filter box through the feed pipe. The hydrophobic microporous membrane filters it, and air bubbles are intercepted and discharged due to surface tension when they pass through. The emulsion is discharged through the discharge pipe.

[0012] Compared with the prior art, the beneficial effects of this utility model are as follows: the staff delivers the raw materials into the emulsification tank, starts the drive mechanism, the drive mechanism drives the stirring mechanism to rotate and stir the materials, and at the same time starts the dispersion mechanism to accelerate the emulsification of the raw materials with ultrasonic waves, and can eliminate the bubbles generated during the emulsification process. After the emulsification is completed, the materials are discharged through the filtration mechanism, which filters them. When the bubbles pass through, they are intercepted and discharged due to surface tension. Attached Figure Description

[0013] Figure 1 This is a front view cross-sectional structural diagram of this utility model;

[0014] Figure 2 This is an isometric structural diagram of the emulsification kettle of this utility model;

[0015] Figure 3 This is a cross-sectional isometric structural diagram of the drive mechanism and stirring mechanism of this utility model;

[0016] Figure 4 This is a cross-sectional isometric structural diagram of the stirring mechanism and dispersing mechanism of this utility model;

[0017] Figure 5 This is a partially enlarged cross-sectional isometric structural diagram of the filtration mechanism of this utility model.

[0018] The attached diagram is labeled as follows: 01, Emulsifying kettle; 11, Kettle body; 12, Feed pipe; 13, Hinge; 14, Sealing cap; 15, Handle; 02, Drive mechanism; 21, Electric motor; 22, Reducer; 23, Drive shaft; 24, Support plate; 03, Stirring mechanism; 31, Support rod; 32, Positioning ring plate; 33, Stirring rod; 34, Connecting plate; 35, Scraper; 04, Dispersion mechanism; 41, Ultrasonic generator; 42, Extension rod; 43, Dispersion disc; 05, Filtration mechanism; 51, Feed pipe; 52, Valve; 53, Filter box; 54, Hydrophobic microporous membrane; 55, Discharge pipe. Detailed Implementation

[0019] To facilitate understanding of this utility model, a more complete description will be given below with reference to the accompanying drawings. This utility model can be implemented in many different forms and is not limited to the embodiments described herein. Rather, these embodiments are provided to make the disclosure of this utility model more thorough and complete. Example 1

[0020] This utility model discloses a vitamin K1 microcapsule preparation emulsification kettle, including an emulsification kettle 01; it also includes a driving mechanism 02, a stirring mechanism 03, a dispersing mechanism 04, and a filtering mechanism 05. The driving mechanism 02 is installed on the emulsification kettle 01 and drives the stirring mechanism 03 to rotate. The stirring mechanism 03 is installed on the driving mechanism 02 and stirs the raw materials. The dispersing mechanism 04 is installed on the emulsification kettle 01 and uses ultrasound to add the raw materials for emulsification. The filtering mechanism 05 is installed on the emulsification kettle 01 and filters the discharged materials. The emulsification vessel 01 includes a vessel body 11, a feed pipe 12, a hinge 13, a sealing cover 14, and a handle 15. The bottom end of the vessel body 11 is connected to the ground, and the interior of the vessel body 11 has a cavity. The bottom end of the feed pipe 12 communicates with the top end of the vessel body 11. The hinge 13 is mounted on the feed pipe 12, the sealing cover 14 is mounted on the hinge 13, and the handle 15 is mounted on the sealing cover 14. The drive mechanism 02 includes a motor 21, a reducer 22, a transmission shaft 23, and a support plate 24. The motor 21 is mounted on the vessel body 11. The reducer 22 is mounted on the vessel body 11, and the drive shaft 23 is rotatably mounted in the cavity of the vessel body 11 and longitudinally connected to the reducer 22. The bottom end of the support plate 24 is connected to the top end of the drive shaft 23. The stirring mechanism 03 includes two sets of support rods 31, a positioning ring plate 32, four sets of stirring rods 33, two sets of connecting plates 34, and two sets of scrapers 35. The bottom ends of the two sets of support rods 31 are connected to the top end of the support plate 24. A groove is opened inside the cavity of the vessel body 11, and the positioning ring plate 32 is rotatably mounted in the groove of the vessel body 11. The bottom end of the positioning ring plate 32 is connected to the top end of the two sets of support rods 31, and the top ends of the four sets of stirring rods 33 are all connected to the bottom end of the positioning ring plate 32. The connecting plate 34 is connected and installed between two adjacent sets of stirring rods 33, and two sets of scrapers 35 are respectively installed on the two sets of support rods 31. The dispersion mechanism 04 includes an ultrasonic generator 41, an extension rod 42 and a dispersion disk 43. The ultrasonic generator 41 is installed on the vessel body 11, the extension rod 42 is installed in the cavity of the vessel body 11, and the dispersion disk 43 is installed on the extension rod 42.During operation, the operator first opens the sealing cover 14 using handle 15, and feeds the raw materials for vitamin K1 microcapsule preparation into the cavity of the vessel body 11 through the feed pipe 12. Then, the sealing cover 14 is closed to prevent outside air from entering and ensure the device's airtightness. The motor 21 is then started. The motor 21 drives the support plate 24 to rotate via the reducer 22. The support plate 24 drives two sets of support rods 31 to rotate, which in turn drives the positioning ring plate 32 and two sets of scrapers 35 to rotate. The positioning ring plate 32 rotates within the groove to maintain the stability of the stirring mechanism 03 during rotation. The positioning ring plate 32 drives four sets of stirring rods 33 and two sets of connecting plates 34 to rotate, stirring the raw materials and accelerating emulsification. The two sets of scrapers 35 rotate to scrape off the emulsion adhering to the inner wall of the vessel body 11. Simultaneously, the ultrasonic generator 41 is started. The ultrasonic generator 41 drives the dispersion disc 43 to rotate via the extension rod 42. The dispersion disc 43 utilizes the ultrasonic cavitation effect to break the surface tension of bubbles, causing them to rupture and accelerating the dispersion of the raw materials into an emulsion. Example 2

[0021] like Figures 1 to 5 As shown, this utility model discloses a vitamin K1 microcapsule preparation emulsifying kettle, based on Example 1. The filtration mechanism 05 includes a feed pipe 51, a valve 52, a filter box 53, a hydrophobic microporous membrane 54, and a discharge pipe 55. The top end of the feed pipe 51 is connected to the bottom end of the kettle body 11. The valve 52 is installed on the feed pipe 51. The top end of the filter box 53 is connected to the bottom end of the feed pipe 51. The hydrophobic microporous membrane 54 is slidably installed on the filter box 53. The discharge pipe 55 is connected to the inside of the filter box 53. During operation, firstly, the operator operates the handle 15 to open the sealing cover 14, and feeds the vitamin K1 microcapsule preparation raw materials into the cavity of the kettle body 11 through the feed pipe 12. Then, the sealing cover 14 is closed to prevent outside air from entering and ensure the sealing of the device. The motor 21 is started, and the motor 21 drives the support plate 24 and the support plate 24 to rotate through the reducer 22. 24 drives two sets of support rods 31 to rotate, which in turn drives the positioning ring plate 32 and two sets of scrapers 35 to rotate. The positioning ring plate 32 rotates in the groove to maintain the stability of the stirring mechanism 03 during rotation. The positioning ring plate 32 drives four sets of stirring rods 33 and two sets of connecting plates 34 to rotate to stir the raw materials and accelerate the emulsification of the raw materials. The two sets of scrapers 35 rotate to scrape off the emulsion adhering to the inner wall of the vessel body 11. At the same time, the ultrasonic generator 41 is started. The ultrasonic generator 41 drives the dispersion plate 43 to rotate through the extension rod 42. The dispersion plate 43 uses the ultrasonic cavitation effect to destroy the surface tension of the bubbles and cause them to break down. At the same time, it accelerates the dispersion of the raw materials into an emulsion. When the raw materials are completely emulsified, the valve 52 is opened, and the emulsion is transported to the filter box 53 through the conveying pipe 51. The hydrophobic microporous membrane 54 filters it. When the bubbles pass through, they are intercepted and discharged due to surface tension. The emulsion is discharged through the discharge pipe 55.

[0022] The electric motor 21, reducer 22, and ultrasonic generator 41 of this utility model are commercially available. Technical personnel in this industry only need to install and operate them according to the accompanying instruction manual, without requiring any creative work from those skilled in the art.

[0023] The above description is only a preferred embodiment of the present utility model. It should be noted that for those skilled in the art, several improvements and modifications can be made without departing from the technical principles of the present utility model, and these improvements and modifications should also be considered within the protection scope of the present utility model.

Claims

1. A vitamin K1 microcapsule preparation emulsification vessel, comprising an emulsification vessel (01); characterized in that, It also includes a drive mechanism (02), a stirring mechanism (03), a dispersing mechanism (04), and a filtering mechanism (05). The drive mechanism (02) is installed on the emulsification tank (01) and drives the stirring mechanism (03) to rotate. The stirring mechanism (03) is installed on the drive mechanism (02) and stirs the raw materials. The dispersing mechanism (04) is installed on the emulsification tank (01) and uses ultrasonic waves to add raw materials for emulsification. The filtering mechanism (05) is installed on the emulsification tank (01) and filters the discharged materials. The emulsification tank (01) includes a tank body (11), a feed pipe (12), a hinge (13), a sealing cover (14), and a handle (15). The bottom end of the tank body (11) is connected to the ground. The tank body (11) has a cavity inside. The bottom end of the feed pipe (12) is connected to the top end of the tank body (11). The hinge (13) is installed on the feed pipe (12). The sealing cover (14) is installed on the hinge (13). The handle (15) is installed on the sealing cover (14). The dispersion mechanism (04) includes an ultrasonic generator (41), an extension rod (42) and a dispersion disk (43). The ultrasonic generator (41) is mounted on the vessel body (11), the extension rod (42) is mounted inside the cavity of the vessel body (11), and the dispersion disk (43) is mounted on the extension rod (42).

2. The vitamin K1 microcapsule preparation emulsifying vessel as described in claim 1, characterized in that, The drive mechanism (02) includes a motor (21), a reducer (22), a transmission shaft (23), and a support plate (24). The motor (21) is mounted on the vessel body (11), the reducer (22) is mounted on the vessel body (11), the transmission shaft (23) is rotatably mounted in the cavity of the vessel body (11) and longitudinally connected to the reducer (22), and the bottom end of the support plate (24) is connected to the top end of the transmission shaft (23).

3. The vitamin K1 microcapsule preparation emulsifying vessel as described in claim 2, characterized in that, The stirring mechanism (03) includes two sets of support rods (31), a positioning ring plate (32), four sets of stirring rods (33), two sets of connecting plates (34), and two sets of scrapers (35). The bottom ends of the two sets of support rods (31) are connected to the top ends of the support plates (24). The cavity of the vessel body (11) has a groove. The positioning ring plate (32) is rotatably installed in the groove of the vessel body (11), and the bottom end of the positioning ring plate (32) is connected to the top ends of the two sets of support rods (31). The top ends of the four sets of stirring rods (33) are all connected to the bottom ends of the positioning ring plate (32). The connecting plates (34) are connected and installed between two adjacent sets of stirring rods (33). The two sets of scrapers (35) are respectively installed on the two sets of support rods (31).

4. The vitamin K1 microcapsule preparation emulsifying vessel as described in claim 1, characterized in that, The filtration mechanism (05) includes a feed pipe (51), a valve (52), a filter box (53), a hydrophobic microporous membrane (54), and a discharge pipe (55). The top end of the feed pipe (51) is connected to the bottom end of the vessel body (11). The valve (52) is installed on the feed pipe (51). The top end of the filter box (53) is connected to the bottom end of the feed pipe (51). The hydrophobic microporous membrane (54) is slidably installed on the filter box (53). The discharge pipe (55) is connected to the inside of the filter box (53).

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