Multifunctional kit

Abstract

The utility model provides a multifunctional kit which is internally provided with M electrochemical test strips and N dry chemical test strips, namely, the multifunctional kit with consumables can be used for detecting M electrochemical detection items and N dry chemical detection items by being matched with a multifunctional detection instrument; a sample tube mounting groove 311, a sampling groove 312, a TIP head grabbing groove 313 and a TIP head discarding groove 314 are arranged, so that sampling and sample adding can be conveniently completed in one multifunctional kit, and then the multifunctional kit can be matched with a multifunctional detection instrument to realize full-automatic detection of M electrochemical detection items and N dry chemical detection items.

Description

Technical Field

[0001] The embodiments of this utility model relate to the field of biomarker detection technology, specifically to a multifunctional reagent kit. Background Technology

[0002] Most current testing devices are single-function devices. For example, a blood pressure monitor can measure blood pressure, a blood glucose meter can measure blood glucose, and a blood lipid meter can measure blood lipids, etc.

[0003] Furthermore, current blood glucose and blood lipid testing devices require users to collect blood samples, use a pipette to draw the sample, add it to the display area of ​​the reagent card, and then manually place the reagent card into the instrument for testing and reading. This sample aspiration and addition process is quite complex and unsuitable for general users.

[0004] Furthermore, if multiple testing items need to be tested, different testing instruments need to be operated multiple times, resulting in numerous and complicated operating steps for the user.

[0005] To enable miniaturized testing instruments to perform tests on a variety of items and improve the convenience of testing, it is necessary to design corresponding multifunctional reagent kits. Utility Model Content

[0006] An embodiment of this utility model provides a multifunctional reagent kit 100, comprising:

[0007] The top cover 10, the test strip support 20 and the box body 30 are arranged sequentially from top to bottom, as well as M electrochemical test strips and N dry chemical test strips arranged between the top cover 10 and the box body 30.

[0008] The upper cover 10 is provided with M electrochemical test strip application holes 11 and N dry chemical test strip application holes 12, and the M electrochemical test strip application holes 11 and the N dry chemical test strip application holes 12 all penetrate the upper and lower surfaces of the upper cover 10.

[0009] The box 30 includes a sampling area 31 and a sample addition and detection area 32. The sampling area 31 is provided with a sample tube mounting slot 311, a sampling slot 312, a TIP head grabbing slot 313 and a TIP head discarding slot 314.

[0010] The sample tube mounting groove 311 is used to support the sample tube 40 and to connect the sample tube 40. The sample tube mounting groove 311 and the sampling groove 312 are connected by a flow channel.

[0011] The test strip support 20 is disposed above the sample application and detection area 32. The test strip support 20 and the sample application and detection area 32 cooperate to fix and support the M electrochemical test strips and the N dry chemical test strips.

[0012] In some optional embodiments, the M electrochemical test strips and the N dry chemical test strips are disposed in the sample application and detection area 32.

[0013] In some alternative embodiments, the test strip support 20 is disposed above the sample application and detection area 32.

[0014] In some alternative embodiments, the sample tube mounting slot 311 is connected to the sampling slot 312 via a U-shaped flow channel 315.

[0015] In some alternative embodiments, the bends of the U-shaped flow channel (315) are formed into a sealed structure by ultrasonic welding.

[0016] In some alternative embodiments, the sample tube mounting groove (311) is in sealing contact with the sample tube (40) through a tapered surface that can pierce the middle of the sealing cap of the sample tube (40).

[0017] In some optional embodiments, the TIP head gripping slot (313) is provided with three centering springs (3131) for limiting and fixing the TIP head.

[0018] In some alternative embodiments, the sample tube mounting slot (311) is provided with two prompting springs (3113) to indicate that the sample tube (40) is installed in place when the sample tube (40) is installed in place.

[0019] In some optional embodiments, the M electrochemical test strip sample application holes 11 and the N dry chemical test strip sample application holes 12 are hollow inverted truncated cones.

[0020] In some optional embodiments, the horizontal projections of the sample application areas of the M electrochemical test strips and the sample application areas of the N dry chemical test strips do not overlap.

[0021] In some optional embodiments, the test strip support 20 is provided with M staggered electrochemical test strip channels 21, one end of each electrochemical test strip channel 21 is provided with an electrochemical sample loading channel 211, and the electrochemical sample loading channels 211 of the lower layer of adjacent electrochemical test strip channels 21 are exposed from the electrochemical sample loading channels 211 of the upper layer of electrochemical test strip channels 21.

[0022] In some optional embodiments, the sample loading and detection area 32 further includes a positioning guide plate 323 for positioning and guiding the housing 30 of the multifunctional reagent kit 100.

[0023] In some optional embodiments, the positioning guide plate 323 is provided with N dry chemical detection holes 322, which are located below the corresponding dry chemical test strips 321.

[0024] In some optional embodiments, the test strip support 20 is provided with a downwardly protruding pressing strip 24, the pressing strip 24 being provided with N dry chemical sample diversion holes 23, the dry chemical sample diversion holes 23 penetrating the upper and lower surfaces of the pressing strip 24.

[0025] In some alternative embodiments, the protruding clamping strip 24 is fixed to the positioning guide plate 323 by a positioning element, and the N dry chemical test strips 321 are disposed between the protruding clamping strip 24 and the positioning guide plate 323.

[0026] In some alternative embodiments, an electrochemical test strip 22 is attached to the upper or lower surface of each electrochemical test strip channel 21.

[0027] In some alternative embodiments, the reaction end of each electrochemical test strip 22 is close to the electrochemical sample delivery channel 211 of the corresponding electrochemical test strip channel 21, and the pin end of each electrochemical test strip 22 is far away from the electrochemical sample delivery channel 211 of the corresponding electrochemical test strip channel 21.

[0028] In some optional embodiments, the electrochemical test strip channel 21 is provided with an anti-siphon groove 212 between the electrochemical sample dispensing guide groove 211 and the end of the electrochemical test strip channel 21 away from the electrochemical sample dispensing guide groove 211.

[0029] To provide a multifunctional reagent kit for a multifunctional detector, the multifunctional reagent kit provided in this embodiment of the invention contains M electrochemical test strips and N dry chemical test strips, i.e., a multifunctional reagent kit with consumables. It can be used with a multifunctional detector to detect M electrochemical and N dry chemical detection items. Furthermore, by setting up a sample tube mounting slot 311, a sampling slot 312, a TIP head grasping slot 313, and a TIP head discarding slot 314, sampling and sample addition can be easily completed in one multifunctional reagent kit. Thus, it can be used with a multifunctional detector to achieve fully automated detection of M electrochemical and N dry chemical detection items. Attached Figure Description

[0030] Other features, objects, and advantages of the present invention will become more apparent from the following detailed description of non-limiting embodiments with reference to the accompanying drawings. The drawings are for illustrative purposes only and are not intended to limit the scope of the invention. In the drawings:

[0031] Figure 1AThis is an external perspective view of an embodiment 100 of the multifunctional reagent kit according to the present invention;

[0032] Figure 1B for Figure 1A The diagram shows the multifunctional reagent kit 100 after the top cover 10 explodes from the test strip support 20 and the box body 30.

[0033] Figure 2A This is a three-dimensional schematic diagram of the test strip support 20 and the box body 30 after removing the top cover 10 according to an embodiment of the multifunctional reagent kit 100 of the present invention.

[0034] Figure 2B for Figure 2A The diagram shows the aftermath of the explosion of the two upper electrochemical test strips 22 and the rest of the multifunctional reagent kit 100.

[0035] Figure 2C for Figure 2B The diagram shows the multifunctional reagent kit 100 after the test strip support 20 and the box body 30 have exploded.

[0036] Figure 2D yes Figure 2C The diagram shows the aftermath of the explosion of the dry chemical test strip 321 from the box 30 in the multifunctional reagent kit 100.

[0037] Figure 2E yes Figure 2D A three-dimensional schematic diagram of the multifunctional reagent kit 100 as viewed from below;

[0038] Figure 3 This is a three-dimensional schematic diagram of the sample tube 40, detection circuit board 50, and TIP head 60 assembled with the multifunctional reagent kit 100 according to the present invention.

[0039] Figure 4A and Figure 4B These are perspective schematic diagrams of an embodiment of the sample tube 40 according to the present invention in an upright state and an inverted state, respectively.

[0040] Figure 4C and Figure 4D Exploded views of an embodiment of the sample tube 40 according to the present invention in both upright and inverted states;

[0041] Figure 4E This is a three-dimensional schematic diagram of the sealing tube cap 42 of this utility model in an upright position.

[0042] Figure 5 This is a cross-sectional view of the sample tube mounting groove 311, the U-shaped flow channel 315, and the sample tube 40 in one embodiment of the multifunctional reagent kit 100 according to the present invention.

[0043] Figure 6 This is a cross-sectional view of the sampling slot 312, the TIP head gripping slot 313, and the U-shaped flow channel 315 in the sampling area 31 of the multifunctional reagent kit 100 according to one embodiment of the present invention.

[0044] Figure 7A and Figure 7B These are top and bottom views, respectively, of an embodiment of the sampling area 31 in the multifunctional reagent kit 100 according to this utility model.

[0045] Explanation of reference numerals in the attached figures:

[0046] 100-Multifunctional reagent kit; 10-Top cover; 11-Electrochemical test strip sample application hole; 12-Dry chemical test strip sample application hole; 20-Test strip support; 21-Electrochemical test strip channel; 211-Electrochemical sample application guide groove; 212-Anti-siphon groove; 22-Electrochemical test strip; 221-Reaction end of electrochemical test strip; 222-Pin end of electrochemical test strip; 23-Dry chemical sample application guide hole; 24-Protruding clamping strip; 30-Box body; 31-Sampling area; 311-Sample tube mounting slot; 3111-Guide barrel; 3112-Sample flow guide hole; 3113-Indicator spring; 312-Sampling slot; 313-TI P-head gripping groove; 3131-centering spring; 314-TIP head discarding groove; 315-U-shaped flow channel; 3151-first flow channel; 3152-second flow channel; 3153-third flow channel; 3154-fourth flow channel; 3155-fifth flow channel; 32-sample loading and detection area; 321-dry chemical test strip; 3211-dry chemical sample loading area; 322-dry chemical detection hole; 323-positioning guide plate; 3231-positioning guide spring; 40-sample tube; 41-tube body; 42-sealing tube cap; 421-rubber stopper; 4211-small circular hole; 422-ventilation groove; 50-detection circuit board; 60-TIP head. Detailed Implementation

[0047] The embodiments of this utility model are described in detail below. Examples of these embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals denote the same or similar elements or elements having the same or similar functions throughout. The embodiments described below with reference to the accompanying drawings are exemplary and intended to explain this utility model, and should not be construed as limiting this utility model.

[0048] It should be noted that, where there is no conflict, the embodiments and features in the embodiments of this utility model can be combined with each other. The present utility model will now be described in detail with reference to the accompanying drawings and embodiments.

[0049] It should be understood that in the description of this utility model, the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "clockwise", "counterclockwise", etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this utility model.

[0050] Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of this utility model, unless otherwise stated, "a plurality of" means two or more, unless otherwise expressly defined.

[0051] In this utility model, unless otherwise explicitly specified and limited, the terms "installation," "connection," "linking," and "fixing," etc., should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model according to the specific circumstances.

[0052] In this invention, unless otherwise explicitly specified and limited, "above" or "below" the second feature can include direct contact between the first and second features, or contact between the first and second features through another feature between them. Furthermore, "above," "over," and "on top" of the second feature includes the first feature directly above or diagonally above the second feature, or simply indicates that the first feature is at a higher horizontal level than the second feature. "Below," "below," and "under" the second feature includes the first feature directly below or diagonally below the second feature, or simply indicates that the first feature is at a lower horizontal level than the second feature.

[0053] The following is for reference. Figure 1A and Figure 1B ,in, Figure 1A This is a perspective view of one embodiment of the multifunctional reagent kit 100 according to the present invention. Figure 1B for Figure 1A The diagram shows the multifunctional reagent kit 100 after the top cover 10 explodes from the test strip support 20 and the box body 30.

[0054] like Figure 1A and Figure 1B As shown, the multifunctional reagent kit 100 may include, from top to bottom, a top cover 10, a test strip support 20, and a box body 30, as well as M electrochemical test strips and N dry chemical test strips disposed between the top cover 10 and the box body 30. Here, M and N are positive integers. In the various figures of this utility model, M and N are 2 for example. It can be understood that the values ​​of M and N can be designed according to the actual needs of the scenario.

[0055] The top cover 10 is provided with M electrochemical test strip application holes 11 and N dry chemical test strip application holes 12.

[0056] The M electrochemical test strip application holes 11 and the N dry chemical test strip application holes 12 all penetrate the upper and lower surfaces of the top cover 10.

[0057] M sample application wells 11 of the electrochemical test strips correspond one-to-one with the sample application areas of the M electrochemical test strips, used to apply samples to the reaction areas of the corresponding electrochemical test strips below through the sample application wells 11. The reaction areas of the electrochemical test strips may contain immobilized active substances such as enzymes. Blood reacts with these active substances through a capillary action, generating a microcurrent. Different concentrations of the analyte produce different microcurrents. Subsequently, the electrochemical detection results (e.g., blood glucose, blood ketone, or uric acid levels) can be calculated by detecting the intensity of these currents.

[0058] N sample application wells 12 of the dry chemical test strip correspond one-to-one with the sample application areas of the N dry chemical test strips, used for adding samples through the sample application wells 12 to the corresponding sample application areas of the dry chemical test strips below. Thus, when the sample to be tested is added to the sample application well 12, it enters the sample application area of ​​the dry chemical test strip through the well. During the uniform and rapid downward diffusion process, blood cells are filtered out, and the sample reacts with the enzymes and chemicals in the reaction layer, resulting in a color change. The intensity of this color is directly proportional to the concentration of the analyte. Subsequently, the reflectance intensity of the sample application well 12 can be measured to obtain the photoelectric conversion result, which is then used for further calculations to obtain the dry chemical detection result, such as the blood lipid detection result.

[0059] The box body 30 may include a sampling area 31 and a sample addition and detection area 32.

[0060] The sampling area 31 is equipped with a sample tube mounting slot 311, a sampling slot (or, negative pressure suction slot) 312, a TIP head grabbing slot 313 and a TIP head discarding slot 314.

[0061] The sample tube mounting slot 311 is used to support and connect the sample tube 40, which can hold the sample to be tested (e.g., a blood sample).

[0062] Here, the sample tube 40 can be equipped with a sealing cap. The middle part of the cap of the sample tube 40 can be made of a relatively soft material. A sharp structure can pierce the aforementioned material. For example, it can be made of silicone. The part of the sample tube mounting groove 311 that contacts the cap of the sample tube 40 can pierce the middle part of the cap of the sample tube 40. When the cap of the sample tube 40 is inverted and placed face down in the sample tube mounting groove 311, the part of the sample tube mounting groove 311 that contacts the cap of the sample tube 40 can pierce the middle part of the sealing cap of the sample tube 40, and the sample tube mounting groove 311 and the sample tube 40 can form a sealing contact. In this way, the sample to be tested in the sample tube 40 can be drawn into the sampling groove 312 under the action of negative pressure through the connecting flow channel between the sample tube mounting groove 311 and the sampling groove 312, thereby realizing the aspiration of the sample to be tested.

[0063] The sampling slot 312 and the sample tube mounting slot 311 are connected by a flow channel. In this way, after the sample tube 40 is installed in the sample tube mounting slot 311, a negative pressure is drawn into the sampling slot 312, which in turn generates a negative pressure in both the sampling slot 312 and the sample tube 40. This allows the sample to be tested in the sample tube 40 to enter the sampling slot 312 from the sample tube mounting slot 311 through the connected flow channel. The sample can then be drawn from the sampling slot 312 manually or automatically.

[0064] TIP head grabbing slot 313, TIP grabbing slot 312 can accommodate at least one TIP head.

[0065] Before adding the sample, the TIP tip can be picked up from the TIP tip gripping slot 313 manually or automatically and attached to the pipette or the sampling tip of the automatic sampling device.

[0066] TIP head discard slot 314 is used to release unwanted TIP heads into the TIP head discard slot 314 after the sample aspiration and loading tasks are completed.

[0067] M electrochemical test strips and N dry chemical test strips are placed in the sample application and detection area 32.

[0068] Here, the M electrochemical test strips can correspond to the same or different detection items. Optionally, the M electrochemical test strips can correspond to M different electrochemical detection items.

[0069] Here, the N dry chemical test strips can correspond to the same or different detection items. Optionally, the N dry chemical test strips can correspond to N different dry chemical detection items.

[0070] Understandably, when M is greater than or equal to 2, the multifunctional reagent kit 100 contains at least two electrochemical test strips, supporting at least two electrochemical detection items. When N is greater than or equal to 2, the multifunctional reagent kit 100 contains at least two dry chemical test strips, supporting at least two dry chemical detection items.

[0071] The test strip support 20 is positioned above the sample application and detection area 32 of the box body 30. The test strip support 20 and the sample application and detection area 32 of the box body 30 cooperate to fix and support M electrochemical test strips and N dry chemical test strips, and ensure that the sample application holes 11 of the M electrochemical test strips correspond one-to-one with the sample application areas of the M electrochemical test strips, and the sample application holes 12 of the N dry chemical test strips correspond one-to-one with the sample application areas of the N dry chemical test strips.

[0072] Optionally, the M electrochemical test strip sample application holes 11 and the N dry chemical test strip sample application holes 12 can be designed as hollow inverted frustum shapes. Since the inner diameter of the inverted frustum is larger at the top and smaller at the bottom, it can facilitate liquid flow during sample application, reduce the positional accuracy requirements of the M electrochemical test strip sample application holes 11 and the N dry chemical test strip sample application holes 12, and reduce the requirements for sample application accuracy, that is, reduce the sample application difficulty requirements for users or automatic sample application equipment.

[0073] The multifunctional reagent kit 100 provided in the above embodiments, by setting M electrochemical test strips and N dry chemical test strips, can realize the detection of M electrochemical detection items and N dry chemical detection items in conjunction with a miniaturized detection instrument. Furthermore, by setting sample tube mounting slot 311, sampling slot 312, TIP head grasping slot 313, and TIP head discarding slot 314, the sample sampling, sample addition, and detection operations can be conveniently completed in one multifunctional reagent kit 100, simplifying the operation process and reducing complexity.

[0074] Various implementation methods can be adopted here, with M electrochemical test strips and N dry chemical test strips placed between the top cover 10 and the box body 30. In order to minimize the size of the multifunctional reagent kit 100 and make effective use of the internal space of the multifunctional reagent kit 100, the M electrochemical test strips and N dry chemical test strips can be arranged in multiple staggered layers, as long as it is possible to add samples to the corresponding electrochemical test strip's sample application area (or reaction area) through the sample application hole 11 provided in the top cover 10, and to add samples to the corresponding dry chemical test strip's sample application area through the sample application hole 12 provided in the top cover 10.

[0075] In some alternative implementations, please refer to Figure 2A and Figure 2B .in, Figure 2AThis is a perspective view of the test strip support 20 and the box body 30 after removing the top cover 10 according to an embodiment of the multifunctional reagent kit 100 of this utility model. Figure 2B for Figure 2A The diagram shows the aftermath of the explosion of the two upper electrochemical test strips 22 and the rest of the multifunctional reagent kit 100.

[0076] like Figure 2A and Figure 2B As shown, the test strip support 20 is provided with M' groups (such as... Figure 2A and Figure 2B As shown, M' is the 2) electrochemical test strip channel, and each set of electrochemical test strip channels includes M'' (e.g. Figure 2A and Figure 2B As shown, M'' represents the 2) layers of staggered electrochemical test strip channels 21, with an electrochemical sample loading channel 211 at one end of each channel. The electrochemical sample loading channels 211 of the lower layer of adjacent electrochemical test strip channels 21 are exposed from the electrochemical sample loading channels 211 of the upper layer, thus allowing sample loading through the sample loading holes 11 of the upper cover 10 into the electrochemical sample loading channels 211 of each channel.

[0077] Each electrochemical test strip channel 21 is attached with an electrochemical test strip 22. For example, the electrochemical test strip 22 can be attached to the upper or lower surface of the electrochemical test strip channel 21. The front end (or reaction end) 221 of the electrochemical test strip 22 is close to the electrochemical sample delivery channel 211 of the electrochemical test strip channel 21, and the rear end (or pin end) 222 of the electrochemical test strip 22 is away from the electrochemical sample delivery channel 211 of the electrochemical test strip channel 21. When a liquid sample (e.g., blood) enters the electrochemical sample dispensing channel 211 of the electrochemical test strip channel 21 through the sample dispensing hole 11 of the top cover 10, the front end (or reaction end) 221 of the electrochemical test strip 22 is close to the electrochemical sample dispensing channel 211 of the electrochemical test strip channel 21. As the front end (or reaction end) 221 of the electrochemical test strip 22 comes into contact with the blood, the blood is drawn to the rear end (or pin end) 222 of the electrochemical test strip 22 by siphon. Then, the electrochemical detection module can perform microcurrent detection on the rear end (or pin end) 222 of the electrochemical test strip 22 and convert the microcurrent data into specific electrochemical concentration values ​​(e.g., blood glucose value, blood ketone value, or uric acid value). Optionally, to save space, starting from the topmost electrochemical test strip channel 21, in every two adjacent electrochemical test strip channels 21, an electrochemical test strip 22 can be attached to the upper surface of the upper electrochemical test strip channel 21 and to the lower surface of the lower electrochemical test strip channel 21. This allows for the placement of electrochemical detection modules above the upper electrochemical test strip channel 21 and below the lower electrochemical test strip channel 21, respectively, to perform micro-current detection on the rear end (or pin end) 222 of the two electrochemical test strips 22, thereby obtaining the corresponding electrochemical concentration values ​​(e.g., blood glucose, blood ketone, or uric acid values) of the two electrochemical test strips 22. Figure 2A and Figure 2B Only two adjacent layers of electrochemical test strip channels 21 are shown in the image. It is understood that multiple two-layer electrochemical test strip channels 21 can be configured according to actual needs. Furthermore, Figure 2A and Figure 2B The image only shows two sets of electrochemical test strip channels arranged side by side. However, one, three, or more sets of electrochemical test strip channels can be set up according to actual needs.

[0078] Optionally, such as Figure 2B and Figure 2C As shown, Figure 2C for Figure 2BThe diagram shows the multifunctional reagent kit 100 after the test strip support 20 and the housing 30 have exploded. An anti-siphon groove 212 can be provided on the electrochemical test strip channel 21 between the electrochemical sample dispensing channel 211 and the end of the electrochemical test strip channel 21 furthest from the electrochemical sample dispensing channel 211. This way, after the sample to be tested enters the electrochemical sample dispensing channel 211 through the electrochemical sample dispensing hole 11, the sample (e.g., blood) is prone to capillary siphoning in the smooth structure, causing it to flow to other areas. The anti-siphon groove 212 can cut off the sample from entering the area outside the electrochemical test strip channel 21 due to capillary siphoning, thus ensuring that the sample can reach the reaction end 221 of the electrochemical test strip 22 and ultimately achieve electrochemical detection through the pin 222.

[0079] N dry chemical test strips can be placed in the sample application and detection area 32 of the test strip support 20 or the box 30.

[0080] Please refer to Figure 2A , Figure 2B and Figure 2C .like Figure 2A , Figure 2B and Figure 2C As shown, the sample application and detection area 32 of the box 30 is provided with N dry chemical test strips 321. For example, the N dry chemical test strips 321 can be arranged end to end along a first direction (i.e., the extension direction of the dry chemical test strips 321), or they can be arranged side by side along a second direction (i.e., a second direction perpendicular to the first direction), or they can be arranged in an array along the first and second directions. Figure 2C As shown, two dry chemical test strips 321 extend end to end along a first direction. Each dry chemical test strip 321 has a dry chemical sample application area 3211.

[0081] The sample addition and detection area 32 of the box body 30 or the test strip support 20 is provided with a dry chemical sample addition channel that overlaps with the dry chemical sample addition area 3211 of each dry chemical test strip 321 in the horizontal projection direction.

[0082] Optionally, such as Figure 2C As shown, the dry chemical sample dispensing guide hole 23 can be set between the two sets of electrochemical test strip channels 21. The dry chemical sample dispensing guide hole 23 penetrates the upper and lower surfaces of the test strip support 20, thereby enabling the dispensing of the dry chemical test strip 321 below through the dry chemical sample dispensing guide hole 23. Furthermore, the dry chemical sample dispensing guide hole 23 and the two sets of electrochemical test strip channels 21 can be integrated into a single design to prevent the loss of the test sample.

[0083] In some alternative implementations, such as Figure 2A , 2BAs shown in Figure 2C, the middle part of the test strip support 20, that is, the part between the two sets of electrochemical test strip channels, is a downwardly protruding pressing strip 24. The dry chemical sample dispensing guide hole 23 is disposed in the above-mentioned protruding pressing strip 24 to save space. Here, the dry chemical sample dispensing guide hole 23 penetrates through the upper and lower surfaces of the protruding pressing strip 24.

[0084] Furthermore, since the dry chemical test strip application hole 12 of the upper cover 10 overlaps with the dry chemical application area 3211 of each dry chemical test strip 321 in the horizontal projection direction, that is, the dry chemical application guide hole 23 and the dry chemical application area 3211 of the dry chemical test strip 321 are sequentially arranged below the dry chemical test strip application hole 12 of the upper cover 10 in the horizontal projection direction. In this way, it is possible to apply the sample to the corresponding dry chemical application area 3211 of the dry chemical test strip 321 through the dry chemical test strip application hole 12 of the upper cover 10 and through the dry chemical application guide hole 23.

[0085] It should be noted that each dry chemical test strip 321 can be equipped with at least one reaction zone, and each reaction zone can correspond to different detection items. Optionally, the dry chemical sample application zone 3211 can be set at the center of the extension direction of the dry chemical test strip 321. In this way, the sample to be tested can flow evenly from the central dry chemical sample application zone 3211 of the dry chemical test strip 321 to other reaction zones. By setting different functional reaction layers in each reaction zone, specific reactions are performed on the biochemical characteristics of different detection items (e.g., cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG)). Then, the reflectance intensity of different reaction zones of the dry chemical test strip 321 is measured by a photoelectric detection module, and photoelectric conversion is performed to obtain the photoelectric conversion result. The photoelectric conversion result is then used to calculate the corresponding dry chemical detection result (e.g., the concentration of different blood lipid concentration indicators, such as total cholesterol (TC), triglycerides (TG), and high-density lipoprotein cholesterol (HDL-C)).

[0086] The sample application and detection area 32 of the housing 30 is also provided with dry chemical detection wells 322 corresponding to each reaction zone on each dry chemical test strip 321. Through the dry chemical detection wells 322, photoelectric detection of the corresponding reaction zones on the dry chemical test strip 321 can be achieved. Please refer to... Figure 2D , Figure 2D yes Figure 2C The diagram shows the aftermath of the dry chemical test strip 321 exploding from the housing 30 in the multifunctional reagent kit 100. (See diagram below.) Figure 2D As shown, the dry chemical detection well 322 can be located below the corresponding dry chemical test strip 321.

[0087] Alternatively, please refer to Figure 2E , Figure 2E yes Figure 2DThe multifunctional reagent kit 100 shown is a three-dimensional schematic diagram viewed from a lower perspective. (See diagram below.) Figure 2E As shown, the sample addition detection area 32 of the box body 30 also includes a positioning guide plate 323. The positioning guide plate 323 is used to position and guide the box body 30 of the multifunctional reagent kit 100. Specifically, at least one (e.g., four) positioning guide springs 3231 are provided around the positioning guide plate 323. When the multifunctional reagent kit 100 is assembled into the guide groove in the detection instrument, the positioning guide springs 3231 can adaptively restrict the movement of the multifunctional reagent kit 100 in the up, down, left, and right directions and eliminate the gaps in these two directions. This allows the electrochemical test strip 22 and the dry chemical test strip 321 to fit seamlessly with the corresponding parts of the test strip support 20 and the box body 30 in the multifunctional reagent kit 100, making the detection results more stable.

[0088] Optionally, the dry chemical detection well 322 can be located inside the positioning guide plate 323 of the multifunctional reagent kit 100, which can further save space.

[0089] Optionally, the dry chemical test strip 321 is disposed between the protruding pressing strip 24 and the positioning guide plate 323, and the protruding pressing strip 24 is fixed on the positioning guide plate 323 by a positioning element (e.g., a positioning pin). In this way, the dry chemical test strip 321 can be precisely limited and fixed, and the dry chemical test strip 321 can be pressed, thereby making it easier for the sample to be tested to diffuse on the dry chemical test strip 321.

[0090] In some alternative implementations, please refer to Figure 3 , Figure 3 This is a three-dimensional schematic diagram of the sample tube 40, detection circuit board 50, and TIP head 60 assembled with the multifunctional reagent kit 100 according to this utility model. Figure 3 As shown, firstly, the sample tube 40 is installed with its sealed cap facing down into the sample tube mounting slot 311, ensuring a sealed contact between the sample tube 40 and the sample tube mounting slot 311. Subsequently, the TIP head 60 can be grasped from the TIP head grasping slot 313, and samples are taken through the sampling slot 312. Then, the TIP head 60 can be inserted into the electrochemical test strip application port 11 or the dry chemical test strip application port 12 to apply samples to the electrochemical test strip 22 or the dry chemical test strip 321. The detection circuit board 50 is inserted into the housing 30, enabling electrochemical detection of the electrochemical test strip 22 or photoelectric detection of the dry chemical test strip 321.

[0091] In some alternative implementations, please refer to Figure 4A , Figure 4B , Figure 4C and Figure 4D , Figure 4A and Figure 4B These are perspective schematic diagrams of an embodiment of the sample tube 40 according to the present invention in both upright and inverted states. Figure 4C and Figure 4D These are exploded views of an embodiment of the sample tube 40 according to the present invention in both upright and inverted states.

[0092] like Figure 4A , Figure 4B , Figure 4C and Figure 4D As shown, the sample tube 40 includes a tube body 41 and a sealing cap 42.

[0093] Please refer to Figure 4E , Figure 4E This is a three-dimensional schematic diagram of the sealing cap 42 of this utility model in an upright position, taken from one perspective. Figure 4E As shown, a rubber stopper 421 is provided at the end of the sealing tube cap 42 away from the tube body 41. The rubber stopper 421 is used to seal the sample to be tested in the sample tube 40. When the rubber stopper 421 is punctured by the guide barrel 3111 of the sample tube mounting groove 311, the sample to be tested is guided into the sample tube mounting groove 311 and forms a sealed contact with the sample tube mounting groove 311.

[0094] Optionally, such as Figure 4A , Figure 4B and Figure 4C As shown, the end face of the sealing tube cap 42 is provided with a venting groove 422. The venting groove 422 penetrates the inner wall and the outer wall of the sealing tube cap 42. It is used to form a channel for air circulation in the sample tube 40 when the sample to be tested is sucked in the sample tube 40 by suction negative pressure after the sample tube 40 is installed in the sample mounting slot 311.

[0095] Optionally, a filter screen may also be provided on the rubber stopper 421 to filter the liquid flowing from the sample tube 40 into the sample tube mounting groove 311, so as to ensure the quality of the filtered sample.

[0096] Optionally, a small circular hole 4211 is provided inside the rubber stopper 421 to guide the sample to be tested in the sample tube 40 to the lower flow channel and then into the sample tube mounting groove 311.

[0097] Optionally, the small circular hole 4211 of the rubber stopper 421 of the sealing tube cap 42 can be configured as an inner conical surface, and the connection with the blood can be configured as a circular hole or a "cross" groove. When the sample tube 40 is installed upside down into the sample tube mounting groove 311, a sealing structure is formed between the rubber stopper 421 of the sealing tube cap 42 and the guide barrel 3111 of the sample tube mounting groove 311, thereby preventing the sample to be tested in the sample tube 40 from flowing out and avoiding leakage. Finally, by aspirating the sample into the sampling groove 312, the circular hole or cross groove can be broken under the action of the above-mentioned aspiration pressure to form an aspiration channel.

[0098] Alternatively, please refer to Figure 1A , Figure 5 and Figure 6 , Figure 5 This is a cross-sectional view of the sample tube mounting groove 311, the U-shaped flow channel 315, and the sample tube 40 in one embodiment of the multifunctional reagent kit 100 according to the present invention. Figure 6 This is a cross-sectional view of the sampling slot 312, the TIP head gripping slot 313, and the U-shaped flow channel 315 in the sampling area 31 of the multifunctional reagent kit 100 according to one embodiment of the present invention. Figure 1A , Figure 5 and Figure 6 As shown, the sample tube mounting slot 311 flows through the sampling slot 312 via a U-shaped flow channel 315. The U-shaped flow channel 315 includes a first flow channel 3151, a second flow channel 3152, a third flow channel 3153, a fourth flow channel 3154, and a fifth flow channel 3155 connected in sequence. The first flow channel 3151 is parallel to the extending direction of the guide barrel 3111 and connects the guide barrel 3111 and the second flow channel 3152 of the sample tube mounting slot 311. The second flow channel 3152 is perpendicular to the extending direction of the electrochemical test strip channel 21 and the extending direction of the guide barrel 3111. The third flow channel 3153 is parallel to the extending direction of the electrochemical test strip channel 21. The fourth flow channel 3154 is parallel to the extending direction of the guide barrel 3111. The fifth flow channel 3155 is parallel to the second flow channel 3152 and connects the sampling slot 312 and the fourth flow channel 3154. This is to take into account the manufacturing process of the parts; using a U-shaped flow channel can simplify the manufacturing complexity of the multifunctional reagent kit. Optionally, the bends of the U-shaped flow channel 315, namely the junctions of the first flow channel 3151 and the second flow channel 3152, the second flow channel 3152 and the third flow channel 3153, the third flow channel 3153 and the fourth flow channel 3154, and the fourth flow channel 3154 and the fifth flow channel 3155, can be ultrasonically welded to form a sealing structure to improve the sealing performance of the U-shaped flow channel 315. Figure 1A The direction indicated by the dashed arrow is the flow direction of the sample to be tested.

[0099] Specifically, such as Figure 1A and Figure 1B As shown, the sample tube mounting groove 311 can be a groove of various shapes. A guide barrel 3111 can be provided in the sample tube mounting groove 311. The guide barrel 3111 can be provided with sample guide holes 3112 penetrating the upper and lower surfaces of the guide barrel 3111. The sample guide holes 3112 connect the pipe (e.g., U-shaped flow channel 315) between the sample tube mounting groove 311 and the sampling groove 312. The outer wall of the guide barrel 3111 can be connected to the sealing cap 42 of the sample tube 40 (e.g., Figure 4A , Figure 4B , Figure 4C and Figure 4E A conical seal is formed between the sample tube 40 and the sample tube 40, and a rubber stopper 421 is provided at the end of the sample tube 40 that is away from the tube body 41. The inner wall of the end of the sample tube 40 that is away from the tube body 41 is completely matched with the outer wall of the guide barrel 3111. During the process of inverting the sample tube 40 into the sample tube mounting groove 311, the guide barrel 3111 can pierce the middle of the rubber stopper 421 provided at the end of the sample tube 40 that is away from the tube body 41, and a conical seal structure can be formed between the guide barrel 3111 and the rubber stopper 421. When no negative pressure is generated, the sample to be tested remains in the sample tube 40; when a negative pressure is generated in the sample tube 40 and the sample tube mounting groove 311 (e.g., negative pressure from the sampling groove 312), the sample to be tested can flow from the sample tube 40 into the sample tube mounting groove 311, for example, into the sample guide hole 3112, and enter the sampling groove 312 through the U-shaped flow channel 315, and then the sample to be tested can be drawn from the sampling groove 312. As an example, the guide barrel 3111 can be a hollow frustum.

[0100] In some alternative implementations, please refer to Figure 7A and Figure 7B , Figure 7A and Figure 7B Figures 7A and 7B are respectively a top view and a bottom view of an embodiment of the sampling area 31 in the multifunctional reagent kit 100 of this utility model. Figure 7B As shown, three centering springs 3131 are provided in the TIP head gripping slot 313 to limit and fix the TIP head. That is, the TIP head is held by the three centering springs 3131 to prevent the TIP head from falling out of the TIP head gripping slot 313.

[0101] In some alternative implementations, refer to Figure 7A and Figure 7B As shown in Figure 7A and Figure 7B As shown, the sample tube mounting slot 311 is equipped with two indicator springs 3113, which are used to indicate that the sample tube 40 is installed in place. For example, the user can be reminded to install the sample tube 40 by sound or a change in force.

[0102] In some alternative embodiments, the sample tube mounting groove 311 can be in sealing contact with the sample tube 40 through an inclined conical surface, which can pierce the middle of the rubber stopper 421 provided at the end of the sample tube 40's sealing cap 42 away from the tube body 41.

[0103] The following explains how to use, for example Figure 1A , Figure 1B The working process of the multifunctional reagent kit 100 shown is as follows.

[0104] The first step is to prepare 40 sample tubes.

[0105] Here, sample tube 40 contains the sample to be tested, such as a blood sample.

[0106] The second step is to install the sealing cap 42 of the sample tube 40 downwards onto the sample tube mounting slot 311 of the multifunctional reagent kit 100.

[0107] Optionally, a prompting spring 3113 is provided in the sample tube mounting slot 311, which can be used to confirm that the sample tube 40 is installed in place by the sound or change in force emitted by the prompting spring 3113.

[0108] During the process of installing the sample tube 40 into the sample tube mounting slot 311, the sample tube mounting slot 311 will puncture the middle of the sealing cap 42 of the sample tube 40, for example, by puncturing the middle of the sealing cap 42 of the sample tube 40 through the oblique conical surface of the outer side wall of the guide barrel 3111. However, since the sample tube 40 is provided with a breathable groove 422, the sample tube 40 is connected to the atmosphere. Therefore, after the sample tube 40 is inverted, the sample to be tested will still remain in the sample tube 40 without the generation of negative pressure.

[0109] The third step is to apply negative pressure to the sampling tank 312 so that the sample to be tested flows from the sample tube 40 into the sampling tank 312.

[0110] Use a pipette or an automatic sample loading module to apply negative pressure to the sample collection chamber 312.

[0111] In this way, the sample to be tested can flow from the sample tube 40 into the sample tube mounting groove 311, for example, into the sample guide hole 3112, and enter the sampling groove 312 through the U-shaped flow channel 315.

[0112] The fourth step is to grab the TIP head from the TIP head grabbing slot 313, use the grabbed TIP head to draw the sample to be tested from the sampling slot 312, and then add the sample to the M electrochemical test strip sample application holes 11 and / or N dry chemical test strip sample application holes 12, and then release the TIP head into the TIP head discarding slot 314.

[0113] The sampling and sample addition operations can be completed through steps one through six described above. Subsequent testing can be performed on M electrochemical test strips and / or N dry chemical test strips to complete the corresponding detection items.

[0114] The flowcharts and block diagrams in the accompanying drawings illustrate the architecture, functionality, and operation of possible implementations of systems, methods, and computer program products according to various embodiments of the present invention. In this regard, each block in a flowchart or block diagram may represent a module, segment, or portion of code containing one or more executable instructions for implementing a specified logical function. It should also be noted that in some alternative implementations, the functions indicated in the blocks may occur in a different order than those indicated in the drawings. For example, two consecutively indicated blocks may actually be executed substantially in parallel, and they may sometimes be executed in reverse order, depending on the functions involved. It should also be noted that each block in the block diagrams and / or flowcharts, and combinations of blocks in the block diagrams and / or flowcharts, can be implemented using a dedicated hardware-based system that performs the specified function or operation, or using a combination of dedicated hardware and computer instructions.

[0115] The units or modules described in the embodiments of this utility model can be implemented in software or hardware. The names of the units or modules do not, in certain circumstances, constitute a limitation on the unit or module itself.

[0116] The above description is merely a preferred embodiment of this utility model and an explanation of the technical principles employed. Those skilled in the art should understand that the scope of this utility model is not limited to the specific combination of the above-described technical features, but also includes other technical solutions formed by arbitrary combinations of the above-described technical features or their equivalents without departing from the inventive concept. For example, technical solutions formed by substituting the above-described features with (but not limited to) technical features of the utility model in this utility model that have similar functions.

Claims

1. A multifunctional reagent kit, characterized in that, include: The top cover (10), test strip support (20) and box body (30) are arranged sequentially from top to bottom, and M electrochemical test strips and N dry chemical test strips are arranged between the top cover (10) and the box body (30); The upper cover (10) is provided with M electrochemical test strip application holes (11) and N dry chemical test strip application holes (12), and the M electrochemical test strip application holes (11) and the N dry chemical test strip application holes (12) all penetrate the upper and lower surfaces of the upper cover (10); The box body (30) includes a sampling area (31) and a sample addition and detection area (32). The sampling area (31) is provided with a sample tube mounting slot (311), a sampling slot (312), a TIP head grabbing slot (313), and a TIP head discarding slot (314). The sample tube mounting slot (311) is used to support the sample tube (40) and to connect the sample tube (40). The sample tube mounting slot (311) and the sampling slot (312) are connected by a flow channel. The test strip support (20) is positioned above the sample application and detection area (32). The test strip support (20) and the sample application and detection area (32) cooperate to fix and support the M electrochemical test strips and the N dry chemical test strips.

2. The multifunctional reagent kit according to claim 1, characterized in that, The M electrochemical test strips and the N dry chemical test strips are arranged in the sample application and detection area (32), and the test strip support (20) is arranged above the sample application and detection area (32).

3. The multifunctional reagent kit according to claim 1, characterized in that, The sample tube mounting groove (311) is connected to the sampling groove (312) through a U-shaped flow channel (315), and the bend of the U-shaped flow channel (315) is formed by ultrasonic welding to form a sealed structure.

4. The multifunctional reagent kit according to claim 1, characterized in that, The sample tube mounting groove (311) is in sealed contact with the sample tube (40) through a conical surface, which can pierce the middle of the sealing cap of the sample tube (40).

5. The multifunctional reagent kit according to claim 1, characterized in that, The TIP head gripping slot (313) is provided with three centering springs (3131) for limiting and fixing the TIP head. The sample tube mounting slot (311) is provided with two prompting springs (3113) for prompting the sample tube (40) to be installed in place when the sample tube (40) is installed in place.

6. The multifunctional reagent kit according to claim 1, characterized in that, The M electrochemical test strip sample application wells (11) and the N dry chemical test strip sample application wells (12) are hollow inverted truncated cones.

7. The multifunctional reagent kit according to claim 1, characterized in that, The horizontal projections of the sample application areas of the M electrochemical test strips and the sample application areas of the N dry chemical test strips do not overlap. The test strip support (20) is provided with M staggered electrochemical test strip channels (21), and one end of the electrochemical test strip channel (21) is provided with an electrochemical sample delivery channel (211). The electrochemical sample delivery channels (211) of the lower layer of the two adjacent layers of electrochemical test strip channels (21) are exposed from the electrochemical sample delivery channel (211) of the upper layer of electrochemical test strip channel (21). The sample loading and detection area (32) also includes a positioning guide plate (323) for positioning and guiding the box (30) of the multifunctional reagent kit; The positioning guide plate (323) is provided with N dry chemical detection holes (322), which are located below the corresponding dry chemical test strips (321); The test strip support (20) is provided with a downward protruding pressing strip (24), and the protruding pressing strip (24) is provided with N dry chemical sample guide holes (23), which penetrate the upper and lower surfaces of the protruding pressing strip (24); The protruding pressing strip (24) is fixed on the positioning guide plate (323) by a positioning element, and the N dry chemical test strips (321) are arranged between the protruding pressing strip (24) and the positioning guide plate (323).

8. The multifunctional reagent kit according to claim 7, characterized in that, An electrochemical test strip (22) is attached to the upper or lower surface of each electrochemical test strip channel (21).

9. The multifunctional reagent kit according to claim 8, characterized in that, The reaction end of each electrochemical test strip (22) is close to the electrochemical sample delivery groove (211) of the corresponding electrochemical test strip channel (21), and the pin end of each electrochemical test strip (22) is far away from the electrochemical sample delivery groove (211) of the corresponding electrochemical test strip channel (21).

10. The multifunctional reagent kit according to claim 7, characterized in that, The electrochemical test strip channel (21) has an anti-siphon groove (212) between the electrochemical sample delivery groove (211) and the end of the electrochemical test strip channel (21) away from the electrochemical sample delivery groove (211).

Images