Thin-layer sample application auxiliary device for drug inspection

Abstract

The utility model discloses a thin-layer sample application auxiliary device for drug inspection, and relates to the technical field of drug inspection. The sample application mechanism comprises a lifting disc, a rotating rod is rotationally arranged at the bottom end of the lifting disc, a mounting frame is fixedly arranged at the bottom end of the rotating rod, sample application assemblies distributed in an array mode are mounted on the outer side of the mounting frame, each sample application assembly comprises a micro needle head, each sample application assembly comprises a fixing rod, and a fixing disc is fixedly arranged at the bottom end of each fixing rod; a positioning assembly is installed at the bottom end of the fixing disc, a ball is fixedly arranged at the top end of the fixing rod, and a slope is fixedly arranged at the bottom end of the lifting disc. According to the utility model, the mounting frame, the rotating rod, the plurality of sample application components and other structures are matched with one another, so that automatic switching and accurate positioning of multiple pipes can be realized, a plurality of samples or different solvents can be accurately treated simultaneously, the sample application speed and consistency are greatly improved, the working efficiency is improved, human errors are reduced, and the production cost is reduced. Therefore, the accuracy and the reliability of medicine inspection are ensured.

Description

Technical Field

[0001] This utility model relates to the field of pharmaceutical testing technology, specifically to a thin-layer spotting auxiliary device for pharmaceutical testing. Background Technology

[0002] Pharmaceutical testing uses systematic testing methods to verify the quality, safety, and efficacy of drugs, ensuring their compliance with relevant standards and regulations. Thin-layer chromatography (TLC) is a commonly used sample preparation technique in pharmaceutical testing. It is used to spot trace amounts of components or impurities onto a thin-layer plate for component separation and analysis. This helps detect impurities, residues, or active ingredients in drugs, thereby improving the accuracy and efficiency of the testing.

[0003] In scenarios requiring the processing of multiple samples or different solvents, it is difficult to process multiple samples or different solvents simultaneously efficiently and accurately, which can easily lead to errors, omissions, or confusion, affecting the accuracy and reproducibility of the detection. To address these issues, the inventors propose a thin-layer spotting auxiliary device for pharmaceutical testing. Utility Model Content

[0004] To address the problem of the inconvenience of simultaneously processing different solvents, the purpose of this invention is to provide an auxiliary device for thin-layer spotting in pharmaceutical testing.

[0005] To solve the above-mentioned technical problems, the present invention adopts the following technical solution: a thin-layer spotting auxiliary device for drug testing, comprising an operating table and a spotting mechanism, wherein the spotting mechanism comprises a lifting plate, a rotating rod rotatably provided at the bottom end of the lifting plate, a mounting frame fixedly provided at the bottom end of the rotating rod, spotting components arranged in an array on the outside of the mounting frame, the spotting components comprising micro-needles, the spotting components comprising a fixing rod, the fixing rod being movably inserted into the mounting frame, a fixing plate fixedly provided at the bottom end of the fixing rod, a positioning component installed at the bottom end of the fixing plate, a ball fixedly provided at the top end of the fixing rod, a compression spring movably sleeved on the outside of the fixing rod, and a slope fixedly provided at the bottom end of the lifting plate.

[0006] Preferably, the positioning component includes a positioning frame, which is fixedly installed at the bottom of the fixed plate. A threaded rod is threadedly inserted into the positioning frame, and a clamping block is rotatably provided at the end of the threaded rod. A turntable is fixedly provided at the end of the threaded rod away from the clamping block, and the micro-needle is installed inside the positioning frame.

[0007] Preferably, a movable frame is slidably provided on the top of the operating table, a movable block is slidably provided on the outside of the movable frame, the sampling mechanism is installed on the outside of the movable block, a soft pad is fixedly provided on the end of the clamping block away from the threaded rod, a connector is installed on the outside of the micro-needle, and clamping components are symmetrically distributed on the top of the operating table.

[0008] Preferably, the bottom of the operating platform is fixed with shock-absorbing pads arranged in a rectangular array, a transmission rod is rotatably inserted inside the lifting plate, a first gear is fixed on the outside of the transmission rod, a second gear is fixed on the outside of the rotating rod, the first gear and the second gear mesh with each other, a motor is installed at the top of the lifting plate, and the end of the motor output shaft is inserted through the lifting plate and fixedly connected to the transmission rod.

[0009] Compared with the prior art, the beneficial effects of this utility model are as follows:

[0010] 1. In this utility model, by setting up a mounting frame, a rotating rod and multiple sample spotting components, the structure can be coordinated to realize automatic switching and precise positioning of multiple tubes, accurately process multiple samples or different solvents at the same time, greatly improve the spotting speed and consistency, improve work efficiency, reduce human error, and thus ensure the accuracy and reliability of drug testing.

[0011] 2. In this utility model, by setting up a positioning frame, a threaded rod and a clamping block and other structures to cooperate with each other, the micro needle can be easily installed and disassembled, making it convenient for replacement, maintenance and cleaning. Attached Figure Description

[0012] To more clearly illustrate the technical solutions in the embodiments of this utility model or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this utility model. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0013] Figure 1 This is a schematic diagram of the overall structure of this utility model.

[0014] Figure 2 This is a side view of the overall structure of this utility model.

[0015] Figure 3 This is a schematic diagram of the sampling mechanism of this utility model;

[0016] Figure 4 This utility model Figure 3 Enlarged structural diagram at point A in the middle;

[0017] Figure 5 This is a cross-sectional schematic diagram of the mounting bracket and its connecting structure of this utility model;

[0018] Figure 6 This is a schematic diagram of the slope structure of this utility model.

[0019] In the diagram: 1. Operating table; 11. Moving frame; 12. Moving block; 13. Sampling mechanism; 14. Lifting plate; 15. Clamping assembly; 16. Shock-absorbing foot pad; 17. Micro-needle; 2. Rotating rod; 21. Mounting frame; 22. Sampling assembly; 23. Fixing rod; 24. Fixing plate; 25. Positioning assembly; 26. Sphere; 27. Compression spring; 28. Slope; 3. Positioning frame; 31. Threaded rod; 32. Clamping block; 33. Soft pad; 34. Turntable; 35. Connector; 4. Transmission rod; 41. Gear No. 1; 42. Gear No. 2; 43. Motor. Detailed Implementation

[0020] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0021] like Figure 1-6 As shown, this utility model provides a thin-layer chromatography spotting auxiliary device for pharmaceutical testing, including an operating table 1 and a spotting mechanism 13. The spotting mechanism 13 is used to spot samples onto a thin-layer plate. The spotting mechanism 13 includes a lifting plate 14, a rotating rod 2 rotatably mounted at the bottom end of the lifting plate 14, and a mounting frame 21 fixed at the bottom end of the rotating rod 2. The mounting frame 21 is used to support and mount spotting components 22. Spotting components 22 are arranged in an array on the outside of the mounting frame 21. The spotting components 22 include microneedles 17, which are used to spot samples onto the thin-layer plate. The sample is dispensed using a dispensing assembly 22, which includes a fixed rod 23 that is movably inserted into a mounting frame 21. A fixed plate 24 is fixedly mounted at the bottom of the fixed rod 23, and a positioning assembly 25 is mounted at the bottom of the fixed plate 24. A ball 26 is fixedly mounted at the top of the fixed rod 23, and a compression spring 27 is movably sleeved on the outside of the fixed rod 23. A slope 28 is fixedly mounted at the bottom of the lifting plate 14. Under the action of the compression spring 27, the micro-needle 17 moves upward, causing one of the micro-needles 17 to bulge downward, facilitating sample dispensing.

[0022] The positioning component 25 includes a positioning frame 3, which is fixedly installed at the bottom of the fixed plate 24. A threaded rod 31 is threadedly inserted into the positioning frame 3. A clamping block 32 is rotatably provided at the end of the threaded rod 31. A turntable 34 is fixedly provided at the end of the threaded rod 31 away from the clamping block 32. A micro-needle 17 is installed inside the positioning frame 3.

[0023] By adopting the above technical solution, the micro-needle 17 can be installed through the clamping block 32, and the micro-needle 17 can be easily installed and removed, making it convenient for replacement, maintenance and cleaning.

[0024] A movable frame 11 is slidably provided at the top of the operating table 1, and a movable block 12 is slidably provided on the outside of the movable frame 11. The sampling mechanism 13 is installed on the outside of the movable block 12.

[0025] By adopting the above technical solution, the movable frame 11 moves on the operating table 1 by electric drive, and the movable block 12 moves on the movable frame 11 by electric drive, thereby driving the sampling mechanism 13 to move in all directions on the operating table 1.

[0026] A soft pad 33 is fixedly provided at the end of the clamping block 32 away from the threaded rod 31, and a connector 35 is installed on the outside of the micro-needle 17.

[0027] By adopting the above technical solution, the soft pad 33 can protect the micro-needle 17, and the connector 35 is used to connect with an external micro-pump for drug delivery.

[0028] The top of the operating table 1 is equipped with symmetrically distributed clamping components 15.

[0029] By adopting the above technical solution, the clamping assembly 15 can position and install the thin plate on the operating table 1. It is mainly composed of springs and pressure plates, and the pressure plate presses it onto the operating table 1.

[0030] The bottom of the control panel 1 is fixed with shock-absorbing feet 16 arranged in a rectangular array.

[0031] By adopting the above technical solution, the shock-absorbing foot pad 16 can play the role of shock absorption and buffering for the device.

[0032] A transmission rod 4 is rotatably inserted inside the lifting plate 14. A first gear 41 is fixedly installed on the outside of the transmission rod 4, and a second gear 42 is fixedly installed on the outside of the rotating rod 2. The first gear 41 and the second gear 42 mesh with each other.

[0033] By adopting the above technical solution, the transmission rod 4 rotates, driving the first gear 41 to rotate. The rotation of the first gear 41 drives the meshing second gear 42 to rotate, thereby causing the rotating rod 2 to rotate.

[0034] A motor 43 is installed at the top of the lifting plate 14. The end of the output shaft of the motor 43 is inserted through the lifting plate 14 and fixedly connected to the transmission rod 4.

[0035] By adopting the above technical solution, the end of the output shaft of motor 43 rotates, driving the transmission rod 4 to rotate.

[0036] Working principle: First, four microneedles 17 are connected to four micropumps via connectors 35. Each micropump is connected to one of four different drug solutions. The thin-layer plate is placed on the operating table 1. When sample application is required, the sample is applied to the thin-layer plate through the microneedles 17. When a different drug needs to be changed, the motor 43 is started. The output shaft of the motor 43 rotates, driving the transmission rod 4 to rotate. The rotation of the transmission rod 4 drives the first gear 41 to rotate, which in turn drives the meshing second gear 42 to rotate. The rotation of the second gear 42 drives the rotating rod 2 to rotate, which in turn drives the mounting bracket 21 to rotate. The mounting frame 21 rotates, causing the spotting assembly 22 to rotate, so that the ball 26 slides at the bottom of the lifting plate 14. As it passes the slope 28, the ball 26 moves downward along the slope 28. The downward movement of the ball 26 causes the fixing rod 23 to move downward, which in turn causes the corresponding micro-needle 17 to move downward. When the ball 26 is not disengaged from the slope 28, it moves upward under the action of the compression spring 27. This allows for automatic switching and precise positioning of multiple tubes, accurately processing multiple samples or different solvents simultaneously, significantly improving the spotting speed and consistency, increasing work efficiency, reducing human error, and thus ensuring the accuracy and reliability of drug testing.

[0037] Obviously, those skilled in the art can make various modifications and variations to this utility model without departing from its spirit and scope. Therefore, if these modifications and variations fall within the scope of the claims of this utility model and their equivalents, this utility model also intends to include these modifications and variations.

Claims

1. A thin-layer sampling auxiliary device for pharmaceutical testing, comprising an operating table (1) and a sampling mechanism (13), characterized in that: The sampling mechanism (13) includes a lifting plate (14), a rotating rod (2) is rotatably provided at the bottom end of the lifting plate (14), a mounting frame (21) is fixedly provided at the bottom end of the rotating rod (2), and sampling components (22) arranged in an array are installed on the outside of the mounting frame (21). The sampling components (22) include micro needles (17). The spotting component (22) includes a fixing rod (23), which is movably inserted into the mounting frame (21). A fixing plate (24) is fixedly provided at the bottom end of the fixing rod (23), and a positioning component (25) is installed at the bottom end of the fixing plate (24). A ball (26) is fixedly provided at the top end of the fixing rod (23), and a compression spring (27) is movably sleeved on the outside of the fixing rod (23). A slope (28) is fixedly provided at the bottom end of the lifting plate (14).

2. The thin-layer spotting auxiliary device for pharmaceutical testing as described in claim 1, characterized in that, The positioning component (25) includes a positioning frame (3), which is fixedly installed at the bottom of the fixed plate (24). A threaded rod (31) is threadedly inserted into the positioning frame (3). A clamping block (32) is rotatably provided at the end of the threaded rod (31). A turntable (34) is fixedly provided at the end of the threaded rod (31) away from the clamping block (32). The micro-needle (17) is installed inside the positioning frame (3).

3. The thin-layer spotting auxiliary device for pharmaceutical testing as described in claim 1, characterized in that, The top of the operating table (1) is provided with a movable frame (11), and a movable block (12) is provided on the outside of the movable frame (11). The sampling mechanism (13) is installed on the outside of the movable block (12).

4. The thin-layer spotting auxiliary device for pharmaceutical testing as described in claim 1, characterized in that, The clamping block (32) is fixedly provided with a soft pad (33) at one end away from the threaded rod (31), and a connector (35) is installed on the outside of the micro needle (17).

5. The thin-layer spotting auxiliary device for pharmaceutical testing as described in claim 1, characterized in that, The top of the operating table (1) is equipped with symmetrically distributed clamping components (15).

6. The thin-layer spotting auxiliary device for pharmaceutical testing as described in claim 1, characterized in that, The bottom of the operating table (1) is fixed with shock-absorbing foot pads (16) arranged in a rectangular array.

7. The thin-layer spotting auxiliary device for pharmaceutical testing as described in claim 1, characterized in that, A transmission rod (4) is rotatably inserted inside the lifting plate (14). A first gear (41) is fixedly installed on the outside of the transmission rod (4), and a second gear (42) is fixedly installed on the outside of the rotating rod (2). The first gear (41) and the second gear (42) mesh with each other.

8. The thin-layer spotting auxiliary device for pharmaceutical testing as described in claim 1, characterized in that, A motor (43) is installed at the top of the lifting plate (14), and the end of the output shaft of the motor (43) is inserted through the lifting plate (14) and fixedly connected to the transmission rod (4).

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