Liquid separating device for tangential flow filtering system

Abstract

The utility model relates to a liquid separating device for a tangential flow filtering system, which comprises a cover plate, a back plate and a mounting plate, the cover plate is hinged with the back plate, and the mounting plate is mounted at one end of the back plate far away from the cover plate; a main hose mounting groove and a plurality of branch hose mounting grooves which correspond to each other are formed in the side wall of one end, opposite to the back plate, of the cover plate, and the branch hose mounting grooves are communicated with the main hose mounting groove; a main hose and a branch hose are respectively mounted in the main hose mounting groove and the branch hose mounting groove; a plurality of unblocking mechanisms in one-to-one correspondence with the branch hose mounting grooves are mounted on the mounting plate, and the unblocking mechanisms are arranged to be capable of unblocking the branch hoses; a locking mechanism is mounted on the back plate, and the locking mechanism is arranged to be capable of locking the cover plate and the back plate. According to the utility model, automatic switching of different liquids introduced into the tangential flow filtering system can be realized, the labor cost is reduced, and the working efficiency of tangential flow filtering is improved.

Description

Technical Field

[0001] This utility model relates to the field of tangential flow filtration technology, and in particular to a liquid separation device for a tangential flow filtration system. Background Technology

[0002] Tangential flow filtration is a fundamental operational unit in biopharmaceutical processes. It utilizes hollow fiber components (with pore sizes tailored to different molecular weight cutoffs) within the tangential flow filter to separate cells and their derivatives from the feed solution, thereby selectively separating the target product. For example, in vaccine or antibody production, when the feed solution (such as cell culture medium) flows into a tangential flow filter, intact cells are directly retained, while derivatives released after cell disruption (such as proteins, viral vectors, or DNA fragments) are selectively separated based on their molecular weight differences. That is, small-molecule metabolic waste and other impurities are discharged with the filtrate, while large-molecule target products (such as antibodies or vaccine components) are retained, thus achieving the separation of the target product.

[0003] When performing tangential flow filtration, different liquids need to be introduced into the tangential flow filtration system, such as alkali, water, buffer solution, and feed solution (e.g., cell culture medium), depending on the actual working conditions. Specifically, before performing tangential flow filtration, alkali and water need to be introduced sequentially into the tangential flow filtration system to disinfect, rinse, and clean the tubing and tangential flow filter. Then, buffer solution needs to be introduced into the tangential flow filtration system to wet the tangential flow filter. Finally, feed solution can be introduced into the tangential flow filtration system to perform the tangential flow filtration operation.

[0004] However, currently, the above operations require manual switching of the different liquids and their introduction into the tangential flow filtration system, which is time-consuming and labor-intensive, greatly increasing labor costs and reducing the efficiency of tangential flow filtration.

[0005] Therefore, how to achieve automatic switching of different liquids introduced into the tangential flow filtration system, that is, to eliminate the need for manual intervention to sequentially introduce different liquids into the tangential flow filtration system, thereby reducing labor costs and improving the efficiency of tangential flow filtration, has become an urgent problem to be solved. Utility Model Content

[0006] The purpose of this invention is to provide a liquid separation device for a tangential flow filtration system to solve the problems existing in the prior art.

[0007] To achieve the above objectives, this utility model provides the following solution:

[0008] This utility model provides a liquid distribution device for a tangential flow filtration system, comprising a cover plate, a back plate, and a mounting plate, wherein:

[0009] The cover plate is hinged to the back plate, and the mounting plate is installed on the back plate at the end away from the cover plate;

[0010] The cover plate and the back plate are provided with corresponding main hose mounting slots and several branch hose mounting slots on the side wall opposite to each other, and the several branch hose mounting slots are connected to the main hose mounting slots; the main hose mounting slots and the branch hose mounting slots are respectively used to install the main hose and the branch hose.

[0011] The mounting plate is equipped with a plurality of unblocking mechanisms that correspond one-to-one with the mounting slots of the branch hoses. The unblocking mechanisms are configured to be able to unblock the branch hoses.

[0012] A locking mechanism is installed on the back plate, which is configured to lock the cover plate to the back plate.

[0013] According to one embodiment of the present utility model, the unblocking mechanism includes a branch telescopic motor mounted on the mounting plate, and a plurality of branch telescopic motors are arranged in a one-to-one correspondence with a plurality of branch hose mounting slots. A branch unblocking block is installed on the telescopic end of the branch telescopic motor.

[0014] The back plate has a plurality of branch hose mounting slots that correspond one-to-one with the branch hose mounting slots and are connected to the branch hose mounting slots. A plurality of branch hose blocking blocks are located in the plurality of branch hose blocking holes. The end of the branch hose blocking block away from the branch telescopic motor is used to block the branch hose.

[0015] According to one embodiment of the present invention, the end of the branch block away from the branch telescopic motor is a hemispherical structure;

[0016] The cover plate has a plurality of branch hemispherical grooves at one end near the back plate, which correspond one-to-one with the branch block. The hemispherical structure of the branch block is adapted to the branch hemispherical groove and is configured to be able to move into the branch hemispherical groove.

[0017] According to one embodiment of the present invention, the locking mechanism includes a locking rod rotatably mounted on the back plate, and both the cover plate and the back plate are provided with communicating locking grooves. The locking rod is configured to be displaceable into the locking groove.

[0018] The locking rod is threaded to a locking knob at one end away from the back plate. The locking knob is positioned so that it can abut against the end of the cover plate away from the back plate to lock the cover plate to the back plate.

[0019] According to one embodiment of the present invention, a locking mounting block is detachably installed on the back plate, and a locking rod is rotatably mounted on the locking mounting block. The locking rod is rotatably connected to the back plate through the locking mounting block.

[0020] According to one embodiment of the present utility model, the end of the cover plate away from the back plate is provided with a locking knob placement groove that communicates with the locking groove, and the locking knob placement groove is adapted to the end of the locking knob near the locking rod.

[0021] When the cover plate is locked to the back plate, the end of the locking knob near the locking rod is located in the locking knob placement groove and abuts against the inner wall of the end of the locking knob placement groove away from the back plate.

[0022] According to one embodiment of the present utility model, a main road telescopic motor corresponding to the main road hose mounting groove is installed on the mounting plate, and the main road telescopic motor is located on the same side of a plurality of branch road telescopic motors. A main road block is installed on the telescopic end of the main road telescopic motor.

[0023] The back plate has a main road unblocking hole that communicates with the main road hose mounting groove. The main road unblocking block is located in the main road unblocking hole, and the end of the main road unblocking block away from the main road telescopic motor is used to unblock the main road hose.

[0024] According to one embodiment of the present invention, the end of the main road blocking block away from the main road telescopic motor is a hemispherical structure;

[0025] The cover plate has a main road hemispherical groove at one end near the back plate, which corresponds to the main road block. The hemispherical structure of the main road block is adapted to the main road hemispherical groove and is configured to be able to move into the main road hemispherical groove.

[0026] According to one embodiment of the present invention, the top ends of the cover plate and the back plate are fitted with hinges, and the cover plate and the back plate are hinged to each other by the hinges;

[0027] The bottom end of the back plate is provided with a locking mounting block mounting groove that communicates with the locking groove, and the locking mounting block mounting groove is adapted to the locking mounting block. The locking mounting block can be detachably installed in the locking mounting block mounting groove so as to be detachably connected to the back plate.

[0028] According to one embodiment of the present invention, both the cover plate and the back plate are double-layered structures.

[0029] This utility model has at least the following technical effects:

[0030] This utility model provides a liquid separation device for a tangential flow filtration system. First, by setting up a locking mechanism, a main hose mounting groove and several branch hose mounting grooves, this utility model can securely and detachably install the pipes (i.e., the main hose and the branch hoses) onto the cover plate and the back plate.

[0031] Secondly, by setting up a locking mechanism, a cover plate, a back plate, and a plugging mechanism, this utility model can realize the automatic switching of different liquids introduced into the tangential flow filtration system, eliminating the need for manual intervention to sequentially introduce different liquids into the tangential flow filtration system, thereby reducing labor costs and improving the working efficiency of tangential flow filtration. Attached Figure Description

[0032] To more clearly illustrate the technical solutions in the embodiments of this utility model or the prior art, the drawings used in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this utility model. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0033] Figure 1 This is a schematic diagram of the overall structure of this utility model;

[0034] Figure 2 for Figure 1 A schematic diagram of the overall structure from another angle;

[0035] Figure 3 for Figure 2 A magnified view of a portion of point A in the middle;

[0036] Figure 4 for Figure 2 A schematic diagram of the overall structure from another angle;

[0037] Figure 5 for Figure 4 A schematic diagram of the overall structure from another angle;

[0038] Figure 6 This is a schematic diagram of the overall structure of the cover plate in this utility model;

[0039] Figure 7 for Figure 6 A schematic diagram of the overall structure from another angle;

[0040] Figure 8 This is a schematic diagram of the overall structure of the back plate in this utility model;

[0041] Figure 9 for Figure 8 A schematic diagram of the overall structure without the main hose and branch hoses;

[0042] Figure 10 for Figure 9 A magnified view of a portion of point B in the middle;

[0043] Figure 11 This is a schematic diagram of the overall structure of the mounting plate in this utility model;

[0044] Figure 12 This is a schematic diagram of the overall structure of the locking mounting block, locking rod, and locking knob in this utility model;

[0045] Figure 13 for Figure 12 A schematic diagram of the overall structure from another angle;

[0046] Explanation of reference numerals in the attached figures:

[0047] 1. Cover plate; 2. Back plate; 3. Mounting plate; 4. Locking mounting block; 5. Locking rod; 6. Locking knob; 7. Locking groove; 8. Branch telescopic motor; 9. Main telescopic motor; 10. Branch block; 11. Main block; 12. Branch block hole; 13. Main block hole; 14. Main hose mounting groove; 15. Branch hose mounting groove; 16. Locking knob placement groove; 17. Main hose; 18. Branch hose. Detailed Implementation

[0048] The features and exemplary embodiments of various aspects of this utility model will be described in detail below. To make the objectives, technical solutions, and advantages of this utility model clearer, the following detailed description is provided in conjunction with the accompanying drawings and specific embodiments. It should be understood that the specific embodiments described herein are only configured to explain this utility model and to exemplarily illustrate the principles of this utility model, and are not configured to limit this utility model. In addition, the structural components in the drawings are not necessarily drawn to scale. For example, the dimensions of some structural components or regions in the drawings may be enlarged for other structural components or regions to aid in the understanding of the embodiments of this utility model.

[0049] The directional terms used in the following description refer to the directions shown in the figures and are not intended to limit the specific structure of the embodiments of this utility model. In the description of this utility model, it should be noted that, unless otherwise stated, the terms "installation," "connection," and "joining" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a direct connection or an indirect connection through an intermediate medium. Those skilled in the art can understand the specific meaning of the above terms in this utility model according to the specific circumstances.

[0050] Furthermore, the terms "comprising," "including," "having," or any other variations thereof are intended to cover non-exclusive inclusion, such that a structure or component that includes a list of elements includes not only those elements but also other structural elements that are not expressly listed or inherent to the structure or component. Without further limitations, an element defined by the phrase "comprising..." does not exclude the presence of other identical elements in the article or apparatus that includes the element.

[0051] Spatial relation terms such as "below," "under," "under," "low," "above," "on," and "high" are used for descriptive convenience to explain the positioning of one element relative to a second element, indicating that these terms are intended to cover different orientations of the device, in addition to those different from those shown in the figure. Furthermore, phrases such as "one element on / below another element" can indicate that two elements are in direct contact, or that there are other elements between the two elements. In addition, terms such as "first" and "second" are also used to describe individual elements, areas, parts, etc., without specifically indicating order or sequence, and should not be considered restrictive. Similar terms are used throughout the description to represent similar elements.

[0052] For those skilled in the art, this invention can be implemented without some of these specific details. The following description of the embodiments is merely intended to provide a better understanding of the invention by illustrating examples.

[0053] In this embodiment, there may be descriptions such as "this device". Those skilled in the art should understand that "this device" refers to a liquid separation device for a tangential flow filtration system provided by this utility model.

[0054] In this embodiment, there may be descriptions such as "staff". Those skilled in the art should understand that the description of "staff" is only for the convenience of describing the implementation of this utility model. It is just an exemplary general concept and is not specifically limited to a particular person.

[0055] Reference Figure 1-13 This utility model provides a liquid separation device for a tangential flow filtration system, the device comprising at least a cover plate 1, a back plate 2, and a mounting plate 3, wherein:

[0056] Reference Figure 1 The cover plate 1 and the back plate 2 are hinged together, and the mounting plate 3 is installed on the back plate 2 at the end away from the cover plate 1.

[0057] In this embodiment, refer to Figure 1 , Figure 4 and Figure 5 ,by Figure 4For example, cover plate 1 is located on back plate 2. Figure 4 On the left side of the middle, while the mounting plate 3 is located on the back plate 2. Figure 4 On the right side of the middle.

[0058] In this embodiment, refer to Figure 1 Hinges (known in the art) are installed at the top of the cover plate 1 and the back plate 2. One end of the hinge is installed at the top of the cover plate 1 and the other end of the hinge is installed at the top of the back plate 2, thereby enabling the cover plate 1 and the back plate 2 to be hinged together.

[0059] In this embodiment, refer to Figure 4 and Figure 5 There is a certain distance between the mounting plate 3 and the back plate 2, and the mounting plate 3 can be connected to the back plate 2 by a number of bolts (known in the art).

[0060] In this embodiment, refer to Figure 1 , Figure 2 , Figure 4 and Figure 5 The cover plate 1 and the back plate 2 have the same shape and volume, and both can be cuboid structures. (Refer to...) Figure 5 The mounting plate 3 can be a flat cuboid structure, and its volume can be slightly smaller than that of the back plate 2.

[0061] In this embodiment, refer to Figure 1 Both the cover plate 1 and the back plate 2 can be double-layered structures, and the size of the double-layered structures of both is the same (i.e., both the cover plate 1 and the back plate 2 are equally divided double-layered structures). The double-layered structures of the cover plate 1 and the back plate 2 can be connected by bolts (not shown in the figure and known in the art), and are not particularly limited here. The double-layered structure allows for higher structural strength of the cover plate 1 and the back plate 2.

[0062] According to one embodiment of the present invention, referring to... Figure 7-9 On the side wall opposite to the back plate 2 (i.e., on the side wall where the cover plate 1 and the back plate 2 are in contact), there are corresponding main hose mounting grooves 14 and several branch hose mounting grooves 15 (i.e., the main hose mounting grooves 14 and several branch hose mounting grooves 15 on the cover plate 1 are respectively set to correspond one-to-one with the main hose mounting grooves 14 and several branch hose mounting grooves 15 on the back plate 2), and the several branch hose mounting grooves 15 are all connected to the main hose mounting grooves 14.

[0063] In this embodiment, refer to Figure 7-9The main hose mounting groove 14 and the branch hose mounting groove 15 are both semi-circular structures with the same cross-sectional area. Therefore, when the cover plate 1 contacts the back plate 2, the main hose mounting groove 14 and the branch hose mounting groove 15 opened on the cover plate 1 and the main hose mounting groove 14 and the branch hose mounting groove 15 opened on the back plate 2 will form cylindrical structures respectively. This allows the main hose 17 and the branch hose 18 to be installed inside the main hose mounting groove 14 and the branch hose mounting groove 15 respectively.

[0064] In this embodiment, the main hose 17 and the branch hose 18 can both be silicone hoses known in the art, and no particular limitation is made here.

[0065] In this embodiment, the connection between the main hose 17 and the branch hose 18 can be made using a "tee" (not shown in the figure) known in the art, and is not particularly limited here.

[0066] In this embodiment, refer to Figure 7-9 The main hose mounting groove 14 can be set along the horizontal direction of the cover plate 1 and the back plate 2, while several branch hose mounting grooves 15 can all be set along the vertical direction of the cover plate 1 and the back plate 2 (i.e., Figure 9 (Horizontal and vertical directions in the middle).

[0067] Preferably, refer to Figure 7-9 The number of branch hose mounting slots 15 can be four, and the four branch hose mounting slots 15 are equally spaced. Since there are four branch hose mounting slots 15, there are also four branch hoses 18, so that alkali solution, water, buffer solution and material solution (such as cell culture medium) can be introduced into the four branch hoses 18 respectively.

[0068] In this embodiment, refer to Figure 9 The four branch hose mounting slots 15 are located below the main hose mounting slot 14.

[0069] In addition, refer to Figure 5 In this embodiment, the back plate 2 is located away from the side wall of the cover plate 1 (i.e., Figure 5 Threaded holes are provided at the four corners of the right side wall of the back plate 2. Therefore, the back plate 2 in this device can be bolted to the components of the tangential flow filtration system, thereby enabling the device to be installed and used in the tangential flow filtration system. Further details are omitted here.

[0070] According to one embodiment of the present invention, a plurality of unblocking mechanisms are installed on the mounting plate 3, which correspond one-to-one with a plurality of branch hose mounting slots 15. The unblocking mechanisms are configured to unblock the branch hoses 18, thereby realizing automatic switching of different liquids (such as the aforementioned alkaline solution, water, buffer solution and feed solution).

[0071] In this embodiment, specifically, referring to Figure 2 , Figure 4 , Figure 5 and Figure 11 The unblocking mechanism includes branch telescopic motors 8 mounted on the mounting plate 3, and several branch telescopic motors 8 are arranged in a one-to-one correspondence with several branch hose mounting slots 15. A branch unblocking block 10 is installed on the telescopic end (i.e. the output end of the branch telescopic motor 8).

[0072] In this embodiment, refer to Figure 5 The end of the mounting plate 3 away from the back plate 2 can be bolted to a frame, and the branch telescopic motor 8 can be bolted to this frame, thereby connecting the branch telescopic motor 8 to the mounting plate 3.

[0073] In this embodiment, specifically, referring to Figure 8-10 The back plate 2 has several branch pipe blocking holes 12, each corresponding to and connected to a number of branch hose mounting slots 15. Each branch pipe blocking hole 12 also corresponds to a number of branch pipe blocking blocks 10, which are located within the holes 12. The end of each branch pipe blocking block 10 furthest from the branch telescopic motor 8 can be used to block the branch hose 18; that is, the end of the branch pipe blocking block 10 furthest from the branch telescopic motor 8 can compress the branch hose 18, thereby blocking or unclogging it.

[0074] In this embodiment, refer to Figure 10 Both the branch passage block 12 and the branch passage block 10 can be cylindrical structures, and the diameter of the branch passage block 12 and the cross-sectional diameter of the branch passage block 10 can be exactly the same. That is, when the branch passage block 10 moves in the branch passage block 12, the side wall of the branch passage block 10 will slide and engage with the inner wall of the branch passage block 12, which can provide a limiting effect for the branch passage block 10 and further ensure the stability of the branch passage block 10 moving in the branch passage block 12.

[0075] Furthermore, referring to Figure 9-11 The end of the branch block 10 away from the branch telescopic motor 8 is a hemispherical structure. When the end of the branch block 10 away from the branch telescopic motor 8 squeezes the branch hose 18, the spherical surface of the hemispherical structure of the branch block 10 can prevent the branch hose 18 from being squeezed and broken, thus ensuring the smooth operation of the tangential flow filtration.

[0076] Furthermore, referring to Figure 7The cover plate 1 has several branch hemispherical grooves that correspond one-to-one with several branch block 10s at one end near the back plate 2. The several branch hemispherical grooves also correspond one-to-one with several branch block holes 12. The hemispherical structure of the branch block 10 is adapted to the branch hemispherical groove and is configured to allow the hemispherical structure of the branch block 10 to be moved as a whole into the branch hemispherical groove.

[0077] In this embodiment, refer to Figure 7 Several branch hemispherical grooves are formed in several branch hose mounting grooves 15 on the cover plate 1.

[0078] In this embodiment, when the branch block 10 completely seals the branch hose 18, that is, when the branch block 10 squeezes the branch hose 18 completely closed, the branch block 10 will extend into the branch hemispherical groove and cooperate with the inner wall of the branch hemispherical groove. Therefore, by setting the branch hemispherical groove, the tightness of the sealing of the branch hose 18 can be improved.

[0079] According to one embodiment of the present invention, a locking mechanism is installed on the back plate 2. The locking mechanism is configured to lock the cover plate 1 and the back plate 2 together, that is, when the cover plate 1 and the back plate 2 are in contact, the locking mechanism can lock the two together.

[0080] In this embodiment, there can be two locking mechanisms, which are installed symmetrically at the bottom of the back plate 2 in sequence.

[0081] In this embodiment, specifically, referring to Figure 2-4 , Figure 12 and Figure 13 The locking mechanism includes a locking rod 5 rotatably mounted on the back plate 2. Both the cover plate 1 and the back plate 2 are provided with interconnected locking grooves 7. The locking rod 5 is configured to be able to move into the locking groove 7.

[0082] In this embodiment, refer to Figure 12 The locking rod 5 can be a cylindrical structure.

[0083] In this embodiment, refer to Figure 2 and Figure 3 The locking rod 5 is installed at the bottom end of the back plate 2, that is, the locking rod 5 is installed at the end of the back plate 2 away from the hinge (i.e., the locking rod 5 is installed at the bottom end of the back plate 2). Figure 2 (Bottom of the middle backplate 2).

[0084] In this embodiment, refer to Figure 3 The width of the locking groove 7 can be the same as the cross-sectional diameter of the locking rod 5.

[0085] In this embodiment, the rotation direction of the locking rod 5 on the back plate 2 is the same as the groove depth direction of the locking groove 7.

[0086] In this embodiment, the end of the locking rod 5 furthest from the back plate 2 (i.e. Figure 2 The left end of the locking rod 5 is threaded with a locking knob 6, which is located near the end of the locking rod 5 (i.e., the left end of the locking rod 5). Figure 2 The right end of the locking knob 6 is configured to abut against the end of the cover plate 1 away from the back plate 2 (i.e., Figure 2 (From the left end of the middle cover plate 1), thereby locking the cover plate 1 and the back plate 2.

[0087] In one embodiment of this utility model, when the cover plate 1 and the back plate 2 are in contact, the locking knob 6 can be turned in advance and moved away from the locking rod 5. Then, the locking rod 5 is rotated into the locking groove 7, and the locking knob 6 is turned again and moved closer to the locking rod 5 until the locking knob 6 abuts against the side wall of the cover plate 1. At this time, the locking knob 6 and the side wall of the cover plate 1 will be in contact through friction, thereby locking the cover plate 1 and the back plate 2.

[0088] Furthermore, referring to Figure 3 A locking mounting block 4 is detachably installed on the back plate 2, and a locking rod 5 is rotatably installed on the locking mounting block 4, that is, the locking rod 5 is rotatably connected to the back plate 2 through the locking mounting block 4.

[0089] In this embodiment, the rotational connection between the locking rod 5 and the locking mounting block 4 is not particularly limited. For example, a rotating rod can be installed at each end of the locking rod 5. These two rotating rods can extend into the locking mounting block 4 and rotate in cooperation with the locking mounting block 4, thereby realizing the rotational connection between the locking rod 5 and the locking mounting block 4.

[0090] In this embodiment, specifically, referring to Figure 3 The bottom end of the back plate 2 is provided with a locking mounting block mounting groove that communicates with the locking groove 7, and the locking mounting block mounting groove is compatible with the locking mounting block 4. Thus, the locking mounting block 4 can be detachably installed in the locking mounting block mounting groove, thereby realizing the detachable connection between the locking mounting block 4 and the back plate 2.

[0091] In this embodiment, the detachable connection method between the locking mounting block 4 and the locking mounting block mounting groove is not particularly limited. For example, the locking mounting block 4 and the locking mounting block mounting groove can be an interference fit with a tenon and mortise structure. Alternatively, the locking mounting block 4 and the locking mounting block mounting groove can be connected by bolts (not shown in the figure).

[0092] In this embodiment, the locking mounting block 4 can be a U-shaped structure, and the locking mounting block mounting groove can be a cuboid structure.

[0093] Furthermore, referring to Figure 3 and Figure 6 The cover plate 1 has a locking knob placement groove 16 connected to the locking groove 7 at the end away from the back plate 2, and the locking knob placement groove 16 is adapted to the end of the locking knob 6 near the locking rod 5; when the cover plate 1 is locked to the back plate 2, the end of the locking knob 6 near the locking rod 5 is located in the locking knob placement groove 16 and abuts against the inner wall of the end of the locking knob placement groove 16 away from the back plate 2.

[0094] In one embodiment of this utility model, by setting the locking knob placement groove 16, the firmness of the connection (abutment) between the locking knob 6 and the cover plate 1 can be improved, and the locking effect can be further improved.

[0095] According to one embodiment of the present invention, referring to Figure 4 , Figure 5 and Figure 11 The mounting plate 3 is equipped with a main road telescopic motor 9 that corresponds to the main road hose mounting groove 14, and the main road telescopic motor 9 is located on the same side of several branch road telescopic motors 8 (four in this embodiment). The telescopic end of the main road telescopic motor 9 is equipped with a main road block 11.

[0096] In this embodiment, the main road telescopic motor 9 can also be installed on the aforementioned frame.

[0097] In this embodiment, refer to Figure 8 and Figure 9 The back plate 2 has a main road unblocking hole 13 that communicates with the main road hose mounting groove 14. The main road unblocking hole 13 is also correspondingly provided with a main road unblocking block 11, which is located inside the main road unblocking hole 13. The end of the main road unblocking block 11 away from the main road telescopic motor 9 can be used to unblock the main road hose 17, that is, the end of the main road unblocking block 11 away from the main road telescopic motor 9 can squeeze the main road hose 17 to achieve unblocking of the main road hose 17.

[0098] In this embodiment, both the main road blockage hole 13 and the main road blockage block 11 can be cylindrical structures, and the diameter of the main road blockage hole 13 and the cross-sectional diameter of the main road blockage block 11 can be exactly the same (i.e., the same as the matching method of the branch road blockage block 10 in the branch road blockage hole 12). This can further ensure the stability of the main road blockage block 11 moving within the main road blockage hole 13.

[0099] In this embodiment, since the main road telescopic motor 9 is located on the same side of the four branch road telescopic motors 8, that is, the main road through-blocking hole 13 is also located on the same side of the four branch road hose mounting slots 15, when the main road through-blocking block 11 completely blocks the main road hose 17, the four branch road hoses 18 can be blocked at the same time.

[0100] In one embodiment of this utility model, the main road telescopic motor 9 and the main road unblocking block 11 can be used to unblock the main road hose 17, thereby better adapting to different working conditions.

[0101] Furthermore, referring to Figure 9-11 The end of the main road block 11 furthest from the main road telescopic motor 9 is a hemispherical structure. Similarly, like the hemispherical structure of the branch road block 10, the hemispherical structure of the main road block 11 can prevent the main road hose 17 from being squeezed and broken, ensuring the smooth operation of the tangential flow filtration. This will not be elaborated further here.

[0102] Furthermore, referring to Figure 7 The cover plate 1 has a main road hemispherical groove at one end near the back plate 2, which corresponds to the main road block 11. The main road hemispherical groove also corresponds to the main road block hole 13. The hemispherical structure of the main road block 11 is adapted to the main road hemispherical groove and is configured to be able to move the entire hemispherical structure of the main road block 11 into the main road hemispherical groove.

[0103] In this embodiment, refer to Figure 7 The main road hemispherical groove is opened in the main road hose installation groove 14 on the cover plate 1.

[0104] In this embodiment, similarly, the cooperation between the branch block 10 and the branch hemispherical groove is the same as described above. By setting the main hemispherical groove, the tightness of the main hose 17 can be improved.

[0105] In this embodiment, both the main telescopic motor 9 and the branch telescopic motor 8 are existing technologies known in the art. For example, any telescopic motor suitable for this device and known in the art can be used, and no particular limitation is made here.

[0106] Furthermore, those skilled in the art should understand that although this device is applicable to the automatic switching of alkali, water, buffer solution and feed liquid in a tangential flow filtration system in this embodiment, it can also be applied to any working scenario that requires liquid switching, that is, this device is not limited to use in tangential flow filtration systems.

[0107] The above embodiments of this utility model can be combined with each other and have corresponding technical effects.

[0108] The above are merely preferred embodiments of the present utility model and are not intended to limit the present utility model. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present utility model shall be included within the protection scope of the present utility model.

Claims

1. A liquid separation device for a tangential flow filtration system, characterized in that, Includes a cover plate (1), a back plate (2), and a mounting plate (3), wherein: The cover plate (1) is hinged to the back plate (2), and the mounting plate (3) is installed on the back plate (2) at the end away from the cover plate (1); The cover plate (1) and the back plate (2) are provided with corresponding main hose mounting grooves (14) and several branch hose mounting grooves (15) on the side wall opposite to each other. The several branch hose mounting grooves (15) are connected to the main hose mounting grooves (14). The main hose mounting grooves (14) and the branch hose mounting grooves (15) are respectively used to install the main hose (17) and the branch hose (18). The mounting plate (3) is equipped with a plurality of unblocking mechanisms that correspond one-to-one with the plurality of branch hose mounting slots (15). The unblocking mechanisms are configured to be able to unblock the branch hoses (18). A locking mechanism is installed on the back plate (2), which is configured to lock the cover plate (1) to the back plate (2).

2. The liquid separation device for a tangential flow filtration system according to claim 1, characterized in that, The unblocking mechanism includes branch telescopic motors (8) installed on the mounting plate (3). Several branch telescopic motors (8) are arranged in a one-to-one correspondence with several branch hose mounting slots (15). A branch unblocking block (10) is installed on the telescopic end of the branch telescopic motor (8). The back plate (2) has a plurality of branch pipe holes (12) that correspond one-to-one with the plurality of branch hose mounting slots (15) and are connected to the plurality of branch hose mounting slots (15). A plurality of branch pipe blocks (10) are located in the plurality of branch pipe holes (12). The end of the branch pipe block (10) away from the branch telescopic motor (8) is used to block the branch hose (18).

3. The liquid separation device for a tangential flow filtration system according to claim 2, characterized in that, The end of the branch block (10) away from the branch telescopic motor (8) is a hemispherical structure; The cover plate (1) has a plurality of branch hemispherical grooves that correspond one-to-one with the branch block (10) at one end near the back plate (2), and the hemispherical structure of the branch block (10) is adapted to the branch hemispherical groove and is configured to be able to move into the branch hemispherical groove.

4. The liquid separation device for a tangential flow filtration system according to claim 1, characterized in that, The locking mechanism includes a locking rod (5) rotatably mounted on the back plate (2). Both the cover plate (1) and the back plate (2) are provided with interconnected locking grooves (7). The locking rod (5) is configured to be able to move into the locking groove (7). The locking rod (5) is threaded with a locking knob (6) at one end away from the back plate (2). The locking knob (6) is positioned so that it can abut against the end of the cover plate (1) away from the back plate (2) to lock the cover plate (1) and the back plate (2).

5. The liquid separation device for a tangential flow filtration system according to claim 4, characterized in that, A locking mounting block (4) is detachably installed on the back plate (2), and the locking rod (5) is rotatably installed on the locking mounting block (4). The locking rod (5) is rotatably connected to the back plate (2) through the locking mounting block (4).

6. The liquid separation device for a tangential flow filtration system according to claim 4, characterized in that, The cover plate (1) has a locking knob placement groove (16) connected to the locking groove (7) at one end away from the back plate (2), and the locking knob placement groove (16) is adapted to the end of the locking knob (6) near the locking rod (5). When the cover plate (1) is locked to the back plate (2), the end of the locking knob (6) near the locking rod (5) is located in the locking knob placement groove (16) and abuts against the inner wall of the end of the locking knob placement groove (16) away from the back plate (2).

7. The liquid separation device for a tangential flow filtration system according to claim 2, characterized in that, The mounting plate (3) is equipped with a main road telescopic motor (9) corresponding to the main road hose mounting groove (14), and the main road telescopic motor (9) is located on the same side of several branch road telescopic motors (8). The telescopic end of the main road telescopic motor (9) is equipped with a main road block (11). The back plate (2) is provided with a main road blockage hole (13) that is connected to the main road hose mounting groove (14). The main road blockage block (11) is located in the main road blockage hole (13). The end of the main road blockage block (11) away from the main road telescopic motor (9) is used to block the main road hose (17).

8. The liquid separation device for a tangential flow filtration system according to claim 7, characterized in that, The end of the main road block (11) away from the main road telescopic motor (9) is a hemispherical structure; The cover plate (1) has a main road hemispherical groove at one end near the back plate (2) that corresponds to the main road block (11), and the hemispherical structure of the main road block (11) is adapted to the main road hemispherical groove and is configured to be able to move into the main road hemispherical groove.

9. The liquid separation device for a tangential flow filtration system according to claim 5, characterized in that, The top of the cover plate (1) and the back plate (2) are fitted with hinges, and the cover plate (1) and the back plate (2) are hinged to each other by the hinges; The bottom end of the back plate (2) is provided with a locking mounting block mounting groove that communicates with the locking groove (7), and the locking mounting block mounting groove is adapted to the locking mounting block (4). The locking mounting block (4) is detachably installed in the locking mounting block mounting groove so as to be detachably connected to the back plate (2).

10. The liquid separation device for a tangential flow filtration system according to claim 1, characterized in that, Both the cover plate (1) and the back plate (2) are double-layer structures.

Images