Nuclear magnetic tube sample injector heating device of nuclear magnetic resonance spectrometer

Abstract

The utility model discloses a heating device for a nuclear magnetic tube sample injector of a nuclear magnetic resonance spectrometer, which can be used for heating and preserving heat of a nuclear magnetic tube. The nuclear magnetic tube sample injector heating device of the nuclear magnetic resonance spectrometer comprises a heating device arranged in a sample injection device on the nuclear magnetic resonance spectrometer, the sampling device comprises a machine body; the machine body is provided with a turntable mounting cavity; a driving device mounting cavity is arranged below the turntable mounting cavity; the turntable mounting cavity and the driving device mounting cavity are separated by a partition plate; a first turntable and a second turntable are sequentially arranged in the turntable mounting cavity from top to bottom; the heating device comprises an annular heating piece arranged on the partition plate. Air holes are formed in the second turntable; heat conducting rods which are uniformly distributed along the circumference are arranged on the second turntable; the lower end of the heat conduction rod penetrates through the second rotating disc and extends to the position above the partition plate. By adopting the device, the liquid nuclear magnetic sample in the nuclear magnetic tube can be always kept in a liquid state, and smooth detection is ensured.

Description

Technical Field

[0001] This utility model relates to the field of heat preservation and heating technology for nuclear magnetic resonance tube sample introduction devices, and in particular to a heating device for a nuclear magnetic resonance tube sample introduction device for a nuclear magnetic resonance spectrometer. Background Technology

[0002] Nuclear magnetic resonance (NMR) spectrometry is a sophisticated instrument that uses the magnetic resonance phenomenon of atomic nuclei in a magnetic field to analyze the molecular structure, chemical environment, and dynamic behavior of matter. It has wide applications in chemistry, biology, materials science, and pharmaceutical research and development.

[0003] When a nuclear magnetic resonance spectrometer is used to test a sample, it needs to deliver the sample through a sampler. The main function of the sampler is to store the NMR tube sample. Nuclear magnetic resonance spectrometers have samplers of various specifications, such as 24-well samplers and 60-well samplers.

[0004] Existing injectors all have a storage tube installed in the storage hole of the injector, and then a limiting sleeve is fitted on the upper end of the NMR tube. The NMR tube is then placed into the storage tube, and the limiting sleeve is used to position the NMR tube in the storage tube.

[0005] When using nuclear magnetic resonance (NMR) spectroscopy to analyze liquid NMR samples, there are various deuterated reagents available, commonly including deuterated chloroform, heavy water, deuterated DMSO, deuterated acetone, deuterated acetonitrile, deuterated benzene, deuterated methanol, deuterated pyridine, and deuterated dichloromethane. Because these liquid NMR samples have different melting points, when analyzing them in low-temperature environments (such as winter), some liquid NMR samples, with melting points higher than the ambient temperature (e.g., deuterated DMSO has a melting point of around 20.2 °C), may solidify, leading to test failure.

[0006] Because existing sample injectors can only store NMR tubes and cannot maintain or heat them, testing liquid NMR samples in low-temperature environments requires air conditioning to raise the room temperature (which is ineffective in winter with poor air circulation). This necessitates a considerable amount of time for the ambient temperature to exceed the melting point of the liquid NMR sample. This reduces the equipment's adaptability, making testing difficult and requiring the system to wait until the ambient temperature is suitable before proceeding. Utility Model Content

[0007] The technical problem to be solved by this utility model is to provide a heating device for the NMR tube of a nuclear magnetic resonance spectrometer that can heat and keep the NMR tube at a constant temperature, maintain the liquid NMR sample inside the NMR tube in a liquid state, and ensure smooth detection.

[0008] The technical solution adopted by this utility model to solve its technical problem is: a heating device for the nuclear magnetic resonance tube sampler of a nuclear magnetic resonance spectrometer, including a heating device installed in the sampler of the nuclear magnetic resonance spectrometer.

[0009] The sample introduction device includes a body; the body has a turntable mounting cavity; a drive device mounting cavity is provided below the turntable mounting cavity; the turntable mounting cavity and the drive device mounting cavity are separated by a partition.

[0010] The turntable mounting cavity is provided with a first turntable and a second turntable arranged from top to bottom; there is a gap between the first turntable and the second turntable; the first turntable is provided with mounting holes evenly distributed along the circumference; the second turntable is provided with through holes corresponding one-to-one with the mounting holes of the first turntable; a driving device for driving the first turntable and the second turntable to rotate is provided below the partition plate.

[0011] A nuclear magnetic resonance tube storage cylinder is installed in the mounting hole on the first turntable; both ends of the nuclear magnetic resonance tube storage cylinder have openings, and the lower end of the nuclear magnetic resonance tube storage cylinder passes through the through hole of the second turntable;

[0012] The heating device includes an annular heating element disposed on the partition; a vent hole is provided on the second turntable; a heat-conducting rod is disposed on the second turntable and evenly distributed along the circumference; the lower end of the heat-conducting rod passes through the second turntable and extends above the partition.

[0013] Specifically, the annular heating element includes an annular heating resistor and a heat sink disposed on the annular heating resistor; a temperature sensor is disposed inside the turntable mounting cavity, and a display is disposed on the body to display the temperature detected by the temperature sensor.

[0014] Furthermore, a vertical cavity is provided on one side of the turntable mounting cavity; the bottom of the vertical cavity is separated from the drive device mounting cavity by a second partition.

[0015] The turntable mounting cavity is provided with a first vent hole and a second vent hole that communicate with the vertical cavity on one side.

[0016] The first vent and the second vent are located above and below the second turntable, respectively; a small exhaust fan is installed inside the first vent.

[0017] Furthermore, an annular groove is provided on the partition plate at the bottom of the inner cavity of the machine body; annular heating elements are provided on both the outer and inner sides of the annular groove; one end of the heat-conducting rod extends into the annular groove.

[0018] Specifically, the heat-conducting rod is made of copper.

[0019] Specifically, a heat insulation cylinder is provided between the first turntable and the second turntable.

[0020] Furthermore, a heat insulation layer is provided on the inner wall of the machine body.

[0021] The beneficial effects of this invention are as follows: The nuclear magnetic resonance (NMR) tube sampler heating device of the NMR spectrometer described in this invention achieves heating of the turntable mounting cavity by setting an annular heating device below the second turntable, thereby enabling heating and heat preservation of the NMR tube stored in the turntable mounting cavity. This prevents the liquid sample inside the NMR tube from solidifying due to low temperature, ensuring smooth detection and improving the applicability of the NMR spectrometer.

[0022] Secondly, by setting up a vertical cavity, and by setting vent holes and an exhaust fan between the vertical cavity and the turntable mounting cavity, as well as vent holes on the second turntable, air circulation between the first and second turntables in the turntable mounting cavity is achieved. This facilitates the transfer of heat emitted by the heating element installed at the bottom of the turntable mounting cavity into the space between the first and second turntables, ensuring uniform heating and temperature throughout the entire turntable mounting cavity. It also facilitates the heating of the gas in the NMR storage tube, thereby improving the heating effect.

[0023] Furthermore, by setting up heat-conducting rods to facilitate heat conduction, the heating effect can be further improved. Attached Figure Description

[0024] Figure 1 This is a three-dimensional schematic diagram of the nuclear magnetic resonance spectrometer in this embodiment of the present invention;

[0025] Figure 2 This is a perspective view of the nuclear magnetic resonance spectrometer's nuclear magnetic tube sampler in an embodiment of this utility model;

[0026] Figure 3 This is a top view of the nuclear magnetic resonance spectrometer's nuclear magnetic tube sampler in an embodiment of this utility model;

[0027] Figure 4 This is a schematic diagram of the heating device for the nuclear magnetic resonance spectrometer's nuclear magnetic resonance tube sampler in an embodiment of this utility model.

[0028] Figure 5 This is a schematic diagram of the structure of the nuclear magnetic resonance spectrometer's nuclear magnetic resonance tube sampler with a separate vertical cavity in an embodiment of this utility model;

[0029] Figure 6 This is a perspective view of the overall internal structure of the nuclear magnetic resonance spectrometer's nuclear magnetic tube sampler and heater in this embodiment of the present invention;

[0030] Figure 7 yes Figure 6 An explosion diagram.

[0031] The image shows:

[0032] 100-Nuclear magnetic resonance spectrometer, 200-Sample introduction device, 210-Main body, 211-Drive device mounting cavity, 220-First turntable, 230-Second turntable, 240-Baffle plate, 250-Drive device, 251-Rotating shaft, 260-Annular heating element, 270-Top cap, 280-Nuclear magnetic tube storage cylinder, 290-Heat insulation cylinder. Detailed Implementation

[0033] The present invention will be further described below with reference to the accompanying drawings and embodiments.

[0034] like Figures 1 to 4 As shown, the nuclear magnetic resonance spectrometer sampler heating device of the present invention includes a heating device disposed in the sampler 200 on the nuclear magnetic resonance spectrometer 100.

[0035] The sample introduction device 200 includes a body 210; the body 210 has a turntable mounting cavity; a drive device mounting cavity 211 is provided below the turntable mounting cavity; the turntable mounting cavity and the drive device mounting cavity 211 are separated by a partition 240.

[0036] The turntable mounting cavity is provided with a first turntable 220 and a second turntable 230 arranged sequentially from top to bottom; there is a gap between the first turntable 220 and the second turntable 230; the first turntable 220 is provided with mounting holes evenly distributed along the circumference; the second turntable 230 is provided with through holes corresponding one-to-one with the mounting holes of the first turntable 220; a driving device 250 for driving the first turntable 220 and the second turntable 230 to rotate is provided below the partition plate 240;

[0037] A nuclear magnetic resonance tube storage cylinder 280 is provided in the mounting hole on the first turntable 220; both ends of the nuclear magnetic resonance tube storage cylinder 280 have openings, and the lower end of the nuclear magnetic resonance tube storage cylinder 280 passes through the through hole of the second turntable 230.

[0038] The heating device includes an annular heating element 260 disposed on the partition plate 240; a vent hole 232 is disposed on the second turntable 230; a heat-conducting rod 231 is disposed on the second turntable 230 and evenly distributed along the circumference; the lower end of the heat-conducting rod 231 passes through the second turntable 230 and extends above the partition plate 240.

[0039] Specifically, the driving device 250 employs a drive motor, which has a rotating shaft 251 that passes sequentially through the second turntable 230 and the first turntable 220. A first heat-insulating limiting bushing 252 is provided on the rotating shaft 251 between the first turntable 220 and the second turntable 230; a first heat-insulating limiting bushing 253 is provided on the rotating shaft between the second turntable 230 and the partition plate 240. A top cap 270 is provided at one end of the rotating shaft 251 that passes through the first turntable 220; the top cap 270 is threadedly engaged with the rotating shaft 251.

[0040] A temperature sensor is installed on the side wall of the turntable mounting cavity to detect the temperature inside the turntable mounting cavity.

[0041] Specifically, the annular heating element 260 includes an annular heating resistor 261 and a heat sink 262 disposed on the annular heating resistor 261. A temperature sensor is disposed inside the turntable mounting cavity, and a display is disposed on the body (210) to display the temperature detected by the temperature sensor. That is, the temperature sensing device can be a thermometer with a temperature sensor.

[0042] In practical applications, a limiting sleeve is fitted onto the upper end of the NMR tube, which is then placed into the NMR tube storage cylinder 280. The limiting sleeve positions the NMR tube within the storage cylinder 280. Then, the annular heating element 260 on the partition 240 is activated to heat the turntable mounting cavity; simultaneously, a temperature sensor within the turntable mounting cavity detects the temperature. When the temperature reaches the set temperature, the annular heating element 260 is turned off; when the temperature falls below the set temperature, the annular heating element 260 is turned on to continue heating, thus ensuring a constant temperature within the turntable mounting cavity. Furthermore, an automatic controller can be set to achieve automatic temperature regulation. A temperature range can also be set; when the temperature reaches the maximum set temperature, the annular heating element 260 is automatically deactivated; when the temperature falls below the minimum set temperature, the annular heating element 260 is automatically turned on to continue heating, thus ensuring that the temperature within the turntable mounting cavity remains within a certain range.

[0043] By controlling the temperature inside the rotating disk mounting cavity, solidification of the liquid sample inside the NMR tube is avoided, thus ensuring smooth testing, reducing the equipment's environmental requirements, and improving its applicability.

[0044] In one feasible embodiment, in order to improve the heating effect, a vertical cavity 212 is further provided on one side of the turntable mounting cavity; the bottom of the vertical cavity 212 is separated from the drive device mounting cavity 211 by a second partition 213.

[0045] The turntable mounting cavity is provided with a first vent hole and a second vent hole 214 that communicate with the vertical cavity 212 on one side;

[0046] The first vent and the second vent 214 are located above and below the second turntable 230, respectively; a small exhaust fan 215 is provided inside the first vent.

[0047] In one feasible embodiment, to further ensure safety, an annular groove 241 is provided on the partition 240 at the bottom of the inner cavity of the body 210; annular heating elements 260 are provided on both the outer and inner sides of the annular groove 241; one end of the heat-conducting rod 231 extends into the annular groove 241. Specifically, the heat-conducting rod 231 is made of copper.

[0048] In one feasible embodiment, to ensure heat preservation, a heat insulation cylinder 290 is provided between the first turntable 220 and the second turntable 230. A heat insulation layer is provided on the inner wall of the body 210.

Claims

1. A heating device for the nuclear magnetic resonance (NMR) tube sampler of a nuclear magnetic resonance (NMR) spectrometer, characterized in that: Including a heating device installed in the sample introduction device (200) on the nuclear magnetic resonance spectrometer (100); The sample introduction device (200) includes a body (210); the body (210) has a turntable mounting cavity; a drive device mounting cavity (211) is provided below the turntable mounting cavity; the turntable mounting cavity and the drive device mounting cavity (211) are separated by a partition (240); The turntable mounting cavity is provided with a first turntable (220) and a second turntable (230) arranged sequentially from top to bottom; there is a gap between the first turntable (220) and the second turntable (230); the first turntable (220) is provided with mounting holes evenly distributed along the circumference; the second turntable (230) is provided with through holes corresponding one-to-one with the mounting holes of the first turntable (220); a driving device (250) for driving the first turntable (220) and the second turntable (230) to rotate is provided below the partition plate (240). A nuclear magnetic resonance tube storage cylinder (280) is provided in the mounting hole on the first turntable (220); both ends of the nuclear magnetic resonance tube storage cylinder (280) have openings, and the lower end of the nuclear magnetic resonance tube storage cylinder (280) passes through the through hole of the second turntable (230); The heating device includes an annular heating element (260) disposed on the partition plate (240); the second turntable (230) is provided with a vent hole (232); the second turntable (230) is provided with a heat-conducting rod (231) evenly distributed along the circumference; the lower end of the heat-conducting rod (231) passes through the second turntable (230) and extends above the partition plate (240).

2. The nuclear magnetic resonance (NMR) tube sampler heating device for a nuclear magnetic resonance spectrometer as described in claim 1, characterized in that: The annular heating element (260) includes an annular heating resistor (261) and a heat sink (262) disposed on the annular heating resistor (261). A temperature sensor is installed inside the turntable mounting cavity, and a display is installed on the body (210) to display the temperature detected by the temperature sensor.

3. The nuclear magnetic resonance (NMR) tube sampler heating device for a nuclear magnetic resonance spectrometer as described in claim 2, characterized in that: A vertical cavity (212) is provided on one side of the turntable mounting cavity; the bottom of the vertical cavity (212) is separated from the drive device mounting cavity (211) by a second partition (213); The turntable mounting cavity is provided with a first vent hole and a second vent hole (214) that communicate with the vertical cavity (212). The first vent and the second vent (214) are located above and below the second turntable (230), respectively; a small exhaust fan (215) is provided in the first vent.

4. The nuclear magnetic resonance (NMR) tube sampler heating device for a nuclear magnetic resonance spectrometer as described in claim 2, characterized in that: An annular groove (241) is provided on the partition plate (240) at the bottom of the inner cavity of the body (210); annular heating elements (260) are provided on both the outer and inner sides of the annular groove (241); one end of the heat-conducting rod (231) extends into the annular groove (241).

5. The nuclear magnetic resonance (NMR) tube sampler heating device for a nuclear magnetic resonance spectrometer as described in claim 1, characterized in that: The heat-conducting rod (231) is made of copper.

6. The nuclear magnetic resonance (NMR) tube sampler heating device for a nuclear magnetic resonance spectrometer as described in claim 1, characterized in that: A heat insulation cylinder (290) is provided between the first turntable (220) and the second turntable (230).

7. The nuclear magnetic resonance (NMR) tube sampler heating device for a nuclear magnetic resonance spectrometer as described in claim 1, characterized in that: A heat insulation layer is provided on the inner wall of the body (210).

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