High performance liquid chromatograph convenient to operate

Abstract

The utility model discloses a high performance liquid chromatograph convenient to operate, which comprises a chromatograph main body, a chromatographic column and a column temperature box, the column temperature box comprises a box body, a sliding chute, a fixing clamp, a sample injection joint and a sample discharge joint, the sliding chute is arranged on the inner side of the box body, and the fixing clamp is arranged on the sliding chute. The fixing clamp, the sample introduction joint and the sample discharge joint are slidably connected with the box body through the sliding grooves, the sample introduction joint is communicated with the chromatographic instrument main body through a sample introduction pipeline, and the sample discharge joint is communicated with the chromatographic instrument main body through a sample discharge pipeline. The sample inlet connector and the sample outlet connector are respectively provided with a plug connecting seat, the sample inlet connector and the sample outlet connector are respectively provided with a rotating motor, the rotating motors are used for driving the plug connecting seats to rotate, and the fixing clamps are used for preventing the chromatographic column from rotating relative to the plug connecting seats. According to the device, the rotary motor is arranged to be matched with the plug connecting seat, so that the chromatographic column can be more conveniently and reliably mounted.

Description

Technical Field

[0001] This utility model relates to the field of chromatography technology, and in particular to an easy-to-operate high-performance liquid chromatograph. Background Technology

[0002] High-performance liquid chromatography (HPLC) is a precision analytical instrument widely used in chemistry, biomedicine, and environmental monitoring. It uses a high-pressure pump to drive the mobile phase, carrying the sample through a chromatographic column, and utilizes the differences in the distribution of different components between the stationary and mobile phases to achieve efficient separation and detection. Traditional equipment typically consists of modular components such as injection valves, columns, and detectors, relying on manual operation for tubing connections and sealing plug installation. For example, manually tightening stainless steel connectors ensures leak-free operation. While this design can meet diverse separation needs in conventional laboratories, it suffers from inconvenience and instability. Because operators cannot consistently apply the same tightening force, loose plugs can lead to mobile phase leakage under high pressure, contaminating the experimental environment, interfering with detection signals, and potentially corroding instrument components. Over-tightening, on the other hand, can deform gaskets or wear threads, shortening connector lifespan and increasing maintenance costs over time. Furthermore, frequent manual loading and unloading can introduce human error, affecting column packing uniformity or injection accuracy, thus reducing analytical repeatability. Therefore, the field of chromatography needs to develop an HPLC system that improves the ease and reliability of column installation. Utility Model Content

[0003] In view of the above-mentioned prior art, the present invention provides an easy-to-operate high-performance liquid chromatograph, and the main technical problem to be solved is how to improve the convenience and reliability of chromatographic column installation.

[0004] To achieve the above objectives, the technical solution of this utility model embodiment is implemented as follows:

[0005] An easy-to-operate high-performance liquid chromatograph includes a chromatograph body, a chromatographic column, and a column oven. The column oven includes a chamber, a slide, a clamp, an injection connector, and an outlet connector. The slide is disposed inside the chamber. The clamp, the injection connector, and the outlet connector are all slidably connected to the chamber body via the slide. The injection connector is connected to the chromatograph body via an injection pipe, and the outlet connector is connected to the chromatograph body via an outlet pipe. Both the injection connector and the outlet connector are provided with plug connectors. Both the injection connector and the outlet connector are provided with rotary motors. The rotary motors are used to drive the plug connectors to rotate, and the clamp is used to prevent the chromatographic column from rotating relative to the plug connectors.

[0006] Preferably, the column oven is provided with a plurality of the aforementioned grooves, and the fixing clamp, the sample inlet connector, and the sample outlet connector can be connected to any of the aforementioned grooves.

[0007] Preferably, the inner side of the chute is provided with a cross-shaped groove, and the connection points of the fixing clamp, the sample inlet connector, and the sample outlet connector with the chute are all provided with cross-shaped sliders that cooperate with the cross-shaped groove.

[0008] Preferably, the fixing clamp includes a first clamping block, a second clamping block, and an adjusting nut.

[0009] Preferably, the first clamping block is provided with a first rack on the side near the adjusting nut, and the second clamping block is provided with a second rack on the side near the adjusting nut. The adjusting nut is configured as a bidirectional nut with the same pitch at the upper and lower ends but opposite thread directions. Both the first rack and the second rack mesh with the adjusting nut.

[0010] Preferably, a rotary knob is provided on one side of the adjusting nut, and the surface of the rotary knob is provided with anti-slip texture.

[0011] Preferably, both the first clamping block and the second clamping block are provided with a V-shaped groove in the middle, and the angle of the V-shaped groove is 60 degrees.

[0012] Preferably, the plug connector includes a housing, a rubber layer, a plug mounting base, and a plug body, wherein the plug mounting base is internally connected to the housing through the rubber layer.

[0013] Preferably, a bearing structure is provided on the inner side of the plug mounting base, and the output end of the rotary motor can drive the inner side of the bearing structure to rotate.

[0014] The beneficial effects of this utility model are as follows: This application provides a column oven for mounting the chromatographic column. The device includes a sliding groove, a fixing clamp, an injection connector, and an outlet connector. All three connectors are slidably connected to the oven body via the sliding groove, allowing the operator to adjust their positions on the groove according to the column length and secure the column using the fixing clamp. Both the injection and outlet connectors are equipped with a rotating motor. Plugs are mounted on plug connector seats, and the rotating motors rotate through these seats, causing the plug connector seats to be threaded onto both sides of the chromatographic column.

[0015] In summary, this application, by incorporating a rotating motor in conjunction with a plug connector, enables more convenient and reliable column installation. Attached Figure Description

[0016] Figure 1 This is a schematic diagram of the structure of an easy-to-operate high-performance liquid chromatograph according to Embodiment 1 of this application;

[0017] Figure 2 This is a cross-sectional view of the cross-shaped slider in Embodiment 1 of this application;

[0018] Figure 3 This is a cross-sectional view of the fixing clip in Embodiment 2 of this application;

[0019] Figure 4 This is a cross-sectional view of the sample inlet connector in Embodiment 2 of this application;

[0020] Explanation of icon numbers:

[0021] 1. Chromatograph body; 2. Column oven;

[0022] 201. Housing; 202. Slide groove; 203. Fixing clamp; 204. Sample inlet connector; 205. Sample outlet connector; 206. Sample inlet pipe; 207. Sample outlet pipe; 208. Plug connector; 209. Rotating motor; 210. Cross-shaped groove; 212. Cross-shaped slider; 213. First clamping block; 214. Second clamping block; 215. Adjusting nut; 216. First rack; 217. Second rack; 218. Rotating knob; 219. V-shaped groove; 220. Outer shell; 221. Rubber layer; 222. Plug mounting base; 223. Plug body; 224. Adjusting track; 225. Bearing structure; 226. Transmission gear; 227. Gear ring structure. Detailed Implementation

[0023] The technical solution of this utility model will be further described in detail below with reference to the accompanying drawings and specific embodiments. Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this utility model belongs. The terminology used in this specification of this utility model is for the purpose of describing particular embodiments only and is not intended to limit the utility model. In the following description, the expression "some embodiments" refers to a subset of all possible embodiments; however, it should be understood that "some embodiments" can be the same subset or different subsets of all possible embodiments and can be combined with each other without conflict.

[0024] It should also be noted that when an element is referred to as being "fixed to" another element, it can be directly attached to the other element or there may be an intervening element. When an element is referred to as being "connected to" another element, it can be directly connected to the other element or there may be an intervening element. The terms "vertical," "horizontal," "inner," "outer," "left," "right," and similar expressions used herein are for illustrative purposes only and do not represent the only possible implementation.

[0025] Example 1

[0026] See attached document Figure 1-2 This application provides an easy-to-operate high-performance liquid chromatograph, including a chromatograph body 1, a chromatographic column, and a column oven 2. The column oven includes a chamber 201, a slide groove 202, a fixing clamp 203, an injection connector 204, and an outlet connector 205. The slide groove 202 is disposed inside the chamber 201. The fixing clamp 203, the injection connector 204, and the outlet connector 205 are all slidably connected to the chamber 201 via the slide groove 202. The injection connector 204 is used for injection. Pipeline 206 is connected to the chromatograph body 1. The sample outlet connector 205 is connected to the chromatograph body 1 through the sample outlet pipe 207. Both the sample inlet connector 204 and the sample outlet connector 205 are provided with plug connectors 208. Both the sample inlet connector 204 and the sample outlet connector 205 are provided with rotary motors 209. The rotary motors 209 are used to drive the plug connectors 208 to rotate. The fixing clamp 203 is used to prevent the chromatographic column from rotating relative to the plug connectors 208. This device includes a column oven 2 for mounting the chromatographic column. It also features a slide groove 202, a fixing clamp 203, an injection connector 204, and an outlet connector 205. The fixing clamp 203, injection connector 204, and outlet connector 205 are all slidably connected to the oven body 201 via the slide groove 202. This allows the operator to adjust the positions of the fixing clamp 203, injection connector 204, and outlet connector 205 on the slide groove 202 according to the length of the chromatographic column, and to use the fixing clamp 203 to hold and fix the chromatographic column. Both the injection connector 204 and outlet connector 205 are equipped with a rotary motor 209. Plugs are mounted on plug connector seats 208, and the rotary motors 209 rotate through the plug connector seats 208, thereby threading the plug connector seats 208 onto both sides of the chromatographic column. In summary, this device, with its rotary motor 209 and plug connector seats 208, enables more convenient and reliable chromatographic column installation.

[0027] Specifically, the column oven 2 is provided with a number of the slide grooves 202. The fixing clamp 203, the injection connector 204 and the outlet connector 205 can be connected to any of the slide grooves 202, so that multiple chromatographic columns can be installed in the column oven 2 at the same time, thereby improving space utilization.

[0028] Specifically, the inner side of the slide groove 202 is provided with a cross-shaped groove 210, and the connection points of the fixing clamp 203, the sample inlet connector 204, and the sample outlet connector 205 with the slide groove 202 are all provided with cross-shaped sliders 212 that cooperate with the cross-shaped groove 210. By setting the cross-shaped groove 210 and the cross-shaped sliders 212, this device makes the connection between the fixing clamp 203, the sample inlet connector 204, and the sample outlet connector 205 and the slide groove 202 more stable, reducing shaking and displacement.

[0029] Example 2

[0030] See attached document Figure 3-4 The difference between this embodiment and the previous embodiment is that the fixing clamp 203 includes a first clamping block 213, a second clamping block 214, and an adjusting nut 215. By setting the adjusting nut 215, this device can adjust the distance between the first clamping block 213 and the second clamping block 214 to ensure the clamping effect on the chromatographic column.

[0031] Specifically, the first clamping block 213 is provided with a first rack 216 on the side near the adjusting nut 215, and the second clamping block 214 is provided with a second rack 217 on the side near the adjusting nut 215. The adjusting nut 215 is a bidirectional nut with the same pitch at the upper and lower ends but opposite thread directions. Both the first rack 216 and the second rack 217 mesh with the adjusting nut 215. The first clamping block 213 and the second clamping block 214 can slide on the adjusting track 224 through the adjusting nut 215. This device sets the upper and lower ends of the adjusting nut 215 to have the same pitch and opposite thread directions, so that when the adjusting nut 215 is turned, the first rack 216 and the second rack 217 can synchronously drive the first clamping block 213 and the second clamping block 214 to move the same distance in opposite directions, ensuring that the axis of the chromatographic column of different thicknesses is always kept at the same height, which facilitates the connection of the plug connector 208 to the chromatographic column.

[0032] Specifically, a rotating knob 218 is provided on one side of the adjusting nut 215, and the surface of the rotating knob 218 is provided with anti-slip texture. The rotating knob 218, in conjunction with the anti-slip texture, allows the operator to more conveniently adjust the distance between the first clamping block 213 and the second clamping block 214 manually.

[0033] Specifically, both the first clamping block 213 and the second clamping block 214 have a V-shaped groove 219 in the middle, and the angle of the V-shaped groove 219 is 60 degrees. Common chromatographic columns have hexagonal bolts near the end cap for easy tightening by operators using wrenches or other tools. This device, by setting the V-shaped groove 219 to a 60-degree angle, can more tightly fit the hexagonal bolts on the chromatographic column, making the clamping more reliable.

[0034] Specifically, the plug connector 208 includes a housing 220, a rubber layer 221, a plug mounting base 222, and a plug body 223. The plug mounting base 222 is internally connected to the housing 220 via the rubber layer 221. By incorporating the rubber layer 221, this device allows for slight misalignment of the plug body 223 when it is connected to the chromatographic column via threads, provided the axis is not perfectly aligned. Furthermore, the lateral displacement generated during the connection of the plug body 223 to the chromatographic column causes the cross-shaped slider 212 to move slightly on the cross groove 202. Combined with the buffering and displacement at the rubber layer 221, this ensures a reliable connection between the plug body 223 and the chromatographic column.

[0035] Specifically, a bearing structure 225 is provided inside the plug mounting base 222, and the output end of the rotating motor 209 can drive the inner side of the bearing structure 225 to rotate. (See attached diagram) Figure 4 In this embodiment, the drive motor is fixedly connected to the outside of the bearing structure 225, the output end of the rotating motor 209 is connected to the drive gear 226, and the inner extension of the bearing structure 225 is provided with a gear ring structure 227. The gear ring structure 227 meshes with the drive gear 226, so that the rotating motor 209 can drive the inner side of the bearing structure 225 to rotate. The operator can set the rotating motor 209 to different power to ensure that the tightening degree is appropriate and to avoid leakage or damage.

[0036] The above are merely specific embodiments of this utility model, but the protection scope of this utility model is not limited thereto. Any variations or substitutions that can be easily conceived by those skilled in the art within the technical scope disclosed in this utility model should be included within the protection scope of this utility model. The protection scope of this utility model should be determined by the protection scope of the stated claims.

Claims

1. A user-friendly high-performance liquid chromatograph, comprising a chromatograph body (1), a chromatographic column, and a column oven (2), characterized in that, The column temperature chamber includes a chamber body (201), a slide groove (202), a fixing clamp (203), an injection connector (204), and an outlet connector (205). The slide groove (202) is located inside the chamber body (201). The fixing clamp (203), the injection connector (204), and the outlet connector (205) are all slidably connected to the chamber body (201) through the slide groove (202). The injection connector (204) is connected to the chromatograph body (1) through an injection pipe (206). The sample outlet connector (205) is connected to the chromatograph body (1) through the sample outlet pipe (207). Both the sample inlet connector (204) and the sample outlet connector (205) are provided with plug connectors (208). Both the sample inlet connector (204) and the sample outlet connector (205) are provided with rotary motors (209). The rotary motors (209) are used to drive the plug connectors (208) to rotate. The fixing clamp (203) is used to prevent the chromatographic column from rotating relative to the plug connectors (208).

2. The easy-to-operate high-performance liquid chromatograph according to claim 1, characterized in that, The column oven (2) is provided with a plurality of the slides (202), and the fixing clamp (203), the sample inlet connector (204) and the sample outlet connector (205) can be connected to any of the slides (202).

3. The easy-to-operate high-performance liquid chromatograph according to claim 1, characterized in that, The inner side of the slide groove (202) is provided with a cross-shaped groove (210), and the connection between the fixing clamp (203), the sample inlet connector (204) and the sample outlet connector (205) and the slide groove (202) is provided with a cross-shaped slider (212) that cooperates with the cross-shaped groove (210).

4. The easy-to-operate high-performance liquid chromatograph according to claim 1, characterized in that, The fixing clamp (203) includes a first clamping block (213), a second clamping block (214), and an adjusting nut (215).

5. The easy-to-operate high-performance liquid chromatograph according to claim 4, characterized in that, The first clamping block (213) is provided with a first rack (216) on the side near the adjusting nut (215), and the second clamping block (214) is provided with a second rack (217) on the side near the adjusting nut (215). The adjusting nut (215) is configured as a bidirectional nut with the same pitch at the upper and lower ends but opposite thread directions. Both the first rack (216) and the second rack (217) mesh with the adjusting nut (215).

6. The easy-to-operate high-performance liquid chromatograph according to claim 5, characterized in that, A rotating knob (218) is provided on one side of the adjusting nut (215), and the surface of the rotating knob (218) is provided with anti-slip texture.

7. The easy-to-operate high-performance liquid chromatograph according to claim 6, characterized in that, Both the first clamping block (213) and the second clamping block (214) are provided with V-shaped grooves (219) in the middle, and the angle of the V-shaped grooves (219) is 60 degrees.

8. The easy-to-operate high-performance liquid chromatograph according to claim 1, characterized in that, The plug connector (208) includes a housing (220), a rubber layer (221), a plug mounting base (222), and a plug body (223). The plug mounting base (222) is internally connected to the housing (220) through the rubber layer (221).

9. The easy-to-operate high-performance liquid chromatograph according to claim 8, characterized in that, The inner side of the plug mounting base (222) is provided with a bearing structure (225), and the output end of the rotating motor (209) can drive the inner side of the bearing structure to rotate.

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