A polypeptide pharmaceutical intermediate purification device

Abstract

The utility model relates to polypeptide purification's technical field especially, it is a kind of polypeptide pharmaceutical intermediate purification device, it provides support and purification space for equipment main body by support structure, the inside of support structure is driven by sealing device fast in and out by driving device, to facilitate the replacement of equipment internal component quickly, reduce the time occupied by equipment cleaning, increase equipment purification sealing property by sealing structure, increase support structure main body sealing property by connecting structure, improve the practicability of device, including support structure, driving device, connecting structure and sealing structure, driving device is installed on support structure, connecting structure is installed on driving device, sealing structure is installed on connecting structure.

Description

Technical Field

[0001] This utility model relates to the technical field of polypeptide purification, and in particular to a device for purifying polypeptide pharmaceutical intermediates. Background Technology

[0002] Peptides are compounds composed of three or more amino acid molecules linked by peptide bonds. They are functional nutrients that are most active, easily absorbed, and capable of stimulating the human regenerative system, falling between large protein molecules and small amino acid molecules. In the pharmaceutical field, peptide drugs are widely used to treat various diseases due to their small molecular weight, high activity, and easy absorption. During peptide preparation, some unnecessary impurities are generated, such as intermediates, byproducts, and solvent residues. These impurities may affect the efficacy of the target peptide. Therefore, the main purpose of purification is to remove these impurities and control their content within a reasonable and safe range.

[0003] The existing Chinese utility model patent with application number CN202022053591.2 relates to a polypeptide purification and preparation device, including a shell, a top cover, a bottom cover, a liquid guide tube, a solution inlet, a control valve, a clamping assembly, and a fixing assembly, etc. It has the characteristics of good sealing and high chemical stability, avoiding gaps between the bottom surface of the outer frame and the upper surface of the limiting plate.

[0004] However, the above-mentioned device is difficult to clean the screen plate in actual use, and the equipment cannot operate normally during the cleaning process, which affects the production efficiency of the equipment. Utility Model Content

[0005] To address the aforementioned technical problems, this utility model provides a peptide pharmaceutical intermediate purification device that uses a support structure to provide support and purification space for the main body of the device, and a driving device to quickly move the sealing device into and out of the support structure, thereby facilitating rapid replacement of internal components and reducing the time spent on cleaning the device. The sealing structure increases the purification sealing performance of the device, and the connecting structure increases the sealing performance of the main body of the support structure, thus improving the practicality of the device.

[0006] This invention relates to a purification device for polypeptide pharmaceutical intermediates, comprising a support structure, a driving device, a connecting structure, and a sealing structure. The driving device is mounted on the support structure, the connecting structure is mounted on the driving device, and the sealing structure is mounted on the connecting structure. The support structure provides support and purification space for the main body of the device. The driving device drives the sealing device to quickly enter and exit the interior of the support structure, thereby facilitating rapid replacement of internal components and reducing the time spent on cleaning the device. The sealing structure increases the sealing performance of the purification process, and the connecting structure increases the sealing performance of the main body of the support structure, thus improving the practicality of the device.

[0007] Preferably, the support structure includes a first support, an upper reaction chamber, a middle connecting chamber, and a lower discharge chamber. The upper reaction chamber is located at the top of the first support, the middle connecting chamber is located at the middle of the first support, and the lower discharge chamber is located at the bottom of the first support. The upper reaction chamber, the middle connecting chamber, and the lower discharge chamber are on the same vertical line, with gaps between each pair. The gaps between the upper reaction chamber, the middle connecting chamber, and the lower discharge chamber facilitate the entry of the driving device to drive the sealing device to complete the drug purification process. This also facilitates the quick removal of internal components for replacement and cleaning, improving the practicality of the device.

[0008] Preferably, the drive device includes a second bracket, a reducer, a motor, a main shaft, sleeves, and connecting pipes. The main shaft is mounted on the side of the upper reaction chamber and the lower discharge chamber via the second bracket. A reducer is mounted on the upper surface of the second bracket, and the output end of the reducer is connected to the main shaft. A motor is mounted on the reducer. A set of sleeves is fitted onto the upper and lower parts of the main shaft, and connecting pipes are connected to the sides of the sleeves. The two sets of connecting pipes can enter the gap between the upper reaction chamber, the middle connecting chamber, and the lower discharge chamber as the main shaft rotates. When the motor is turned on, the power is transmitted to the main shaft through the reducer, causing the main shaft to rotate. The rotating main shaft drives the two sets of sleeves to rotate, thereby driving the two sets of connecting pipes to enter and exit the support structure, which facilitates the quick replacement and cleaning of the internal components of the equipment and improves the practicality of the device.

[0009] Preferably, it also includes one-way bearings, with two sets of sleeves respectively mounted on the main shaft through a set of one-way bearings, and the two sets of one-way bearings rotating in opposite directions; by controlling the rotation direction of the main shaft, the upper or lower single connecting pipe can be controlled to enter or exit the support structure, thereby improving the practicality of the device.

[0010] Preferably, the connecting structure includes an annular airbag and a guide ring. Sealing grooves are provided on the upper and lower end edges of the connecting pipe. Sealing grooves are also provided on the lower end face of the upper reaction chamber, the upper and lower end faces of the middle connecting chamber, and the upper end face of the lower discharge chamber, corresponding to the position of the connecting pipe. An annular airbag is installed in each of these sealing grooves. A set of guide rings is provided on the bottom inner side of the connecting pipe, the bottom inner side of the upper reaction chamber, and the bottom inner side of the middle connecting chamber. By using multiple sets of guide rings, the amount of liquid entering the gap between the connecting pipe and the supporting structure during the process of the liquid entering the lower discharge chamber from the upper reaction chamber is reduced. When the connecting pipe is inside the supporting structure, high-pressure gas is introduced into the annular airbag, causing the annular airbag to expand into the sealing groove on its corresponding connecting pipe, sealing the gap between the connecting pipe and the supporting structure, thus improving the practicality of the device.

[0011] Preferably, the sealing structure includes an annular mounting plate, a purification rack, a sealing ring, a filter screen, and connecting bolts. An annular mounting plate is located on the upper inner side of the connecting pipe. The purification rack is connected to the lower end face of the annular mounting plate via multiple sets of connecting bolts. A filter screen is installed in the middle of the purification rack. A sealing groove is provided between the purification rack and the annular mounting plate, and a sealing ring is placed in the sealing groove. The drug solution is purified through the filter screen, and the purification rack can be quickly disassembled and replaced when the filter screen needs cleaning, reducing the impact of equipment cleaning time on equipment production. The sealing ring increases the sealing between the annular mounting plate and the purification rack, improving the practicality of the device.

[0012] Compared with the prior art, the beneficial effects of this utility model are as follows: the support structure provides support and purification space for the main body of the equipment, the driving device drives the sealing device to quickly enter and exit the interior of the support structure, thereby facilitating the rapid replacement of internal components of the equipment and reducing the time occupied by equipment cleaning; the sealing structure increases the purification sealing performance of the equipment; and the connecting structure increases the sealing performance of the main body of the support structure, thereby improving the practicality of the device. Attached Figure Description

[0013] Figure 1 This is a schematic diagram of the isometric structure of this utility model;

[0014] Figure 2 This is a cross-sectional structural diagram of the present invention;

[0015] Figure 3 This is an isometric structural diagram of the sealing device of this utility model;

[0016] Figure 4 This is a partially enlarged structural schematic diagram of the present invention;

[0017] Figure 5 This is an isometric structural diagram of the sleeve and connecting pipe of this utility model;

[0018] The following are labels in the attached diagram: 1. First support; 2. Upper reaction chamber; 3. Middle connecting chamber; 4. Lower discharge chamber; 5. Second support; 6. Reducer; 7. Motor; 8. Main shaft; 9. Sleeve; 10. Connecting pipe; 11. One-way bearing; 12. Annular airbag; 13. Guide ring; 14. Annular mounting plate; 15. Purification rack; 16. Sealing ring; 17. Filter screen; 18. Connecting bolt. Detailed Implementation

[0019] To facilitate understanding of this utility model, a more complete description will be given below with reference to the accompanying drawings. This utility model can be implemented in many different forms and is not limited to the embodiments described herein. Rather, these embodiments are provided to make the disclosure of this utility model more thorough and complete.

[0020] Example 1

[0021] Figure 1 , Figure 2 , Figure 3 , Figure 4 , Figure 5 As shown, the drive unit is mounted on the support structure, the connecting structure is mounted on the drive unit, and the sealing structure is mounted on the connecting structure.

[0022] First, the drug solution is added from the top of the upper reaction chamber 2 and purified through the filter screen 17 on the two sets of connecting pipes 10. When the filter screen 17 needs to be cleaned, the gas in the annular air bag 12 is extracted. Then, the motor 7 is turned on to transmit power to the main rotating shaft 8 through the reducer 6. By controlling the rotation direction of the main rotating shaft 8, the upper or lower connecting pipe 10 is controlled to rotate out of the support structure. Then, the purification rack 15 can be removed and replaced.

[0023] The supporting structure includes a first support 1, an upper reaction chamber 2, a middle connecting chamber 3, and a lower discharge chamber 4. The upper reaction chamber 2 is located at the top of the first support 1, the middle connecting chamber 3 is located at the middle of the first support 1, and the lower discharge chamber 4 is located at the bottom of the first support 1. The upper reaction chamber 2, the middle connecting chamber 3, and the lower discharge chamber 4 are on the same vertical line, and there is a gap between each pair.

[0024] The drive unit includes a second bracket 5, a reducer 6, a motor 7, a main shaft 8, a sleeve 9, and a connecting pipe 10. The main shaft 8 is mounted on the side of the upper reaction chamber 2 and the lower discharge chamber 4 via the second bracket 5. The reducer 6 is mounted on the upper end of the second bracket 5. The output end of the reducer 6 is connected to the main shaft 8. The motor 7 is mounted on the reducer 6. A set of sleeves 9 is fitted on the upper and lower parts of the main shaft 8 respectively. The connecting pipe 10 is connected to the side of the sleeve 9. The two sets of connecting pipes 10 can enter the gap between the upper reaction chamber 2, the middle connecting chamber 3, and the lower discharge chamber 4 as the main shaft 8 rotates.

[0025] It also includes a one-way bearing 11, with two sets of sleeves 9 respectively mounted on the main rotating shaft 8 through a set of one-way bearings 11, and the two sets of one-way bearings 11 have opposite rotational directions;

[0026] The connection structure includes an annular airbag 12 and a guide ring 13. The upper and lower end faces of the connecting pipe 10 are provided with sealing grooves. The lower end face of the upper reaction chamber 2, the upper and lower end faces of the middle connecting chamber 3, and the upper end face of the lower discharge chamber 4 are provided with sealing grooves corresponding to the position of the connecting pipe 10, and the annular airbag 12 is installed in the sealing groove. A set of guide rings 13 are respectively provided at the bottom of the inner side of the connecting pipe 10, the bottom of the inner side of the upper reaction chamber 2, and the bottom of the inner side of the middle connecting chamber 3.

[0027] The sealing structure includes an annular mounting plate 14, a purification rack 15, a sealing ring 16, a filter screen 17, and connecting bolts 18. An annular mounting plate 14 is provided on the upper part of the inner side of the connecting pipe 10. The purification rack 15 is connected to the lower end face of the annular mounting plate 14 by multiple sets of connecting bolts 18. A filter screen 17 is installed in the middle of the purification rack 15. A sealing groove is provided between the purification rack 15 and the annular mounting plate 14, and a sealing ring 16 is placed in the sealing groove.

[0028] The support structure provides support and purification space for the main body of the equipment. The drive device moves the sealing device quickly into and out of the support structure, which facilitates the rapid replacement of internal components and reduces the time spent on equipment cleaning. The sealing structure increases the purification sealing performance of the equipment, and the connection structure increases the sealing performance of the main body of the support structure, thus improving the practicality of the device.

[0029] like Figures 1 to 5 As shown, this utility model discloses a polypeptide pharmaceutical intermediate purification device. During operation, the drug solution is first added from the upper part of the upper reaction chamber 2 and purified through the filter screen 17 on the two sets of connecting pipes 10. When the filter screen 17 needs to be cleaned, the gas in the annular air bag 12 is extracted. Then, the motor 7 is turned on to transmit power to the main rotating shaft 8 through the reducer 6. By controlling the rotation direction of the main rotating shaft 8, the upper or lower connecting pipe 10 is controlled to rotate out of the support structure. Then, the purification rack 15 can be removed and replaced.

[0030] The motor 7, reducer 6, annular airbag 12, and one-way bearing 11 of the polypeptide pharmaceutical intermediate purification device of this utility model are commercially available. Technical personnel in this industry only need to install and operate them according to the accompanying instruction manual, without requiring any creative work from those skilled in the art.

[0031] The above description is only a preferred embodiment of the present utility model. It should be noted that for those skilled in the art, several improvements and modifications can be made without departing from the technical principles of the present utility model, and these improvements and modifications should also be considered within the protection scope of the present utility model.

Claims

1. A purification device for polypeptide pharmaceutical intermediates; characterized in that, The device includes a support structure, a drive unit, a connection structure, and a sealing structure. The drive unit is mounted on the support structure, the connection structure is mounted on the drive unit, and the sealing structure is mounted on the connection structure. The support structure includes a first bracket (1), an upper reaction chamber (2), a middle connection chamber (3), and a lower discharge chamber (4). The upper reaction chamber (2) is located at the top of the first bracket (1), the middle connection chamber (3) is located at the middle of the first bracket (1), and the lower discharge chamber (4) is located at the bottom of the first bracket (1). The upper reaction chamber (2), the middle connection chamber (3), and the lower discharge chamber (4) are on the same vertical straight line, with gaps between each pair. The drive unit includes a second bracket (5), a reducer (6), a motor (7), a main shaft (8), a sleeve (9), and a connecting pipe (10). The main shaft (8) is mounted on the side of the upper reaction chamber (2) and the lower discharge chamber (4) via the second bracket (5). The reducer (6) is mounted on the upper end face of the second bracket (5). The output end of the reducer (6) is connected to the main shaft (8). A motor (7) is installed on the reducer (6). A set of sleeves (9) is fitted on the upper and lower parts of the main shaft (8). A connecting pipe (10) is connected to the side of the sleeve (9). The two sets of connecting pipes (10) can follow the rotation of the main shaft (8) and enter into the gap between the upper reaction chamber (2), the middle connecting chamber (3) and the lower discharge chamber (4). The connection structure includes an annular airbag (12) and a guide ring ( 13) Sealing grooves are provided on the upper and lower ends of the connecting pipe (10). Sealing grooves are provided on the lower end of the upper reaction chamber (2), the upper and lower ends of the middle connecting chamber (3), and the upper end of the lower discharge chamber (4) corresponding to the position of the connecting pipe (10). An annular airbag (12) is installed in the sealing groove. A set of guide rings (13) are provided on the bottom of the inner side of the connecting pipe (10), the bottom of the inner side of the upper reaction chamber (2), and the bottom of the inner side of the middle connecting chamber (3).

2. The polypeptide pharmaceutical intermediate purification device as described in claim 1, characterized in that, It also includes a one-way bearing (11), with two sets of sleeves (9) respectively mounted on the main shaft (8) through a set of one-way bearings (11), and the two sets of one-way bearings (11) have opposite rotational directions.

3. The polypeptide pharmaceutical intermediate purification device as described in claim 2, characterized in that, The sealing structure includes an annular mounting plate (14), a purification rack (15), a sealing ring (16), a filter screen (17), and connecting bolts (18). An annular mounting plate (14) is provided on the upper part of the inner side of the connecting pipe (10). The purification rack (15) is connected to the lower end face of the annular mounting plate (14) by multiple sets of connecting bolts (18). A filter screen (17) is installed in the middle of the purification rack (15). A sealing groove is provided between the purification rack (15) and the annular mounting plate (14), and a sealing ring (16) is placed in the sealing groove.

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