A clamping device

By designing the base, gasket, and cover structure of the clamping device, the independent reaction of each sample capture area is ensured, which solves the problem of low accuracy of existing chip clamp reaction chambers and improves the accuracy of reverse transcription reaction.

CN224313507UActive Publication Date: 2026-06-02BOAO BIOLOGICAL CO LTD +2
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Utility models(China)
Current Assignee / Owner
BOAO BIOLOGICAL CO LTD
Filing Date
2025-07-07
Publication Date
2026-06-02

AI Technical Summary

Technical Problem

Existing chip fixtures provide reaction chambers with low accuracy for the sample capture region, resulting in low accuracy of reverse transcription reaction results.

Method used

A clamping device is provided, including a base, washers, a pressure plate, and a cover plate. The washers correspond one-to-one with the sample capture areas, the pressure plate overlaps with the washers, and the cover plate applies a load to ensure that the washers are in close contact with the chip. Reaction reagents are added to each area through a through-slot to reduce the impact of misalignment and improve the accuracy of the reaction chamber.

Benefits of technology

This improved the accuracy of reverse transcription reactions in spatial transcriptomics chips, reduced the influence of adjacent regions, ensured that each region reacted independently, and enhanced the accuracy of the reaction chambers.

✦ Generated by Eureka AI based on patent content.

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    Figure CN224313507U_ABST
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Abstract

This application discloses a clamping device that places a spatial transcriptomics chip in a storage slot of a base and places a gasket on the top surface of the spatial transcriptomics chip, such that the chambers of the gasket correspond one-to-one with the sample capture areas on the spatial transcriptomics chip. The chambers can accommodate the corresponding sample capture areas, and the gaskets can separate adjacent sample capture areas, so that each sample capture area can undergo reverse transcription independently, reducing mutual interference between adjacent sample capture areas. A pressure plate is placed on the top surface of the gasket, and the pressure plate coincides with the gasket in the vertical direction. When the cover plate is closed, the pressure plate can uniformly transfer the load applied by the cover plate to the gasket in the vertical direction, so that the gasket can be in close contact with the spatial transcriptomics chip in the vertical direction, reducing the misalignment between the chambers and the sample capture areas caused by the annular load of the cover plate, and improving the accuracy of the reverse transcription reaction of the spatial transcriptomics chip.
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