A centrifugal plasma separation cup

By introducing a collection sleeve and sealing system into the centrifugal plasma separation cup, secondary separation of plasma is achieved, solving the problem of quality degradation caused by plasma friction and improving plasma quality and collection efficiency.

CN224371682UActive Publication Date: 2026-06-19SHANXI ZHONGCHENG BIOTECHNOLOGY CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Utility models(China)
Current Assignee / Owner
SHANXI ZHONGCHENG BIOTECHNOLOGY CO LTD
Filing Date
2025-06-19
Publication Date
2026-06-19

AI Technical Summary

Technical Problem

Existing centrifugal plasma separation cups cause excessive foaming during the separation process due to plasma friction and agitation, which affects plasma quality and protein content, especially reducing factor IIIV content.

Method used

A centrifugal plasma separation cup, comprising a collection sleeve, a mandrel tube, and a seal, was designed. The secondary separation of plasma is achieved through the arc-shaped structure of the collection sleeve and the sealing system, reducing friction and improving separation efficiency.

Benefits of technology

It improved plasma quality, reduced foam production, increased the number of plasma components separated per batch, shortened collection time, and increased plasma protein and factor IIIV content.

✦ Generated by Eureka AI based on patent content.

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    Figure CN224371682U_ABST
Patent Text Reader

Abstract

The utility model discloses a centrifugal plasma separation cup, include: cup body, the entrance of cup body is installed with the plasma collection sleeve of arc structure, be provided with the gland for fixing plasma collection sleeve on the cup body mouth, install the mandrel pipe in the cup body, the mandrel pipe is set up upper and lower mouth after passing through plasma collection sleeve and gland, be provided with the sealing element for sealing mandrel pipe on the gland, the protective cover is sleeved on the sealing element. Because setting up plasma collection sleeve in the cup body, can reach the secondary separation of plasma, because the structure of plasma collection sleeve, can make the blood volume of single -time into separation cup increase, the more plasma component of single -time separation, reduced the demand time of total amount, through the plasma collection sleeve plasma collection body of shortening to 20mm plus or minus 1mm, when and gather plasma contact to plasma collection surface when single -time circulation stops, reduced the friction, reduced the generation of foam in the plasma collection process, improved the plasma quality.
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Description

Technical Field

[0001] This utility model relates to the field of blood separation technology, and in particular to a centrifugal plasma separation cup. Background Technology

[0002] Human blood products, due to their unique biological characteristics, have demonstrated strong therapeutic effects in long-term clinical practice and are increasingly recognized and valued in modern medicine. Blood products are an important resource in healthcare. Healthy human plasma, as a crucial raw material for blood product production, directly impacts the production, supply, and clinical use of blood products. After decades of development, domestic blood product manufacturers have made significant improvements in production processes and equipment.

[0003] Plasma collection is a technique that involves collecting whole blood from a person, returning the formed elements such as red blood cells to the donor, and only collecting plasma. Currently, centrifugal plasma dispensing cups are used to separate the plasma. However, due to the friction and agitation of the plasma during centrifugation, this device produces a lot of foam in the collected plasma, which reduces the quality of the plasma and lowers the levels of protein and factor IIIV. Utility Model Content

[0004] In view of the above-mentioned defects or deficiencies, the purpose of this utility model is to provide a centrifugal plasma separation cup.

[0005] To achieve the above objectives, the technical solution of this utility model is as follows:

[0006] A centrifugal plasma separation cup includes: a cup body, an arc-shaped collection sleeve installed at the inlet of the cup body, a pressure cap for fixing the collection sleeve on the opening of the cup body, a mandrel tube installed inside the cup body, the mandrel tube passing through the collection sleeve and the pressure cap and having upper and lower openings; a sealing element for sealing the mandrel tube is provided on the pressure cap, and a protective cover is fitted on the sealing element.

[0007] The slurry collecting sleeve includes: a slurry collecting body, a slurry outlet slit provided along the upper edge of the slurry collecting body, an upper slurry collecting concave surface provided inside the slurry collecting body, and a slurry collecting surface provided on the outer surface of the slurry collecting body.

[0008] The upper slurry collecting concave surface has a concave structure, and the angle between it and the inner wall of the slurry collecting body is within the range of degrees.

[0009] A mandrel seat is installed between the pressure cap and the fixed slurry collecting sleeve. The upper end of the mandrel seat passes through the slurry collecting sleeve and the pressure cap and is provided with upper and lower openings. The mandrel tube is installed at the lower end of the mandrel seat, and a mandrel upper seat is fitted on the mandrel seat.

[0010] The mandrel seat includes: a mandrel seat skirt, a mandrel seat skirt surface mounted on the mandrel seat skirt, a three-point upper plane of the mandrel seat provided on the mandrel seat skirt surface, an output tube being clamped on the three-point upper plane of the mandrel seat, and the upper and lower openings being provided on the output tube.

[0011] The mandrel seat has three evenly spaced support ribs on its three-point upper plane.

[0012] The mandrel upper seat includes: a mandrel upper seat skirt and a mandrel upper seat lower plane, wherein the lower plane of the mandrel upper seat is fitted onto the mandrel seat skirt.

[0013] The mandrel seat skirt and the upper mandrel seat skirt form a smooth slurry receiving gap, and the three supporting ribs on the upper plane of the three points of the mandrel seat make a slurry discharge gap between the mandrel seat and the upper mandrel seat.

[0014] The sealing components include: a graphite ring, a rubber cup, and a ceramic ring A, which are installed on the gland from bottom to top.

[0015] Includes the following steps:

[0016] 1) Whole blood containing anticoagulant is infused from the top opening and enters the cup through the mandrel tube;

[0017] 2) The cup body rotates at high speed as it is installed on the plasma collection device;

[0018] 3) After the slurry collection sleeve, gland, and seal are fixedly connected, they are rotated rapidly to form a dynamic sealing system;

[0019] 4) As the blood rotates at high speed in the cup, the cells separate. Red blood cells are thrown to the outer layer by centrifugal force, while the lighter plasma is in the inner layer. The plasma in the inner layer gradually comes into contact with the collection sleeve and overflows upward along the collection sleeve.

[0020] 5) The plasma overflowing into the arc-shaped surface of the collection sleeve is centrifuged again. As the amount of plasma increases, it overflows along the lower opening of the protective cover, and the collected plasma is collected.

[0021] 6) As plasma is collected, red blood cells gradually move towards the center until they reach the overflow outlet under the protective shield, at which point separation stops.

[0022] Compared with the prior art, the beneficial effects of this utility model are as follows:

[0023] This invention provides a centrifugal plasma separation cup. Due to the inclusion of a collection sleeve within the cup, secondary separation of plasma can be achieved. The structure of the collection sleeve increases the volume of blood entering the separation cup at a time, resulting in more plasma components being separated in a single step and reducing the total time required. By shortening the collection sleeve to collect plasma to 20mm±1mm, friction is reduced when the plasma stops and comes into contact with the collection surface, thus reducing foam generation during plasma collection and improving plasma quality.

[0024] Furthermore, by reducing the outer diameter of the mandrel seat skirt and the upper mandrel seat skirt to 38mm±1mm, the plasma separation time is extended, improving plasma quality. The design of the upper collection concave surface (at an angle of 65°±5° with the collection body) allows for a second, brief separation of plasma on the upper collection concave surface, further improving plasma quality. Additionally, increasing the plasma outlet gap to 2mm±0.5mm allows for faster plasma flow during collection, reducing the total required time. Finally, increasing the gap between the mandrel seat skirt and the upper mandrel seat skirt to greater than 0.7mm further accelerates plasma flow during collection, reducing the total required time. Attached Figure Description

[0025] Figure 1 This is a schematic diagram of the structure of the centrifugal plasma separation cup of this utility model;

[0026] Figure 2 yes Figure 1 A cross-sectional schematic diagram;

[0027] Figure 3 This is a schematic diagram of the centrifugal plasma separation cup collection sleeve structure of the present invention;

[0028] Figure 4 yes Figure 3 A cross-sectional schematic diagram;

[0029] Figure 5 This is a schematic diagram of the centrifugal plasma separation cup core bearing structure of this utility model;

[0030] Figure 6 This is a schematic diagram of the upper seat structure of the centrifugal plasma separation cup core shaft of this utility model;

[0031] Figure 7 This is a schematic diagram of the combined structure of the centrifugal plasma separation cup mandrel upper seat and mandrel seat of this utility model.

[0032] Figure 8 yes Figure 7 A cross-sectional schematic diagram;

[0033] Figure 9 This is a schematic cross-sectional view of the centrifugal plasma separation cup of this utility model during use.

[0034] In the diagram, 1000 is the protective cover, 2000 is the cup body, 3000 is the slurry collection sleeve, 3001 is the upper slurry collection concave surface, 3002 is the slurry collection surface, 3003 is the slurry collection body, 3004 is the slurry outlet seam, 4000 is the mandrel seat, 4001 is the upper plane of the mandrel seat at three points, 4002 is the mandrel seat skirt, 4003 is the mandrel seat surface, 5000 is the upper mandrel seat, 5001 is the upper mandrel seat skirt, 5002 is the lower plane of the upper mandrel seat, 6000 is the pressure cap, 7000 is the mandrel tube, 8000 is the graphite ring, 9000 is the rubber cup, and A000 is the ceramic ring. Detailed Implementation

[0035] The present invention will now be described in detail with reference to the accompanying drawings. Obviously, the described embodiments are only a part of the embodiments of the present invention, and not all of them. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention without creative effort are within the protection scope of the present invention.

[0036] like Figure 1 , 2 As shown, this utility model provides a centrifugal plasma separation cup, comprising: a cup body 2000, an arc-shaped collection sleeve 3000 installed at the inlet of the cup body 2000, a pressure cap 6000 for fixing the collection sleeve 3000 provided on the inlet of the cup body 2000, a mandrel tube 7000 installed inside the cup body 2000, the mandrel tube 7000 passing through the collection sleeve 3000 and the pressure cap 6000 and having upper and lower openings; a sealing element for sealing the mandrel tube 7000 provided on the pressure cap 6000, and a protective cover 1000 fitted on the sealing element.

[0037] The slurry collecting sleeve 3000 includes an upper slurry collecting concave surface 3001, a slurry collecting surface 3002, a slurry collecting body 3003, and a slurry outlet slit 3004. The mandrel seat 4000 includes a mandrel seat three-point upper plane 4001, a mandrel seat skirt 4002, and a mandrel seat skirt surface 4003. The mandrel upper seat 5000 includes a mandrel upper seat skirt 5001 and a mandrel upper seat lower plane 5002.

[0038] Specifically, such as Figure 3 , 4 As shown, the slurry collecting sleeve 3000 includes: a slurry collecting body 3003, a slurry outlet slit 3004 provided along the upper edge of the slurry collecting body 3003, an upper slurry collecting concave surface 3001 provided inside the slurry collecting body 3003, and a slurry collecting surface 3002 provided on the outer surface of the slurry collecting body 3003. Furthermore, the upper slurry collecting concave surface 3001 has a concave structure, and the angle between it and the inner wall of the slurry collecting body 3003 is in the range of 60 degrees to 70 degrees.

[0039] The outer diameter of the slurry collecting surface 3002 of the slurry collecting sleeve 3000 is designed to be 42mm±1mm; the length of the slurry collecting body 3003 of the slurry collecting sleeve 3000 is designed to be 20mm±2mm; and the width of the slurry outlet 3004 of the slurry collecting sleeve 3000 is designed to be 2mm±0.5mm.

[0040] Preferably, such as Figure 5-8 As shown, a mandrel seat 4000 is installed between the pressure cap 6000 and the fixed slurry collection sleeve 3000. The upper end of the mandrel seat 4000 passes through the slurry collection sleeve 3000 and the pressure cap 6000 and is provided with upper and lower openings. The mandrel tube 7000 is installed at the lower end of the mandrel seat 4000, and a mandrel upper seat 5000 is fitted on the mandrel seat 4000. The mandrel seat 4000 includes: a mandrel seat skirt 4002, a mandrel seat skirt surface 4003 installed on the mandrel seat skirt 4002, a mandrel seat three-point upper plane 4001 provided on the mandrel seat skirt surface 4003, an output tube 4004 clamped on the mandrel seat three-point upper plane 4001, the upper and lower openings being provided on the output tube, and the mandrel seat three-point upper plane 4001 consisting of three evenly arranged support ribs.

[0041] In this utility model, the outer diameter of the mandrel seat skirt 4002 and the upper mandrel seat skirt (5001) is designed to be 38mm±1mm; the upper plane 4001 of the three points of the mandrel seat is designed with three supporting ribs with a height greater than 0.7mm to ensure that the slurry discharge gap between the mandrel seat 4000 and the upper mandrel seat 5000 is greater than 0.7mm.

[0042] The mandrel upper seat 5000 includes a mandrel upper seat skirt 5001 and a mandrel upper seat lower plane 5002, the mandrel upper seat lower plane 5002 being fitted onto the mandrel seat skirt 4003. The mandrel seat skirt 4002 and the mandrel upper seat skirt 5001 form a smooth slurry receiving gap, and the three supporting ribs of the three-point upper plane 4001 of the mandrel seat ensure that the slurry discharge gap between the mandrel seat 4000 and the mandrel upper seat 5000 is greater than 0.7mm.

[0043] More preferably, the sealing element includes: a graphite ring 8000, a rubber cup 9000, and a ceramic ring A000, which are sequentially installed on the pressure cap 6000 from bottom to top. The ceramic ring A000 is bonded and fixed to the upper part of the pressure cap 6000, the graphite ring 8000 is fitted onto the lower part of the rubber cup 9000, and the protective cover 1000 is bonded and fixed to the output pipe.

[0044] The separation method of this utility model includes the following steps:

[0045] 1) Whole blood containing anticoagulant is infused from the top opening, passing through the mandrel tube 7000 into the cup body 2000;

[0046] 2) The cup body 1000 rotates at high speed by being installed on the plasma collection device;

[0047] 3) After the slurry collection sleeve 3000, the gland 6000 and the sealing element are fixedly connected, they are rotated rapidly to form a dynamic sealing system;

[0048] Because the slurry collecting sleeve 3000, the pressure cap 6000, and the ceramic ring A000 are fixedly bonded to the separating cup and rotate at high speed, the graphite ring 8000, in conjunction with the rubber cup 9000, forms a dynamic sealing system with the ceramic ring A000.

[0049] 4) As the blood rotates at high speed in the cup 2000, the cells are separated. Red blood cells are thrown to the outer layer by centrifugal force, while the lighter plasma is in the inner layer. The plasma in the inner layer gradually comes into contact with the collection sleeve 3000 and overflows upward along the collection sleeve 3000.

[0050] Specifically, as blood enters, the high-speed rotation of the cup 3000 causes the blood to gradually separate into layers within the cup 3000. Heavier red blood cells are thrown to the outer layer by centrifugal force, while lighter plasma cells are in the inner layer. As blood continues to enter, the plasma in the inner layer gradually comes into contact with the plasma collection surface 3002 of the plasma collection sleeve and overflows upward from the plasma outlet 3004 along the plasma collection body 3003.

[0051] 5) The plasma overflowing into the arc-shaped surface of the collection sleeve 3000 is centrifuged again. As the amount of plasma increases, it overflows along the lower opening of the protective cover 1000 and is collected.

[0052] Specifically, the plasma overflowing into the concave surface 3001 of the plasma collection sleeve will form a centrifugal separation zone again at the concave surface, further centrifuging the plasma and improving its quality. As the amount of plasma at the upper concave surface 3001 increases, the plasma will overflow from the gap between the mandrel seat skirt 4002 and the upper mandrel seat skirt 5001, overflowing along the lower outlet of the protective cover, and the collected plasma will be collected.

[0053] 6) As plasma is collected, red blood cells will gradually move towards the center until they reach the overflow port of the protective shield 1000, at which point separation will stop.

[0054] As plasma is collected, red blood cells gradually move towards the center until they reach the overflow outlet under the protective shield 1000. Once detected, the equipment stops separating and transfers the red blood cells to the donor for the next collection and separation, until the required collection volume is reached.

[0055] like Figure 9 As shown, the reduced collection surface 4002 of the collection sleeve in this invention increases the volume of blood entering the separation cup at one time, resulting in more plasma components being separated at one time and reducing the total required time.

[0056] The shortened collection sleeve 3003 reduces friction and plasma foam generation when the plasma comes into contact with the collection surface 3002 at the end of a single cycle, thus improving plasma quality.

[0057] The reduced size of the mandrel seat skirt 4002 and the upper mandrel seat skirt 5001 increases the plasma separation time and improves plasma quality.

[0058] The design of the upper concave surface 3001 allows for a second, brief separation of the plasma, improving its quality.

[0059] The increased gap between the slurry outlet 3004 of the collection sleeve and the mandrel seat 4000 and the upper mandrel seat 5000 makes the slurry outlet smoother, improving the quality of plasma while reducing the slurry outlet time.

[0060] It will be apparent to those skilled in the art that the above specific examples are merely preferred embodiments of this utility model. Therefore, any improvements or modifications that those skilled in the art may make to certain parts of this utility model still embody the principles of this utility model and achieve its purpose, and all fall within the scope of protection of this utility model.

Claims

1. A centrifugal plasma separation cup, characterized in that, include: A cup body (2000) is provided with an arc-shaped slurry collection sleeve (3000) installed at the inlet of the cup body (2000). A pressure cap (6000) for fixing the slurry collection sleeve (3000) is provided on the opening of the cup body (2000). A mandrel tube (7000) is installed inside the cup body (2000). The mandrel tube (7000) passes through the slurry collection sleeve (3000) and the pressure cap (6000) and is provided with upper and lower openings. A sealing element for sealing the mandrel tube (7000) is provided on the pressure cap (6000). A protective cover (1000) is fitted on the sealing element.

2. The centrifugal plasma separation cup according to claim 1, characterized in that, The slurry collection sleeve (3000) includes: a slurry collection body (3003), the upper edge of the slurry collection body (3003) is provided with a slurry outlet slit (3004), the slurry collection body (3003) is provided with an upper slurry collection concave surface (3001) inside, and the outer surface of the slurry collection body (3003) is provided with a slurry collection surface (3002).

3. The centrifugal plasma separation cup according to claim 2, characterized in that, The upper slurry collecting concave surface (3001) has a concave structure, and the angle between it and the inner wall of the slurry collecting body (3003) is between 60 degrees and 70 degrees.

4. A centrifugal plasma separation cup according to claim 1 or 2, characterized in that, A mandrel seat (4000) is installed between the pressure cap (6000) and the fixed slurry collection sleeve (3000). The upper end of the mandrel seat (4000) passes through the slurry collection sleeve (3000) and the pressure cap (6000) and is provided with upper and lower openings. The mandrel tube (7000) is installed at the lower end of the mandrel seat (4000). A mandrel upper seat (5000) is fitted on the mandrel seat (4000).

5. The centrifugal plasma separation cup according to claim 4, characterized in that, The mandrel seat (4000) includes: a mandrel seat skirt (4002), a mandrel seat skirt surface (4003) mounted on the mandrel seat skirt (4002), a mandrel seat three-point upper plane (4001) provided on the mandrel seat skirt surface (4003), an output tube (4004) clamped on the mandrel seat three-point upper plane (4001), and the upper and lower openings are provided on the output tube (4004).

6. The centrifugal plasma separation cup according to claim 5, characterized in that, The upper plane (4001) of the mandrel seat consists of three evenly spaced support ribs.

7. A centrifugal plasma separation cup according to claim 6, characterized in that, The mandrel upper seat (5000) includes: a mandrel upper seat skirt (5001) and a mandrel upper seat lower plane (5002), the mandrel upper seat lower plane (5002) being fitted onto the mandrel seat skirt (4003).

8. A centrifugal plasma separation cup according to claim 7, characterized in that, The mandrel seat skirt (4002) and the upper mandrel seat skirt (5001) form a smooth slurry-collecting gap, and the three supporting ribs on the upper plane (4004) of the mandrel seat make a slurry gap between the mandrel seat (4000) and the upper mandrel seat (5000).

9. The centrifugal plasma separation cup according to claim 1 or 2, characterized in that, The sealing components include: a graphite ring (8000), a rubber cup (9000), and a ceramic ring (A000) installed sequentially from bottom to top on the gland (6000).