Cell injection solution anti-clumping oscillation device

Abstract

The utility model relates to cell biomedical technology field discloses a kind of cell injection liquid anti-bunching oscillation device, including vibration plate, the vibration plate upper surface is fixedly connected with stand one, the stand one outer wall is fixedly connected with connecting block one, the connecting block one outer wall is fixedly connected with fixed box, the fixed box upper surface is provided with clamping assembly;The clamping assembly includes multiple clamping plate one and clamping plate two, the clamping plate one and clamping plate two lower surface are all fixedly connected with fixed block one, the fixed block one inner wall is slidably connected with connecting rod, the clamping plate one and clamping plate two inner wall sliding joint include multiple clamping plate one and clamping plate two, the clamping plate one and clamping plate two lower surface are all fixedly connected with fixed block one limit rod.The utility model in, by setting up the clamping assembly of reasonable structure on vibration plate, utilize rack-gear linkage structure between clamping plate one and clamping plate two, realized the synchronous adjustable of jig spacing.

Description

Technical Field

[0001] This utility model relates to the field of cell biomedical technology, and in particular to a cell injection solution anti-clumping oscillation device. Background Technology

[0002] In the fields of cell preparations and biopharmaceuticals, the homogeneity of cell injection solutions directly affects their therapeutic efficacy and stability. Especially before transportation, storage, or use, cells are prone to aggregation and sedimentation due to prolonged standing time, forming cell clumps that affect the uniform distribution of active ingredients and consequently the injection effect. Therefore, to ensure that cell injection solutions are thoroughly mixed and prevent clumping before use, the development of an anti-clumping device with continuous oscillation function is particularly necessary. Such a device needs to be able to perform gentle, continuous, and uniform oscillation on the test tube containing the injection solution, thereby maintaining the dispersed state of the cells and improving the effectiveness and safety of the formulation.

[0003] Currently available cell injection solution shaking devices typically use a motor-driven or eccentric wheel-driven platform to generate reciprocating or circular motion, thereby agitating the liquid and preventing clumping. These devices are generally equipped with clamps to hold the test tubes containing the injection solution, ensuring stability during shaking. Traditional clamps are mostly fixed-size structures, such as spring clamps, silicone grooves, or screw fasteners, which can constrain the displacement of the test tubes to a certain extent and achieve positioning through friction or structural fastening. The entire system relies on physical vibration to promote uniform mixing of the cell suspension, which helps improve the dispersion of the formulation.

[0004] However, most existing clamping structures are designed for a single size, limiting their adaptability. In practical use, different experimental or production needs often require changing to test tubes of different sizes. Traditional clamps cannot automatically or flexibly adjust to these size changes, resulting in unstable fixation of the test tubes or problems with clamping them too tightly or too loosely. This not only affects the oscillation efficiency but may also cause safety hazards such as test tube breakage or slippage, severely limiting the applicability and ease of operation of the device. Utility Model Content

[0005] To overcome the above shortcomings, this utility model provides a cell injection solution anti-clustering oscillation device, which aims to improve the problem that the existing clamp structure generally has a single fixing method, resulting in insufficient adaptability.

[0006] To achieve the above objectives, the present invention provides the following technical solution: a cell injection solution anti-agglomeration oscillation device, comprising a vibrating plate, a column fixedly connected to the upper surface of the vibrating plate, a connecting block fixedly connected to the outer wall of the column, a fixing box fixedly connected to the outer wall of the connecting block, and a clamping component provided on the upper surface of the fixing box;

[0007] The clamping assembly includes multiple clamping plates 1 and 2. A fixing block 1 is fixedly connected to the lower surface of each clamping plate 1 and 2. A connecting rod is slidably connected to the inner wall of the fixing block 1. Limiting rods are slidably connected to the inner walls of each clamping plate 1 and 2. The lower surfaces of each clamping plate 1 and 2 are slidably connected to the upper surface of a fixed box. A rack 1 is fixedly connected to the lower surface of each clamping plate 1, and a rack 2 is fixedly connected to the lower surface of each clamping plate 2. A gear is rotatably connected to the inner wall of the fixed box. Rack 1 and rack 2 are respectively meshed and connected to both sides of the outer wall of the gear. A threaded rod is fixedly connected to the outer wall of rack 2.

[0008] Furthermore, a protective pad is fixedly connected to the upper surface of the vibration plate, a second column is slidably connected to the inner wall of the first column, a second connecting block is fixedly connected to the outer wall of the first column, a fixing plate is rotatably connected to the inner wall of the second connecting block, a spring is fixedly connected to one end of the fixing plate, a second fixing block is fixedly connected to the outer wall of the fixing plate, the outer wall of the second fixing block is slidably connected to the inner wall of the second column, a protective plate is fixedly connected to the upper surface of the second column, and a silicone pad is fixedly connected to the lower surface of the protective plate.

[0009] Furthermore, the lower surface of the vibration plate is fixedly connected to the body, the lower surface of the body is fixedly connected to the base, the outer wall of the body is fixedly connected to the display screen, the outer wall of the body is fixedly connected to the switch, and multiple clamping plates one and clamping plates two are all arranged on the upper surface of the fixed box.

[0010] Furthermore, one end of the spring is fixedly connected to the outer wall of the fixing plate, and the fixing plate is disposed on one side of the outer wall of the column.

[0011] Furthermore, the outer wall of the threaded rod is threadedly connected to the inner wall of the fixed box, and the outer wall of the rack is slidably connected to the inner wall of the fixed box.

[0012] Furthermore, the outer wall of the rack is slidably connected to the inner wall of the fixed box, and the connecting rod is located below the limiting rod.

[0013] Furthermore, a vibration motor is fixedly connected to the inner wall of the machine body, and the output end of the vibration motor is fixedly connected to the lower surface of the vibration plate.

[0014] Furthermore, a telescopic rod is fixedly connected to the upper surface of the vibration plate, and the upper surface of the telescopic rod is fixedly connected to the lower surface of the protective plate.

[0015] This utility model has the following beneficial effects:

[0016] 1. In this utility model, by setting a reasonably structured clamping assembly on the vibrating plate and utilizing the rack and pinion linkage structure between clamping plate one and clamping plate two, the clamping distance is synchronously adjustable, which can adapt to test tubes of different diameters. This effectively solves the problems of unstable clamping and poor adaptability of existing devices. This structure not only makes the force on the test tube more uniform during the vibration process, avoiding displacement or loosening, but also realizes a multi-point limiting structure through the cooperation of connecting rods and limiting rods, improving the overall clamping stability and safety. It is suitable for simultaneous operation of multiple test tubes, which is conducive to the uniform mixing of cell injection solution and prevents clumping and sedimentation.

[0017] 2. In this utility model, by setting an adjustable height protective plate mechanism above the clamp structure, combined with a silicone pad and spring limiting structure, the protective plate can be flexibly adjusted in position according to different test tube lengths and liquid heights, ensuring an effective elastic fit between the upper opening of the test tube and the protective plate. This prevents liquid splashing, test tube movement, or breakage during oscillation. At the same time, by setting a telescopic rod to enhance the vertical guiding and supporting capacity of the protective plate, the stability and safety of use during operation are further improved. Attached Figure Description

[0018] Figure 1 This is a three-dimensional structural diagram of a cell injection solution anti-clumping oscillation device proposed in this utility model;

[0019] Figure 2 This is a schematic diagram of the main body structure of a cell injection solution anti-caking oscillation device proposed in this utility model;

[0020] Figure 3 This is a schematic diagram of the fixing box part of the cell injection solution anti-clumping oscillation device proposed in this utility model;

[0021] Figure 4 This is a schematic diagram of a portion of the clamping plate of a cell injection solution anti-caking oscillation device proposed in this utility model;

[0022] Figure 5 This is a schematic diagram of a portion of the column structure of a cell injection solution anti-clumping oscillation device proposed in this utility model.

[0023] Legend:

[0024] 1. Base; 2. Body; 3. Display screen; 4. Switch; 5. Vibration plate; 6. Protective pad; 7. Column 1; 8. Column 2; 9. Protective plate; 10. Clamping plate 1; 11. Clamping plate 2; 12. Vibration motor; 13. Connecting block 1; 14. Fixing block 1; 15. Silicone pad; 16. Limiting rod; 17. Threaded rod; 18. Rack 1; 19. Connecting rod; 20. Fixing box; 21. Rack 2; 22. Fixing plate; 23. Connecting block 2; 24. Spring; 25. Fixing block 2; 26. Gear; 27. Telescopic rod. Detailed Implementation

[0025] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0026] Reference Figures 1-5 The present invention provides an embodiment of a cell injection solution anti-agglomeration oscillation device, comprising a vibrating plate 5, which is installed on the upper surface of the machine body 2 and is the key platform for the entire vibration transmission. By connecting with the vibration motor 12, it drives the overall vibration of the clamping structure, thereby indirectly preventing the injection solution in the test tube from agglomerating. A column 7 is fixedly connected to the upper surface of the vibrating plate 5, a connecting block 13 is fixedly connected to the outer wall of the column 7, and a fixing box 20 is fixedly connected to the outer wall of the connecting block 13. The fixing box 20 is located on the vibrating plate 5 and is the overall mounting base of the clamping assembly. The clamping components are distributed inside, providing a stable structural space. The clamping assembly is provided on the upper surface of the fixing box 20.

[0027] The clamping assembly includes multiple clamping plates 10 and 11. Clamping plates 11 allow for synchronous adjustment of the clamping spacing, used to clamp test tubes of different sizes and improve stability during oscillation. Fixing blocks 14 are fixedly connected to the lower surfaces of both clamping plates 10 and 11. A connecting rod 19 is slidably connected to the inner wall of the fixing block 14. The connecting rod 19 cooperates with the clamping plates and the limiting rod 16 to form a clamping linkage assembly, ensuring coordinated movement of multiple clamping units during motion. The limiting rod 16 is slidably connected to the inner walls of clamping plates 10 and 11, inserted inside the clamping plates to limit the sliding range of the clamp. To prevent the clamping structure from dislodging or overtraveling during vibration and improve structural safety, the lower surfaces of clamping plate 10 and clamping plate 21 are slidably connected to the upper surface of the fixed box 20. A rack 18 is fixedly connected to the lower surface of clamping plate 10, and a rack 21 is fixedly connected to the lower surface of clamping plate 21. The rack 21 is fixedly connected below clamping plate 21 and meshes with the other side of gear 26. Together with rack 18, it completes the clamping distance adjustment. Gear 26 is rotatably connected to the inner wall of the fixed box 20. Rack 18 and rack 21 are respectively meshed and connected to both sides of the outer wall of gear 26. A threaded rod 17 is fixedly connected to the outer wall of rack 21.

[0028] Reference Figures 1-5A protective pad 6 is fixedly connected to the upper surface of the vibrating plate 5. The protective pad 6 plays a role in shock absorption, buffering, and sound insulation, reducing the impact of rigid impact between structures on the life of the device and the stability of the test tube. A second column 8 is slidably connected to the inner wall of the first column 7. A second connecting block 23 is fixedly connected to the outer wall of the first column 7. A fixing plate 22 is rotatably connected to the inner wall of the second connecting block 23. The fixing plate 22 is used to support the spring 24 and limit the upward or downward movement of the protective structure, providing elastic positioning function for the protective plate 9. A spring 24 is fixedly connected to one end of the fixing plate 22. A second fixing block 25 is fixedly connected to the outer wall of the fixing plate 22. The outer wall of the second fixing block 25 is slidably connected to the inner wall of the second column 8. A protective plate 9 is fixedly connected to the upper surface of the second column 8. The protective plate 9 prevents the test tube from splashing or moving upward due to liquid fluctuations during vibration. Its height is adjustable, and it makes flexible contact with the top of the test tube through the silicone pad 15 to improve the safety of use. The silicone pad 15 is fixedly connected to the lower surface of the protective plate 9, and the body 2 is fixedly connected to the lower surface of the vibration plate 5. The base 1 is fixedly connected to the lower surface of the body 2. The base 1 is used to support the weight of the entire device, providing stable support for the upper structure such as the vibration motor 12 and the body 2, while preventing the entire device from shifting during vibration. Anti-slip pads can be added to the bottom to improve stability. A display screen 3 is fixedly connected to the outer wall of the machine body 2, and a switch 4 is also fixedly connected to the outer wall of the machine body 2. Multiple clamping plates 10 and 11 are all set on the upper surface of the fixed box 20. One end of the spring 24 is fixedly connected to the outer wall of the fixed plate 22. The fixed plate 22 is set on one side of the outer wall of the column 7. The column 7 is vertically installed on the vibration plate 5, serving as a support and sliding guide structure to limit the movement trajectory of the column 8, and to support and assist in the vertical adjustment of the protective structure. The outer wall of the threaded rod 17 is threadedly connected to the inner wall of the fixed box 20. The outer wall of the rack 18 is slidably connected to the inner wall of the fixed box 20, and the outer wall of the rack 21 is slidably connected to the fixed box 20. The inner wall of the machine body 2 has a connecting rod 19 located below the limiting rod 16. A vibration motor 12 is fixedly connected to the inner wall of the machine body 2. The output shaft of the vibration motor 12 is connected to the bottom of the vibration plate 5. It generates vibration through eccentric rotation, which drives the entire upper clamping structure to vibrate, thereby achieving the function of preventing clumping. The output end of the vibration motor 12 is fixedly connected to the lower surface of the vibration plate 5. A telescopic rod 27 is fixedly connected to the upper surface of the vibration plate 5. The upper surface of the telescopic rod 27 is fixedly connected to the lower surface of the protective plate 9. One end of the telescopic rod 27 is fixed to the vibration plate 5, and the other end is fixed to the lower part of the protective plate 9. It is used to provide vertical guidance and support for the protective plate 9 during vibration, and to prevent the protective plate 9 from shifting or shaking due to vibration.

[0029] Working Principle: When this device is needed to perform a shaking operation on the cell injection solution, multiple test tubes containing cell fluid are first placed in a clamping frame consisting of clamping plate 10 and clamping plate 11. Clamping plate 10 and clamping plate 11 are located on the left and right sides of the fixing box 20, respectively. Rack 18 and rack 21 are respectively provided on their lower surfaces. The two racks mesh with gears 26 on the left and right sides of the inner wall of the fixing box 20. By rotating the threaded rod 17 on one side of the device, rack 21 moves horizontally, thereby driving gear 26 to rotate, which in turn drives rack 18 on the other side to move in the opposite direction, thus achieving the shaking operation of clamping plate 10 and clamping plate 11. The clamping plate 11 moves inward or outward synchronously to adjust the clamping distance of the test tubes and adapt to test tubes of different diameters. The clamping plates adopt multiple arrangement forms, with clamping plate 10 and clamping plate 11 arranged alternately. Every three clamping plates are connected to the fixing block 14 through the connecting rod 19 and are positioned by the limiting rod 16. This ensures accurate clamping position when clamping multiple test tubes, improves clamping stability and uniformity. During the oscillation process, the vibrating plate 5 is driven by the vibrating motor 12 to perform high-frequency micro-amplitude vibration, which in turn drives the clamping frame and the clamped test tubes to vibrate synchronously, promoting the internal mixing of the cell injection solution, preventing cell precipitation and clumping, and maintaining its good suspension state before injection or use.

[0030] In addition, to further enhance the safety and adaptability of the operation, a set of height-adjustable protective plates 9 is set above the clamping structure. This structure consists of a first column 7 and a second column 8 that is slidably connected. The protective plate 9 is fixedly connected to the upper surface of the second column 8. A silicone pad 15 is provided below the protective plate 9, which can elastically contact the upper opening of the test tube to form a buffer protection. The height of the protective plate 9 can be manually adjusted by compressing a spring 24. The spring 24 is set between the fixed plate 22 and the second fixed block 25, and cooperates with the second column 8 through the second connecting block 23 to achieve limit fixation. At the same time, a telescopic rod 27 is also set between the protective plate 9 and the oscillation plate to improve the support and guiding stability of the protective structure during vertical vibration. When the user adjusts the protective plate 9 to a suitable height according to the size of the test tube and the liquid volume, the protective plate 9 can stably provide flexible support to the upper end of the test tube, preventing splashing, overflow or test tube displacement caused by violent fluctuations of liquid during oscillation, effectively improving the safety, stability and environmental cleanliness of the operation process.

[0031] Finally, it should be noted that the above description is only a preferred embodiment of the present utility model and is not intended to limit the present utility model. Although the present utility model has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present utility model should be included within the protection scope of the present utility model.

Claims

1. A cell injection solution anti-agglomeration oscillation device, comprising a vibrating plate (5), characterized in that: The upper surface of the vibrating plate (5) is fixedly connected to a column (7), the outer wall of the column (7) is fixedly connected to a connecting block (13), the outer wall of the connecting block (13) is fixedly connected to a fixing box (20), and the upper surface of the fixing box (20) is provided with a clamping component. The clamping assembly includes multiple clamping plates 1 (10) and clamping plates 2 (11). A fixing block 1 (14) is fixedly connected to the lower surface of both clamping plates 1 (10) and clamping plates 2 (11). A connecting rod (19) is slidably connected to the inner wall of the fixing block 1 (14). A limit rod (16) is slidably connected to the inner walls of clamping plates 1 (10) and clamping plates 2 (11). The lower surfaces of clamping plates 1 (10) and clamping plates 2 (11) slide... A rack (18) is fixedly connected to the lower surface of the clamping plate (10) and a rack (21) is fixedly connected to the lower surface of the clamping plate (11). A gear (26) is rotatably connected to the inner wall of the fixed box (20). The rack (18) and rack (21) are respectively meshed and connected to the two sides of the outer wall of the gear (26). A threaded rod (17) is fixedly connected to the outer wall of the rack (21).

2. The cell injection solution anti-agglomeration oscillation device according to claim 1, characterized in that: A protective pad (6) is fixedly connected to the upper surface of the vibrating plate (5). A second column (8) is slidably connected to the inner wall of the first column (7). A second connecting block (23) is fixedly connected to the outer wall of the first column (7). A fixing plate (22) is rotatably connected to the inner wall of the second connecting block (23). A spring (24) is fixedly connected to one end of the fixing plate (22). A second fixing block (25) is fixedly connected to the outer wall of the fixing plate (22). The outer wall of the second fixing block (25) is slidably connected to the inner wall of the second column (8). A protective plate (9) is fixedly connected to the upper surface of the second column (8). A silicone pad (15) is fixedly connected to the lower surface of the protective plate (9).

3. The cell injection solution anti-agglomeration oscillation device according to claim 2, characterized in that: The vibrating plate (5) is fixedly connected to the body (2) on its lower surface. The body (2) is fixedly connected to the base (1) on its lower surface. The body (2) is fixedly connected to the display screen (3) on its outer wall. The body (2) is fixedly connected to the switch (4) on its outer wall. Multiple clamping plates one (10) and clamping plates two (11) are all set on the upper surface of the fixed box (20).

4. The cell injection solution anti-agglomeration oscillation device according to claim 2, characterized in that: One end of the spring (24) is fixedly connected to the outer wall of the fixing plate (22), and the fixing plate (22) is set on one side of the outer wall of the column (7).

5. The cell injection solution anti-agglomeration oscillation device according to claim 2, characterized in that: The outer wall of the threaded rod (17) is threadedly connected to the inner wall of the fixed box (20), and the outer wall of the rack (18) is slidably connected to the inner wall of the fixed box (20).

6. The cell injection solution anti-agglomeration oscillation device according to claim 2, characterized in that: The outer wall of the rack 2 (21) is slidably connected to the inner wall of the fixed box (20), and the connecting rod (19) is located below the limiting rod (16).

7. The cell injection solution anti-agglomeration oscillation device according to claim 3, characterized in that: A vibration motor (12) is fixedly connected to the inner wall of the machine body (2), and the output end of the vibration motor (12) is fixedly connected to the lower surface of the vibration plate (5).

8. The cell injection solution anti-agglomeration oscillation device according to claim 2, characterized in that: A telescopic rod (27) is fixedly connected to the upper surface of the vibration plate (5), and the upper surface of the telescopic rod (27) is fixedly connected to the lower surface of the protective plate (9).

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