An acyclovir wet granulation device

Abstract

The utility model discloses an acyclovir wet granulation device, including reation kettle and fixed mounting on the support column of reation kettle, the inside stirring mechanism of reation kettle is provided with, the bottom of reation kettle is provided with the blanking port, the blanking port is connected with the feed pipe, the feed pipe is connected with screw vacuum pump, the output of screw vacuum pump is communicated and is installed with the granulating pipe, the inside fixed mounting of granulating pipe has the granulating tray, one side of granulating tray is provided with scraper and the air draft component. Through the granulating hole on the granulating tray extrusion, then through the scraper cutting and scraping the extruded particle, at the same time, the air draft component can suck the air outside on one hand, enhances the heat dissipation in the granulating pipe, makes the particle fully cooling and drying, on the other hand, the negative pressure of the air draft component can suck the particle to the direction of far from the scraper, prevents the particle from adhering on the scraper, and the particle is convenient to discharge from the granulating hole below and then enter the material collecting groove.

Description

Technical Field

[0001] This utility model relates to the field of acyclovir wet granulation technology, and in particular to an acyclovir wet granulation apparatus. Background Technology

[0002] Acyclovir, a classic nucleoside antiviral drug, has played a vital role in clinical treatment since its introduction. Its core mechanism of action lies in competitively inhibiting viral DNA polymerase, blocking the extension and replication of the viral DNA chain, especially showing high selectivity against herpes simplex virus and varicella-zoster virus. In early development, scientists optimized its oral bioavailability and tissue permeability through structural modifications, enabling it to cross the blood-brain barrier to treat central nervous system infections. However, limited by its poor water solubility and crystal form stability, its formulation development required a balance between dissolution rate and in vivo release behavior, which laid the groundwork for subsequent process improvements.

[0003] In acyclovir formulation production, wet granulation technology is a key method to improve drug dissolution efficiency. This process mixes drug powder with a binder solution to form uniform particles under specific temperature and humidity conditions. This improves the hydrophobicity of the raw material and regulates the drug release rate by controlling particle porosity. For example, in the wet granulation process, using hydroxypropyl methylcellulose as a binder not only enhances particle hardness but also forms a hydrophilic gel layer, promoting sustained drug release in the gastrointestinal tract. Furthermore, by adjusting the agitator speed and the amount of wetting agent added, the particle size distribution can be precisely controlled, avoiding tablet cracking caused by excessive fine powder, ultimately achieving a dual improvement in formulation quality and production stability.

[0004] Patent document CN217940091U discloses a high-efficiency wet granulation device for acyclovir tablets, including a machine casing. This invention utilizes a stirring device. When preparing acyclovir tablets using this device, a large pulley is driven by a power unit to rotate rapidly. The large pulley, in turn, drives the stirring shaft to rotate. The rotation of the stirring shaft causes six mixing blades to rotate at the bottom of the mixing cylinder, stirring and mixing the drug at the bottom of the cylinder. Simultaneously, a connecting rod fixedly connected to the upper end of the stirring shaft also rotates. The rotation of the connecting rod drives four first stirring blades and four second stirring blades fixedly connected to the connecting rod to rotate, stirring the drug inside the mixing cylinder. Under the combined rotation of the six mixing blades, four first stirring blades, and four second stirring blades, the drug mixing inside the mixing cylinder is more efficient, improving the quality of the drug.

[0005] In the prior art of the aforementioned patent, the granulation process involves extruding granules and then scraping them off with a scraper. However, since the granules are wet, they tend to stick to the blade, affecting subsequent scraping and thus impacting the granulation process. Utility Model Content

[0006] Purpose of the utility model: The purpose of this utility model is to provide an acyclovir wet granulation device to solve the above-mentioned shortcomings in the prior art.

[0007] Technical Solution: An acyclovir wet granulation apparatus includes a reaction vessel and a support column fixedly installed on the reaction vessel. A stirring mechanism is installed inside the reaction vessel. A discharge port is located at the bottom of the reaction vessel, and a conveying pipe is connected to the discharge port. The conveying pipe is connected to a screw vacuum pump. A granulation tube is installed at the output end of the screw vacuum pump. A granulation disc is fixedly installed inside the granulation tube. A scraper and a suction assembly are provided on one side of the granulation disc. The suction assembly and the scraper are connected in a driving connection. A granulation outlet is located at the bottom of the granulation tube, directly below the scraper. A receiving trough is located directly below the granulation outlet.

[0008] As a further description of the above technical solution: the input end of the screw vacuum pump is connected to the feed pipe through a flange connector.

[0009] As a further description of the above technical solution: the exhaust assembly includes two support members fixedly installed inside the granulation tube, a fan drive motor is fixedly installed on the two support members, the drive end of the fan drive motor is connected to the fan blades, a rotating shaft is rotatably installed on the granulation disc, the rotating shaft is connected to the drive end of the fan drive motor through a reduction coupling, and a plurality of scrapers are fixedly installed on the rotating shaft.

[0010] As a further description of the above technical solution: the granulation disc is provided with multiple granulation holes, a blocking disc is provided between the granulation disc and the fan blade, the blocking disc is fixedly connected to the granulation tube, the blocking disc is rotatably connected to the rotating shaft, and the blocking disc is provided with multiple through holes.

[0011] As a further description of the above technical solution: the positions of the multiple through holes are coaxially arranged with the multiple particle outlet holes.

[0012] As a further description of the above technical solution: a filter screen is fixedly installed at one end of the granulation tube.

[0013] As a further description of the above technical solution: the stirring mechanism includes an electric motor fixedly installed at the top of the reactor, the output end of the electric motor is connected to a stirring shaft, and multiple sets of stirring blades are provided on the stirring shaft.

[0014] As a further description of the above technical solution: the top of the reactor is provided with a feeding port.

[0015] Beneficial effects: The raw materials for preparing acyclovir are stirred and reacted in a reactor by a stirring mechanism. After the raw materials have fully reacted, they are drawn out from the feed port and conveying pipe by a screw vacuum pump and enter the granulation tube for granulation. The granules are extruded through the granulation hole on the granulation disc and then cut and scraped off by a scraper. At the same time, the exhaust assembly can draw air outward to enhance heat dissipation inside the granulation tube, so that the granules can be fully cooled and dried. On the other hand, the negative pressure generated by the exhaust assembly can draw the granules away from the scraper, preventing the granules from adhering to the scraper, and facilitating the discharge of the granules from the granulation port below and into the receiving tank. Attached Figure Description

[0016] Figure 1 This is a schematic diagram of the overall three-dimensional structure of an acyclovir wet granulation device proposed in this utility model;

[0017] Figure 2 This is a cross-sectional structural diagram of the present invention;

[0018] Figure 3 This utility model Figure 2 A magnified structural diagram at point A;

[0019] Figure 4 This is a three-dimensional cross-sectional view of the internal structure of the granulation tube of this utility model.

[0020] Legend:

[0021] 1. Support column; 2. Reactor; 3. Motor; 4. Feed port; 5. Stirring shaft; 6. Stirring paddle; 7. Discharge port; 8. Conveyor pipe; 9. Screw vacuum pump; 10. Input end; 11. Flange connector; 12. Granulation pipe; 13. Collection trough; 14. Filter screen; 15. Support component; 16. Fan drive; 17. Fan blade; 18. Rotating shaft; 19. Scraper; 20. Granulation disc; 21. Granulation outlet; 22. Baffle disc; 23. Through hole; 24. Reduction coupling; 25. Granulation outlet. Detailed Implementation

[0022] To make the technical solution of this utility model clearer, the present utility model will be further described in detail below with reference to the accompanying drawings and specific embodiments.

[0023] Reference Figure 1-4A wet granulation apparatus for acyclovir includes a reaction vessel 2 and a support column 1 fixedly mounted on the reaction vessel 2. A stirring mechanism is installed inside the reaction vessel 2. A feed port 7 is located at the bottom of the reaction vessel 2, and a conveying pipe 8 is connected to the feed port 7. The conveying pipe 8 is connected to a screw vacuum pump 9. A granulation tube 12 is connected to the output end of the screw vacuum pump 9. A granulation disc 20 is fixedly mounted inside the granulation tube 12. A scraper 19 and a suction assembly are provided on one side of the granulation disc 20. The suction assembly and the scraper 19 are drively connected. A granulation outlet 25 is located at the bottom of the granulation tube 12, directly below the scraper 19. A receiving trough 13 is provided. The raw materials for preparing acyclovir are stirred and reacted in the reactor 2 by a stirring mechanism. After the raw materials have fully reacted, they are drawn out from the feed port 7 and the conveying pipe 8 by the screw vacuum pump 9 and enter the granulation tube 12 for granulation. The granules are extruded through the granulation hole 21 on the granulation disc 20 and then cut and scraped off by the scraper 19. At the same time, the exhaust assembly can draw air to the outside to enhance the heat dissipation inside the granulation tube 12, so that the granules can be fully cooled and dried. On the other hand, the negative pressure generated by the exhaust assembly can draw the granules away from the scraper 19 to prevent the granules from adhering to the scraper 19, so that the granules can be discharged from the granulation port 25 below and then enter the receiving trough 13.

[0024] As a preferred technical solution in this embodiment, the input end 10 of the screw vacuum pump 9 is connected to the feed pipe 8 through a flange connector 11; the vacuum pump is connected to the feed pipe 8 through the flange connector 11, which can increase the sealing performance and prevent material leakage.

[0025] As a preferred embodiment, the ventilation assembly includes two support members 15 fixedly installed inside the granulation tube 12. A fan drive motor 16 is fixedly installed on the two support members 15. The drive end of the fan drive motor 16 is connected to a fan blade 17. A rotating shaft 18 is rotatably installed on the granulation disc 20. The rotating shaft 18 is connected to the drive end of the fan drive motor 16 through a reduction coupling 24. A plurality of scrapers 19 are fixedly installed on the rotating shaft 18. The support members 15 are used to fix the fan drive motor 16. The fan drive motor 16 can drive the fan blade 17 to rotate, thereby ventilating the inside of the granulation tube 12. It also drives the rotating shaft 18 to rotate at a reduced speed through the reduction coupling 24, thereby controlling the scrapers 19 to scrape off the particles on the granulation disc 20.

[0026] As a preferred technical solution of this embodiment, the granulation disc 20 is provided with a plurality of granulation holes 21, and a blocking disc 22 is provided between the granulation disc 20 and the fan blade 17. The blocking disc 22 is fixedly connected to the granulation tube 12 and rotatably connected to the rotating shaft 18. The blocking disc 22 is provided with a plurality of through holes 23. The blocking disc 22 is provided to prevent the granules cut from the granulation holes 21 from popping out, so that the granules can smoothly enter the receiving trough 13.

[0027] As a preferred technical solution in this embodiment, the positions of the plurality of through holes 23 are coaxially arranged with the plurality of particle outlet holes 21; the opening of the through holes 23 and the particle outlet holes 21 are aligned, and the negative pressure formed by the exhaust fan can more accurately suck up the particles.

[0028] As a preferred technical solution in this embodiment, a filter screen 14 is fixedly installed at one end of the granulation tube 12; the filter screen 14 is provided to prevent dust from entering the interior of the granulation tube 12.

[0029] As a preferred technical solution of this embodiment, the stirring mechanism includes a motor 3 fixedly installed at the top of the reactor 2, and the output end of the motor 3 is connected to a stirring shaft 5. Multiple sets of stirring paddles 6 are provided on the stirring shaft 5. The motor 3 can drive the stirring shaft 5 to rotate, thereby further realizing the stirring paddles 6 to stir the internal slurry.

[0030] As a preferred technical solution in this embodiment, the top of the reactor 2 is provided with a feeding port 4; the raw materials to be mixed and prepared can be added through the feeding port 4.

[0031] The embodiments described above are merely illustrative of several implementations of this utility model, and while the descriptions are relatively specific and detailed, they should not be construed as limiting the scope of this utility model patent. It should be noted that those skilled in the art can make various modifications and improvements without departing from the concept of this utility model, and these all fall within the protection scope of this utility model. Therefore, the protection scope of this utility model patent should be determined by the appended claims.

Claims

1. An acyclovir wet granulation apparatus, comprising a reaction vessel (2) and a support column (1) fixedly mounted on the reaction vessel (2), wherein a stirring mechanism is provided inside the reaction vessel (2), a discharge port (7) is provided at the bottom end of the reaction vessel (2), a conveying pipe (8) is connected to the discharge port (7), and the conveying pipe (8) is connected to a screw vacuum pump (9), characterized in that, The output end of the screw vacuum pump (9) is connected to a granulation tube (12). A granulation disc (20) is fixedly installed inside the granulation tube (12). A scraper (19) and a suction assembly are provided on one side of the granulation disc (20). The suction assembly and the scraper (19) are connected in a transmission. A granulation outlet (25) is opened at the bottom end of the granulation tube (12). The granulation outlet (25) is located directly below the scraper (19). A receiving trough (13) is provided directly below the granulation outlet (25).

2. The acyclovir wet granulation apparatus according to claim 1, characterized in that, The input end (10) of the screw vacuum pump (9) is connected to the feed pipe (8) through a flange connector (11).

3. The acyclovir wet granulation apparatus according to claim 1, characterized in that, The exhaust assembly includes two support members (15) fixedly installed inside the granulation tube (12). A fan drive motor (16) is fixedly installed on the two support members (15). The drive end of the fan drive motor (16) is connected to a fan blade (17). A rotating shaft (18) is rotatably installed on the granulation disc (20). The rotating shaft (18) is connected to the drive end of the fan drive motor (16) through a reduction coupling (24). Multiple scrapers (19) are fixedly installed on the rotating shaft (18).

4. The acyclovir wet granulation apparatus according to claim 1, characterized in that, The granulation disc (20) has multiple granulation holes (21), and a blocking disc (22) is provided between the granulation disc (20) and the fan blade (17). The blocking disc (22) is fixedly connected to the granulation tube (12), and the blocking disc (22) is rotatably connected to the rotating shaft (18). The blocking disc (22) has multiple through holes (23).

5. The acyclovir wet granulation apparatus according to claim 4, characterized in that, The positions of the multiple through holes (23) are coaxially arranged with the multiple particle outlet holes (21).

6. The acyclovir wet granulation apparatus according to claim 1, characterized in that, A filter screen (14) is fixedly installed at one end of the granulation tube (12).

7. The acyclovir wet granulation apparatus according to claim 1, characterized in that, The stirring mechanism includes a motor (3) fixedly installed at the top of the reactor (2), and the output end of the motor (3) is connected to a stirring shaft (5), on which multiple sets of stirring paddles (6) are provided.

8. An acyclovir wet granulation apparatus according to claim 1, characterized in that, The reactor (2) is provided with a feed port (4) at the top.

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