A device for rapid collection of viable exfoliated cells from a body fluid sample

Abstract

The utility model discloses a kind of for effective exfoliation cell quick acquisition device in body fluid sample, including sample collection bottle, switch valve and stationary rack, wherein sample collection bottle top end is provided with liquid inlet, bottom end is provided with liquid outlet;When sample collection bottle is placed on stationary rack, the liquid outlet of sample collection bottle bottom end can be connected with switch valve, and the liquid in bottle can be controlled to flow out or cut off by switch valve.By the sample collection bottle provided by the utility model, after effective cell in body fluid sample is naturally precipitated, supernatant does not need to be poured out through the bottle mouth above collection bottle, but effective exfoliation cell of sedimentation can be directly collected from the liquid outlet of collection bottle bottom, greatly improve the work efficiency of effective exfoliation cell collection.

Description

Technical Field

[0001] This invention relates to the technical field of body fluid specimen collection devices for cell precipitation in cytopathology, and particularly to a device for rapid collection of effective exfoliated cells from body fluid samples. Background Technology

[0002] Non-gynecological exfoliative cytology specimens mainly include serous cavity effusions, urine, peritoneal lavage fluid, pelvic lavage fluid, bronchoalveolar lavage fluid, cyst fluid, cerebrospinal fluid, vitreous fluid, and sputum. Determining the nature of the effusion and accurately identifying its cellular components is crucial for disease diagnosis and clinical treatment.

[0003] Currently, clinical procedures commonly use infusion bottles, glass saline bottles, plastic bottles, drainage bags, and specimen boxes when collecting body fluid samples. Some patients also bring their own beverage bottles, wine bottles, medicine bottles, and condiment bottles for sample submission. These collection containers are usually flat-bottomed, which does not meet the requirements of standardized laboratory construction and biosafety guidelines, and makes it difficult to collect effective exfoliated cell precipitates from body fluid samples for pathological analysis.

[0004] A search revealed Chinese Patent Publication No. CN222081181U, which discloses a body fluid specimen collection device, including a liquid specimen collection bottle and a replaceable cap. The bottom of the liquid specimen collection bottle is designed as a retractable bottom, driven by an external pull ring. The retractable bottom has a conical structure, and under external force, it can be located inside or outside the liquid specimen collection bottle, deforming through extension and retraction. Before stretching and deformation, the retractable bottom is an upright cone shape; after stretching and deformation, it becomes an inverted cone shape, causing cell precipitation to concentrate at the bottom of the bottle. When the supernatant is poured out through the upper bottle opening, the cells are concentrated at the bottom of the cone and are less likely to be poured out of the storage device bottle with the supernatant, thus ensuring the number of cells collected.

[0005] However, the conical bottom of the liquid sample collection bottle has no opening. After cell precipitation, if the supernatant is poured out through the upper opening, excessive force can cause the cells settled at the bottom to resuspend in the supernatant, requiring a certain amount of time for reprecipitation before effective cells can be collected from the body fluid. Furthermore, some patients' serous cavity effusions produce large fibrin clots during precipitation. These fibrin clots resemble large clumps of cotton wool and float on the surface of the effusion. When the bottle is tilted, these fibrin clots can block the opening, preventing the effusion from flowing out from the upper opening. Because of their large size, researchers cannot use syringes or pipettes to bypass the fibrin clots and collect cells from the bottom of the bottle, making the process of collecting effective cells from the body fluid sample even more cumbersome. Utility Model Content

[0006] The purpose of this invention is to at least solve one of the technical problems existing in the prior art, and to provide a device for the rapid collection of exfoliated cells from body fluid samples, which can assist laboratory personnel in the effective and rapid collection of exfoliated cells from body fluids.

[0007] This invention provides a device for rapid collection of effective exfoliated cells from body fluid samples, comprising: a sample collection bottle, a switch valve, and a settling rack;

[0008] The sample collection bottle is made of transparent material, with an inlet at the top and an outlet at the bottom, and graduation lines on the side wall. When the sample collection bottle is placed on the settling rack, the outlet at the bottom of the sample collection bottle can be connected to the switch valve, which can control the flow of liquid in the bottle to either flow out or stop.

[0009] Preferably, the sample collection bottle has a first inlet and a second inlet at its top, a first top cover is provided on the outside of the first inlet, and a second top cover is provided on the outside of the second inlet;

[0010] The diameter of the first inlet is larger than that of the second inlet.

[0011] Preferably, the bottom of the sample collection bottle is provided with an extended bottle wall and a sloping bottle bottom; the sloping bottle bottom is in the shape of an inverted cone, and the liquid outlet is provided at the apex of the inverted cone.

[0012] Preferably, the outer side of the liquid outlet is provided with an external thread; the bottom of the liquid outlet is provided with an elastic sealing film and a bottom cover; the elastic sealing film is fixedly attached to the bottom circumferential wall of the liquid outlet; the bottom cover is detachably fastened to the bottom of the liquid outlet.

[0013] Preferably, the height of the extended bottle wall is higher than the total height of the sloping bottle bottom plus the liquid outlet and the bottom cover.

[0014] Preferably, a filter screen is provided above the sloping bottom of the sample collection bottle inside the sample collection bottle;

[0015] The filter screen has a thin sheet structure, with multiple filter holes of different diameters spaced apart on the middle filter sheet; filter screen connecting rods are arranged around the outer periphery of the filter sheet at intervals; there is a clear liquid gap between the outer periphery of the filter sheet and the inner wall of the sample collection bottle.

[0016] Preferably, the upper end of the switch valve is provided with an upper switch valve interface; the middle part of the switch valve is provided with a rotary valve chamber, and a rotary plug is rotatably disposed inside the rotary valve chamber; a rotary pipe and a rotary support are disposed inside the rotary plug, and the rotation axis of the rotary support is fixedly connected to the rotary handle; the lower part of the switch valve is provided with a lower switch valve interface; the lower switch valve interface can be connected to a flexible hose.

[0017] Preferably, the upper interface of the switch valve has a concentric ring structure with inner and outer layers. The inner wall of the outer ring is provided with an upper interface internal thread that matches the external thread of the liquid outlet. The inner ring of the upper interface of the switch valve is an interface tube, and the top end of the interface tube is provided with at least one spike. The highest point of the spike is lower than the top plane of the upper end of the switch valve. The outer periphery of the interface tube fits against the inner periphery of the liquid outlet.

[0018] Preferably, a sample bottle support platform is provided on the upper part of the settling rack, and a settling hole is provided at the bottom of the sample bottle support platform; a centrifuge tube placement hole is provided below the settling hole.

[0019] This utility model has the following beneficial effects:

[0020] 1. The sample collection bottle provided by this utility model has an outlet at the bottom. After the cells have settled naturally, it is not necessary to pour out the supernatant through the upper bottle opening. Instead, the effective detached cells precipitated in the body fluid sample can be collected directly from the outlet at the bottom of the bottle.

[0021] 2. The sample collection bottle provided by this utility model is equipped with a filter screen, which can effectively block the fibrin clots that coagulate in the serous cavity effusion, and effectively collect the exfoliated cells.

[0022] 3. The switch valve provided by this utility model is inserted into the liquid outlet at the bottom of the sample collection bottle by rotating and inserting. The movement is small and stable, and will not cause excessive shaking, thus avoiding excessive movement that could cause the precipitated cells to resuspend.

[0023] 4. The static rack provided by this utility model can set up the sample collection bottle, providing sufficient operating space for the rotation connection of the switch valve, and realizing the collection of liquid from the bottom. Attached Figure Description

[0024] The present invention will be further described below with reference to the accompanying drawings and embodiments;

[0025] Figure 1 This is an image of the sample collection bottle for a rapid collection device that effectively removes exfoliated cells from body fluid samples.

[0026] Figure 2 A diagram showing the open state of the inlet of the sample collection bottle;

[0027] Figure 3 This is a diagram of the internal structure of the sample collection bottle;

[0028] Figure 4 A detailed diagram of the sealing structure of the liquid outlet at point A of the sample collection bottle;

[0029] Figure 5 Exploded view of the sealing structure of the liquid outlet of the sample collection bottle;

[0030] Figure 6 A detailed diagram of the filter screen connection structure at point B of the sample collection bottle;

[0031] Figure 7 This is a schematic diagram of the sample collection bottle in a static state.

[0032] Figure 8 A cross-sectional view of the sample collection bottle in its static state;

[0033] Figure 9 A schematic diagram of the external appearance of the switching valve of a device for rapid collection of exfoliated cells from body fluid samples.

[0034] Figure 10 This is a cross-sectional view of the valve in the closed state.

[0035] Figure 11 Cross-sectional view of the valve in the open state;

[0036] Figure 12 This is a detailed cross-sectional view of the upper interface at point C of the switching valve.

[0037] Figure 13 Detailed diagram of the connection at point D after the upper interface of the switch valve is screwed into the outlet of the sample collection bottle;

[0038] Figure 14 This is a schematic diagram of the static rack structure of a device for rapid collection of effectively exfoliated cells from body fluid samples.

[0039] Legend:

[0040] 1. Sample collection bottle; 1a. Extended bottle wall; 2. Sloping bottle bottom; 3. First inlet; 3a. First top cap; 4. Second inlet; 4a. Second top cap; 5. Outlet; 5a. Outlet external thread; 6. Filter screen; 6a. Filter hole; 6b. Filter screen connecting rod; 6c. Clear liquid gap; 7. Elastic sealing membrane; 8. Bottom cap; 9. Graduation line; 10. Switch valve; 11. Upper interface of switch valve; 11a. Internal thread of upper interface; 11b. Interface tube; 11c. Spike; 12. Rotary plug; 12a. Rotary tube; 13. Rotary handle; 13a. Rotary support; 14. Lower interface of switch valve; 15. Hose; 16. Stagnation rack; 16a. Sample bottle support platform; 16b. Stagnation hole; 16c. Centrifuge tube placement hole. Detailed Implementation

[0041] This section will describe in detail the specific embodiments of the present utility model. The preferred embodiments of the present utility model are shown in the accompanying drawings. The purpose of the drawings is to supplement the textual description with graphics, so that people can intuitively and vividly understand each technical feature and the overall technical solution of the present utility model, but they should not be construed as limiting the scope of protection of the present utility model.

[0042] Reference Figure 1-14 This invention provides a device for rapid collection of effective exfoliated cells from body fluid samples, including a sample collection bottle 1, a switch valve 10, and a settling rack 16. The sample collection bottle 1 is made of transparent material, with an inlet at the top and an outlet at the bottom, and graduation lines 9 on the side wall for collecting body fluid samples and observing the volume and sedimentation state of the sample inside the bottle. When the sample collection bottle 1 is placed on the settling rack 16, the outlet at the bottom of the sample collection bottle 1 can be connected to the switch valve 10. The switch valve 10 can control the flow of liquid in the bottle to either stop or stop, making it convenient for researchers to collect effective exfoliated cells from the body fluid sample that has settled at the bottom of the bottle.

[0043] Furthermore, such as Figure 2 As shown, the sample collection bottle 1 has two inlets at its top: a first inlet 3 and a second inlet 4. The diameter of the first inlet 3 is larger than that of the second inlet 4. The first inlet 3 is used for introducing body fluid samples through a large-diameter collection device, such as a medical storage bag. The second inlet 4 is used for introducing body fluid samples through a small-diameter collection device, such as a medical suction tube. A first cap 3a is provided on the outside of the first inlet 3, and a second cap 4a is provided on the outside of the second inlet 4. The first cap 3a and the second cap 4a are fixedly connected to the first inlet 3 and the second inlet 4, respectively, by a flexible connecting rod. After the body fluid sample collection is completed, the first cap 3a and the second cap 4a are closed to prevent sample contamination or spillage during transportation.

[0044] Furthermore, such as Figures 3 to 6 As shown, the bottom of the sample collection bottle 1 is provided with an extended bottle wall 1a and a sloping bottle bottom 2; the sloping bottle bottom 2 is in the shape of an inverted cone, and a liquid outlet 5 is provided at the apex of the inverted cone; when the sample collection bottle 1 is placed on the settling rack 16, the liquid outlet 5 can be connected to the switch valve 10.

[0045] A filter screen 6 is installed above the sloping bottom 2 inside the sample collection bottle 1. The filter screen 6 can prevent fibrin blocks in the serous cavity effusion from sinking and blocking the outlet 5.

[0046] Furthermore, such as Figures 4 to 5As shown, the outlet 5 has an external thread 5a on its outer side; the bottom of the outlet 5 is provided with an elastic sealing film 7 and a bottom cover 8. The elastic sealing film 7 is made of a highly elastic material and fits snugly against the bottom circumferential wall of the outlet 5. It cannot be easily torn, but it can be punctured by sharp objects; when the elastic sealing film 7 is punctured by sharp objects, it will retract to the circumferential wall. The bottom cover 8 is made of elastic rubber and is detachably fastened to the bottom of the outlet 5 to protect the elastic sealing film 7 from being punctured by sharp objects.

[0047] When the sample collection bottle 1 is not in use, the first top cap 3a and the second top cap 4a seal the first inlet 3 and the second inlet 4, respectively; the elastic sealing film 7 seals the outlet 5, and the bottom cap 8 protects the elastic sealing film 7 from being punctured by sharp objects. The height of the extended bottle wall 1a is higher than the total height of the sloping bottle bottom 2 plus the outlet 5 and the bottom cap 8, so that the sample collection bottle 1 can be placed on a horizontal table.

[0048] Furthermore, such as Figure 6 As shown, the filter screen 6 has a thin sheet structure, with multiple filter holes 6a of different diameters spaced apart on the middle filter sheet to intercept irregular flocculent fibrin aggregates; filter screen connecting rods 6b are arranged around the outer periphery of the filter sheet at intervals to fix it to the inner wall of the sample collection bottle 1; there is a clear liquid gap 6c between the outer periphery of the filter sheet and the inner wall of the sample collection bottle 1 to allow the clear liquid to pass over the irregular flocculent fibrin aggregates in the middle and continue to precipitate.

[0049] Because the fibrin clots in the serous cavity effusion are irregular, soft, flocculent aggregates, when there is a large amount of fluid in the bottle, the fibrin clots tend to float in the upper middle part of the liquid and will not block the filter holes 6a on the filter screen 6. As the liquid flows out, the floating fibrin clots will descend with the liquid surface and gradually block the filter holes 6a on the filter screen from the center outwards. Because there is a clear liquid gap 6c between the outer periphery of the filter screen and the inner wall of the sample collection bottle 1, the irregular and extremely soft but relatively fixed fibrin clots are unlikely to completely block all the space of the filter screen 6. At this time, the effective exfoliated cells that need to be collected have already been discharged with the clear liquid at the bottom of the sloping bottle 2 and the bottom of the outlet 5.

[0050] Specifically, sample collection bottle 1 can be made of transparent medical plastic.

[0051] When using sample collection bottle 1, place it on a level table for easy introduction of liquid samples. Select either the first cap 3a or the second cap 4a according to the diameter of the liquid collection device. First, pour in a certain amount of cell fixative, which is used to fix the precipitated effective cells and maintain their unique biological activity. The poured cell fixative should at least cover the bottom area 2 of the sloping bottle. Then, insert the liquid collection device into the first inlet 3 or the second inlet 4, wait for the liquid sample to be introduced, close the first cap 3a or the second cap 4a, and transport the sample collection bottle to the pathology testing center.

[0052] like Figures 7 to 8 As shown, after the sample collection bottle 1 is transported to the pathology testing center, the sample collection bottle 1 is placed on the settling rack 16, the bottom cap 8 is removed, the upper end of the closed switch valve 10 is inserted into the elastic sealing film 7, and the switch valve 10 is rotated to make it tightly connected to the outlet 5; after the accumulated fluid has settled, one end of the tubing 15 is connected to the lower end of the switch valve, the other end of the tubing 15 is placed into the collection device, and the switch valve 10 is opened to collect the effective exfoliated cells in the body fluid sample.

[0053] Furthermore, such as Figures 9 to 12 As shown, the upper end of the switch valve 10 is provided with an upper switch valve interface 11; a through pipe is provided inside the upper switch valve interface 11 for connecting to the outlet 5; a rotary valve chamber is provided in the middle of the switch valve, and a rotary plug 12 is rotatably installed inside the rotary valve chamber; a rotary through pipe 12a and a rotary support 13a are provided inside the rotary plug 12, and the rotation shaft of the rotary support 13a is fixedly connected to the rotary handle 13. The rotary plug 12 can be rotated in the rotary valve chamber by rotating the handle 13, thereby connecting or disconnecting the rotary through pipe 12a from the through pipe inside the upper switch valve interface 11; a lower switch valve interface 14 is provided at the lower part of the switch valve 10, and a through pipe that can connect to the rotary through pipe 12a is provided inside the lower switch valve interface 14; a multi-layered convex ring is provided at the lower end of the outer wall of the lower switch valve interface 14. When one end of the hose 15 is sleeved on the outer wall of the lower switch valve interface 14, the multi-layered convex ring can increase the friction.

[0054] It is understandable that the upper port 11 and the lower port 14 of the switching valve are detachably fitted with matching soft covers to keep the internal passage of the switching valve sealed when not in use.

[0055] Furthermore, such as Figure 12As shown, the upper interface 11 of the switch valve has a concentric ring structure with inner and outer layers. The inner wall of the outer ring is provided with an upper interface inner thread 11a that is adapted to the external thread 5a of the liquid outlet. The inner ring of the upper interface 11 of the switch valve is an interface tube 11b. The top of the interface tube 11b is provided with at least one spike 11c. The highest point of the spike 11c is slightly lower than the top plane of the upper interface 11 of the switch valve to avoid scratching the experimental personnel when not in use. The interface tube 11b and the spike 11c are made of hard plastic. The outer circumference of the interface tube 11b fits with the inner circumference of the liquid outlet 5. The upper end has a certain slope and the height is slightly higher than the highest spiral point of the upper interface inner thread 11a. The thickness is relatively thin.

[0056] When using, such as Figure 13 As shown, the sample collection bottle 1 is placed on the settling rack 16, the bottom cap 8 is removed, and the closed switch valve 10 is aligned with the outlet 5. The upper interface 11 of the switch valve is slightly raised so that the spike 11c pierces the elastic sealing film 7. The upper interface 11 of the switch valve is raised until the internal thread 11a of the upper interface abuts the external thread 5a of the outlet. The upper interface 11 of the switch valve is rotated, and the spike 11c rotates and cuts the elastic sealing film 7. The elastic sealing film 7 is pushed up from the cut and elastically retracts to the outer circumference, and is pushed by the interface tube 11b into the gap between the upper interface 11 of the switch valve and the outlet 5.

[0057] Furthermore, such as Figure 14 As shown, a sample bottle support platform 16a is provided on the upper part of the settling rack 16, and a settling hole 16b is provided at the bottom of the sample bottle support platform 16a; the sample bottle support platform 16a and the settling hole 16b can set up the sample collection bottle 1, leaving sufficient space for the switch valve 10 to connect to the liquid outlet 5; a centrifuge tube placement hole 16c is provided below the settling hole 16b, which is used to place the collection device (e.g., 50 ml centrifuge tube); the center of the settling hole 16b and the centrifuge tube placement hole 16c are on the same vertical line.

[0058] With the settling rack 16 provided by this utility model, the experimenter can complete the precipitation of body fluid samples by connecting the sample collection bottle 1 and the switch valve 10, or wait for the body fluid samples in the sample collection bottle 1 to settle before connecting the switch valve 10.

[0059] Specifically, place the sample collection bottle 1 on the sample bottle support 16a on the upper part of the settling rack 16, so that the center line of the outlet 5 is aligned with the center of the settling hole 16b and the centrifuge tube placement hole 16c; after the body fluid sample has settled, remove the bottom cap 8; remove the closed switch valve 10, remove the upper interface soft cap, keep the lower interface soft cap, and lift the closed switch valve 10 from the gap between the settling hole 16b and the centrifuge tube placement hole 16c, aligning it with the center line of the outlet 5, and rotate the upper interface of the switch valve. 11. Fully insert the interface tube 11b into the outlet 5, remove the soft cap at the lower interface of the switch valve 10, and fit a suitable length of flexible tube 15 onto the outer wall of the lower interface 14 of the switch valve. Place the collection device in the centrifuge tube placement hole 16c (centrifuge tube placement hole), put the other end of the flexible tube 15 into the collection device, and turn the rotating handle 13 to connect the rotating tube 12a inside the rotating plug 12 to the internal channel of the switch valve, so that the effective cell serum flows into the collection device; until the collection is complete, close the switch valve 10.

[0060] This invention provides a sample collection bottle with an outlet at the bottom, along with a matching valve and a settling rack, enabling cells to naturally settle at the bottom of the bottle and allowing for controlled collection. After natural cell settling, there is no need to pour out the supernatant through the top of the bottle; instead, effectively detached cells can be collected directly from the outlet at the bottom of the bottle, significantly improving work efficiency.

[0061] The sample collection bottle provided by this invention is equipped with a filter screen, which can effectively block fibrin clots that coagulate in the serous cavity fluid, prevent the fibrin clots from sinking and clogging the outlet at the bottom of the collection bottle, and enable rapid and effective collection of detached cells.

[0062] The embodiments of the present utility model have been described in detail above with reference to the accompanying drawings. However, the present utility model is not limited to the above embodiments. Within the scope of knowledge possessed by those skilled in the art, various changes can be made without departing from the spirit of the present utility model.

Claims

1. A device for rapid collection of exfoliated cells from bodily fluid samples, characterized in that, include: Sample collection bottle (1), switch valve (10) and settling rack (16); The sample collection bottle (1) is made of transparent material, with an inlet at the top and an outlet (5) at the bottom, and graduation lines (9) on the side wall. When the sample collection bottle (1) is placed on the stationary rack (16), the outlet (5) at the bottom of the sample collection bottle (1) can be connected to the switch valve (10), and the switch valve (10) can control the flow of liquid in the bottle to flow out or to stop the flow.

2. The device for rapid collection of effectively exfoliated cells from body fluid samples according to claim 1, characterized in that, The sample collection bottle (1) has a first liquid inlet (3) and a second liquid inlet (4) at its top. A first top cover (3a) is provided on the outside of the first liquid inlet (3), and a second top cover (4a) is provided on the outside of the second liquid inlet (4). The diameter of the first liquid inlet (3) is larger than that of the second liquid inlet (4).

3. The device for rapid collection of effectively exfoliated cells from body fluid samples according to claim 1, characterized in that, The sample collection bottle (1) is provided with an extended bottle wall (1a) and a sloping bottle bottom (2) at the bottom; the sloping bottle bottom (2) is in the shape of an inverted cone, and the liquid outlet (5) is provided at the apex of the inverted cone.

4. The device for rapid collection of effectively exfoliated cells from body fluid samples according to claim 3, characterized in that, The outlet (5) is provided with an external thread (5a) on the outside; an elastic sealing film (7) and a bottom cover (8) are provided at the bottom of the outlet (5); the elastic sealing film (7) is fixedly attached to the bottom circumferential wall of the outlet (5); the bottom cover (8) is detachably fastened to the bottom of the outlet (5).

5. The device for rapid collection of effectively exfoliated cells from body fluid samples according to claim 4, characterized in that, The height of the extended bottle wall (1a) is higher than the total height of the sloping bottle bottom (2) plus the liquid outlet (5) and the bottom cover (8).

6. The device for rapid collection of effective exfoliated cells from body fluid samples according to claim 3, characterized in that, A filter screen (6) is provided above the sloping bottom (2) inside the sample collection bottle (1). The filter screen (6) is a thin sheet structure, with multiple filter holes (6a) of different diameters spaced apart on the middle filter sheet; filter screen connecting rods (6b) are arranged around the outer periphery of the filter sheet at intervals; there is a clear liquid gap (6c) between the outer periphery of the filter sheet and the inner wall of the sample collection bottle (1).

7. The device for rapid collection of effective exfoliated cells from body fluid samples according to claim 5, characterized in that, The upper end of the switch valve (10) is provided with a switch valve upper interface (11); the middle part of the switch valve (10) is provided with a rotary valve chamber, and a rotary plug (12) is rotatably provided inside the rotary valve chamber; a rotary pipe (12a) and a rotary support (13a) are provided inside the rotary plug (12), and the rotation axis of the rotary support (13a) is fixedly connected to the rotary handle (13); the lower part of the switch valve (10) is provided with a switch valve lower interface (14); the switch valve lower interface (14) can be connected to a hose (15).

8. The device for rapid collection of effectively exfoliated cells from body fluid samples according to claim 7, characterized in that, The upper interface (11) of the switch valve has a concentric ring structure with inner and outer layers. The inner wall of the outer ring is provided with an upper interface inner thread (11a) that is adapted to the external thread (5a) of the liquid outlet. The inner ring of the upper interface (11) of the switch valve is an interface tube (11b). The top end of the interface tube (11b) is provided with at least one spike (11c). The highest point of the spike (11c) is lower than the top plane of the upper interface (11) of the switch valve. The outer periphery of the interface tube (11b) fits against the inner periphery of the liquid outlet (5).

9. The device for rapid collection of effectively exfoliated cells from body fluid samples according to claim 1, characterized in that, The sample bottle support platform (16a) is provided on the upper part of the static rack (16), and a static hole (16b) is provided at the bottom of the sample bottle support platform (16a); a centrifuge tube placement hole (16c) is provided below the static hole (16b).

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