An apparatus for dry-chemical chromogenic substrate method detection
By designing top and bottom isolation components and utilizing a sliding seal structure of a transparent observation plate and delivery body, the problem of dry chemical test strips being exposed to the external environment during the testing process is solved, resulting in higher testing accuracy.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- SHANGHAI VASCUTECH DIAGNOSIS CO LTD
- Filing Date
- 2025-07-11
- Publication Date
- 2026-06-26
Smart Images
Figure CN224416724U_ABST
Abstract
Description
Technical Field
[0001] This utility model relates to the technical field of dry chemical analysis and testing equipment, and more specifically, to a device for detection using the dry chemical chromogenic substrate method. Background Technology
[0002] Dry chemistry analysis, as opposed to wet chemistry, refers to a method where liquid test samples are directly added to commercially available dry reagent strips specifically manufactured for different projects. The moisture in the sample acts as a solvent, triggering a specific chemical reaction for analysis. This enzymatic-based analytical method, also known as dry reagent chemistry or solid-phase chemistry, employs reflectance spectrometry or differential electrode methods for measurement. Its main characteristics include: high accuracy and speed (results typically within 3-4 minutes); ease of operation, requiring no daily calibration; and no need for any equipment storage. Other reagents or any solutions can be prepared; no sample pretreatment is required, and the multilayer membrane has selective filtration function, thereby reducing the influence of interfering substances during the measurement process; the sample volume is small, and the water during the reaction is supplied by the liquid component in the sample, improving the measurement sensitivity; the multilayer membrane based on the differential electrode method is for single use, thus having the advantages of conventional electrode methods without their disadvantages; in some cases, it can replace the wet chemistry method for emergency samples, and can also be used for preliminary screening of genetic thrombotic diseases, while existing test strips for dry chemistry testing need to be exposed to air during use, which can easily cause contamination of the test strips. The applicant has a prior patent application: Chinese patent publication (announcement) number CN217443177U discloses a test strip for detecting heparin anticoagulants using a dry chemistry chromogenic substrate method. This patented technology uses a push plate to drive a connecting rod to move, thereby causing the connecting rod to drive a baffle to move. The baffle opens or closes the observation tube during movement. This allows the observation tube to be opened when the test sample is added and closed afterward, enabling observation of the reaction between the test sample and the test strip inside the tube in the closed state. This avoids the influence of external environmental factors on the test results after the test strip is exposed to the external environment during the testing process, thus improving detection accuracy. However, the technical solution disclosed in the above patent still has at least the following problems: In this technical solution, the test strip is also exposed to the external environment when it is installed in the observation tube; and when the test sample is added, the observation tube is opened, exposing the test strip to the external environment as well. Since the test strip is still exposed to the external environment in both stages, external environmental factors can also affect the test results. Utility Model Content
[0003] The purpose of this invention is to provide a device for detection using the dry chemical chromogenic substrate method, which can further avoid exposing the test strip to the external environment and greatly improve the accuracy of the detection results.
[0004] The embodiments of this utility model are implemented as follows:
[0005] This application provides an apparatus for detection using a dry chemical chromogenic substrate method, comprising a base with test holes, including:
[0006] A top isolation assembly includes a transparent observation plate. The top of the base has a first through groove communicating with the test hole. The transparent observation plate is disposed in the first through groove and can slide into the test hole along the extension direction of the first through groove to block the test hole.
[0007] The bottom isolation assembly includes an upper plate and a lower plate. The bottom of the base has a second through groove for feeding test strips. The second through groove communicates with the test hole. The lower plate and the upper plate are combined to form a conveyor. The lower plate located on the side of the upper plate has a test strip groove for placing test strips. The conveyor is disposed in the second through groove and can move along the extension direction of the second through groove into the test hole, so that the test strip reaches the test area of the test hole.
[0008] In some embodiments of this utility model, a first push rod for pushing the transparent observation plate to slide along the first through groove is connected to the transparent observation plate. A first guide groove parallel to the extension direction of the first through groove is provided on the base. The first through groove is connected to the first guide groove. The free end of the first push rod passes through the first guide groove, and the first push rod can slide freely along the extension direction of the first guide groove.
[0009] In some embodiments of this utility model, the conveying body is provided with a second push rod for pushing the conveying body to move along the extension direction of the second through groove. The second push rod passes through the upper plate and the lower plate in sequence and is threadedly connected to both the upper plate and the lower plate. The base is provided with a second guide groove parallel to the extension direction of the second through groove. The second through groove communicates with the second guide groove. The free end of the second push rod passes through the second guide groove, and the second push rod can slide freely along the extension direction of the second guide groove.
[0010] In some embodiments of this utility model, a first auxiliary push rod is connected to the upper plate, which can push the upper plate to move along the extension direction of the second through groove. A third guide groove is provided on the base, which is parallel to the extension direction of the second through groove. The second through groove is connected to the third guide groove. The free end of the first auxiliary push rod passes through the third guide groove, and the first auxiliary push rod can slide freely along the extension direction of the third guide groove.
[0011] In some embodiments of this utility model, a second auxiliary push rod is connected to the lower plate, the second auxiliary push rod can push the lower plate to move along the extension direction of the second through groove, a fourth guide groove is provided on the base parallel to the extension direction of the second through groove, the second through groove communicates with the fourth guide groove, the free end of the second auxiliary push rod passes through the fourth guide groove, and the second auxiliary push rod can slide freely along the extension direction of the fourth guide groove.
[0012] It should be noted that in other embodiments, the lower plate can also be directly fixed to the bottom of the test hole, so that the test strip slot is within the detection area. Before detection, the test strip needs to be placed in the test strip slot, and the upper plate and lower plate should be aligned. Thus, in this embodiment, the second through groove only needs to be used to guide the upper plate and slide in a sealing fit with it.
[0013] In some embodiments of this utility model, the transparent observation plate is sealed to the inner wall of the first through groove.
[0014] In some embodiments of this utility model, the conveying body is sealed to the inner wall of the second through groove.
[0015] In some embodiments of this utility model, the transparent observation plate is provided with a sample liquid injection hole, and two transparent membrane flaps are provided on the transparent observation plate. The two transparent membrane flaps are spliced together to form a membrane valve, and the membrane valve covers the sample liquid injection hole.
[0016] Compared with the prior art, the embodiments of this utility model have at least the following advantages or beneficial effects:
[0017] This invention provides an apparatus for detection using a dry chemical chromogenic substrate method. In this apparatus, a top isolation component provides isolation before and during the observation phase, effectively preventing the test strip from contacting the external environment at the test well end. Specifically, the transparent observation plate seals the test well after the sample is added, preventing contact with the external environment and improving detection accuracy. Users can directly observe changes in the test strip through the transparent observation plate. The bottom isolation component ensures that the test strip is not exposed to the external environment when installed in the test well, while also facilitating test strip replacement. Specifically, the test strip slot on the lower plate is used to hold the test strip. When the upper plate and plate body are combined, they seal the test strip slot, preventing contact between the test strip and the external environment during installation. The lower and upper plate bodies are combined to form a conveyor, which is then fed into the bottom of the test well along a second through-slot. This completes the test strip installation. After installation, the conveyor effectively seals the second through-slot, ensuring no contact with the external environment during the detection phase. In this way, the top and bottom isolation components work together to further prevent the test strip from being exposed to the external environment, greatly improving the accuracy of the test results. Attached Figure Description
[0018] To more clearly illustrate the technical solutions of the embodiments of this utility model, the drawings used in the embodiments will be briefly introduced below. It should be understood that the following drawings only show some embodiments of this utility model and should not be regarded as a limitation on the scope. For those skilled in the art, other related drawings can be obtained based on these drawings without creative effort.
[0019] Figure 1 This is a three-dimensional structural diagram of an embodiment of the present utility model;
[0020] Figure 2 This is a schematic diagram of the three-dimensional cross-sectional structure of the second push rod in an embodiment of this utility model;
[0021] Figure 3 This is a schematic diagram of the installation structure of the conveyor body in an embodiment of this utility model;
[0022] Figure 4 This is a schematic diagram of the three-dimensional cross-sectional structure of the first auxiliary push rod in an embodiment of this utility model;
[0023] Figure 5 This is a three-dimensional cross-sectional structural diagram of the fourth guide groove in an embodiment of this utility model;
[0024] Figure 6 This is a three-dimensional cross-sectional structural diagram of the first through groove in an embodiment of this utility model;
[0025] Figure 7 This is a schematic diagram of the three-dimensional cross-sectional structure of the first push rod in an embodiment of this utility model.
[0026] Icons: 1-Base; 2-Test hole; 3-Transparent observation plate; 4-First through groove; 5-Conveyor body; 501-Upper plate; 502-Lower plate; 6-Second through groove; 7-Test paper slot; 8-First push rod; 9-First guide groove; 10-Second push rod; 11-Second guide groove; 13-First auxiliary push rod; 14-Third guide groove; 15-Second auxiliary push rod; 16-Fourth guide groove; 17-Transparent membrane flap. Detailed Implementation
[0027] To make the objectives, technical solutions, and advantages of the embodiments of this utility model clearer, the technical solutions of the embodiments of this utility model will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this utility model, and not all embodiments. The components of the embodiments of this utility model described and shown in the accompanying drawings can generally be arranged and designed in various different configurations.
[0028] Therefore, the following detailed description of the embodiments of the present invention provided in the accompanying drawings is not intended to limit the scope of the claimed invention, but merely to illustrate selected embodiments of the invention. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention without inventive effort are within the scope of protection of the present invention.
[0029] Example
[0030] Please refer to Figures 1-7 , Figures 1-7 As shown, this embodiment provides an apparatus for detection using a dry chemical chromogenic substrate method, including a base 1 with a test hole 2, a top isolation component, and a bottom isolation component. The top isolation component includes a transparent observation plate 3. A first through groove 4 communicating with the test hole 2 is formed on the top of the base 1. The transparent observation plate 3 is disposed within the first through groove 4 and can slide along the extension direction of the first through groove 4 into the test hole 2, sealing the test hole 2. The top isolation component serves to isolate the test strip before and during the observation stage, effectively preventing the test strip from contacting the external environment at the end of the test hole 2 during the process. Specifically, the transparent observation plate 3 can seal the test hole 2 during the observation stage after the test sample is added, preventing contact with the external environment and improving detection accuracy. The user can directly observe the changes in the test strip through the transparent observation plate 3. The first through groove 4 allows the transparent observation plate 3 to move along its extension direction, thereby changing its position within the test hole 2 as needed.
[0031] The aforementioned bottom isolation assembly includes an upper plate 501 and a lower plate 502. A second through groove 6 for feeding test strips is provided at the bottom of the base 1. The second through groove 6 communicates with the test hole 2. The lower plate 502 overlaps with the upper plate 501 to form a conveyor 5. A test strip slot 7 for placing test strips is provided on the lower plate 502 located on the side of the upper plate 501. The conveyor 5 is disposed within the second through groove 6 and can move along the extension direction of the second through groove 6 into the test hole 2, allowing the test strip to reach the test area of the test hole 2 (in this embodiment, the circumferential area near the center line of the test hole 2). The aforementioned bottom isolation assembly is used to ensure that the test strip is prevented from contacting the external environment when installed in the test hole 2, while also facilitating test strip replacement. Specifically, the test strip slot 7 on the lower plate 502 is used to place the test strip. After the upper plate 501 overlaps with the plate, it forms a seal on the test strip slot 7, thus preventing the test strip in the test strip slot 7 from contacting the external environment during installation. The lower plate 502 and the upper plate 501 are overlapped to form a conveyor body 5, which is then fed into the bottom of the test hole 2 along the second through groove 6. This completes the installation of the test strip. After installation, the conveyor body 5 effectively seals the second through groove 6, ensuring that it will not come into contact with the external environment during the testing phase. The second through groove 6 is used to move the conveyor body 5 along its extension direction, allowing the conveyor body 5 to change its position within the test hole 2 as needed.
[0032] It should be noted that the first through groove 4 and the second through groove 6 actually serve a guiding function, ensuring that the corresponding transparent observation plate 3 can only move along the extension direction of the first through groove 4, and the conveyor body 5 can only move along the extension direction of the second through groove 6. Furthermore, to ensure a seal between the transparent observation plate 3 and the first through groove 4, the cross-sectional shape of the transparent observation plate 3 is perfectly matched to the cross-sectional shape of the first through groove 4. Similarly, to ensure a seal between the conveyor plate and the second through groove 6, the cross-sectional shape of the conveyor plate is also perfectly matched to the cross-sectional shape of the second through groove 6. Additionally, in this embodiment, to ensure accurate overlap between the upper plate 501 and the lower plate 502, a stepped limiting structure (not shown in the figure) is adopted for the upper plate 501 and the plate body.
[0033] Please refer to Figures 1-7 In some embodiments of this example, a first push rod 8 is connected to the transparent observation plate 3 for pushing the transparent observation plate 3 to slide along the first through groove 4. A first guide groove 9 parallel to the extending direction of the first through groove 4 is provided on the base 1, and the first through groove 4 and the first guide groove 9 are connected. The free end of the first push rod 8 passes through the first guide groove 9, and the first push rod 8 can slide freely along the extending direction of the first guide groove 9. The first push rod 8 is used to push the transparent observation plate 3 to slide along the extending direction of the first through groove 4. The first guide groove 9 can guide the first push rod 8, and at the same time, the first guide groove 9 can also allow the first push rod 8 to extend out of the base 1, making it convenient for the user to push the first push rod 8.
[0034] Please refer to Figure 1 and Figure 2 Furthermore, in some embodiments of this example, the conveying body 5 is provided with a second push rod 10 for pushing the conveying body 5 to move along the extension direction of the second through groove 6. The second push rod 10 passes through the upper plate 501 and the lower plate 502 in sequence, and is threadedly connected to both the upper plate 501 and the lower plate 502. A second guide groove 11 parallel to the extension direction of the second through groove 6 is provided on the base 1, and the second through groove 6 communicates with the second guide groove 11. The free end of the second push rod 10 passes through the second guide groove 11, and the second push rod 10 can slide freely along the extension direction of the second guide groove 11. The second push rod 10 has the same function as the first push rod 8, and is mainly used to push the conveying body 5 to slide. Since the conveyor body 5 consists of an upper plate 501 and a lower plate 502, in order to make the upper plate 501 and the lower plate 502 move synchronously, the second push rod 10 passes through the upper plate 501 and the lower plate 502 and is threadedly connected to the upper plate 501 and the lower plate 502. In this way, the upper plate 501 and the lower plate 502 can be connected to complete synchronous movement. After the conveyor body 5 is fed into the test hole 2 to a certain extent, the second push rod 10 can be rotated to separate the second push rod 10 from the lower plate 502, thus facilitating the subsequent misalignment and separation of the upper plate 501 and the lower plate 502. The aforementioned second guide groove 11 not only serves a guiding function, but also allows the second push rod 10 to extend out of the base 1, making it convenient for the user to move the second push rod 10.
[0035] Please refer to Figures 1-5 In this embodiment, a first auxiliary push rod 13 is connected to the upper plate 501. The first auxiliary push rod 13 can push the upper plate 501 to move along the extension direction of the second through groove 6. A third guide groove 14 parallel to the extension direction of the second through groove 6 is provided on the base 1, and the second through groove 6 and the third guide groove 14 are connected. The free end of the first auxiliary push rod 13 passes through the third guide groove 14, and the first auxiliary push rod 13 can slide freely along the extension direction of the third guide groove 14. The first auxiliary push rod 13 is actually only used to move the upper plate 501 along the extension direction of the second through groove 6. The third guide groove 14 guides the first auxiliary rod, and at the same time, it can allow the first auxiliary rod to extend out of the base 1, making it convenient for the user to move the first auxiliary push rod 13.
[0036] Please refer to Figure 1 , Figure 4 and Figure 5In some embodiments of this utility model, a second auxiliary push rod 15 is connected to the lower plate 502. The second auxiliary push rod 15 can push the lower plate 502 to move along the extension direction of the second through groove 6. A fourth guide groove 16 parallel to the extension direction of the second through groove 6 is provided on the base 1. The second through groove 6 and the fourth guide groove 16 are connected. The free end of the second auxiliary push rod 15 passes through the fourth guide groove 16, and the second auxiliary push rod 15 can slide freely along the extension direction of the fourth guide groove 16. The aforementioned second auxiliary push rod 15 is actually only used to move the lower plate 502 along the extension direction of the second through groove 6. The aforementioned fourth guide groove 16 guides the second auxiliary rod, and at the same time, it can allow the second auxiliary rod to extend out of the base 1, making it convenient for the user to move the second auxiliary push rod 15.
[0037] In some application scenarios of this embodiment, the transparent observation plate 3 is sealed to the inner wall of the first through groove 4, and the conveying body 5 is sealed to the inner wall of the second through groove 6. Specifically, the inner walls of the observation plate and the first through groove 4, as well as the inner walls of the conveying body 5 and the second through groove 6, all adopt a sealing sliding structure (not shown in the figure). The specific sealing sliding structure is an existing structure, such as a sliding sealing ring structure (not shown in the figure), in which a groove is opened circumferentially on the transparent observation plate 3, and a sealing ring is laid in the groove; semi-annular grooves are respectively opened on the upper plate 501 and the lower plate 502, and semi-annular sealing rings are respectively set in the semi-annular grooves of the plate ring.
[0038] Please refer to Figure 1 and Figure 7 It is worth noting that in this embodiment, the transparent observation plate 3 has a sample injection hole. Two transparent membrane flaps 17 are provided on the transparent observation plate 3, and these two flaps are joined to form a membrane valve, which covers the sample injection hole. In its actual state, the gap between the two transparent membrane flaps 17 is normally sealed, separating the external environment from the interior of the test hole 2. When a sample needs to be injected, a pipette containing the sample is inserted along the gap between the two transparent membrane flaps 17, and the sample is dripped. During this process, the two transparent membrane flaps 17 adhere tightly to the outer wall of the pipette under their own elastic potential energy, achieving a sealing effect. Thus, the entire process of injecting the sample remains sealed, preventing the observation tube from opening and the test strip from being exposed to the external environment when the sample is dripped in, further improving the accuracy of the test results.
[0039] During manufacturing, the test strip is first placed into the test strip slot 7 of the lower plate 502 under a special storage environment. Then, the upper plate 501 is overlapped with the lower plate 502 to seal the test hole 2 and prevent it from contacting the external environment.
[0040] In use, the user first uses the second pusher 10 to push the delivery body 5 into the test hole 2, allowing the test strip to enter the test area. After completing the above steps, the user uses the first pusher 8 to move the transparent observation plate 3 along the first through groove 4 into the test hole 2 and seals the test hole 2. Then, the user uses the first auxiliary pusher 13 to cause the upper plate 501 and lower plate 502 to separate, exposing the test strip in the test strip slot 7 to the detection area. Finally, the pipette containing the test sample is inserted along the gap between the two transparent membrane flaps 17 and the liquid is dispensed. After the test sample comes into contact with the test strip, the test result can be observed through the transparent observation plate 3.
[0041] The above are merely preferred embodiments of this utility model and are not intended to limit the scope of this utility model. Various modifications and variations can be made to this utility model by those skilled in the art. Any modifications, equivalent substitutions, or improvements made within the spirit and principles of this utility model should be included within the protection scope of this utility model.
Claims
1. An apparatus for dry chemical chromogenic substrate method detection comprising a base having a test well formed therein, characterised in that, include: A top isolation assembly includes a transparent observation plate. The top of the base has a first through groove communicating with the test hole. The transparent observation plate is disposed in the first through groove and can slide into the test hole along the extension direction of the first through groove to block the test hole. The bottom isolation assembly includes an upper plate and a lower plate. The bottom of the base has a second through groove for feeding test strips. The second through groove communicates with the test hole. The lower plate and the upper plate are combined to form a conveyor. The lower plate located on the side of the upper plate has a test strip groove for placing test strips. The conveyor is disposed in the second through groove and can move along the extension direction of the second through groove into the test hole, so that the test strip reaches the test area of the test hole.
2. The device for the detection of dry-chemical chromogenic substrates method according to claim 1, characterized in that, The transparent observation plate is connected to a first push rod for pushing the transparent observation plate to slide along the first through groove. The base is provided with a first guide groove parallel to the extension direction of the first through groove. The first through groove is connected to the first guide groove. The free end of the first push rod passes through the first guide groove, and the first push rod can slide freely along the extension direction of the first guide groove.
3. The device for the detection of dry-chemical chromogenic substrates method according to claim 1, characterized in that, The conveyor body is provided with a second push rod for pushing the conveyor body to move along the extension direction of the second through groove. The second push rod passes through the upper plate and the lower plate in sequence and is threadedly connected to both the upper plate and the lower plate. The base is provided with a second guide groove parallel to the extension direction of the second through groove. The second through groove is connected to the second guide groove. The free end of the second push rod passes through the second guide groove and the second push rod can slide freely along the extension direction of the second guide groove.
4. The apparatus for detection using the dry chemical chromogenic substrate method according to claim 3, characterized in that, A first auxiliary push rod is connected to the upper plate. The first auxiliary push rod can push the upper plate to move along the extension direction of the second through groove. A third guide groove is provided on the base, which is parallel to the extension direction of the second through groove. The second through groove is connected to the third guide groove. The free end of the first auxiliary push rod passes through the third guide groove, and the first auxiliary push rod can slide freely along the extension direction of the third guide groove.
5. The device for the detection of dry-chemical chromogenic substrates method according to claim 3, characterized in that, A second auxiliary push rod is connected to the lower plate. The second auxiliary push rod can push the lower plate to move along the extension direction of the second through groove. A fourth guide groove is opened on the base, which is parallel to the extension direction of the second through groove. The second through groove is connected to the fourth guide groove. The free end of the second auxiliary push rod passes through the fourth guide groove, and the second auxiliary push rod can slide freely along the extension direction of the fourth guide groove.
6. The device for the detection of dry-chemical chromogenic substrates method according to claim 1, characterized in that, The transparent observation plate is sealed to the inner wall of the first through groove.
7. The device for the detection of dry-chemical chromogenic substrates method according to claim 1, characterized in that, The conveyor body is sealed to the inner wall of the second through groove.
8. The device for the detection of dry-chemical chromogenic substrates according to any one of claims 1-7, characterized in that, The transparent observation plate has a sample liquid injection hole and two transparent membrane flaps. The two transparent membrane flaps are spliced together to form a membrane valve, which covers the sample liquid injection hole.