A constant temperature shaking incubator for drug development

Abstract

This utility model discloses a constant temperature shaking incubator for drug development, relating to the technical field of drug development equipment. It includes a chamber and a shaking mechanism. A culture concave tray is mounted on the upper end of the shaking mechanism. Multiple sets of guide blocks are parallelly installed inside the culture concave tray. Multiple sets of sliding seats are slidably installed on the outer wall of each set of guide blocks. Multiple sets of fixing mechanisms are provided inside the culture concave tray. This utility model, by setting up fixing mechanisms, can fix culture containers of different specifications with the cooperation of a semi-circular seat, a semi-circular clamping plate, a connecting plate, a connecting rod, a supporting spring, and a circular plate, without the need to replace parts, improving the equipment's versatility. Furthermore, under the action of the supporting spring, it can provide a continuous and uniform clamping force. The silicone anti-slip pad increases the coefficient of friction, so even under high-frequency shaking, the container has no risk of sliding or tipping, effectively avoiding sample leakage.

Description

Technical Field

[0001] This utility model relates to the field of drug development equipment technology, and in particular to a constant temperature oscillating incubator for drug development. Background Technology

[0002] In the field of modern drug development, the constant temperature shaking incubator is a core piece of equipment for key experiments such as cell culture, microbial fermentation, and enzyme reaction testing. Its performance directly affects the accuracy and reliability of experimental data. With the continuous upgrading of drug development technology, more stringent requirements have been placed on the stability of the culture environment, the precision of sample processing, and the ease of equipment operation. However, existing constant temperature shaking incubators have gradually revealed many technical defects in practical applications, making it difficult to meet the needs of high-end drug development experiments.

[0003] However, in terms of the fixation and compatibility of culture containers, traditional support components in existing technologies mostly adopt fixed slots or universal shelf designs. Fixed slots can only match culture flasks of specific sizes. When dealing with various containers commonly used in drug development (such as 24-well plates, 50ml centrifuge tubes, and 1000ml Erlenmeyer flasks), it is necessary to frequently replace the support components, which is cumbersome and inefficient. Although universal shelves can hold different containers, they lack an effective fixing structure. During the shaking process, the containers are prone to sliding, colliding, or even tipping over and leaking, which not only contaminates the culture chamber but also causes the loss of valuable experimental samples. Utility Model Content

[0004] The purpose of this invention is to solve the problems existing in the prior art by proposing a constant temperature oscillating incubator for drug development.

[0005] To achieve the above objectives, the present invention adopts the following technical solution: a constant temperature shaking incubator for drug development, comprising a chamber and a shaking mechanism, wherein a culture concave plate is installed at the upper end of the shaking mechanism, and multiple sets of guide blocks are installed in parallel inside the culture concave plate, and multiple sets of slide blocks are slidably installed on the outer wall of each set of guide blocks, and multiple sets of fixing mechanisms are provided inside the culture concave plate.

[0006] The fixing mechanism includes a semi-circular base and a semi-circular clamp. Two sets of connecting plates are installed on the outer wall of the semi-circular clamp. Four sets of connecting rods are provided at one end of the semi-circular base. Four sets of storage slots are opened inside the semi-circular base. A circular plate is slidably installed inside each set of storage slots. A support spring is installed on the inner wall of each set of storage slots.

[0007] Preferably, one end of each of the four sets of connecting rods passes through one end of the semicircular seat and is fixed to one end of each of the four sets of circular plates.

[0008] Preferably, each pair of connecting rods is fixed to one end of a connecting plate, and the other end of the four sets of supporting springs is fixed to one end of each of the four sets of circular plates.

[0009] Preferably, one end of each set of semicircular seats is fixed to one end of a set of slides, and one end of the semicircular clamp is in contact with one end of the semicircular seat.

[0010] Preferably, each set of slides has a threaded bolt at its upper end, and the lower ends of the bolts are in contact with the upper ends of the guide blocks.

[0011] Preferably, a sealing cover is hinged to the upper surface of the box, a heating mechanism is installed on both inner side walls of the box, and a cooling mechanism and a temperature sensor are installed on both inner side walls of the box.

[0012] Preferably, a control panel is installed at one end of the housing, the lower end of the oscillation mechanism is fixed to the bottom of the housing, and both sets of the heating mechanism, cooling mechanism, temperature sensor and oscillation mechanism are signal connected to the control panel.

[0013] Compared with the prior art, the advantages and positive effects of this utility model are as follows:

[0014] 1. In this utility model, by setting a fixing mechanism, culture containers of different specifications can be fixed with the cooperation of a semi-circular seat, a semi-circular clamping plate, a connecting plate, a connecting rod, a supporting spring and a circular plate, without the need to replace parts, thus improving the versatility of the equipment. Secondly, under the action of the supporting spring, a continuous and uniform clamping force can be provided, and the silicone anti-slip pad increases the coefficient of friction, so that even under high-frequency oscillation, the container has no risk of sliding or tipping over, effectively avoiding sample leakage.

[0015] 2. In this utility model, the combination design of guide block and slide block enables the fixing mechanism to freely adjust the spacing in the horizontal direction. With the help of bolts, the slide block can be fixed in a suitable position on the guide block, thus achieving stable positioning of the slide block and preventing displacement during vibration. Attached Figure Description

[0016] Figure 1 A three-dimensional structural schematic diagram of a constant temperature shaking incubator for drug development is provided for this utility model;

[0017] Figure 2 This utility model provides a partial top view of a constant temperature shaking incubator for drug development;

[0018] Figure 3 This utility model provides a schematic diagram of the sliding base and fixing mechanism of a constant temperature shaking incubator for drug development;

[0019] Figure 4An exploded view of the fixing mechanism of a constant temperature oscillating incubator for drug development is provided for this utility model.

[0020] Legend: 1. Box body; 11. Control panel; 12. Sealing cover; 13. Heating mechanism; 14. Cooling mechanism; 15. Temperature sensor; 17. Oscillation mechanism; 18. Culture tray; 2. Guide block; 21. Slide; 22. Bolt; 3. Fixing mechanism; 31. Semicircular seat; 32. Semicircular clamp; 33. Connecting plate; 34. Connecting rod; 35. Storage slot; 36. Support spring; 37. Circular plate. Detailed Implementation

[0021] To better understand the above-mentioned objectives, features, and advantages of this utility model, the present utility model will be further described below with reference to the accompanying drawings and embodiments. It should be noted that, unless otherwise specified, the embodiments and features described in these embodiments can be combined with each other.

[0022] Many specific details are set forth in the following description in order to provide a full understanding of the present invention. However, the present invention may also be implemented in other ways different from those described herein. Therefore, the present invention is not limited to the specific embodiments disclosed in the following specification.

[0023] Example 1: As Figure 1 , Figure 2 , Figure 3 and Figure 4 As shown, this utility model provides a constant temperature shaking incubator for drug development, including a box body 1 and a shaking mechanism 17. A culture concave plate 18 is installed at the upper end of the shaking mechanism 17. Multiple sets of guide blocks 2 are installed in parallel inside the culture concave plate 18. Multiple sets of slide seats 21 are slidably installed on the outer wall of each set of guide blocks 2. Multiple sets of fixing mechanisms 3 are provided inside the culture concave plate 18.

[0024] The fixing mechanism 3 includes a semi-circular seat 31 and a semi-circular clamping plate 32. Two sets of connecting plates 33 are installed on the outer wall of the semi-circular clamping plate 32. Four sets of connecting rods 34 are provided at one end of the semi-circular seat 31. Four sets of storage slots 35 are opened inside the semi-circular seat 31. A circular plate 37 is slidably installed inside each set of storage slots 35. A support spring 36 is installed on the inner wall of each set of storage slots 35. One end of each of the four sets of connecting rods 34 passes through one end of the semi-circular seat 31 and is fixed to one end of each of the four sets of circular plates 37. Every two sets of connecting rods 34 are fixed to one end of a set of connecting plates 33. The other ends of the four sets of support springs 36 are fixed to one end of each of the four sets of circular plates 37. One end of each set of semi-circular seats 31 is fixed to one end of a set of sliding blocks 21. One end of the semi-circular clamping plate 32 is in contact with one end of the semi-circular seat 31.

[0025] A sealing cover 12 is hinged to the upper surface of the housing 1. Heating mechanisms 13 are installed on both inner side walls of the housing 1. Cooling mechanisms 14 and temperature sensors 15 are installed on both inner side walls of the housing 1. A control panel 11 is installed at one end of the housing 1. The lower end of the oscillation mechanism 17 is fixed to the inner bottom of the housing 1. Both sets of heating mechanisms 13, cooling mechanisms 14, temperature sensors 15 and oscillation mechanisms 17 are connected to the control panel 11 via signals.

[0026] The specific settings and functions of this embodiment are described below. The housing 1 serves as the basic frame of the equipment, providing a stable installation platform. The sealing cover 12, which is hinged on the upper surface, is made of high-strength transparent material. When closed, it fits tightly against the edge of the housing. With the sealing strip on the edge, it can achieve an IP65 dustproof and waterproof seal, effectively isolating external temperature and humidity interference. A heat insulation layer is added to the inside of the sealing cover 12 to further reduce the temperature loss inside the housing.

[0027] Heating mechanisms 13 are symmetrically installed on the two inner side walls of the housing 1. They use nickel-chromium alloy heating tubes, which have high heating efficiency and uniform temperature rise. A cooling mechanism 14 is installed on the other inner side wall. It uses compression cooling technology to form a complementary temperature control with the heating mechanism 13. The temperature sensor 15 uses a high-precision PT1000 probe to collect temperature data at different locations in real time.

[0028] The control panel 11 at one end of the enclosure 1 is equipped with a 7-inch touch screen, which supports Chinese / English bilingual operation interface and can intuitively display parameters such as real-time temperature curve, oscillation frequency, and running time. It has a built-in STM32 series microprocessor with fast response speed, which can accurately process the signals of various sensors and control the actuator. The control panel 11 is also equipped with an emergency stop button and a USB data export interface for convenient experimental data archiving and traceability.

[0029] The oscillation mechanism 17 is installed at the bottom of the box 1. It is driven by a brushless DC motor and equipped with a planetary gear reducer. It can provide a continuously adjustable oscillation frequency of 10-300RPM with an adjustment accuracy of 1RPM. The motor output shaft is connected to the eccentric wheel transmission structure through a coupling. Four sets of shock-absorbing pads are installed at the bottom of the oscillation mechanism 17 to reduce the vibration transmission to the tabletop during operation through elastic buffering.

[0030] The culture concave plate 18 fixed at the upper end of the oscillation mechanism 17 is made of 304 stainless steel by one-piece stamping and the surface is electrolytically polished, making it corrosion-resistant and easy to clean. Multiple sets of guide blocks 2 are installed in parallel inside the culture concave plate 18. Multiple sets of slide blocks 21 are slidably installed on each set of guide blocks 2. Wear-resistant sliders are embedded in the bottom of the slide blocks 21, forming a precise fit with the guide blocks 2.

[0031] Each set of slides 21 is equipped with a set of fixing mechanisms 3, including a semi-circular seat 31 and a semi-circular clamping plate 32. The semi-circular seat 31 is made of engineering plastic injection molding. Four sets of storage slots 35 are opened on the inner side. Support springs 36 and circular plates 37 are installed in the slots. One end of the four sets of connecting rods 34 is fixed to the circular plate 37, and the other end passes through the semi-circular seat 31 and is connected to two sets of connecting plates 33. The connecting plates 33 are then fixed to the semi-circular clamping plate 32. The inner wall of the semi-circular clamping plate is pasted with a silicone anti-slip pad and the surface is provided with a wavy texture. It forms an adjustable clamping space with the semi-circular seat 31, which is suitable for various sizes of culture containers.

[0032] The multi-zone temperature sensor 15 forms a closed-loop control with the heating mechanism 13 and the cooling mechanism 14. Combined with the PID algorithm of the microprocessor, it meets the culture requirements of sensitive samples such as stem cells and viruses. The heating mechanism 13 and the cooling mechanism 14 adopt independent zone control, which can quickly switch the working mode according to the culture requirements, greatly shortening the experimental preparation time.

[0033] Example 2: Figure 2 , Figure 3 and Figure 4 As shown, multiple sets of guide blocks 2 are installed in parallel inside the culture concave tray 18. Multiple sets of slide blocks 21 are slidably installed on the outer wall of each set of guide blocks 2. Bolts 22 are threadedly connected to the upper end of each set of slide blocks 21. The lower ends of the multiple sets of bolts 22 are in contact with the upper ends of the multiple sets of guide blocks 2 respectively.

[0034] The overall effect of this embodiment is that multiple sets of guide blocks 2 are installed in parallel inside the culture concave tray 18, and multiple sets of slide blocks 21 are slidably installed on each set of guide blocks 2. Wear-resistant sliders are embedded in the bottom of the slide blocks 21, forming a precise fit with the guide blocks 2. This allows the fixing mechanism 3 to freely adjust the spacing in the horizontal direction. The bolts 22 at the upper end of the slide blocks 21 adopt a butterfly handle design. After tightening, they can make close contact with the guide blocks 2, achieving stable positioning of the slide blocks 21 and preventing displacement during vibration.

[0035] The method of use and working principle of this device: First, open the sealing cover 12, pull the semi-circular clamp 32 to move it outward, then place the culture container inside the semi-circular seat 31, and slowly release the semi-circular clamp 32. Under the elastic force of the four sets of support springs 36, the support springs 36 drive the connecting rods 34 to move through the circular plate 37. At this time, the four sets of connecting rods 34 drive the semi-circular clamp 32 to move through the two sets of connecting plates 33, and fix the culture container inside the semi-circular seat 31. After that, fix the culture container on each set of fixing mechanism 3 one by one through the above steps.

[0036] Then, adjust the distance between adjacent culture containers as needed. Slide the sliding block 21 on the guide block 2 and move it to the appropriate position. Then rotate the bolt 22 so that it rotates on the threaded sliding block 21 until it abuts against the guide block 2. The sliding block 21 can then be fixed on the guide block 2.

[0037] Finally, by setting values ​​on the control panel 11, the control panel 11 will control the operation of the two sets of heating mechanisms 13, cooling mechanisms 14 and oscillation mechanisms 17. The temperature sensor 15 will monitor the interior of the chamber 1 in real time and transmit signals to the control panel 11 in real time, so that the control panel 11 can accurately control the operation of the heating mechanism 13, cooling mechanism 14 and oscillation mechanism 17.

[0038] The above are merely preferred embodiments of this utility model and are not intended to limit the utility model in any other way. Any person skilled in the art may make changes or modifications to the above-disclosed technical content to create equivalent embodiments for application in other fields. However, any simple modifications, equivalent changes, and modifications made to the above embodiments based on the technical essence of this utility model without departing from the technical solution of this utility model shall still fall within the protection scope of this utility model.

Claims

1. A constant temperature oscillation incubator for drug research and development, comprising a cabinet (1) and an oscillation mechanism (17), characterized in that: The upper end of the oscillation mechanism (17) is equipped with a culture concave plate (18). Multiple sets of guide blocks (2) are installed in parallel inside the culture concave plate (18). Multiple sets of slide blocks (21) are slidably installed on the outer wall of each set of guide blocks (2). Multiple sets of fixing mechanisms (3) are provided inside the culture concave plate (18). The fixing mechanism (3) includes a semi-circular seat (31) and a semi-circular clamp (32). Two sets of connecting plates (33) are installed on the outer wall of the semi-circular clamp (32). Four sets of connecting rods (34) are provided at one end of the semi-circular seat (31). Four sets of storage slots (35) are opened inside the semi-circular seat (31). A circular plate (37) is slidably installed inside each set of storage slots (35). A support spring (36) is installed on the inner wall of each set of storage slots (35).

2. The constant temperature shaking incubator for drug research and development according to claim 1, characterized in that: One end of each of the four sets of connecting rods (34) passes through one end of the semicircular seat (31) and is fixed to one end of each of the four sets of circular plates (37).

3. The constant temperature shaking incubator for drug research and development according to claim 2, characterized in that: Each pair of connecting rods (34) is fixed to one end of a connecting plate (33), and the other end of the four sets of supporting springs (36) is fixed to one end of the four sets of circular plates (37).

4. The constant temperature shaking incubator for drug research and development of claim 3, wherein: One end of each set of semicircular seats (31) is fixed to one end of a set of slides (21), and one end of the semicircular clamp (32) is in contact with one end of the semicircular seat (31).

5. The constant temperature shaking incubator for drug research and development of claim 1, wherein: Each set of slide blocks (21) has a threaded bolt (22) connected to its upper end, and the lower ends of the bolts (22) are in contact with the upper ends of the guide blocks (2).

6. The constant temperature shaking incubator for drug research and development according to claim 1, characterized in that: The upper surface of the box (1) is hinged with a sealing cover (12), and heating mechanisms (13) are installed on both inner side walls of the box (1). Cooling mechanisms (14) and temperature sensors (15) are installed on both inner side walls of the box (1).

7. The constant temperature shaking incubator for drug development according to claim 6, characterized in that: A control panel (11) is installed at one end of the housing (1). The lower end of the oscillation mechanism (17) is fixed to the bottom of the housing (1). The two sets of heating mechanism (13), cooling mechanism (14), temperature sensor (15) and oscillation mechanism (17) are all connected to the control panel (11) via signal.

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