A raw material separation device for biopharmaceutical polypeptides

Abstract

This utility model relates to the field of biopharmaceutical polypeptide raw material processing technology, specifically a raw material separation device for biopharmaceutical polypeptides. It includes a base, a vibrating motor, and a pneumatic telescopic rod. A combined base plate is fixedly installed on the center of the top surface of the base. Support frames are fixedly installed on the top surfaces of the four corners of the combined base plate, and a vibrating motor is fixedly installed in the middle partition of the support frame. A sealed protective frame is fixedly installed at the top of the support frame. This utility model allows for sealed collection of qualified particles separated from the filter screen into the particle guiding chamber via an external pneumatic conveying device after a sealed connection to an external pipeline through a discharge pipe. The width of the particle guiding chamber gradually decreases to improve collection efficiency. During the collection process using pneumatic pressure, the vibrating motor simultaneously drives the filter screen to vibrate and separate, further improving the efficiency of qualified particles passing through the filter screen for separation.

Description

Technical Field

[0001] This utility model relates to the field of biopeptide raw material processing technology, and in particular to a raw material separation device for biopeptides. Background Technology

[0002] Biopharmaceutical peptide raw material processing is used to prepare high-purity peptide raw materials with well-defined structures and specific biological activities. The processing steps include separation. When separating and processing freeze-dried peptide intermediate raw materials, the freeze-dried peptide intermediates have a porous block structure. After freeze-drying, they are loose and spongy. They need to be lightly crushed into particles and then separated by particle size separation to separate the large, uncrushed pieces from the qualified particles.

[0003] Existing biopeptide raw material separation devices use drum screens to process and separate lyophilized peptide intermediates, resulting in low filtration accuracy. Additionally, the lack of proper sealing during separation makes it easy for pulverized particles to escape.

[0004] Therefore, to address the above issues, an innovative design was developed based on the existing raw material separation device for biopeptides. Utility Model Content

[0005] To overcome the problem that common biopharmaceutical peptide raw material separation devices, when using drum screens for separation, have insufficient sealing, which easily leads to the escape of pulverized particles.

[0006] The technical solution of this utility model is as follows: a raw material separation device for biopharmaceutical polypeptides, comprising a base, a vibrating motor, and a pneumatic telescopic rod. A combined base plate is fixedly installed on the center of the top surface of the base with bolts. A support frame is fixedly installed on the top surface of the four corners of the combined base plate, and a vibrating motor is fixedly installed in the middle partition of the support frame. A sealing protective frame is fixedly installed at the top of the support frame, and a discharge pipe is fixedly installed at the bottom of the sealing protective frame. A crushing and processing chamber and a particle guiding chamber are arranged inside the sealing protective frame, and the particle guiding chamber is located below the crushing and processing chamber. A filter screen is installed inside the bottom of the crushing and processing chamber. A U-shaped support frame is welded and fixedly installed on the side of the top surface of the base. A pneumatic telescopic rod is fixedly installed on the bottom surface of the top middle end of the U-shaped support frame, and a combined circular plate is fixedly installed at the telescopic end of the pneumatic telescopic rod.

[0007] Preferably, a rubber pad is provided at the connection between the combined base plate and the base, and rubber washers are installed at the bolt connection between the combined base plate and the base, and the bolts are symmetrically and alternately distributed on the combined base plate.

[0008] Preferably, the crushing and processing chamber is interconnected with the internal space of the discharge pipe through the particle guiding chamber, and the crushing and processing chamber is connected to the filter screen by a snap-fit ​​connection.

[0009] Preferably, a connecting sleeve is fixedly installed on the bottom surface of the combined circular plate, and a receiving hole is provided in the center of the connecting sleeve. A supporting ball is installed inside the receiving hole, and a connecting shaft is provided on the bottom surface of the supporting ball. The connecting shaft passes through the receiving hole and the bottom surface of the connecting sleeve. A pressure plate is installed at the bottom end of the connecting shaft, and a convex ball is provided on the bottom surface of the pressure plate. A limit frame is provided on the side of the bottom surface of the pressure plate, and the limit frame is located inside the crushing and processing chamber.

[0010] Preferably, the connecting sleeves are evenly distributed on the combined circular plate, and the top diameter of the receiving hole in the connecting sleeve is larger than the bottom diameter of the receiving hole. The diameter of the supporting ball is smaller than the top diameter of the receiving hole, and the diameter of the supporting ball is larger than the bottom diameter of the receiving hole. The top and bottom connection areas of the receiving hole are arranged with an inclined structure.

[0011] Preferably, the connecting shaft and the supporting ball are integrated into one structure, and the diameter of the connecting shaft is smaller than the bottom diameter of the receiving hole, and the connecting shaft is connected to the pressure plate by welding.

[0012] Preferably, the pressure plate, the convex balls, and the limiting frame are integrated into a single structure, with the convex balls evenly distributed on the pressure plate, and the connection between the limiting frame and the crushing and processing chamber is a snap-fit ​​seal. The height of the limiting frame plus the thickness of the filter screen is less than the height of the crushing and processing chamber.

[0013] The beneficial effects of this utility model are:

[0014] 1. After being sealed and connected to an external pipeline through a discharge pipe, qualified particles separated from the filter screen and placed inside the particle guiding chamber are collected by an external pneumatic conveying device. The width of the particle guiding chamber is gradually reduced to improve collection efficiency. During the collection process using air pressure, the efficiency of qualified particles passing through the filter screen is further improved by the vibration motor driving the filter screen to vibrate and separate the particles.

[0015] 2. The pneumatic telescopic rod can be combined with the pressure plate and filter screen to form a sealed combination with the crushing and processing chamber through the combined circular plate, maintaining the light pressure crushing of the freeze-dried peptide intermediate. When the vibrating motor drives the filter screen to vibrate and separate, the blocky freeze-dried peptide intermediate in the crushing and processing chamber can collide with the convex ball to break it up. Separation is carried out during the sealing process. At the same time, the blocky freeze-dried peptide intermediate is further crushed through vibration separation, improving the separation efficiency. Attached Figure Description

[0016] Figure 1 The diagram shown is a three-dimensional structural schematic of the overall assembly of this utility model.

[0017] Figure 2The diagram shown is a three-dimensional structural diagram of the separation of the pressure plate and the sealing and protective frame of this utility model.

[0018] Figure 3 The diagram shown is a three-dimensional cross-sectional view of the sealing and protective frame of this utility model.

[0019] Figure 4 The diagram shown is a three-dimensional structural schematic of the pressure plate of this utility model from an upward perspective.

[0020] Figure 5 The diagram shown is a three-dimensional cross-sectional view of the pressure plate of this utility model.

[0021] Explanation of reference numerals in the attached drawings: 1. Base; 2. Combined base plate; 3. Support frame; 4. Vibration motor; 5. Sealing and protective frame; 6. Discharge pipe; 7. Crushing and processing chamber; 8. Particle guiding chamber; 9. Filter screen; 10. U-shaped support frame; 11. Pneumatic telescopic rod; 12. Combined circular plate; 13. Connecting sleeve; 14. Storage hole; 15. Support ball; 16. Connecting shaft; 17. Pressure plate; 18. Convex ball; 19. Limiting frame. Detailed Implementation

[0022] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0023] Please see Figures 1-5 This utility model provides a technical solution: a raw material separation device for biopeptides, including a base 1, a vibrating motor 4, and a pneumatic telescopic rod 11. A combined base plate 2 is fixedly installed on the center of the top surface of the base 1 by bolts. A support frame 3 is fixedly installed on the top surface of the four corners of the combined base plate 2. A vibrating motor 4 is fixedly installed in the middle partition of the support frame 3. A sealing protective frame 5 is fixedly installed at the top of the support frame 3. A discharge pipe 6 is fixedly installed at the bottom of the sealing protective frame 5. A crushing and processing chamber 7 and a particle guiding chamber 8 are arranged inside the sealing protective frame 5. The particle guiding chamber 8 is located below the crushing and processing chamber 7. A filter screen 9 is installed inside the bottom of the crushing and processing chamber 7. A U-shaped support frame 10 is welded and fixedly installed on the side of the top surface of the base 1. A pneumatic telescopic rod 11 is fixedly installed on the bottom surface of the top middle end of the U-shaped support frame 10. A combined circular plate 12 is fixedly installed at the telescopic end of the pneumatic telescopic rod 11.

[0024] A rubber pad is provided at the connection between the combined base plate 2 and the base 1, and rubber washers are installed at the bolt connection between the combined base plate 2 and the base 1. The bolts are symmetrically and staggered on the combined base plate 2, which facilitates the buffering and weakening of the vibration of the subsequent vibration motor 4 after installation by the rubber pad and rubber washers, thus maintaining stability.

[0025] The crushing and processing chamber 7 is interconnected with the internal space of the particle guiding chamber 8 and the discharge pipe 6. The crushing and processing chamber 7 is connected to the filter screen 9 by a snap-fit ​​connection, which facilitates the rapid collection of particles inside the particle guiding chamber 8 and the discharge pipe 6 after the discharge pipe 6 is sealed and combined with the external pipeline by a pneumatic conveying device.

[0026] A connecting sleeve 13 is fixedly installed on the bottom surface of the combined circular plate 12, and a receiving hole 14 is provided in the center of the connecting sleeve 13. A supporting ball 15 is installed inside the receiving hole 14, and a connecting shaft 16 is provided on the bottom surface of the supporting ball 15. The connecting shaft 16 passes through the receiving hole 14 and the bottom surface of the connecting sleeve 13. A pressure plate 17 is installed at the bottom end of the connecting shaft 16, and a convex ball 18 is provided on the bottom surface of the pressure plate 17. A limit frame 19 is provided on the side of the bottom surface of the pressure plate 17. The limit frame 19 is located inside the crushing and processing chamber 7. The connecting sleeves 13 are evenly distributed on the combined circular plate 12, and the top of the receiving hole 14 in the connecting sleeve 13 is... The diameter of the support ball 15 is larger than the bottom diameter of the receiving hole 14, and the diameter of the support ball 15 is smaller than the top diameter of the receiving hole 14. The top and bottom connection areas of the receiving hole 14 are set with an inclined structure. According to the structural characteristics of the receiving hole 14, the support ball 15 slides and vibrates within the receiving hole 14. This ensures that when the support ball 15 vibrates, it will not cause the connecting sleeve 13, the combined circular plate 12, and the pneumatic telescopic rod 11 to vibrate. At the same time, the pneumatic telescopic rod 11 can drive the pressure plate 17 to move up and down to prevent separation and center misalignment.

[0027] The connecting shaft 16 and the supporting ball 15 are integrated into one structure. The diameter of the connecting shaft 16 is smaller than the bottom diameter of the receiving hole 14. The connecting shaft 16 and the pressure plate 17 are connected by welding. The supporting ball 15 can perform synchronous vibration and movement through the combination of the connecting shaft 16 and the pressure plate 17. The connecting shaft 16 will not come into contact with the connecting sleeve 13 when it vibrates.

[0028] The pressure plate 17, the convex ball 18, and the limiting frame 19 are integrated into a single structure. The convex balls 18 are evenly distributed on the pressure plate 17, and the connection between the limiting frame 19 and the crushing and processing chamber 7 is a snap-fit ​​seal. The height of the limiting frame 19 plus the thickness of the filter screen 9 is less than the height of the crushing and processing chamber 7, which allows the pressure plate 17 to drive the convex balls 18 and the limiting frame 19 to apply pressure and crush the freeze-dried peptide intermediate inside the crushing and processing chamber 7. At the same time, the convex balls 18 facilitate the rapid collision and crushing of the blocky freeze-dried peptide intermediate during subsequent vibration.

[0029] Working principle: According to Figures 1-5 First, the discharge pipe 6 can be sealed and connected to the external pipeline. Then, the air pressure difference is quickly extracted using a pneumatic conveying device. The freeze-dried polypeptide intermediate raw material is placed on the upper surface of the filter screen 9 inside the crushing and processing chamber 7. The pneumatic telescopic rod 11 is activated, which drives the combined circular plate 12 and the pressure plate 17 to descend smoothly. This causes the pressure plate 17 to slide the limiting frame 19 into the crushing and processing chamber 7. The bottom surface of the limiting frame 19 fits against the top surface of the filter screen 9 to limit the movement and seal the inside of the crushing and processing chamber 7. At the same time, the pressure plate 17 applies pressure to the freeze-dried peptide intermediate through the convex ball 18, causing the freeze-dried peptide intermediate to break. Simultaneously, after the pressure plate 17 is sealed and limited by the limiting frame 19, the pneumatic telescopic rod 11 drives the combined circular plate 12 to descend slightly, causing the support ball 15 in the receiving hole 14 to rise and separate from the inner wall of the connecting sleeve 13. The support ball 15 is suspended in the receiving hole 14, which facilitates the subsequent protection work during the vibration process and avoids the combined circular plate 12 and the pneumatic telescopic rod 11 from vibrating.

[0030] according to Figures 1-4 The vibration motor 4 is started, which drives the support frame 3 and the sealed protective frame 5 to vibrate. The amplitude is 2-4mm and the frequency is 25Hz. This causes the blocky freeze-dried peptide intermediates in the crushing and processing chamber 7 to collide with the convex ball 18 and the pressure plate 17 during vibration and be quickly crushed. The particles are then separated by the filter screen 9, which is made of 304 stainless steel with a mesh size of 80-200. The qualified particles fall into the particle guiding chamber 8 and are quickly discharged and collected by the air pressure difference. At the same time, the vibration is coordinated with the air pressure difference and the sealing of the crushing and processing chamber 7 to improve the separation efficiency.

[0031] The above is the entire working process of the device, and all contents not described in detail in this specification are existing technologies known to those skilled in the art.

[0032] Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A raw material separation device for biopharmaceutical polypeptides, comprising a base (1), a vibration motor (4) and a pneumatic telescopic rod (11), characterized in that: A combined base plate (2) is fixedly installed on the top center bolt of the base (1). A support frame (3) is fixedly installed on the top surface of the four corners of the combined base plate (2). A vibration motor (4) is fixedly installed in the middle partition of the support frame (3). A sealing protection frame (5) is fixedly installed at the top of the support frame (3). A discharge pipe (6) is fixedly installed at the bottom of the sealing protection frame (5). A crushing and processing chamber (7) and a particle guiding chamber (8) are provided inside the sealing protection frame (5). The particle guiding chamber (8) is located below the crushing and processing chamber (7). A filter screen (9) is installed inside the bottom of the crushing and processing chamber (7). A U-shaped support frame (10) is welded and fixedly installed on the top side of the base (1). A pneumatic telescopic rod (11) is fixedly installed on the bottom surface of the top middle end of the U-shaped support frame (10). A combined circular plate (12) is fixedly installed at the end of the telescopic rod of the pneumatic telescopic rod (11).

2. The device for separating raw materials for biopharmaceutical polypeptides according to claim 1, characterized in that: A rubber pad is provided at the connection between the combined base plate (2) and the base (1), and rubber washers are installed at the bolt connection between the combined base plate (2) and the base (1), and the bolts are symmetrically and alternately distributed on the combined base plate (2).

3. The device according to claim 1, wherein the device is used for separating a raw material of a biopharmaceutical polypeptide. The crushing and processing chamber (7) is connected to the internal space of the discharge pipe (6) through the particle guiding chamber (8), and the crushing and processing chamber (7) is connected to the filter screen (9) by a snap-fit ​​connection.

4. The device according to claim 1, wherein the device is used for separating a raw material of a biopharmaceutical polypeptide. The bottom surface of the combined circular plate (12) is fixedly installed with a connecting sleeve (13), and the center of the connecting sleeve (13) is provided with a receiving hole (14). A supporting ball (15) is installed inside the receiving hole (14), and a connecting shaft (16) is provided on the bottom surface of the supporting ball (15). The connecting shaft (16) passes through the receiving hole (14) and the bottom surface of the connecting sleeve (13). A pressure plate (17) is installed at the bottom end of the connecting shaft (16), and a convex ball (18) is provided on the bottom surface of the pressure plate (17). A limit frame (19) is provided on the side of the bottom surface of the pressure plate (17), and the limit frame (19) is located inside the crushing and processing chamber (7).

5. The device according to claim 4, wherein the device is used for separating a raw material of a biopharmaceutical polypeptide. The connecting sleeves (13) are evenly distributed on the combined circular plate (12), and the top diameter of the receiving hole (14) in the connecting sleeve (13) is greater than the bottom diameter of the receiving hole (14). The diameter of the supporting ball (15) is smaller than the top diameter of the receiving hole (14), and the diameter of the supporting ball (15) is greater than the bottom diameter of the receiving hole (14). The top and bottom connection areas of the receiving hole (14) are set with an inclined structure.

6. The device according to claim 4, wherein the device is used for separating a raw material of a biopharmaceutical polypeptide. The connecting shaft (16) and the supporting ball (15) are integrated into one structure, and the diameter of the connecting shaft (16) is smaller than the bottom diameter of the receiving hole (14). The connecting shaft (16) and the pressure plate (17) are connected by welding.

7. The device according to claim 4, wherein the device is used for separating a raw material of a biopharmaceutical polypeptide. The pressure plate (17), the convex ball (18), and the limiting frame (19) are integrated into a single structure. The convex balls (18) are evenly distributed on the pressure plate (17). The limiting frame (19) is connected to the crushing and processing chamber (7) by a snap-fit ​​seal. The height of the limiting frame (19) plus the thickness of the filter screen (9) is less than the height of the crushing and processing chamber (7).

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