An oil adjuvant inactivated vaccine mixing apparatus

Abstract

The utility model discloses an oil adjuvant inactivated vaccine mixing equipment relates to inactivated vaccine mixing technical field, including heating jar, the inside cooperation and installation of heating jar have mixing jar, the bottom of mixing jar is conical structure, the bottom of mixing jar is equipped with the liquid outlet, the bottom fixed mounting of heating jar has the transfusion pipe, the bottom setting of heating jar installs and is equipped with filling assembly, the top setting of heating jar installs and is equipped with stirring assembly. The utility model design scheme is through the bottom of mixing jar conical structure's design, the bottom of mixing jar is equipped with the liquid outlet, under the action of filling assembly, the vaccine in mixing jar is discharged outward through the liquid outlet and fills, the vaccine in mixing jar will be under the direction of the conical surface, all from the discharge of mixing jar, avoid the vaccine residual in mixing jar, thereby avoid the waste condition to take place.

Description

Technical Field

[0001] This utility model relates to the field of inactivated vaccine mixing technology, and in particular to an oil adjuvant inactivated vaccine mixing device. Background Technology

[0002] Inactivated vaccines are vaccines made by first culturing viruses or bacteria and then inactivating them with heat or chemical agents (usually β-propiolactone or formalin). Inactivated vaccines can be composed of whole viruses or bacteria or fragments of them, which are called split vaccines. The production of split vaccines involves further purifying the microorganisms until the vaccine contains only the required antigenic components (such as pneumococcal polysaccharides). It can be either a protein vaccine or a polysaccharide vaccine. Protein vaccines include toxoids (inactivated bacterial toxins) and subunit vaccines.

[0003] The production process of inactivated vaccines involves cultivation, inactivation, purification, formulation, filling, and packaging. Formulation involves mixing the vaccine stock solution in a suitable ratio before filling, but this method results in a relatively long time interval between these steps. Therefore, current technology typically involves directly placing the formulated vaccine stock solution into the filling device for mixing before completing the filling operation, thereby reducing the subsequent production time of the vaccine stock solution.

[0004] However, the vaccine containers of existing inactivated vaccine mixing equipment are not easy to clean. After each filling, there will be vaccine residue at the bottom of the container, causing unnecessary waste. In addition, the height of the stirring blades of the existing mixing equipment cannot be adjusted, which cannot adapt to different mixing needs, resulting in poor versatility of the equipment. Utility Model Content

[0005] In order to overcome the above-mentioned defects in the prior art, the present invention provides an oil adjuvant inactivated vaccine mixing device.

[0006] The technical solution adopted by this utility model to solve its technical problem is: an oil adjuvant inactivated vaccine mixing device, including a heating tank, a mixing tank installed inside the heating tank, the bottom of the mixing tank having a conical structure, a liquid outlet provided at the bottom end of the mixing tank, an infusion pipe fixedly installed at the bottom of the heating tank, a filling assembly installed at the bottom of the heating tank, and a stirring assembly installed at the top of the heating tank. The stirring assembly includes a top cover, which is fixedly installed on the top of the heating tank. A drive shaft is rotatably installed at the top center of the top of the top cover, a stirring rod is slidably installed on the drive shaft, and fastening bolts are fitted on the side wall of the drive shaft.

[0007] Furthermore, the top end of the infusion tube is provided with a threaded hole, the bottom end of the infusion nozzle is provided with a threaded part that matches the threaded hole, the top end of the mixing tank is provided with a boss, and a ring handle is fixedly installed on the top end of the boss.

[0008] Furthermore, an installation groove is provided at the center of the top of the top cover, and an injection tube is fixedly installed on the bottom wall of the installation groove near the edge. A sealing cap is installed at the top of the injection tube, and a cover plate is fixedly installed at the top of the installation groove. A first through hole corresponding to the position of the injection tube is provided on the cover plate, and a second through hole is provided at the center of the cover plate.

[0009] Furthermore, a stirring motor is fixedly installed on the cover plate, a first gear is fixedly installed on the power output shaft of the stirring motor, and a second gear that meshes with the first gear is provided on the drive shaft.

[0010] Furthermore, the stirring rod has a hexagonal cross-section, and stirring blades are fixedly installed at the bottom end of the stirring rod.

[0011] Furthermore, the outer diameter of the mixing tank is smaller than the inner diameter of the heating tank, and a cavity is provided between the mixing tank and the heating tank. A heating pipe is fixedly installed at the bottom of the cavity, and a heater is fixedly installed at the bottom of the heating tank. The heating pipe passes through the bottom wall of the heating tank and is connected to the heater. A water pipe is fixedly installed at the lower end of the outer wall of the heating tank. The water pipe is connected to the cavity, and a water pipe connector is installed at the end of the water pipe away from the heating tank.

[0012] Furthermore, the filling assembly includes a filling box, the heating tank is fixedly installed on the top of the filling box, the filling box is hollow inside, a filling pump is provided inside the filling box, the filling pump is fixedly installed at the bottom of the heating tank, the inlet pipe is connected to the inlet end of the filling pump, an outlet pipe is fixedly installed at the outlet end of the filling pump, a weighing instrument is fixedly installed on the bottom wall of the filling box, the weighing instrument is located directly below the outlet pipe, and a filling port is opened on the front side wall of the filling box.

[0013] Furthermore, a positioning frame is provided above the weighing instrument, and the positioning frame is fixedly installed on the inner side wall of the filling box, and the positioning frame is provided with a limiting groove.

[0014] Furthermore, the bottom of the filling box is fixedly installed with support legs near the four ends, and a controller is fixedly installed on the front side wall of the filling box.

[0015] The beneficial effects of this utility model are:

[0016] 1. The design of this utility model is based on the conical structure at the bottom of the mixing tank, with a dispensing nozzle at the bottom. Under the action of the filling component, the vaccine in the mixing tank is discharged outward through the dispensing nozzle for filling. Under the guidance of the conical surface, all the vaccine in the mixing tank is discharged from the mixing tank, avoiding vaccine residue in the mixing tank and thus avoiding waste.

[0017] 2. The design of this utility model features a stirring rod that is slidably mounted on the drive shaft. The stirring rod is fixed to the drive shaft by fastening bolts. After loosening the fastening bolts, the height of the stirring rod can be adjusted to adapt to different mixing needs, which helps to improve the versatility of the equipment. Attached Figure Description

[0018] The present invention will be further described below with reference to the accompanying drawings and embodiments.

[0019] Figure 1 This is a three-dimensional structural diagram of the present invention;

[0020] Figure 2 This is the front view of the present invention;

[0021] Figure 3 This is a top view of the present invention;

[0022] Figure 4 for Figure 2 Schematic diagram of the cross-sectional structure along the AA direction;

[0023] Figure 5 for Figure 3 Schematic diagram of the cross-sectional structure in the middle BB direction;

[0024] Figure 6 for Figure 4 A magnified view of a portion of region C.

[0025] In the diagram: 1. Heating tank, 2. Mixing tank, 201. Dispensing nozzle, 202. Threaded part, 203. Boss, 204. Ring handle, 3. Infusion pipe, 301. Threaded hole, 4. Top cover, 401. Mounting groove, 5. Drive shaft, 6. Stirring rod, 7. Fastening bolt, 8. Injection pipe, 9. Sealing cap, 10. Cover plate, 1001. First through hole, 1002. Second through hole, 11. Stirring motor, 12. First gear, 13. Second gear, 14. Stirring blade, 15. Cavity, 16. Heating pipe, 17. Heater, 18. Water pipe, 19. Water pipe connector, 20. Filling tank, 21. Filling pump, 22. Dispensing pipe, 23. Weighing instrument, 24. Filling port, 25. Positioning frame, 26. Limiting groove, 27. Support leg, 28. Controller. Detailed Implementation

[0026] To more clearly illustrate the technical solution of this utility model, the following description is made in conjunction with the accompanying drawings. Obviously, the drawings described below are only one embodiment of this utility model. For those skilled in the art, other embodiments can be obtained based on these drawings and embodiments without creative effort, and all of them fall within the protection scope of this utility model.

[0027] according to Figure 1-6 As shown, an oil adjuvant inactivated vaccine mixing device includes a heating tank 1, a mixing tank 2 installed inside the heating tank 1, the bottom of the mixing tank 2 having a conical structure, a liquid outlet 201 at the bottom end of the mixing tank 2, an infusion pipe 3 fixedly installed at the bottom of the heating tank 1, a filling assembly installed at the bottom of the heating tank 1, and a stirring assembly installed at the top of the heating tank 1. The stirring assembly includes a top cover 4, which is fixedly installed on the top of the heating tank 1 by bolts. A drive shaft 5 is rotatably installed at the top center of the top of the top cover 4 via a bearing. A stirring rod 6 is slidably installed on the drive shaft 5, and fastening bolts 7 are fitted on the side wall of the drive shaft 5.

[0028] In this embodiment, the top end of the infusion tube 3 is provided with a threaded hole 301, the bottom end of the outlet 201 is provided with a threaded part 202 that matches the threaded hole 301, the top end of the mixing tank 2 is provided with a boss 203, and the top end of the boss 203 is fixedly installed with a ring handle 204. When installing the mixing tank 2, the outlet 201 and the infusion tube 3 are connected together by a threaded engagement, and the ring handle 204 is used to facilitate the user to rotate the mixing tank 2.

[0029] In this embodiment, a mounting groove 401 is provided at the center of the top of the top cover 4. An injection tube 8 is fixedly installed on the bottom wall of the mounting groove 401 near the edge. A sealing cap 9 is installed at the top of the injection tube 8. A cover plate 10 is fixedly installed at the top of the mounting groove 401 by bolts. A first through hole 1001 is provided on the cover plate 10, which corresponds to the position of the injection tube 8. A second through hole 1002 is provided at the center of the cover plate 10. The injection tube 8 and the drive shaft 5 are respectively avoided through the first through hole 1001 and the second through hole 1002. The user can inject the vaccine to be mixed into the mixing tank 2 through the injection tube 8.

[0030] In this embodiment, a stirring motor 11 is fixedly installed on the cover plate 10. The power output end of the stirring motor 11 extends into the mounting groove 401. A first gear 12 is fixedly installed on the power output shaft of the stirring motor 11. A second gear 13 that meshes with the first gear 12 is welded onto the drive shaft 5. The stirring motor 11 drives the first gear 12 for transmission. With the cooperation of the first gear 12 and the second gear 13, the drive shaft 5 rotates. The stirring rod 6 has a hexagonal cross-section. A stirring blade 14 is fixedly installed at the bottom end of the stirring rod 6. The stirring rod 6 rotates synchronously with the drive shaft. The stirring blade 14 at the bottom end of the stirring rod 6 stirs the vaccine in the mixing tank 2.

[0031] In this embodiment, the outer diameter of the mixing tank 2 is smaller than the inner diameter of the heating tank 1. A cavity 15 is provided between the mixing tank 2 and the heating tank 1. A heating pipe 16 is fixedly installed at the bottom of the cavity 15. A heater 17 is fixedly installed at the bottom of the heating tank 1. The heating pipe 16 passes through the bottom wall of the heating tank 1 and is connected to the heater 17. The connection between the heating pipe 16 and the heating tank 1 is sealed. A water pipe 18 is fixedly installed at the lower end of the outer wall of the heating tank 1. The water pipe 18 is connected to the cavity 15. A water pipe connector 19 is installed at the end of the water pipe 18 away from the heating tank 1. The water pipe 18 is connected to a water supply device (not shown in the figure) through the water pipe connector 19. The water supply device injects pure water into the cavity 15 and heats the water in the cavity 15 through the heating pipe 16, thereby heating the vaccine in the mixing tank 2 in a water bath.

[0032] In this embodiment, the filling assembly includes a filling box 20. A heating tank 1 is fixedly installed on the top of the filling box 20 by bolts. The filling box 20 is hollow inside. A filling pump 21 is installed inside the filling box 20. The filling pump 21 is fixedly installed at the bottom of the heating tank 1. An infusion pipe 3 is connected to the inlet end of the filling pump 21. An outlet pipe 22 is fixedly installed at the outlet end of the filling pump 21. A weighing instrument 23 is fixedly installed on the bottom wall of the filling box 20. The weighing instrument 23 is located directly below the outlet pipe 22. A filling port 24 is opened on the front side wall of the filling box 20. During filling, the vaccine canister is placed on the weighing instrument 23, and the mouth of the vaccine canister is aligned with the outlet pipe 22. The vaccine in the mixing tank 2 is drawn out and filled into the vaccine canister by the filling pump 21. At the same time, the filling volume is accurately measured by the weighing instrument 23. After the set value is reached, the filling pump 21 stops filling.

[0033] In this embodiment, a positioning frame 25 is provided above the weighing instrument 23. The positioning frame 25 is fixedly installed on the inner side wall of the filling box 20. The positioning frame 25 is provided with a limiting groove 26. The size of the limiting groove 26 matches the size of the vaccine bottle. When placing the vaccine bottle, the positioning frame 25 assists the user in placing the vaccine bottle to avoid the situation where the mouth of the vaccine bottle is not aligned with the dispensing tube 22.

[0034] In this embodiment, support legs 27 are fixedly installed at the bottom of the filling tank 20 near the four ends. A controller 28 is fixedly installed on the front side wall of the filling tank 20. The controller 28 is connected to the stirring motor 11, heater 17, filling pump 21 and weighing instrument 23 through wires. The user controls the start and stop of the equipment through the controller 28. The controller 28 is also equipped with a display screen, which can display the operating parameters of the equipment, such as temperature and stirring speed, so that the operator can monitor and adjust the operating status of the equipment in real time.

[0035] In use, after removing the sealing cap 9, the user installs tools such as a funnel onto the injection tube 8 to pour the vaccine to be mixed into the mixing tank 2. Then, according to the mixing requirements, the user loosens the fastening bolt 7 to adjust the height of the stirring rod 6. The stirring rod 6 is engraved with scale markings (not shown in the figure), allowing the user to accurately adjust the height of the stirring rod 6 to adapt to different mixing needs, thus improving the versatility of the equipment. During mixing, the stirring motor 11 drives the stirring rod 6 to rotate, and the stirring blades 14 stir the vaccine in the mixing tank 2, while simultaneously heating the cavity 1 of the tank 1. Water is filled into cavity 15, and the water in cavity 15 is heated by heating pipe 16, thereby heating the vaccine in mixing tank 2 in a water bath. After mixing is completed, the user places the vaccine can on weighing instrument 23 and aligns the can opening with the outlet pipe 22. The filling pump 21 draws out the vaccine from mixing tank 2 and fills it into the vaccine can. At the same time, the filling volume is accurately measured by weighing instrument 23. After the set value is reached, the filling pump 21 stops filling. The vaccine in mixing tank 2 will be completely discharged from mixing tank 2 under the guidance of the conical surface, avoiding vaccine residue in mixing tank 2 and thus avoiding waste.

[0036] The above embodiments are merely exemplary embodiments of this utility model and are not intended to limit this utility model. The scope of protection of this utility model is defined by the claims. Those skilled in the art can make various modifications or equivalent substitutions to this utility model within its substance and scope of protection, and such modifications or equivalent substitutions should also be considered to fall within the scope of protection of this utility model.

Claims

1. An oil adjuvant inactivated vaccine mixing device, comprising a heating tank (1), characterized in that: The heating tank (1) is fitted with a mixing tank (2). The bottom of the mixing tank (2) is conical. The bottom of the mixing tank (2) is provided with a liquid outlet (201). The bottom of the heating tank (1) is fixedly installed with an infusion pipe (3). The bottom of the heating tank (1) is provided with a filling assembly. The top of the heating tank (1) is provided with a stirring assembly. The stirring assembly includes a top cover (4). The top cover (4) is fixedly installed on the top of the heating tank (1). A drive shaft (5) is rotatably installed at the top center of the top of the top cover (4). A stirring rod (6) is slidably installed on the drive shaft (5). Fastening bolts (7) are fitted on the side wall of the drive shaft (5).

2. The oil adjuvant inactivated vaccine mixing device according to claim 1, characterized in that, The infusion tube (3) has a threaded hole (301) at the top end, and the outlet (201) has a threaded part (202) at the bottom end that matches the threaded hole (301). The mixing tank (2) has a boss (203) at the top end, and a ring handle (204) is fixedly installed on the top end of the boss (203).

3. The oil adjuvant inactivated vaccine mixing device according to claim 1, characterized in that, The top cover (4) has an installation groove (401) at the center of the top. An injection tube (8) is fixedly installed on the bottom wall of the installation groove (401) near the edge. A sealing cap (9) is installed on the top of the injection tube (8). A cover plate (10) is fixedly installed on the top of the installation groove (401). A first through hole (1001) is opened on the cover plate (10) with a position corresponding to the position of the injection tube (8). A second through hole (1002) is opened at the center of the cover plate (10).

4. The oil adjuvant inactivated vaccine mixing device according to claim 3, characterized in that, A stirring motor (11) is fixedly installed on the cover plate (10), a first gear (12) is fixedly installed on the power output shaft of the stirring motor (11), and a second gear (13) that meshes with the first gear (12) is provided on the drive shaft (5).

5. The oil adjuvant inactivated vaccine mixing device according to claim 4, characterized in that, The stirring rod (6) has a hexagonal cross-section, and a stirring blade (14) is fixedly installed at the bottom end of the stirring rod (6).

6. The oil adjuvant inactivated vaccine mixing device according to claim 1, characterized in that, The outer diameter of the mixing tank (2) is smaller than the inner diameter of the heating tank (1). A cavity (15) is provided between the mixing tank (2) and the heating tank (1). A heating pipe (16) is fixedly installed at the bottom of the cavity (15). A heater (17) is fixedly installed at the bottom of the heating tank (1). The heating pipe (16) passes through the bottom wall of the heating tank (1) and is connected to the heater (17). A water pipe (18) is fixedly installed at the lower end of the outer wall of the heating tank (1). The water pipe (18) is connected to the cavity (15). A water pipe connector (19) is installed at the end of the water pipe (18) away from the heating tank (1).

7. The oil adjuvant inactivated vaccine mixing device according to claim 1, characterized in that, The filling assembly includes a filling tank (20), a heating tank (1) is fixedly installed on the top of the filling tank (20), the filling tank (20) is hollow inside, a filling pump (21) is provided inside the filling tank (20), the filling pump (21) is fixedly installed at the bottom of the heating tank (1), the infusion pipe (3) is connected to the inlet end of the filling pump (21), the outlet end of the filling pump (21) is fixedly installed with an outlet pipe (22), a weighing instrument (23) is fixedly installed on the bottom wall of the filling tank (20), the weighing instrument (23) is located directly below the outlet pipe (22), and a filling port (24) is opened on the front side wall of the filling tank (20).

8. The oil adjuvant inactivated vaccine mixing device according to claim 7, characterized in that, The weighing instrument (23) is provided with a positioning frame (25) above it. The positioning frame (25) is fixedly installed on the inner side wall of the filling box (20). The positioning frame (25) is provided with a limiting groove (26).

9. The oil adjuvant inactivated vaccine mixing device according to claim 7, characterized in that, The bottom of the filling box (20) is fixedly installed with support legs (27) near the four ends, and a controller (28) is fixedly installed on the front side wall of the filling box (20).

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