A low temperature heparin sodium precipitation collection device

Abstract

The utility model belongs to heparin sodium precipitation technical field, concretely is a kind of heparin sodium low-temperature precipitation collection device, including pivot, still including annular filter screen, setting in the lower of reaction kettle, annular filter screen bottom end is fixed with fixed plate, and fixed plate upper rotary plate, rotary plate both sides are fixed with the scraping blade that is attached with annular filter screen inner wall, heat conduction plate, be spiral and be fixed in the cavity that reaction kettle is opened, heat conduction plate and cavity form spiral flow channel, the upper and lower ends of reaction kettle are respectively equipped with with the liquid outlet pipe and liquid inlet pipe that communicate with cavity;The utility model can be collected to heparin sodium precipitation by the bucket-shaped container formed by annular filter screen and fixed plate, rotary plate drives scraping blade to rotate in annular filter screen inner wall scraping, avoid its blockage, secondly, realize the quick and even cooling of material in reaction kettle by heat conduction plate.

Description

Technical Field

[0001] This invention belongs to the field of heparin sodium precipitation technology, and in particular relates to a low-temperature precipitation and collection device for heparin sodium. Background Technology

[0002] Heparin sodium is a widely used anticoagulant drug in clinical practice. In its industrial production, the low-temperature precipitation method is the core process for separating and purifying the effective components. By controlling the temperature of the reaction system to the critical point of heparin sodium precipitation, the target components are separated from the mother liquor in the form of precipitation, thereby achieving product enrichment.

[0003] Currently, existing cryogenic precipitation collection devices typically insert a suction pipe inside the tank cavity to collect the precipitate. This suction pipe draws out the clear mother liquor from the upper layer of the reaction tank, leaving the precipitate inside. However, during the suction process, the liquid is easily disturbed and often accompanied by a entrapment effect on the lower precipitate, causing some heparin sodium precipitate to be drawn out along with the mother liquor. This not only reduces the yield of heparin sodium but may also increase the difficulty of subsequent mother liquor treatment.

[0004] To address the aforementioned issues, this application proposes a low-temperature precipitation and collection device for heparin sodium. Utility Model Content

[0005] The purpose of this invention is to provide a low-temperature precipitation and collection device for heparin sodium, which solves the problems mentioned in the background art.

[0006] To solve the above-mentioned technical problems, this utility model is achieved through the following technical solution:

[0007] This utility model relates to a low-temperature precipitation and collection device for heparin sodium, including a rotating shaft and an annular filter screen disposed below a reaction vessel. A fixing plate is fixed to the bottom of the annular filter screen, and a rotating plate is located above the fixing plate. Scrapers and heat-conducting plates are fixed on both sides of the rotating plate and are attached to the inner wall of the annular filter screen. The heat-conducting plates are spirally fixed in a cavity opened in the reaction vessel, and the heat-conducting plates and the cavity form a spiral flow channel. The upper and lower ends of the reaction vessel are respectively provided with an outlet pipe and an inlet pipe communicating with the cavity.

[0008] Furthermore, the bottom of the reaction vessel is connected to a discharge pipe, and a valve is provided on the discharge pipe. A transfer box is provided outside the annular filter screen, and a drain pipe is connected to one side of the transfer box. A connecting pipe is connected to the top of the transfer box, and a matching connecting flange is fixedly provided at the upper end of the connecting pipe and the lower end of the discharge pipe.

[0009] Furthermore, a through groove is provided at the bottom of the transfer box, the outer diameter of the fixing plate is the same as the diameter of the through groove, and a sealing rubber ring with an interference fit to the through groove is fixed on the outer wall of the fixing plate. A fixing seat is fixed at the bottom of the fixing plate, and a fixing block is fixed at the bottom of the transfer box. Connecting flanges that cooperate with each other are fixed at the bottom of the fixing block and on the outer wall of the fixing seat, respectively.

[0010] Furthermore, a sealing groove is provided at the bottom end of the discharge pipe, and a fixing ring is fixed at the top end of the annular filter screen. The outer diameter of the fixing ring is equal to the outer diameter of the sealing groove. An annular rubber ring that is interference-fitted with the top end of the fixing ring is provided in the sealing groove.

[0011] Furthermore, a reinforcing rod is provided axially on the outer side of the annular filter screen, and the two ends of the reinforcing rod are respectively fixedly connected to the annular rubber ring and the fixing plate.

[0012] Furthermore, a groove is provided inside the fixed base, and a second motor is fixedly connected to the fixed plate inside the groove, and the output end of the second motor is fixedly connected to the rotating plate.

[0013] Furthermore, a rotating shaft is rotatably installed inside the reaction vessel, and a mixing rod is fixedly provided on the outer wall of the rotating shaft. A motor with its output end fixedly connected to the rotating shaft is fixedly provided at the top of the reaction vessel.

[0014] This utility model has the following beneficial effects:

[0015] This invention uses a barrel-shaped structure formed by an annular filter and a fixed plate to collect heparin sodium precipitate. During collection, the rotating plate can rotate to drive the scraper to scrape along the inner wall of the annular filter, removing the heparin sodium precipitate adhering to the surface of the filter and preventing the filter from being blocked due to precipitate accumulation.

[0016] This invention introduces a low-temperature medium into the cavity through an inlet pipe. After entering the cavity, the low-temperature medium flows along the spiral formed by the heat-conducting plate and the cavity and is discharged through the fixing ring. The spiral channel extends the residence time of the low-temperature medium in the reaction vessel, making the heat transfer more uniform, thereby stabilizing the low-temperature environment in the reaction vessel and avoiding uneven dissolution or crystallization of heparin sodium due to temperature fluctuations.

[0017] Of course, any product implementing this utility model does not necessarily need to achieve all of the advantages described above at the same time. Attached Figure Description

[0018] To more clearly illustrate the technical solutions of the embodiments of this utility model, the accompanying drawings used in the description of the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this utility model. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0019] Figure 1 This is a schematic diagram of the overall appearance structure of this utility model;

[0020] Figure 2 This is a cross-sectional view of the reaction vessel of this utility model;

[0021] Figure 3 This is a cross-sectional view of the discharge pipe and transfer box of this utility model;

[0022] Figure 4 This is a cross-sectional structural diagram of the annular filter screen and fixing base of this utility model;

[0023] The attached diagram lists the components represented by each number as follows:

[0024] In the diagram: 1. Reaction vessel; 101. Cavity; 102. Discharge pipe; 103. Inlet pipe; 2. Rotating shaft; 201. Mixing rod; 3. Motor 1; 4. Discharge pipe; 401. Sealing groove; 5. Transfer box; 501. Fixing block; 502. Through groove; 6. Connecting pipe; 7. Discharge pipe; 8. Annular rubber ring 1; 9. Annular filter screen; 10. Fixing ring; 11. Fixing plate; 1101. Sealing rubber ring 2; 12. Fixing seat; 1201. Tank body; 13. Scraper; 14. Rotating plate; 15. Motor 2; 16. Heat-conducting plate; 17. Reinforcing rod. Detailed Implementation

[0025] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0026] In the description of this utility model, it should be understood that the terms "opening", "upper", "lower", "thickness", "top", "middle", "length", "inner", "around" and other terms indicating orientation or positional relationship are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the components or elements referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this utility model.

[0027] Please see Figure 1 - Figure 4As shown, this utility model is a low-temperature precipitation and collection device for heparin sodium, including a rotating shaft 2 and an annular filter 9, which is set below the reaction tank 1. The bottom end of the annular filter 9 is fixed with a fixing plate 11, and a rotating plate 14 is above the fixing plate 11. Scrapers 13 that fit against the inner wall of the annular filter 9 are fixed on both sides of the rotating plate 14. A heat-conducting plate 16 is spirally fixed in the cavity 101 opened in the reaction tank 1. The heat-conducting plate 16 and the cavity 101 form a spiral flow channel. The upper and lower ends of the reaction tank 1 are respectively provided with an outlet pipe 102 and an inlet pipe 103 that communicate with the cavity 101.

[0028] This embodiment provides a heparin sodium cryogenic precipitation collection device. A feed pipe is fixed at the top of the reaction tank 1. A cryogenic medium (such as frozen brine) is supplied to the reaction tank 1 through the liquid inlet pipe 103 and the liquid outlet pipe 102 to provide cooling liquid circulation. The heat conduction plate 16 is made of a metal material with high thermal conductivity (such as copper alloy). The heat conduction plate 16 accelerates the heat exchange rate and improves the cooling rate of the material in the reaction tank 1. The fixed plate 11 and the annular filter screen 9 form a barrel-shaped container to contain the heparin sodium precipitation. The annular filter screen 9 intercepts the heparin sodium precipitation, and the filtrate is discharged through the mesh. The rotating plate 14 drives the scraper 13 to rotate and scrape along the inner wall of the annular filter screen 9 to prevent the mesh of the annular filter screen 9 from being blocked.

[0029] The bottom of the reaction tank 1 is connected to a discharge pipe 4, and a valve is provided on the discharge pipe 4. A transfer box 5 is provided outside the annular filter screen 9, and a drain pipe 7 is connected to one side of the transfer box 5. A connecting pipe 6 is connected to the top of the transfer box 5, and a matching connecting flange is fixed to the upper end of the connecting pipe 6 and the lower end of the discharge pipe 4. The solution filtered by the annular filter screen 9 enters the transfer box 5 and is discharged through the drain pipe 7. The connecting pipe 6 and the discharge pipe 4 are fixed together by the connecting flange and bolts to achieve a sealed connection. It can be disassembled for cleaning or maintenance later.

[0030] The transfer box 5 has a through groove 502 at its bottom end. The outer diameter of the fixing plate 11 is the same as the diameter of the through groove 502. A sealing rubber ring 1101 that is interference-fitted with the through groove 502 is fixed to the outer wall of the fixing plate 11. A fixing seat 12 is fixed to the bottom end of the fixing plate 11. A fixing block 501 is fixed to the bottom end of the transfer box 5. A connecting flange that matches each other is fixed to the bottom end of the fixing block 501 and the outer wall of the fixing seat 12. The outer diameter of the fixing ring 10 is less than or equal to that of the fixing block 501. The outer diameter of plate 11 is such that after the filtrate is completely discharged, the heparin sodium precipitate is collected in the barrel-shaped container composed of the annular filter screen 9 and the fixed plate 11. The fixed seat 12 and the fixed block 501 are fixed together by connecting flange and bolts. The fixed seat 12 and the fixed block 501 are detachably connected, so the user can remove the fixed seat 12 to remove the fixed plate 11 and the annular filter screen 9. The sealing rubber ring 1101 and the through groove 502 are interference fit to achieve the seal between the transfer box 5 and the fixed plate 11.

[0031] The discharge pipe 4 has a sealing groove 401 at its bottom end, and the annular filter 9 has a fixing ring 10 fixed at its top end. The outer diameter of the fixing ring 10 is equal to the outer diameter of the sealing groove 401. The sealing groove 401 has an annular rubber ring 8 that is interference-fitted with the top end of the fixing ring 10, which enhances the sealing performance between the annular rubber ring 8 and the discharge pipe 4 and prevents gaps between the annular rubber ring 8 and the discharge pipe 4 from causing the heparin sodium solution to be discharged without being filtered by the annular filter 9.

[0032] The annular filter screen 9 is provided with a reinforcing rod 17 on its outer side along the axial direction. The two ends of the reinforcing rod 17 are respectively fixed to the annular rubber ring 8 and the fixing plate 11, thereby improving the structural strength of the annular filter screen 9 and preventing the annular filter screen 9 from deforming.

[0033] The fixed base 12 has a groove 1201, and a motor 15 fixedly connected to the fixed plate 11 is provided in the groove 1201. The output end of the motor 15 is fixedly connected to the rotating plate 14. The motor 15 is used to drive the rotating plate 14 to rotate, thereby driving the two scrapers 13 to rotate and avoiding the clogging of the mesh of the annular filter screen 9.

[0034] The reaction vessel 1 is equipped with a rotating shaft 2, and a mixing rod 201 is fixed on the outer wall of the rotating shaft 2. The top of the reaction vessel 1 is equipped with a motor 3 whose output end is fixed to the rotating shaft 2. The rotating shaft 2 is driven to rotate by the motor 3, which drives the mixing rod 201 to stir and mix the materials in the reaction vessel 1, thereby promoting the formation of sediment.

[0035] It is understood that this utility model can collect heparin sodium precipitate through the barrel-shaped container formed by the annular filter screen 9 and the fixed plate 11. The rotating plate 14 drives the scraper 13 to rotate and scrape the inner wall of the annular filter screen 9 to avoid clogging. Secondly, the heat-conducting plate 16 enables the material in the reaction vessel 1 to cool down quickly and evenly.

[0036] A specific application of the operation process in this embodiment is as follows: the material is fed into the reaction tank 1 through the feed pipe, and the rotating shaft 2 is driven to rotate by the motor 3, so that the mixing rod 201 stirs the material in the reaction tank 1 to promote precipitation. At the same time, a low temperature medium is introduced into the liquid inlet pipe 103. The low temperature medium moves along the heat conduction plate 16 and is finally discharged from the liquid outlet pipe 102. The low temperature medium quickly reduces the temperature of the material in the reaction tank 1, promoting the full precipitation of heparin sodium.

[0037] After the sodium heparin precipitation is complete, open the valve of the discharge pipe 4 to allow the material to enter the annular filter screen 9 through the annular rubber ring 8. The material is filtered through the annular filter screen 9, and the sodium heparin precipitation is collected in the annular filter screen 9. During filtration, start the motor 15. The motor 15 drives the scraper 13 through the rotating plate 14 to scrape off the precipitation adhering to the inner wall of the annular filter screen 9, thus preventing the annular filter screen 9 from clogging. The filtrate enters the transfer box 5 through the mesh and is finally discharged through the drain pipe 7. After the filtrate is completely discharged, the user can remove the fixing seat 12 to take out the annular filter screen 9.

[0038] In the description of this specification, references to terms such as "an embodiment," "example," and "specific example" indicate that a specific feature, structure, material, or characteristic described in connection with that embodiment or example is included in at least one embodiment or example of the present invention. In this specification, illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples.

[0039] The preferred embodiments of this utility model disclosed above are merely illustrative of the present utility model. These preferred embodiments do not exhaustively describe all details, nor do they limit the utility model to the specific implementations described. Clearly, many modifications and variations can be made based on the content of this specification. This specification selects and specifically describes these embodiments to better explain the principles and practical applications of this utility model, thereby enabling those skilled in the art to better understand and utilize it. This utility model is limited only by the claims and their full scope and equivalents.

Claims

1. A heparin sodium cryogenic precipitation and collection device, comprising a rotating shaft (2), characterized in that, Also includes: An annular filter (9) is set below the reaction vessel (1). A fixing plate (11) is fixed at the bottom of the annular filter (9), and a rotating plate (14) is above the fixing plate (11). Scrapers (13) that fit against the inner wall of the annular filter (9) are fixed on both sides of the rotating plate (14). A heat-conducting plate (16) is fixed in a spiral shape in the cavity (101) of the reaction vessel (1). The heat-conducting plate (16) and the cavity (101) form a spiral flow channel. The upper and lower ends of the reaction vessel (1) are respectively provided with an outlet pipe (102) and an inlet pipe (103) that communicate with the cavity (101).

2. The heparin sodium low-temperature precipitation and collection device according to claim 1, characterized in that: The bottom of the reaction vessel (1) is connected to a discharge pipe (4), and a valve is provided on the discharge pipe (4). A transfer box (5) is provided outside the annular filter (9), and a drain pipe (7) is connected to one side of the transfer box (5). A connecting pipe (6) is connected to the top of the transfer box (5), and a connecting flange that matches each other is fixed at the upper end of the connecting pipe (6) and the lower end of the discharge pipe (4).

3. The heparin sodium low-temperature precipitation collection device according to claim 2, characterized in that: The transfer box (5) has a through groove (502) at the bottom. The outer diameter of the fixing plate (11) is the same as the diameter of the through groove (502). The outer wall of the fixing plate (11) is fixed with a sealing rubber ring (1101) that is interference fit with the through groove (502). The bottom of the fixing plate (11) is fixed with a fixing seat (12). The bottom of the transfer box (5) is fixed with a fixing block (501). The bottom of the fixing block (501) and the outer wall of the fixing seat (12) are respectively fixed with mutually matching connecting flanges.

4. The heparin sodium low-temperature precipitation collection device according to claim 3, characterized in that: The bottom end of the discharge pipe (4) is provided with a sealing groove (401), and the top end of the annular filter screen (9) is fixed with a fixing ring (10), and the outer diameter of the fixing ring (10) is equal to the outer diameter of the sealing groove (401). The sealing groove (401) is provided with an annular rubber ring (8) that is interference-fitted with the top end of the fixing ring (10).

5. The heparin sodium low-temperature precipitation and collection device according to claim 4, characterized in that: The annular filter screen (9) is provided with a reinforcing rod (17) on its outer side, and the two ends of the reinforcing rod (17) are respectively fixed to the annular rubber ring (8) and the fixing plate (11).

6. The heparin sodium low-temperature precipitation collection device according to claim 3, characterized in that: The fixed base (12) has a groove (1201) inside, and a motor (15) is fixedly connected to the fixed plate (11) inside the groove (1201), and the output end of the motor (15) is fixedly connected to the rotating plate (14).

7. The heparin sodium low-temperature precipitation collection device according to claim 1, characterized in that: The reaction vessel (1) is rotatably installed with a rotating shaft (2), and a mixing rod (201) is fixed on the outer wall of the rotating shaft (2). The top of the reaction vessel (1) is fixed with a motor (3) whose output end is fixed to the rotating shaft (2).

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