An mRNA in vitro transcription rocker fixing device

Abstract

This invention discloses a mRNA in vitro transcription shaker fixation device, including a fixing plate with side plates connected to both sides. A sliding rod is slidably connected to the side plates, and a clamping rod is slidably connected to the sliding rod via a connecting block. An abutment rod is slidably connected to the clamping rod, and a spring connects the abutment rod to the connecting block. The lower end of the abutment rod abuts against the sliding rod. A groove is formed on the side plate, and the sliding rod is slidably connected to the groove. A synchronization bar connects the sliding rods, and an adjustment mechanism for adjusting the height of the clamping rod is connected to the synchronization bar. The adjustment mechanism includes a locking block and an adjustment plate, which is fixedly connected to the outside of the side plate and has a locking groove. This invention utilizes the clamping rod to clamp and fix the reaction vessel, and the clamping operation is simple; the clamping position can be adjusted by simply pulling the abutment rod. The rubber strip effectively ensures the structural stability of the clamping rod connection.

Description

Technical Field

[0001] This utility model relates to the field of biomedical device technology, and in particular to an mRNA in vitro transcription shaker fixation device. Background Technology

[0002] An in vitro mRNA transcription shaker is a device used for the in vitro synthesis of mRNA. It uses controlled oscillation to ensure uniform mixing of the reaction system, maintain suitable temperature and rotation speed, and promote efficient enzymatic transcription. Parameters can be precisely controlled to reduce local concentration differences, improve mRNA synthesis efficiency and uniformity, and it is widely used in vaccine development, biopharmaceuticals, and other fields.

[0003] mRNA in vitro transcription shakers require a fixation structure to prevent uneven reactions and temperature fluctuations caused by test tube shaking, avoid damage and leakage, and ensure experimental safety and reliable results. However, traditional shaker fixation structures are limited and can only be used for a single product, such as test tubes, but not beakers. Furthermore, traditional fixation structures have poor adjustability, making it easy for containers to vibrate and collide with the fixation structure during shaking, resulting in an inability to achieve a uniform shaking effect.

[0004] Based on this, a shaker fixation device for in vitro mRNA transcription is proposed. Utility Model Content

[0005] The purpose of this invention is to provide an mRNA in vitro transcription shaker fixation device to solve the above-mentioned problems.

[0006] To achieve the above objectives, the present invention adopts the following technical solution:

[0007] An mRNA in vitro transcription shaker fixation device includes a fixation plate, side plates connected to both sides of the fixation plate, a slide rod slidably connected to the side plate, a clamping rod slidably connected to the slide rod via a connecting block, an abutment rod slidably connected to the clamping rod, a spring connecting the abutment rod and the connecting block, and the lower end of the abutment rod abutting against the slide rod.

[0008] Preferably, a sliding groove is provided on the side plate, and the sliding rod is slidably connected to the sliding groove.

[0009] Preferably, a synchronization bar is connected between the slide bars, and an adjustment mechanism for adjusting the height of the clamping rod is connected to the synchronization bar.

[0010] Preferably, the adjustment mechanism includes a locking block and an adjustment plate. The adjustment plate is fixedly connected to the outside of the side plate. A locking groove is provided on the adjustment plate. The locking block is slidably connected to the synchronization bar via a pull rod. A spring is connected between the locking block and the synchronization bar. A second sliding groove is provided on the side plate. The pull rod is slidably connected to the second sliding groove.

[0011] Preferably, a test tube clamp is connected to one side of the side plate.

[0012] Preferably, a rubber strip is connected to the sliding rod, and the rubber strip is positioned directly below the abutment rod.

[0013] In summary, due to the adoption of the above technical solution, the beneficial effects of this utility model are:

[0014] 1. This application adopts a clamping rod structure to clamp and fix the reaction vessel. The clamping operation is simple. The clamping position can be adjusted by simply pulling the abutment rod. The rubber strip effectively ensures the structural stability of the clamping rod connection.

[0015] 2. This application adopts a card block structure, which utilizes the cooperation between the card block and the card slot to quickly adjust the clamping height of the clamping rod, thereby enabling the fixation of reaction vessels of different heights. At the same time, a test tube clamp is provided, which can clamp the test tube by moving the clamping rod to prevent the test tube from tilting when shaken. Attached Figure Description

[0016] Figure 1 A schematic diagram of the overall structure of the fixing device provided according to an embodiment of the present utility model is shown;

[0017] Figure 2 A schematic diagram of the test tube clamp connection provided according to an embodiment of the present invention is shown;

[0018] Figure 3 A schematic diagram of the card block connection provided according to an embodiment of the present invention is shown.

[0019] Legend:

[0020] 1. Fixing plate; 2. Side plate; 3. Adjusting plate; 4. Slot; 5. Slide groove one; 6. Slide groove two; 7. Slide rod; 8. Rubber strip; 9. Synchronizing strip; 10. Connecting block; 11. Clamping rod; 12. Test tube clamp; 13. Locking block; 14. Pull rod; 15. Abutment rod; 16. Spring. Detailed Implementation

[0021] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those skilled in the art without creative effort are within the protection scope of the present utility model.

[0022] Please see Figures 1-3 This utility model provides a technical solution:

[0023] An mRNA in vitro transcription shaker fixation device includes a fixation plate 1 connected above the shaker. After the shaker is started, the fixation plate 1 can be shaken. Side plates 2 are connected to both sides of the fixation plate 1. Sliding rods 7 are slidably connected to the side plates 2. There are two sliding rods 7. The two sliding rods 7 can clamp the container. The sliding rods 7 are slidably connected to the clamping rods 11 through the connecting block 10. The clamping rods 11 are slidably connected to the abutting rods 11. Pulling the abutting rods 15 upward can easily move the clamping rods 11. A spring 16 is connected between the abutting rods 15 and the connecting block 10. The lower end of the abutting rods 15 abuts against the sliding rods 7.

[0024] Specifically, such as Figure 1 As shown, a sliding groove 5 is provided on the side plate 2, and the sliding rod 7 is slidably connected to the sliding groove 5. By setting the sliding groove 5, the stability of the sliding structure of the sliding rod 7 is improved.

[0025] Specifically, such as Figure 1 As shown, a synchronization bar 9 is connected between the slide bars 7. An adjustment mechanism for adjusting the height of the clamping rods 11 is connected to the synchronization bar 9. By setting the synchronization bar 9, it can be ensured that the two clamping rods 11 rise and fall synchronously.

[0026] Specifically, such as Figure 2 and Figure 3 As shown, the adjustment mechanism includes a locking block 13 and an adjustment plate 3. The adjustment plate 3 is fixedly connected to the outside of the side plate 2. The adjustment plate 3 has a locking groove 4. Pulling the pull rod 14 can separate the locking block 13 from the locking groove 4. The spring 16 connected to one side of the locking block 13 can ensure stable docking between the locking block 13 and the locking groove 4. The locking block 13 is slidably connected to the synchronization bar 9 through the pull rod 14. The spring 16 is connected between the locking block 13 and the synchronization bar 9. The side plate 2 has a second sliding groove 6. The pull rod 14 is slidably connected to the second sliding groove 6.

[0027] Specifically, such as Figure 2 and Figure 3 As shown, a test tube clamp 12 is connected to one side of the side plate 2. The test tube clamp 12, together with a single clamping rod 11, can clamp and fix the test tube.

[0028] Specifically, such as Figure 3 As shown, a rubber strip 8 is connected to the slide rod 7. The rubber strip 8 is located directly below the abutment rod 15. By setting the rubber strip 8, the friction force of the lower end of the abutment rod 15 can be increased, thus preventing the abutment rod 15 from shifting.

[0029] In summary, the mRNA in vitro transcription shaker fixation device provided in this embodiment can fix the container for the in vitro transcription reaction of mRNA by placing the container between the clamping rods 11, pulling the pull rod 14, and inserting the locking block 13 into the appropriate locking slot 4, so that the clamping rods 11 move to a suitable height, ensuring that when the clamping rods 11 are close to each other, they can abut against the outside of the container.

[0030] Then pull the abutment rod 15 upward to adjust the position between the clamping rods 11, ensuring that the clamping rods 11 are clamped on the outside of the container. Then release the abutment rod 15. The rubber strip 8 can effectively ensure the stability of the abutment structure of the abutment rod 15.

[0031] When it is necessary to fix a test tube with a small bottom area, the test tube can be placed on one side of the test tube clamp 12, and the clamping rod 11 can be adjusted to clamp the test tube, thereby improving the stability of the in vitro transcription reaction of mRNA in the container.

[0032] The above description of the embodiments enables those skilled in the art to make or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the present invention. Therefore, the present invention is not to be limited to the embodiments shown herein, but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. An mRNA in vitro transcription shaker fixation device, comprising a fixation plate (1), characterized in that, The fixed plate (1) is connected to side plates (2) on both sides. A sliding rod (7) is slidably connected to the side plate (2). A clamping rod (11) is slidably connected to the sliding rod (7) through a connecting block (10). An abutting rod (15) is slidably connected to the clamping rod (11). A spring (16) is connected between the abutting rod (15) and the connecting block (10). The lower end of the abutting rod (15) abuts against the sliding rod (7).

2. The mRNA in vitro transcription shaker fixation device according to claim 1, characterized in that, The side plate (2) is provided with a sliding groove (5), and the sliding rod (7) is slidably connected to the sliding groove (5).

3. The mRNA in vitro transcription shaker fixation device according to claim 2, characterized in that, A synchronizing bar (9) is connected between the slide bars (7), and an adjusting mechanism for adjusting the height of the clamping rod (11) is connected to the synchronizing bar (9).

4. The mRNA in vitro transcription shaker fixation device according to claim 3, characterized in that, The adjustment mechanism includes a locking block (13) and an adjustment plate (3). The adjustment plate (3) is fixedly connected to the outside of the side plate (2). The adjustment plate (3) has a locking groove (4). The locking block (13) is slidably connected to the synchronization bar (9) via a pull rod (14). A spring (16) is connected between the locking block (13) and the synchronization bar (9). The side plate (2) has a second sliding groove (6). The pull rod (14) is slidably connected to the second sliding groove (6).

5. The mRNA in vitro transcription shaker fixation device according to claim 1, characterized in that, A test tube clamp (12) is connected to one side of the side plate (2).

6. The mRNA in vitro transcription shaker fixation device according to claim 1, characterized in that, A rubber strip (8) is connected to the slide bar (7), and the rubber strip (8) is located directly below the abutment bar (15).

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