A device for the separation of uric acid in saliva

Abstract

The utility model provides a device for uric acid separation in saliva belongs to biological detection and analytical chemistry technical field. The utility model relates to a device for uric acid separation in saliva, including empty cylinder, teat, piston rod and the piston of installation in the end of piston rod, the piston is arranged in the inner wall of empty cylinder and slides, the upper end portion fixed mounting piston handle of piston rod, its characterized in that, still include wooden porous channel, wooden porous channel fixed mounting in empty cylinder inside, be located below the piston. The utility model device utilizes the natural permeation characteristic of wooden porous channel and the selective adsorption performance of functionalized nanometer material, effectively solved the problem that uric acid and interfering substance separate with difficulty, significantly improved uric acid detection precision and sensitivity, realizes high -efficient separation, its simple structure, practical, novel, convenient operation, fast, can be widely applied in clinical diagnosis and family health monitoring etc. field, and the application prospect is wide.

Description

Technical Field

[0001] This invention belongs to the field of biological detection and analytical chemistry technology, specifically relating to a device for separating uric acid from saliva. Background Technology

[0002] Uric acid, an important indicator of human metabolism, may indicate diseases such as gout and kidney disease if its levels are abnormal. Saliva, as a non-invasive testing sample, is increasingly becoming an important carrier for biomarker detection due to its convenient collection and rich metabolic information. However, saliva contains low levels of uric acid and a large number of interfering substances (such as ascorbic acid and glutathione). These substances may cross-interact with the detection reaction, affecting the sensitivity and accuracy of uric acid testing. This places high demands on the separation of uric acid and subsequent detection. Effective separation of uric acid from interfering substances is crucial for obtaining high-precision test results. Current technologies mostly rely on chemical reagents or precision instruments, which are not only complex and costly but also difficult to meet the needs of portable testing.

[0003] Therefore, there is an urgent need for a device that can efficiently separate uric acid and remove interfering substances to improve detection accuracy and simplify the operation process. Utility Model Content

[0004] To address the problem of inefficient separation of uric acid from interfering substances in saliva in existing technologies, the present invention aims to provide a device for separating uric acid from saliva. This device utilizes a porous wooden channel to achieve selective separation of uric acid from saliva, thereby improving the accuracy of uric acid detection and reducing the influence of interfering substances.

[0005] To achieve the above objectives, the technical solution adopted by this utility model is as follows:

[0006] This invention provides a device for separating uric acid from saliva, including an empty cylinder, a nipple, a piston rod, and a piston installed at the lower end of the piston rod. The piston is slidably disposed on the inner wall of the empty cylinder, and a piston handle is fixedly installed at the upper end of the piston rod. The device also includes a wooden porous channel, which is fixedly installed inside the empty cylinder and located below the piston to provide a filtration path for the saliva sample.

[0007] Furthermore, the interior of the empty cylinder is equipped with two or more porous wooden channels.

[0008] Furthermore, wood porous channels are longitudinally ordered porous structures formed in natural wood after chemical delignification treatment.

[0009] Furthermore, the surface of the wood porous channel is coated with a functional nanomaterial, that is, the surface of the wood porous channel is modified with functional nanomaterials to form a stable functional coating, so as to achieve selective adsorption of uric acid and effective removal of interfering substances.

[0010] Furthermore, the surface of the wood porous channel is coated with a zeolite imidazole ester framework (ZIF) nanocrystal composite material containing cysteine ​​(Cys). That is, the wood porous channel is modified by growing ZIF@Cys nanocrystals on its surface to form a stable functional coating, which can selectively oxidize and remove interfering substances such as ascorbic acid and glutathione, thereby improving the selectivity and precision of uric acid separation.

[0011] Furthermore, the ZIF@Cys nanocrystal coating on the porous wood channel surface includes ZIF-67@Cys nanocrystal coating, ZIF-8@Cys nanocrystal coating, or ZIF-90@Cys nanocrystal coating.

[0012] Furthermore, a porous wooden channel is provided inside the cylinder near the nipple, and the surface of the porous wooden channel is coated with ZIF-67@Cys nanocrystals.

[0013] Furthermore, three porous wooden channels are provided inside the empty cylinder, and the surfaces of the three porous wooden channels are respectively coated with ZIF-67@Cys nanocrystal coating, ZIF-8@Cys nanocrystal coating and ZIF-90@Cys nanocrystal coating.

[0014] Furthermore, the empty cylinder is configured to be transparent, partially transparent, or opaque.

[0015] Furthermore, the empty cylinder is equipped with a measuring range.

[0016] The beneficial effects of this utility model are:

[0017] This invention utilizes the natural permeability of porous wooden channels and the selective adsorption properties of functionalized nanomaterials to effectively solve the problem of difficult separation of uric acid from interfering substances, significantly improving the accuracy and sensitivity of uric acid detection. Even in cases of complex saliva samples and low uric acid concentrations, it can achieve efficient separation. Its structure is simple, practical, and novel, and its operation is convenient and fast. It can be widely used in clinical diagnosis and home health monitoring, and has broad application prospects. Attached Figure Description

[0018] Figure 1 This is a schematic diagram of the structure of a device for separating uric acid from saliva according to the present invention;

[0019] Figure 2 This is a schematic diagram of the structure of the wooden porous channel of this utility model;

[0020] The meanings of the reference numerals in the attached figures are explained below:

[0021] 1. Empty cylinder; 2. Porous wooden channel; 3. Piston rod; 4. Piston; 5. Piston handle; 6. Nipple. Detailed Implementation

[0022] The present invention will now be described in detail with reference to the embodiments.

[0023] Example 1

[0024] like Figure 1 and Figure 2 As shown, an apparatus for separating uric acid from saliva includes an empty cylinder 1, a nipple 6, a piston rod 3, and a piston 4 mounted on the end of the piston rod. The piston 4 is slidably disposed on the inner wall of the empty cylinder 1. A piston handle 5 is fixedly mounted on the upper end of the piston rod 3. The apparatus also includes a wooden porous channel 2, which is fixedly installed inside the empty cylinder 1 on the side near the nipple 6 and below the piston 4, providing a filtration path for the saliva sample.

[0025] The wood porous channel 2 is made of natural wood that has undergone delignification treatment, and its interior forms a longitudinal porous structure, which is conducive to the diffusion and penetration of the sample.

[0026] The surface of the wood-based porous channel 2 is functionalized to grow a ZIF-67@Cys nanocrystal coating. This coating can selectively adsorb uric acid molecules through chemical coordination, while eliminating interfering substances such as ascorbic acid and glutathione.

[0027] Empty cylinder 1 is transparent and has no graduations.

[0028] The usage method is as follows:

[0029] The piston rod 3 and piston 4 are pressed downward by the piston handle 5, squeezing the saliva sample and causing it to enter the functionalized wood porous channel 2 and flow out from the other end of the functionalized wood porous channel 2. The uric acid molecules in the saliva sample are separated and output through the nipple 6.

[0030] Tests have shown that this device can achieve efficient separation in complex samples with low uric acid concentrations and significantly improve detection accuracy.

[0031] Example 2

[0032] A device for separating uric acid from saliva includes an empty cylinder 1, a nipple 6, a piston rod 3, and a piston 4 mounted on the end of the piston rod. The piston is slidably disposed on the inner wall of the empty cylinder. A piston handle 5 is fixedly mounted on the upper end of the piston rod. The device also includes three wooden porous channels 2, which are fixedly installed inside the empty cylinder 1 on the side near the nipple 6 and below the piston 4, providing a filtration path for the saliva sample.

[0033] Set up three wooden porous channels 2.

[0034] The wood porous channel 2 is made of natural wood that has undergone delignification treatment, and its interior forms a longitudinal porous structure, which is conducive to the diffusion and penetration of the sample.

[0035] The surfaces of three wood-based porous channels 2 were functionalized to grow ZIF-67@Cys nanocrystal layers, ZIF-8@Cys nanocrystal coatings, and ZIF-90@Cys nanocrystal coatings, respectively. These layers can selectively adsorb uric acid molecules through chemical coordination while excluding interfering substances such as ascorbic acid and glutathione.

[0036] The empty cylinder 1 is transparent and has a measuring range.

[0037] The above embodiments are merely preferred solutions of this utility model. All equivalent changes or modifications made to the technical solutions described in the claims of this utility model shall be included within the scope of patent protection of this utility model.

Claims

1. A device for separating uric acid from saliva, comprising an empty cylinder, a nipple, a piston rod, and a piston mounted on the end of the piston rod, the piston being slidably disposed on the inner wall of the empty cylinder, and a piston handle being fixedly mounted on the upper end of the piston rod, characterized in that, It also includes a wood porous channel, which is fixedly installed inside the hollow cylinder and located below the piston. The wood porous channel is a longitudinally ordered porous structure formed by chemically removing lignin from natural wood. The surface of the wood porous channel has a coating of nanocrystalline composite material containing cysteine ​​and a zeolite imidazole ester skeleton structure.

2. The apparatus for separating uric acid from saliva as described in claim 1, characterized in that, The interior of the empty cylinder has two or more porous wooden channels.

3. The apparatus for separating uric acid from saliva as described in claim 1, characterized in that, The porous wooden channel surface has a ZIF-67@Cys nanocrystal coating, a ZIF-8@Cys nanocrystal coating, or a ZIF-90@Cys nanocrystal coating.

4. The apparatus for separating uric acid from saliva as described in claim 1, characterized in that, A porous wooden channel is set inside the cylinder near the nipple, and the surface of the porous wooden channel is coated with ZIF-67@Cys nanocrystals.

5. The apparatus for separating uric acid from saliva as described in claim 1, characterized in that, The interior of the empty cylinder is equipped with three porous wooden channels, the surfaces of which are coated with ZIF-67@Cys nanocrystal coating, ZIF-8@Cys nanocrystal coating, and ZIF-90@Cys nanocrystal coating, respectively.

6. The apparatus for separating uric acid from saliva as described in claim 1, characterized in that, The empty cylinder is set to be transparent, partially transparent, or opaque.

7. The apparatus for separating uric acid from saliva as described in claim 1, characterized in that, The empty cylinder is equipped with a measuring range.

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